GREMLIN Database
LPSRP - Lipopolysaccharide regulatory protein
UniProt: P0AB58 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12691
Length: 389 (300)
Sequences: 6433 (5657)
Seq/√Len: 326.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
264_K267_E4.6831.00
195_D198_R4.5941.00
229_E232_K4.5241.00
84_E87_R4.3531.00
156_E159_K4.2711.00
122_L125_R4.2391.00
297_G300_A4.0581.00
50_Q53_K3.8961.00
76_G92_H2.8991.00
187_A203_L2.7581.00
42_G58_F2.4931.00
148_L164_A2.4751.00
256_Q272_L2.4091.00
114_G130_F2.3081.00
221_G237_L2.3061.00
183_Y202_L2.2461.00
110_I129_M2.2321.00
289_A305_I2.0831.00
58_F74_T2.0561.00
285_E304_Y2.0541.00
144_L163_V2.0301.00
72_H91_I2.0251.00
93_Q113_L1.9931.00
130_F146_Q1.9831.00
224_F232_K1.9781.00
186_L202_L1.9571.00
252_L271_F1.8921.00
190_H198_R1.8901.00
269_A273_Q1.8571.00
131_N147_L1.8551.00
75_L79_F1.8261.00
165_E186_L1.8111.00
92_H112_Q1.8041.00
75_L91_I1.8031.00
288_L292_I1.7941.00
200_M204_K1.7821.00
151_Y159_K1.7761.00
59_L75_L1.7541.00
203_L219_M1.7401.00
147_L163_V1.7141.00
113_L129_M1.7081.00
198_R201_T1.6761.00
237_L254_M1.6651.00
204_K220_M1.6591.00
217_S236_S1.6491.00
161_I186_L1.6271.00
164_A185_E1.6181.00
186_L190_H1.5991.00
127_E147_L1.5911.00
117_Y129_M1.5901.00
117_Y125_R1.5851.00
256_Q275_A1.5671.00
79_F84_E1.5651.00
76_G95_L1.5601.00
117_Y122_L1.5481.00
200_M220_M1.5451.00
220_M236_S1.5411.00
200_M224_F1.5401.00
161_I165_E1.5261.00
55_V79_F1.5161.00
273_Q288_L1.5141.00
220_M224_F1.5121.00
224_F236_S1.5111.00
255_L259_Y1.4831.00
79_F91_I1.4791.00
79_F87_R1.4771.00
113_L117_Y1.4661.00
238_Q255_L1.4581.00
60_D63_K1.4241.00
234_V258_C1.4181.00
147_L151_Y1.4101.00
148_L167_L1.4051.00
234_V238_Q1.3881.00
292_I300_A1.3831.00
190_H195_D1.3811.00
259_Y264_K1.3751.00
111_Q146_Q1.3621.00
72_H94_T1.3621.00
159_K162_D1.3561.00
190_H202_L1.3521.00
45_F50_Q1.3461.00
234_V262_L1.3461.00
218_I254_M1.3411.00
302_Q306_T1.3381.00
234_V255_L1.3271.00
144_L166_R1.3271.00
55_V75_L1.3261.00
52_D82_R1.3241.00
200_M227_K1.3111.00
45_F53_K1.3111.00
42_G61_M1.3021.00
124_D154_T1.3011.00
272_L287_M1.2891.00
224_F229_E1.2811.00
41_A45_F1.2781.00
259_Y267_E1.2721.00
158_Q193_S1.2611.00
110_I133_L1.2611.00
127_E151_Y1.2481.00
89_I113_L1.2471.00
125_R128_D1.2451.00
221_G240_V1.2431.00
151_Y156_E1.2411.00
234_V259_Y1.2251.00
145_Q185_E1.2251.00
127_E131_N1.2021.00
184_C219_M1.1961.00
200_M223_V1.1871.00
255_L271_F1.1691.00
