GREMLIN Database
ACYP - Acylphosphatase
UniProt: P0AB65 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13726
Length: 92 (84)
Sequences: 2151 (1649)
Seq/√Len: 179.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_T61_W3.0151.00
26_E29_R2.8341.00
48_A58_L2.7791.00
9_W43_S2.7171.00
18_G21_Y2.5201.00
11_Y43_S2.4231.00
11_Y74_R2.2991.00
39_L45_E2.1601.00
5_C49_C2.0151.00
8_A59_M1.7221.00
8_A62_L1.7171.00
7_I45_E1.6371.00
24_Q28_K1.6361.00
49_C85_E1.6301.00
5_C47_V1.5511.00
39_L43_S1.5481.00
67_P70_A1.5361.00
46_V62_L1.5261.00
8_A48_A1.4361.00
8_A46_V1.4081.00
6_I79_P1.3841.00
23_T58_L1.3701.00
52_E56_E1.3571.00
59_M77_S1.3281.00
33_T88_D1.3121.00
8_A77_S1.2721.00
66_G70_A1.2421.00
5_C86_L1.2291.00
49_C84_G1.2121.00
48_A62_L1.2061.00
23_T62_L1.2051.00
37_K45_E1.1771.00
7_I35_Y1.1541.00
21_Y25_Y1.1401.00
21_Y24_Q1.1361.00
11_Y76_L1.1151.00
7_I80_H1.1011.00
54_Q57_K1.0701.00
51_E54_Q1.0551.00
30_L58_L1.0501.00
36_A46_V1.0411.00
56_E60_Q1.0381.00
26_E61_W1.0371.00
48_A55_V1.0301.00
47_V80_H0.9810.99
30_L61_W0.9780.99
30_L57_K0.9770.99
26_E30_L0.9710.99
6_I55_V0.9590.99
10_V62_L0.9570.99
63_K75_V0.9540.99
18_G22_T0.9520.99
18_G69_S0.9450.99
32_L50_G0.9300.99
52_E79_P0.9120.99
59_M63_K0.9030.99
23_T48_A0.8700.98
23_T61_W0.8600.98
60_Q63_K0.8580.98
10_V46_V0.8570.98
35_Y47_V0.8460.98
6_I59_M0.8240.98
25_Y28_K0.8210.98
19_F62_L0.8110.97
6_I77_S0.8070.97
35_Y45_E0.8000.97
35_Y46_V0.7960.97
49_C82_P0.7830.97
47_V86_L0.7810.97
46_V58_L0.7660.96
9_W39_L0.7570.96
13_R71_R0.7510.96
18_G25_Y0.7470.96
82_P86_L0.7410.95
49_C86_L0.7370.95
18_G68_R0.7340.95
57_K60_Q0.7250.95
9_W76_L0.7170.95
30_L54_Q0.7120.94
22_T26_E0.7080.94
7_I78_E0.7030.94
5_C80_H0.6960.94
82_P85_E0.6920.94
6_I48_A0.6890.93
33_T49_C0.6820.93
10_V75_V0.6800.93
9_W45_E0.6740.93
86_L90_R0.6730.93
32_L48_A0.6610.92
23_T36_A0.6580.92
47_V85_E0.6510.91
31_G54_Q0.6400.91
63_K77_S0.6380.90
64_S67_P0.6330.90
8_A75_V0.6330.90
56_E79_P0.6280.90
22_T70_A0.6220.89
33_T86_L0.6150.89
87_T90_R0.6080.88
55_V59_M0.6050.88
5_C85_E0.6040.88
50_G54_Q0.6030.88
28_K81_H0.5930.87
52_E87_T0.5900.87
57_K61_W0.5850.86
28_K88_D0.5800.86
54_Q58_L0.5720.85
35_Y39_L0.5720.85
51_E87_T0.5680.85
7_I36_A0.5680.85
56_E77_S0.5630.84
24_Q36_A0.5570.84
13_R18_G0.5540.83
5_C84_G0.5490.83
10_V67_P0.5410.82
72_V75_V0.5380.81
33_T84_G0.5360.81
7_I47_V0.5350.81
14_V44_V0.5330.81
19_F23_T0.5250.80
32_L51_E0.5240.80
64_S68_R0.5150.79
22_T67_P0.5120.78
81_H84_G0.5020.77
35_Y66_G0.5020.77
73_E90_R0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hi1A 3 0.9565 100 0.159 Contact Map
2gv1A 1 0.9891 100 0.164 Contact Map
4g9iA 1 0.9674 100 0.172 Contact Map
3trgA 1 0.9783 100 0.174 Contact Map
1w2iA 2 0.9674 100 0.177 Contact Map
2bjdA 1 0.9783 100 0.177 Contact Map
2lxfA 1 0.9783 100 0.182 Contact Map
2fhmA 1 0.9674 100 0.186 Contact Map
1ulrA 1 0.9457 100 0.193 Contact Map
1urrA 1 1 100 0.202 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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