GREMLIN Database
BHSA - Multiple stress resistance protein BhsA
UniProt: P0AB40 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13436
Length: 85 (85)
Sequences: 265 (158)
Seq/√Len: 17.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_K85_K3.1800.99
69_T82_V3.0940.99
69_T80_T2.4360.95
6_T10_A2.3280.94
72_T78_H2.1620.91
73_G77_L2.0690.89
67_R82_V1.9480.85
5_K61_M1.8070.81
41_A50_L1.8020.80
41_A54_L1.7490.78
54_L66_F1.7280.78
39_I56_Q1.6880.76
8_I30_P1.6820.76
24_V27_Q1.6590.74
55_A82_V1.6090.72
30_P33_Q1.5680.70
19_A61_M1.5600.70
54_L83_I1.5470.69
55_A66_F1.4780.65
45_T75_N1.4590.64
56_Q59_D1.4510.64
36_V43_A1.4430.63
16_M42_N1.4160.62
16_M78_H1.4060.61
25_E29_T1.3970.61
66_F70_S1.3340.57
47_L79_G1.3190.56
30_P46_N1.2850.54
75_N83_I1.2530.52
35_K38_T1.2430.52
43_A76_T1.2410.52
50_L73_G1.2390.52
71_V78_H1.2230.51
43_A64_K1.1550.47
5_K74_P1.1470.46
46_N49_S1.1310.45
13_L18_F1.1300.45
11_A61_M1.1270.45
6_T66_F1.1210.45
33_Q65_S1.0990.43
16_M19_A1.0960.43
8_I28_S1.0840.42
4_V27_Q1.0650.41
22_A68_I1.0610.41
10_A38_T1.0610.41
34_Q67_R1.0590.41
7_L20_S1.0450.40
36_V64_K1.0360.40
19_A43_A1.0270.39
19_A32_G0.9920.37
8_I15_S0.9550.35
27_Q65_S0.9520.35
37_G50_L0.9450.34
29_T39_I0.9160.33
18_F80_T0.8910.32
55_A67_R0.8850.31
14_S18_F0.8840.31
15_S77_L0.8840.31
8_I71_V0.8560.30
35_K82_V0.8520.30
12_I36_V0.8520.30
51_E70_S0.8480.29
3_N49_S0.8460.29
36_V72_T0.8420.29
37_G75_N0.8340.29
25_E30_P0.8140.28
35_K69_T0.8040.27
37_G40_S0.8040.27
41_A64_K0.7940.27
6_T38_T0.7930.27
54_L72_T0.7820.26
5_K35_K0.7510.25
17_S31_E0.7450.25
40_S80_T0.7390.24
39_I44_G0.7380.24
13_L43_A0.7370.24
35_K49_S0.7350.24
25_E33_Q0.7330.24
4_V8_I0.7310.24
47_L68_I0.7170.23
34_Q69_T0.7150.23
13_L16_M0.7140.23
76_T83_I0.7080.23
36_V59_D0.7080.23
21_F25_E0.7010.23
9_A12_I0.6990.23
44_G74_P0.6870.22
33_Q83_I0.6860.22
49_S82_V0.6780.22
50_L54_L0.6710.21
7_L30_P0.6640.21
55_A80_T0.6550.21
47_L70_S0.6540.21
26_V59_D0.6500.21
30_P65_S0.6490.21
35_K83_I0.6470.20
64_K71_V0.6410.20
41_A45_T0.6370.20
33_Q44_G0.6120.19
47_L50_L0.6080.19
32_G64_K0.6080.19
9_A84_Y0.6030.19
21_F27_Q0.6010.19
14_S72_T0.6000.19
27_Q71_V0.5960.19
56_Q65_S0.5940.18
9_A72_T0.5930.18
48_G66_F0.5900.18
49_S52_E0.5860.18
42_N65_S0.5840.18
74_P83_I0.5770.18
5_K34_Q0.5750.18
13_L71_V0.5640.17
14_S21_F0.5620.17
39_I65_S0.5610.17
3_N73_G0.5610.17
56_Q60_E0.5530.17
37_G54_L0.5500.17
25_E66_F0.5460.17
72_T79_G0.5450.17
15_S56_Q0.5450.17
24_V28_S0.5360.16
35_K60_E0.5240.16
24_V44_G0.5220.16
15_S57_K0.5210.16
49_S59_D0.5100.16
27_Q66_F0.5080.16
51_E75_N0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nocA 1 0.9882 99.9 0.249 Contact Map
2jnaA 2 0.9882 99.9 0.262 Contact Map
2m2jA 1 0.7647 99.8 0.418 Contact Map
2ma4A 1 0.7412 99.8 0.442 Contact Map
4evuA 2 0.7529 99.7 0.486 Contact Map
4n4rB 1 0.7176 35.7 0.901 Contact Map
3b55A 1 0.5412 30.8 0.904 Contact Map
3layA 5 0.6941 25.9 0.908 Contact Map
4yv7A 1 0.6 23.7 0.909 Contact Map
2xmoA 1 0.6471 15.6 0.917 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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