GREMLIN Database
EFEO - Iron uptake system component EfeO
UniProt: P0AB24 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13861
Length: 375 (356)
Sequences: 556 (371)
Seq/√Len: 19.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
306_R321_D5.9201.00
17_L20_S5.4171.00
168_K172_L5.1281.00
158_T240_Y5.0481.00
173_Y281_D4.8491.00
238_Q242_D3.8581.00
165_D168_K3.7421.00
202_D282_R3.6951.00
330_I357_P3.6681.00
222_A232_M3.3151.00
346_L351_R3.1881.00
14_V17_L3.1630.99
328_D332_A3.1230.99
160_A172_L3.0990.99
197_I243_V3.0560.99
347_T350_D3.0500.99
205_E211_P2.9420.99
162_K237_E2.9330.99
292_Q340_F2.8980.99
16_A19_S2.8570.99
155_K159_D2.8320.99
204_Y211_P2.8070.99
160_A165_D2.7130.98
48_V113_L2.6340.98
166_I170_K2.6040.98
150_L243_V2.4550.97
202_D283_Y2.4320.97
79_R88_Q2.2630.95
155_K244_V2.2390.95
161_I166_I2.2290.94
216_F243_V2.2090.94
33_K44_M2.0950.92
68_E79_R2.0570.92
132_L257_P2.0490.91
341_E345_K2.0310.91
199_A213_F2.0060.91
167_E170_K1.9330.89
180_Y216_F1.9160.88
196_S238_Q1.9060.88
228_T231_G1.9060.88
178_Q293_A1.8540.87
155_K240_Y1.8410.86
356_G359_T1.8400.86
196_S245_D1.8360.86
170_K227_N1.8300.86
218_R235_Y1.8230.86
12_L17_L1.8190.86
69_I94_L1.8100.85
180_Y246_L1.8060.85
155_K158_T1.7980.85
17_L21_A1.7620.84
134_G138_A1.7250.82
194_D200_R1.6750.80
194_D270_E1.6730.80
221_K226_D1.6410.79
13_S16_A1.6130.78
48_V53_T1.5920.77
265_A269_E1.5850.77
50_A96_P1.5750.76
201_E221_K1.5560.75
162_K233_D1.5540.75
139_Y297_G1.5470.75
214_T242_D1.5390.74
154_T243_V1.5360.74
257_P305_L1.5230.74
180_Y274_S1.5110.73
68_E88_Q1.5040.73
300_K304_L1.5010.72
15_A20_S1.4870.72
38_D62_Q1.4790.71
161_I232_M1.4700.71
146_E179_H1.4690.71
323_N326_K1.4640.70
250_I260_V1.4580.70
105_L109_P1.4200.68
204_Y282_R1.4130.68
180_Y249_R1.4130.68
262_G364_D1.4130.68
98_E114_I1.4030.67
98_E112_K1.3890.66
182_R296_E1.3670.65
204_Y213_F1.3600.65
132_L305_L1.3460.64
104_G109_P1.3450.64
46_I111_G1.3440.64
153_D179_H1.3440.64
309_L368_L1.3390.63
335_R340_F1.3370.63
299_Q328_D1.3340.63
200_R280_E1.3330.63
350_D353_A1.2980.61
313_N367_Q1.2920.61
196_S242_D1.2890.60
325_K329_T1.2780.60
213_F221_K1.2750.59
151_V247_Q1.2620.59
72_G110_K1.2540.58
14_V20_S1.2450.58
180_Y197_I1.2300.57
163_A168_K1.2280.57
36_V68_E1.2270.56
261_V369_R1.2230.56
327_V361_L1.2230.56
16_A20_S1.2230.56
198_D287_D1.2230.56
180_Y320_V1.2170.56
234_Q314_P1.2080.55
284_S294_N1.2000.55
177_R290_D1.2000.55
57_I108_N1.1970.55
332_A335_R1.1910.54
303_D335_R1.1870.54
150_L216_F1.1860.54
352_N359_T1.1860.54
292_Q332_A1.1850.54
204_Y207_K1.1840.54
131_S311_K1.1750.53
100_D112_K1.1670.53
56_I87_S1.1650.53
168_K171_A1.1640.52
292_Q296_E1.1490.51
295_V327_V1.1480.51
268_I327_V1.1420.51
194_D198_D1.1310.50
306_R346_L1.1300.50
68_E90_M1.1280.50
159_D163_A1.1260.50
341_E346_L1.1250.50
38_D63_K1.1220.50
271_V295_V1.1170.49
