GREMLIN Database
LPOB - Penicillin-binding protein activator LpoB
UniProt: P0AB38 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13431
Length: 213 (180)
Sequences: 152 (101)
Seq/√Len: 7.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
123_E139_S3.7270.95
88_V91_M3.1330.88
105_V180_S3.0710.87
167_I201_E2.9750.85
6_R92_L2.9490.85
112_T178_Y2.4980.73
86_P156_D2.2840.66
180_S191_Q2.2740.65
79_D118_A2.2030.63
131_N180_S2.1960.62
87_M167_I2.1560.61
125_L210_V2.1480.61
94_A128_A2.0820.58
152_L157_S2.0150.56
105_V131_N1.9700.54
157_S166_G1.8560.49
101_S132_N1.8500.49
77_H155_Q1.8340.48
21_V24_R1.8320.48
165_I202_I1.8010.47
135_F178_Y1.7840.46
69_A90_K1.7770.46
196_L199_T1.7520.45
102_V131_N1.7470.45
160_T188_P1.7160.44
7_Y101_S1.7140.44
67_Q92_L1.7010.43
79_D182_S1.6990.43
165_I192_M1.6680.42
18_A169_R1.6550.41
103_L169_R1.6380.41
65_E68_T1.6280.40
8_A180_S1.6190.40
16_F141_Q1.5800.38
83_A183_G1.5450.37
116_L125_L1.4780.35
15_M82_G1.4600.34
18_A99_A1.4600.34
152_L170_N1.4590.34
7_Y180_S1.4570.34
77_H81_N1.4460.34
152_L197_V1.4370.33
151_G163_K1.4350.33
101_S185_V1.4320.33
86_P152_L1.4320.33
11_T172_G1.4080.32
56_P59_P1.3900.32
97_V171_V1.3720.31
14_A102_V1.3700.31
67_Q179_S1.3640.31
76_R108_V1.3290.30
93_G134_K1.3220.29
151_G202_I1.3170.29
80_W206_G1.3150.29
6_R184_N1.3150.29
107_S159_G1.3140.29
118_A181_A1.3130.29
19_G136_T1.3120.29
142_Q147_K1.3090.29
151_G161_R1.2990.29
82_G85_Q1.2910.28
62_I76_R1.2870.28
16_F98_T1.2870.28
16_F23_Q1.2790.28
109_N186_N1.2400.27
63_E149_Q1.2350.27
19_G64_H1.2280.26
57_Q79_D1.2070.26
64_H76_R1.2030.26
150_L178_Y1.1980.25
81_N133_G1.1910.25
178_Y195_M1.1830.25
10_I65_E1.1680.25
12_A148_Q1.1540.24
119_A210_V1.1440.24
112_T200_G1.1300.23
18_A98_T1.1280.23
81_N136_T1.1170.23
136_T181_A1.1110.23
117_N184_N1.1060.23
9_L14_A1.1040.23
22_G134_K1.0900.22
13_L141_Q1.0880.22
8_A23_Q1.0790.22
139_S145_M1.0740.22
140_A203_I1.0740.22
72_A167_I1.0730.22
175_Y200_G1.0720.22
174_H203_I1.0520.21
71_P85_Q1.0520.21
86_P161_R1.0430.21
128_A138_V1.0390.21
135_F156_D1.0240.21
151_G156_D1.0150.20
114_G157_S1.0080.20
147_K170_N1.0020.20
69_A74_H0.9890.20
172_G180_S0.9880.20
19_G198_Q0.9770.19
160_T168_A0.9670.19
6_R207_K0.9650.19
167_I177_L0.9560.19
101_S188_P0.9560.19
168_A208_G0.9460.19
151_G166_G0.9450.19
103_L163_K0.9450.19
103_L205_S0.9380.18
137_L199_T0.9370.18
7_Y10_I0.9340.18
108_V159_G0.9310.18
154_P168_A0.9240.18
54_T57_Q0.9230.18
91_M131_N0.9120.18
166_G197_V0.9090.18
152_L156_D0.8970.17
63_E210_V0.8930.17
73_P178_Y0.8870.17
143_L178_Y0.8810.17
85_Q141_Q0.8770.17
80_W151_G0.8750.17
144_S154_P0.8720.17
146_A163_K0.8710.17
24_R111_R0.8680.17
80_W86_P0.8670.17
60_G78_Y0.8640.17
22_G79_D0.8570.17
51_S58_Q0.8480.16
139_S182_S0.8360.16
101_S196_L0.8350.16
70_P74_H0.8320.16
51_S68_T0.8310.16
82_G186_N0.8250.16
10_I108_V0.8250.16
143_L160_T0.8210.16
19_G75_I0.8190.16
22_G203_I0.8120.16
84_M123_E0.8110.16
79_D99_A0.8090.16
161_R193_Q0.8080.15
109_N122_T0.8040.15
157_S206_G0.7980.15
