GREMLIN Database
YCGL - Protein YcgL
UniProt: P0AB43 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13893
Length: 97 (86)
Sequences: 511 (311)
Seq/√Len: 33.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_A70_Y4.2351.00
35_F38_P3.2251.00
63_A70_Y2.6961.00
63_A67_Q2.5671.00
4_V43_I2.4240.99
7_R41_A2.3960.99
55_A60_V2.3730.99
40_L43_I2.3490.99
4_V40_L2.1080.99
22_D26_R1.8290.96
19_E26_R1.8100.96
9_S38_P1.7400.95
2_F45_P1.6950.94
56_D59_K1.6790.94
64_L69_Y1.6270.93
29_E33_K1.5340.91
62_Q66_E1.5060.90
13_Q54_N1.4890.90
57_I64_L1.4210.87
2_F20_K1.3920.86
57_I61_K1.3610.85
82_K85_L1.3570.85
14_T73_L1.3550.85
9_S39_Q1.3360.84
3_C27_V1.3290.83
5_I53_V1.3180.83
80_L84_H1.3090.82
44_L53_V1.3010.82
7_R11_R1.2920.82
13_Q41_A1.2880.81
59_K63_A1.2390.79
6_Y76_P1.2130.77
68_G72_Q1.1660.74
33_K51_K1.1570.74
25_S32_M1.1250.72
18_V24_F1.0860.69
80_L83_Q1.0850.69
49_R61_K1.0590.67
14_T71_L1.0580.67
68_G74_P1.0470.66
82_K86_S1.0450.66
68_G75_P1.0430.66
32_M39_Q1.0400.66
56_D60_V1.0340.65
30_E62_Q1.0220.64
13_Q32_M0.9960.62
79_D82_K0.9920.62
2_F16_L0.9660.60
14_T23_D0.9650.60
1_M10_K0.9590.59
58_E62_Q0.9460.58
16_L27_V0.9340.57
83_Q86_S0.9310.57
47_D57_I0.9120.55
26_R41_A0.9070.55
16_L35_F0.8990.54
8_S14_T0.8860.53
77_P82_K0.8760.52
2_F42_M0.8620.51
6_Y40_L0.8460.50
20_K61_K0.8430.50
11_R34_G0.8380.49
58_E61_K0.8270.48
2_F35_F0.8210.48
34_G69_Y0.8060.46
79_D83_Q0.8000.46
11_R73_L0.7920.45
19_E27_V0.7860.45
30_E69_Y0.7840.45
52_L60_V0.7820.44
35_F73_L0.7610.43
48_G64_L0.7490.42
14_T61_K0.7390.41
70_Y74_P0.7380.41
8_S35_F0.7300.40
45_P64_L0.7000.38
8_S73_L0.6910.37
5_I42_M0.6910.37
32_M38_P0.6840.37
38_P73_L0.6840.37
49_R57_I0.6830.36
17_Y83_Q0.6800.36
5_I56_D0.6730.36
79_D85_L0.6630.35
12_D69_Y0.6620.35
11_R14_T0.6510.34
79_D84_H0.6480.34
42_M45_P0.6440.33
9_S26_R0.6280.32
1_M44_L0.6270.32
76_P79_D0.6210.32
1_M18_V0.6130.31
46_L67_Q0.6120.31
46_L78_E0.6110.31
9_S42_M0.6070.31
21_K24_F0.5960.30
8_S38_P0.5930.30
5_I17_Y0.5920.30
16_L31_L0.5880.29
17_Y55_A0.5870.29
59_K70_Y0.5770.29
3_C61_K0.5650.28
23_D32_M0.5650.28
78_E84_H0.5600.27
26_R49_R0.5580.27
7_R13_Q0.5570.27
1_M23_D0.5550.27
17_Y52_L0.5550.27
19_E64_L0.5540.27
25_S73_L0.5520.27
54_N75_P0.5500.27
72_Q75_P0.5470.27
62_Q73_L0.5410.26
4_V23_D0.5400.26
34_G77_P0.5370.26
54_N83_Q0.5360.26
56_D62_Q0.5320.26
4_V24_F0.5310.26
30_E33_K0.5300.26
50_K54_N0.5290.25
17_Y54_N0.5200.25
24_F84_H0.5150.25
7_R22_D0.5100.24
73_L77_P0.5100.24
50_K57_I0.5080.24
1_M22_D0.5060.24
32_M81_L0.5020.24
9_S53_V0.5010.24
41_A79_D0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2h7aA 1 1 100 0.075 Contact Map
2qmhA 5 0.9175 40.4 0.912 Contact Map
1ko7A 3 0.7423 19.7 0.924 Contact Map
2m4iA 1 0.9175 18.6 0.925 Contact Map
1knxA 5 0.9175 17.9 0.926 Contact Map
2maxA 1 0.7938 16.3 0.927 Contact Map
3tqfA 3 0.7938 15.8 0.927 Contact Map
1k7hA 2 0.9588 13.1 0.93 Contact Map
4noiA 2 0.1031 10.5 0.933 Contact Map
4bpe7 1 0.701 10.4 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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