94_T97_E1.1671.00
183_Y205_K1.1641.00
89_I116_D1.1511.00
259_Y271_F1.1471.00
231_A262_L1.1441.00
232_K235_E1.1431.00
39_Y43_V1.1421.00
269_A295_R1.1411.00
289_A308_Q1.1381.00
69_V95_L1.1331.00
267_E270_E1.1291.00
46_L58_F1.1201.00
127_E154_T1.1091.00
167_L182_F1.0951.00
73_L112_Q1.0931.00
222_R254_M1.0921.00
187_A206_G1.0881.00
53_K56_D1.0861.00
89_I120_A1.0861.00
241_I251_T1.0861.00
225_M237_L1.0811.00
217_S239_R1.0781.00
222_R237_L1.0771.00
292_I297_G1.0731.00
163_V167_L1.0621.00
188_L219_M1.0561.00
300_A303_V1.0541.00
205_K208_A1.0511.00
239_R242_S1.0441.00
266_A295_R1.0331.00
76_G88_A1.0291.00
288_L304_Y1.0271.00
197_D227_K1.0261.00
274_R277_E1.0211.00
151_Y163_V1.0201.00
240_V251_T1.0191.00
168_V182_F1.0171.00
269_A291_I1.0151.00
256_Q268_W1.0021.00
187_A202_L1.0001.00
80_R116_D1.0001.00
42_G54_A0.9991.00
103_Y106_R0.9901.00
207_A217_S0.9881.00
161_I193_S0.9831.00
86_D120_A0.9781.00
107_L133_L0.9761.00
161_I190_H0.9751.00
96_M110_I0.9741.00
149_Q185_E0.9721.00
89_I93_Q0.9671.00
161_I189_Q0.9651.00
196_L223_V0.9641.00
55_V59_L0.9641.00
223_V227_K0.9601.00
93_Q97_E0.9551.00
289_A301_A0.9541.00
110_I132_Q0.9521.00
80_R92_H0.9521.00
286_L289_A0.9421.00
191_M203_L0.9421.00
206_G216_V0.9421.00
45_F57_L0.9321.00
206_G209_A0.9291.00
207_A216_V0.9271.00
144_L167_L0.9231.00
221_G233_A0.9181.00
114_G129_M0.9181.00
106_R110_I0.9181.00
252_L274_R0.9181.00
38_D61_M0.9161.00
292_I304_Y0.9151.00
291_I295_R0.9141.00
65_D68_T0.9131.00
38_D57_L0.9111.00
258_C262_L0.9081.00
303_V307_R0.9031.00
241_I252_L0.9031.00
269_A288_L0.8971.00
43_V58_F0.8931.00
35_L61_M0.8911.00
213_S217_S0.8911.00
337_S341_L0.8881.00
273_Q277_E0.8871.00
95_L98_S0.8751.00
166_R169_K0.8741.00
132_Q135_D0.8691.00
88_A92_H0.8671.00
55_V82_R0.8651.00
267_E271_F0.8631.00
254_M257_T0.8621.00
137_T140_R0.8601.00
133_L143_A0.8601.00
184_C216_V0.8591.00
225_M230_Y0.8581.00
87_R90_R0.8581.00
55_V78_L0.8571.00
62_L71_A0.8491.00
218_I222_R0.8471.00
46_L51_Q0.8401.00
114_G133_L0.8401.00
62_L72_H0.8391.00
205_K209_A0.8361.00
335_K339_M0.8311.00
57_L61_M0.8301.00
188_L203_L0.8281.00
221_G236_S0.8261.00
253_E257_T0.8231.00
230_Y258_C0.8141.00
78_L82_R0.8141.00
165_E198_R0.8131.00
116_D120_A0.8091.00
129_M133_L0.8041.00
148_L163_V0.8031.00
274_R278_E0.8011.00
152_Q189_Q0.8011.00
275_A284_A0.7991.00
148_L160_A0.7991.00
339_M342_R0.7941.00
213_S216_V0.7841.00
61_M64_E0.7821.00
127_E150_I0.7791.00