321_D325_K1.1050.49
295_V328_D1.1000.48
77_E88_Q1.0970.48
219_L235_Y1.0900.48
334_Y350_D1.0870.48
106_L109_P1.0840.47
235_Y242_D1.0820.47
20_S23_M1.0800.47
309_L317_L1.0790.47
12_L16_A1.0710.46
288_L294_N1.0700.46
197_I216_F1.0650.46
75_V364_D1.0640.46
37_T40_Q1.0620.46
291_F343_Y1.0580.46
68_E109_P1.0570.46
19_S22_F1.0560.46
202_D219_L1.0550.45
158_T162_K1.0550.45
156_A172_L1.0480.45
267_L275_K1.0480.45
156_A168_K1.0400.45
275_K280_E1.0390.44
238_Q245_D1.0360.44
271_V364_D1.0310.44
252_E350_D1.0260.44
82_I353_A1.0180.43
11_Q15_A1.0170.43
184_E267_L1.0140.43
364_D369_R1.0120.43
280_E287_D1.0070.42
181_E294_N1.0020.42
49_N116_K0.9940.42
177_R287_D0.9930.42
204_Y214_T0.9900.41
322_A326_K0.9870.41
276_I301_I0.9820.41
132_L308_Q0.9780.41
305_L308_Q0.9780.41
334_Y341_E0.9760.40
181_E275_K0.9730.40
224_F281_D0.9690.40
109_P269_E0.9630.40
31_Q56_I0.9600.40
270_E275_K0.9590.39
335_R338_D0.9580.39
192_D249_R0.9580.39
82_I90_M0.9430.38
320_V358_I0.9420.38
336_T345_K0.9400.38
13_S329_T0.9380.38
228_T233_D0.9220.37
73_V129_L0.9210.37
296_E328_D0.9110.37
322_A349_A0.9110.37
219_L237_E0.9080.36
173_Y309_L0.9070.36
157_F172_L0.9060.36
320_V364_D0.9020.36
245_D249_R0.9010.36
70_L272_A0.8940.36
228_T232_M0.8940.36
288_L297_G0.8910.35
37_T60_H0.8910.35
214_T238_Q0.8890.35
136_I256_P0.8880.35
202_D213_F0.8880.35
48_V69_I0.8860.35
142_Y182_R0.8830.35
94_L231_G0.8810.35
206_Q211_P0.8800.35
326_K357_P0.8800.35
217_H284_S0.8790.35
14_V21_A0.8790.35
191_S369_R0.8780.35
277_S284_S0.8760.34
323_N372_L0.8740.34
176_T255_F0.8740.34
271_V291_F0.8710.34
275_K290_D0.8710.34
171_A335_R0.8710.34
48_V57_I0.8620.34
222_A228_T0.8610.34
289_W342_T0.8560.33
114_I120_T0.8560.33
298_S302_V0.8550.33
347_T351_R0.8520.33
53_T75_V0.8510.33
140_K253_L0.8480.33
55_F246_L0.8470.33
259_K347_T0.8450.33
213_F282_R0.8410.32
134_G137_T0.8400.32
41_C51_G0.8380.32
299_Q325_K0.8320.32
330_I353_A0.8300.32
216_F309_L0.8220.31
148_T244_V0.8190.31
88_Q306_R0.8160.31
352_N356_G0.8130.31
319_K323_N0.8120.31
11_Q14_V0.8110.31
118_E295_V0.8100.31
270_E294_N0.8060.31
348_D352_N0.8060.31
173_Y289_W0.8010.30
148_T152_T0.8000.30
168_K306_R0.7990.30
177_R294_N0.7980.30
102_T105_L0.7970.30
290_D294_N0.7970.30
194_D294_N0.7960.30
201_E282_R0.7960.30
88_Q282_R0.7950.30
281_D286_T0.7940.30
98_E322_A0.7930.30
340_F343_Y0.7920.30
43_P101_M0.7920.30
292_Q328_D0.7900.30
32_V45_T0.7900.30
199_A202_D0.7900.30
163_A170_K0.7890.30
117_G243_V0.7850.29
213_F306_R0.7830.29
284_S290_D0.7830.29
181_E290_D0.7810.29
230_K349_A0.7810.29
35_T56_I0.7760.29
267_L280_E0.7750.29
18_F21_A0.7740.29
75_V302_V0.7730.29
79_R90_M0.7710.29
279_E294_N0.7710.29
271_V365_L0.7690.29
188_E267_L0.7690.29
162_K219_L0.7670.28
162_K352_N0.7620.28
67_W101_M0.7620.28
35_T60_H0.7590.28
181_E284_S0.7590.28
285_H344_D0.7570.28
327_V358_I0.7570.28
160_A264_A0.7570.28