122_T205_S0.7940.15
78_Y209_A0.7900.15
120_E189_T0.7890.15
11_T79_D0.7890.15
164_A174_H0.7880.15
150_L200_G0.7870.15
193_Q202_I0.7830.15
129_L185_V0.7820.15
185_V189_T0.7750.15
64_H118_A0.7730.15
20_C200_G0.7710.15
129_L187_A0.7680.15
69_A117_N0.7650.15
16_F126_R0.7640.15
86_P151_G0.7630.15
189_T207_K0.7600.15
184_N207_K0.7570.14
119_A168_A0.7560.14
168_A210_V0.7460.14
23_Q118_A0.7390.14
161_R169_R0.7370.14
67_Q191_Q0.7360.14
100_G197_V0.7280.14
15_M173_A0.7230.14
169_R195_M0.7220.14
151_G201_E0.7220.14
152_L158_L0.7190.14
129_L188_P0.7140.14
105_V120_E0.7100.14
92_L185_V0.7010.13
146_A151_G0.7010.13
153_S176_V0.6980.13
83_A190_L0.6970.13
155_Q202_I0.6940.13
185_V203_I0.6910.13
7_Y182_S0.6880.13
151_G158_L0.6850.13
51_S133_G0.6850.13
142_Q178_Y0.6810.13
123_E207_K0.6810.13
16_F186_N0.6800.13
107_S171_V0.6790.13
18_A21_V0.6760.13
169_R193_Q0.6760.13
123_E140_A0.6750.13
19_G164_A0.6750.13
68_T180_S0.6700.13
193_Q205_S0.6690.13
118_A172_G0.6690.13
18_A147_K0.6670.13
96_G162_S0.6660.13
53_P145_M0.6630.13
14_A134_K0.6630.13
102_V115_S0.6620.13
101_S174_H0.6570.13
63_E69_A0.6560.13
113_N153_S0.6560.13
152_L193_Q0.6550.13
141_Q144_S0.6540.13
88_V96_G0.6460.12
106_D178_Y0.6430.12
150_L195_M0.6420.12
19_G126_R0.6390.12
155_Q199_T0.6390.12
132_N174_H0.6370.12
136_T190_L0.6330.12
84_M94_A0.6320.12
90_K206_G0.6310.12
14_A135_F0.6280.12
80_W161_R0.6220.12
91_M202_I0.6200.12
61_P82_G0.6190.12
181_A192_M0.6180.12
11_T64_H0.6180.12
18_A107_S0.6120.12
8_A139_S0.6110.12
152_L176_V0.6050.12
190_L193_Q0.6020.12
108_V152_L0.5990.12
16_F21_V0.5990.12
17_L106_D0.5980.12
71_P93_G0.5960.12
76_R87_M0.5950.12
174_H185_V0.5950.12
81_N186_N0.5950.12
65_E79_D0.5940.12
189_T209_A0.5930.12
88_V92_L0.5900.11
74_H165_I0.5880.11
79_D84_M0.5870.11
99_A159_G0.5840.11
7_Y129_L0.5820.11
50_P56_P0.5800.11
7_Y132_N0.5790.11
177_L201_E0.5780.11
7_Y23_Q0.5760.11
8_A18_A0.5750.11
87_M149_Q0.5740.11
118_A209_A0.5720.11
100_G153_S0.5720.11
54_T60_G0.5710.11
118_A137_L0.5700.11
62_I75_I0.5680.11
183_G198_Q0.5670.11
61_P79_D0.5660.11
104_L201_E0.5610.11
164_A178_Y0.5600.11
55_I61_P0.5590.11
150_L158_L0.5560.11
129_L174_H0.5560.11
85_Q155_Q0.5550.11
177_L187_A0.5530.11
51_S82_G0.5530.11
161_R197_V0.5480.11
101_S129_L0.5460.11
129_L172_G0.5420.11
129_L143_L0.5400.11
116_L120_E0.5390.11
111_R182_S0.5350.11
86_P199_T0.5300.11
126_R180_S0.5280.11
103_L146_A0.5270.10
61_P127_N0.5230.10
7_Y189_T0.5220.10
75_I125_L0.5220.10
175_Y201_E0.5140.10
6_R67_Q0.5040.10
18_A132_N0.5020.10
99_A196_L0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2miiA 1 0.9249 100 0.486 Contact Map
4q6vA 1 0.6338 100 0.651 Contact Map
4uv2A 3 0.615 99.8 0.749 Contact Map
4hrvA 2 0.5258 99.2 0.832 Contact Map
3w1eA 1 0.7465 99 0.843 Contact Map
3ly7A 2 0.4648 96.9 0.908 Contact Map
4n4rB 1 0.5023 95.9 0.917 Contact Map
3zbiC 1 0.1268 92.3 0.93 Contact Map
4immA 1 0.5681 88.4 0.936 Contact Map
2hqsA 2 0.5352 88.3 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0071 seconds.