133_L136_E0.7781.00
69_V76_G0.7781.00
59_L63_K0.7781.00
260_Q272_L0.7751.00
146_Q149_Q0.7701.00
304_Y307_R0.7701.00
198_R202_L0.7691.00
36_S40_V0.7681.00
145_Q182_F0.7671.00
183_Y206_G0.7671.00
321_L325_H0.7631.00
152_Q164_A0.7601.00
43_V74_T0.7570.99
334_A341_L0.7560.99
46_L74_T0.7550.99
333_R336_E0.7510.99
162_D165_E0.7480.99
93_Q117_Y0.7470.99
337_S340_V0.7460.99
307_R310_Q0.7430.99
164_A168_V0.7420.99
37_R41_A0.7410.99
111_Q115_R0.7380.99
96_M109_A0.7350.99
149_Q164_A0.7340.99
230_Y234_V0.7250.99
134_T143_A0.7250.99
89_I117_Y0.7230.99
68_T71_A0.7210.99
338_L341_L0.7210.99
96_M113_L0.7180.99
51_Q78_L0.7180.99
160_A189_Q0.7150.99
44_N48_S0.7140.99
167_L170_L0.7130.99
80_R112_Q0.7110.99
95_L109_A0.7090.99
273_Q300_A0.7070.99
191_M196_L0.7050.99
214_A240_V0.7000.99
183_Y186_L0.6990.99
162_D166_R0.6980.99
91_I95_L0.6980.99
42_G57_L0.6970.99
189_Q193_S0.6960.99
74_T77_N0.6950.99
111_Q143_A0.6940.99
165_E190_H0.6940.99
34_R38_D0.6920.99
77_N112_Q0.6910.99
187_A199_A0.6910.99
94_T98_S0.6910.99
163_V166_R0.6870.99
72_H95_L0.6860.99
41_A57_L0.6840.99
74_T112_Q0.6810.99
286_L290_D0.6780.99
126_A150_I0.6770.99
86_D90_R0.6760.99
77_N81_S0.6750.99
38_D60_D0.6720.99
61_M71_A0.6710.99
165_E169_K0.6690.99
276_V285_E0.6680.99
260_Q291_I0.6670.99
56_D60_D0.6670.99
287_M290_D0.6650.99
324_Y328_E0.6650.99
134_T144_L0.6650.99
201_T205_K0.6650.99
60_D64_E0.6650.99
271_F274_R0.6640.99
253_E275_A0.6630.99
114_G147_L0.6610.99
71_A74_T0.6610.99
218_I251_T0.6580.99
114_G126_A0.6560.99
319_H323_D0.6540.99
115_R146_Q0.6540.99
203_L223_V0.6510.98
332_G337_S0.6500.98
300_A304_Y0.6470.98
225_M258_C0.6470.98
38_D64_E0.6470.98
166_R170_L0.6470.98
37_R40_V0.6460.98
236_S240_V0.6440.98
222_R225_M0.6420.98
304_Y308_Q0.6410.98
136_E141_I0.6380.98
131_N159_K0.6370.98
128_D132_Q0.6360.98
336_E340_V0.6350.98
204_K224_F0.6350.98
46_L78_L0.6340.98
253_E284_A0.6310.98
57_L60_D0.6310.98
318_F321_L0.6300.98
190_H193_S0.6300.98
203_L220_M0.6280.98
168_V183_Y0.6280.98
196_L227_K0.6250.98
285_E307_R0.6240.98
257_T260_Q0.6240.98
118_M130_F0.6230.98
54_A58_F0.6210.98
31_E34_R0.6210.98
38_D41_A0.6210.98
329_A334_A0.6180.98
73_L95_L0.6180.98
232_K236_S0.6180.98
237_L241_I0.6180.98
143_A146_Q0.6160.98
336_E339_M0.6140.98
269_A292_I0.6130.98
285_E308_Q0.6120.98
265_T269_A0.6080.98
225_M261_Q0.6080.98
265_T291_I0.6070.98
219_M222_R0.6070.98
272_L276_V0.6070.98
184_C188_L0.6060.98
234_V264_K0.6060.98