85_G160_A0.7560.28
199_A309_L0.7560.28
229_T232_M0.7550.28
334_Y354_L0.7480.27
12_L20_S0.7470.27
270_E290_D0.7460.27
63_K104_G0.7450.27
213_F218_R0.7440.27
136_I140_K0.7420.27
38_D170_K0.7400.27
16_A22_F0.7380.27
194_D280_E0.7370.27
342_T345_K0.7370.27
142_Y200_R0.7350.27
149_Q153_D0.7340.27
322_A325_K0.7330.27
187_A280_E0.7290.26
111_G309_L0.7290.26
96_P117_G0.7260.26
298_S358_I0.7210.26
267_L270_E0.7200.26
265_A305_L0.7200.26
199_A204_Y0.7190.26
96_P118_E0.7160.26
184_E290_D0.7150.26
184_E187_A0.7140.26
46_I113_L0.7110.26
333_K353_A0.7110.26
270_E279_E0.7090.26
161_I222_A0.7080.25
276_I281_D0.7060.25
67_W105_L0.7050.25
141_A145_A0.7050.25
263_G290_D0.7040.25
275_K287_D0.7030.25
219_L245_D0.7010.25
65_L69_I0.7010.25
28_D31_Q0.7000.25
143_V154_T0.6990.25
87_S362_A0.6970.25
200_R282_R0.6960.25
149_Q179_H0.6960.25
77_E92_A0.6940.25
50_A117_G0.6940.25
199_A203_D0.6940.25
271_V275_K0.6930.25
305_L372_L0.6920.25
306_R317_L0.6920.25
213_F255_F0.6920.25
266_G363_E0.6910.25
159_D240_Y0.6890.25
284_S288_L0.6880.24
170_K311_K0.6880.24
357_P363_E0.6880.24
56_I89_K0.6880.24
302_V368_L0.6860.24
242_D286_T0.6850.24
207_K211_P0.6840.24
31_Q295_V0.6830.24
12_L23_M0.6800.24
200_R279_E0.6790.24
150_L309_L0.6780.24
264_A301_I0.6760.24
57_I77_E0.6740.24
15_A19_S0.6740.24
151_V155_K0.6740.24
104_G205_E0.6720.24
20_S25_N0.6700.24
29_V338_D0.6690.24
94_L330_I0.6690.24
40_Q155_K0.6690.24
321_D346_L0.6680.24
66_E84_P0.6660.23
70_L368_L0.6650.23
263_G275_K0.6650.23
312_A338_D0.6640.23
184_E270_E0.6630.23
275_K294_N0.6620.23
234_Q238_Q0.6590.23
83_A87_S0.6580.23
200_R287_D0.6580.23
79_R109_P0.6570.23
300_K303_D0.6560.23
216_F284_S0.6560.23
254_A259_K0.6560.23
218_R232_M0.6560.23
268_I358_I0.6510.23
163_A251_S0.6510.23
25_N28_D0.6510.23
153_D156_A0.6500.23
33_K155_K0.6490.23
310_Q365_L0.6480.23
177_R279_E0.6480.23
186_I298_S0.6460.23
281_D351_R0.6450.23
270_E280_E0.6410.22
174_A183_I0.6410.22
281_D284_S0.6390.22
140_K191_S0.6390.22
331_L346_L0.6390.22
89_K314_P0.6380.22
216_F298_S0.6350.22
43_P68_E0.6320.22
184_E275_K0.6320.22
83_A189_L0.6290.22
191_S262_G0.6290.22
78_E84_P0.6280.22
49_N243_V0.6270.22
177_R288_L0.6260.22
162_K240_Y0.6250.22
323_N360_A0.6220.21
230_K322_A0.6210.21
263_G267_L0.6200.21
150_L368_L0.6190.21
45_T113_L0.6190.21
61_S67_W0.6190.21
197_I219_L0.6180.21
177_R343_Y0.6160.21
65_L68_E0.6140.21
271_V280_E0.6130.21
352_N367_Q0.6120.21
279_E287_D0.6120.21
53_T94_L0.6080.21
35_T69_I0.6070.21
151_V244_V0.6070.21
192_D214_T0.6060.21
13_S17_L0.6060.21
298_S365_L0.6040.21
241_T310_Q0.6030.21
260_V307_P0.6020.21
231_G234_Q0.6020.21
13_S28_D0.6020.21
202_D351_R0.6010.21
250_I342_T0.6000.21
281_D293_A0.5980.20
40_Q322_A0.5960.20
58_Q69_I0.5950.20
68_E81_N0.5940.20
322_A339_G0.5930.20
31_Q89_K0.5930.20
229_T233_D0.5910.20
92_A202_D0.5910.20
166_I229_T0.5910.20
151_V156_A0.5900.20
