GREMLIN Database
YCIN - Protein YciN
UniProt: P0AB61 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12868
Length: 83 (78)
Sequences: 132 (56)
Seq/√Len: 6.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_T80_H3.5930.91
21_I67_M2.5190.67
9_D12_T2.5150.67
10_R46_T2.3340.60
35_G46_T2.2640.58
33_A68_F2.2420.57
61_S64_V2.2060.56
19_K23_E2.1590.54
38_Q80_H2.0650.51
31_I48_D1.9140.45
21_I33_A1.7160.38
22_R79_Y1.7050.38
70_H74_V1.7000.38
16_E61_S1.6840.37
31_I67_M1.6270.35
11_E15_K1.6080.35
64_V68_F1.5200.32
67_M78_K1.4830.31
24_H71_L1.4440.29
14_L33_A1.3870.28
14_L72_A1.3610.27
73_H77_E1.3350.26
53_E60_K1.3160.26
10_R35_G1.2730.24
28_L74_V1.2260.23
61_S77_E1.2190.23
20_I75_L1.2120.23
28_L67_M1.1240.21
41_G49_Y1.1160.20
52_D62_T1.0930.20
12_T46_T1.0830.20
63_A67_M1.0760.19
38_Q44_V1.0530.19
6_Q61_S1.0430.19
33_A72_A1.0340.19
9_D32_E1.0120.18
40_N79_Y1.0120.18
52_D56_L0.9980.18
48_D73_H0.9950.18
5_T16_E0.9870.18
5_T40_N0.9820.17
28_L60_K0.9800.17
32_E79_Y0.9720.17
15_K79_Y0.9700.17
20_I74_V0.9570.17
71_L81_L0.9490.17
6_Q29_A0.9150.16
39_R68_F0.9090.16
14_L36_V0.8920.16
27_T31_I0.8720.15
8_I13_L0.8680.15
19_K27_T0.8650.15
29_A56_L0.8630.15
24_H62_T0.8610.15
4_E54_Q0.8610.15
40_N78_K0.8600.15
27_T46_T0.8480.15
38_Q46_T0.8280.14
29_A59_A0.8180.14
25_E37_T0.8130.14
34_T54_Q0.8100.14
35_G39_R0.7920.14
36_V43_L0.7830.14
12_T29_A0.7820.14
44_V64_V0.7800.14
5_T38_Q0.7790.14
70_H77_E0.7750.13
9_D53_E0.7550.13
10_R41_G0.7540.13
26_D73_H0.7530.13
33_A42_V0.7500.13
9_D29_A0.7380.13
22_R49_Y0.7380.13
31_I50_F0.7300.13
14_L64_V0.7170.13
11_E79_Y0.7110.12
35_G49_Y0.7100.12
68_F72_A0.7050.12
13_L24_H0.6990.12
19_K22_R0.6980.12
33_A49_Y0.6960.12
62_T71_L0.6940.12
22_R78_K0.6930.12
60_K79_Y0.6880.12
32_E35_G0.6820.12
7_P41_G0.6780.12
9_D61_S0.6780.12
67_M73_H0.6610.12
14_L63_A0.6610.12
33_A43_L0.6520.12
8_I15_K0.6490.11
11_E70_H0.6380.11
45_F69_K0.6370.11
38_Q79_Y0.6300.11
16_E34_T0.5870.11
7_P78_K0.5790.10
21_I37_T0.5790.10
21_I31_I0.5780.10
11_E32_E0.5690.10
36_V45_F0.5690.10
23_E48_D0.5670.10
12_T50_F0.5650.10
71_L76_S0.5620.10
25_E61_S0.5600.10
13_L71_L0.5450.10
9_D40_N0.5440.10
11_E59_A0.5420.10
16_E38_Q0.5400.10
59_A70_H0.5380.10
25_E54_Q0.5330.10
31_I63_A0.5300.10
16_E74_V0.5290.10
39_R73_H0.5240.10
13_L28_L0.5150.10
50_F70_H0.5110.10
9_D54_Q0.5000.09
25_E53_E0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3m92A 2 0.9759 100 0.015 Contact Map
2e3nA 1 0.8313 18.5 0.933 Contact Map
2ld7B 1 0.4819 9.1 0.942 Contact Map
3nw0B 1 0.8795 8.8 0.942 Contact Map
2d7cC 1 0.4699 8.3 0.942 Contact Map
1jmoA 1 0.8675 8.3 0.942 Contact Map
1ev7A 2 0.8554 7.4 0.944 Contact Map
4ys0A 1 0.8313 6.8 0.945 Contact Map
2ve7A 1 0.7952 6.8 0.945 Contact Map
1unkA 4 0.747 6.3 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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