240_V243_Q0.6060.98
125_R129_M0.6050.98
37_R44_N0.5990.97
73_L77_N0.5980.97
204_K208_A0.5940.97
188_L191_M0.5930.97
184_C206_G0.5910.97
260_Q265_T0.5880.97
236_S239_R0.5840.97
204_K232_K0.5840.97
91_I98_S0.5830.97
306_T310_Q0.5810.97
59_L87_R0.5810.97
168_V186_L0.5800.97
171_G182_F0.5800.97
253_E256_Q0.5780.97
114_G146_Q0.5770.97
275_A278_E0.5750.97
333_R337_S0.5740.97
225_M233_A0.5740.97
89_I96_M0.5730.97
34_R37_R0.5720.97
92_H113_L0.5710.97
74_T78_L0.5700.96
298_S302_Q0.5690.96
260_Q294_A0.5660.96
332_G335_K0.5650.96
238_Q259_Y0.5650.96
137_T141_I0.5650.96
123_Y127_E0.5640.96
259_Y262_L0.5600.96
256_Q271_F0.5590.96
69_V72_H0.5590.96
68_T72_H0.5590.96
257_T272_L0.5590.96
191_M223_V0.5580.96
118_M153_A0.5570.96
43_V47_L0.5570.96
118_M150_I0.5570.96
257_T287_M0.5570.96
322_M326_L0.5550.96
152_Q157_W0.5550.96
180_A206_G0.5550.96
140_R143_A0.5530.96
56_D59_L0.5520.96
338_L342_R0.5510.96
183_Y187_A0.5510.96
91_I94_T0.5510.96
241_I247_L0.5490.96
233_A237_L0.5490.96
318_F325_H0.5480.96
80_R85_V0.5480.96
130_F147_L0.5470.96
90_R94_T0.5430.95
76_G112_Q0.5410.95
238_Q242_S0.5400.95
144_L170_L0.5390.95
334_A338_L0.5380.95
289_A293_E0.5350.95
299_E303_V0.5350.95
225_M254_M0.5340.95
315_M319_H0.5330.95
276_V284_A0.5320.95
93_Q125_R0.5320.95
334_A337_S0.5310.95
335_K342_R0.5310.95
217_S252_L0.5290.95
237_L258_C0.5280.95
39_Y71_A0.5270.95
92_H116_D0.5260.95
131_N135_D0.5260.95
196_L200_M0.5260.95
76_G91_I0.5260.95
207_A220_M0.5240.94
202_L206_G0.5240.94
238_Q267_E0.5240.94
271_F275_A0.5230.94
157_W196_L0.5230.94
45_F48_S0.5220.94
214_A221_G0.5210.94
260_Q287_M0.5210.94
88_A116_D0.5200.94
217_S224_F0.5200.94
329_A335_K0.5180.94
270_E274_R0.5160.94
329_A333_R0.5150.94
247_L251_T0.5140.94
224_F227_K0.5120.94
307_R311_R0.5110.94
285_E311_R0.5080.93
132_Q136_E0.5070.93
39_Y74_T0.5070.93
145_Q149_Q0.5070.93
79_F82_R0.5020.93
191_M226_A0.5010.93
124_D128_D0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w3bA 2 0.9126 100 0.293 Contact Map
2xpiA 2 0.8149 100 0.325 Contact Map
4rg9A 2 0.7558 100 0.338 Contact Map
5aioA 1 0.7686 100 0.338 Contact Map
4ui9J 2 0.838 100 0.338 Contact Map
4ui9F 2 0.8149 100 0.341 Contact Map
4ui9C 2 0.8201 100 0.342 Contact Map
2y4tA 1 0.8869 100 0.346 Contact Map
3dssA 1 0.7018 100 0.346 Contact Map
4l9pA 1 0.7455 100 0.353 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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