96_P156_A0.5860.20
310_Q317_L0.5860.20
75_V191_S0.5860.20
126_S130_L0.5850.20
334_Y346_L0.5840.20
198_D270_E0.5840.20
183_I271_V0.5840.20
346_L350_D0.5830.20
262_G369_R0.5830.20
88_Q346_L0.5820.20
153_D296_E0.5810.20
127_D134_G0.5800.20
187_A267_L0.5800.20
225_G283_Y0.5790.20
259_K309_L0.5790.20
30_P110_K0.5780.20
158_T237_E0.5780.20
206_Q219_L0.5780.20
290_D297_G0.5780.20
36_V109_P0.5760.20
161_I307_P0.5750.20
311_K322_A0.5750.20
117_G197_I0.5750.20
314_P318_A0.5750.20
61_S102_T0.5740.19
181_E194_D0.5740.19
331_L363_E0.5720.19
330_I363_E0.5720.19
267_L290_D0.5720.19
151_V168_K0.5700.19
299_Q303_D0.5700.19
46_I244_V0.5700.19
147_T352_N0.5690.19
267_L294_N0.5690.19
361_L372_L0.5690.19
12_L28_D0.5670.19
177_R275_K0.5660.19
22_F25_N0.5650.19
241_T328_D0.5650.19
101_M113_L0.5640.19
214_T218_R0.5630.19
272_A362_A0.5630.19
61_S65_L0.5600.19
37_T337_K0.5590.19
97_G103_C0.5560.19
127_D176_T0.5560.19
196_S249_R0.5550.19
270_E274_S0.5540.19
280_E343_Y0.5530.19
271_V324_F0.5510.19
163_A172_L0.5500.19
86_F259_K0.5500.19
19_S332_A0.5500.19
153_D176_T0.5500.19
77_E90_M0.5490.18
37_T62_Q0.5460.18
159_D349_A0.5450.18
70_L73_V0.5450.18
69_I355_K0.5430.18
24_A47_T0.5410.18
194_D284_S0.5410.18
342_T351_R0.5400.18
131_S307_P0.5400.18
147_T309_L0.5400.18
29_V147_T0.5390.18
177_R184_E0.5380.18
12_L19_S0.5370.18
154_T368_L0.5360.18
15_A311_K0.5360.18
20_S315_E0.5350.18
54_Q261_V0.5340.18
280_E294_N0.5330.18
199_A335_R0.5310.18
322_A372_L0.5300.18
73_V110_K0.5300.18
18_F22_F0.5290.18
177_R291_F0.5290.18
232_M283_Y0.5280.18
73_V300_K0.5280.18
144_M161_I0.5270.18
206_Q212_K0.5270.18
83_A100_D0.5250.18
181_E217_H0.5230.18
87_S118_E0.5230.18
201_E331_L0.5220.17
270_E287_D0.5220.17
180_Y265_A0.5210.17
294_N354_L0.5210.17
203_D274_S0.5200.17
75_V317_L0.5180.17
86_F307_P0.5170.17
77_E117_G0.5160.17
90_M256_P0.5140.17
62_Q90_M0.5140.17
30_P235_Y0.5120.17
194_D268_I0.5120.17
281_D298_S0.5110.17
71_K161_I0.5110.17
263_G270_E0.5110.17
140_K246_L0.5110.17
83_A243_V0.5100.17
83_A370_G0.5100.17
286_T289_W0.5090.17
87_S163_A0.5080.17
200_R270_E0.5080.17
251_S336_T0.5070.17
199_A266_G0.5070.17
244_V247_Q0.5060.17
146_E356_G0.5060.17
274_S363_E0.5050.17
114_I345_K0.5030.17
325_K328_D0.5030.17
177_R263_G0.5030.17
183_I246_L0.5020.17
138_A257_P0.5010.17
140_K255_F0.5010.17
206_Q329_T0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wscA 2 0.664 100 0.56 Contact Map
4bgoA 1 0.6667 100 0.588 Contact Map
3pf0A 1 0.6747 100 0.721 Contact Map
4ecgA 1 0.6827 100 0.722 Contact Map
3oyvA 1 0.4533 99.9 0.831 Contact Map
3ay2A 1 0.2373 98.8 0.914 Contact Map
3c75A 1 0.2533 98.7 0.917 Contact Map
1cuoA 1 0.24 98.6 0.919 Contact Map
1qhqA 3 0.2747 98.2 0.927 Contact Map
2ccwA 1 0.24 98.2 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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