EFEO - ECOLI - GREMLIN Contacts

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EFEO - Iron uptake system component EfeO

UniProt:	P0AB24	Sequences: MTINFRRNALQLSVAALFSSAFMANAADVPQVKVTVTDKQCEPMTITVNAGKTQFIIQNHSQKALEWEILKGVMVVEERENIAPGFSQKMTANLQPGEYDMTCGLLTNPKGKLIVKGEATADAAQSDALLSLGGAITAYKAYVMAETTQLVTDTKAFTDAIKAGDIEKAKALYAPTRQHYERIEPIAELFSDLDGSIDAREDDYEQKAADPKFTGFHRLEKALFGDNTTKGMDQYAEQLYTDVVDLQKRISELAFPPSKVVGGAAGLIEEVAASKISGEEDRYSHTDLWDFQANVEGSQKIVDLLRPQLQKANPELLAKVDANFKKVDTILAKYRTKDGFETYDKLTDADRNALKGPITALAEDLAQLRGVLGLD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13861
Length:	375 (356)
Sequences:	556 (371)
Seq/√Len:	19.7

ECOLI - EFEO
BACSU - EFEM

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
306_R	321_D	5.920	1.00
17_L	20_S	5.417	1.00
168_K	172_L	5.128	1.00
158_T	240_Y	5.048	1.00
173_Y	281_D	4.849	1.00
238_Q	242_D	3.858	1.00
165_D	168_K	3.742	1.00
202_D	282_R	3.695	1.00
330_I	357_P	3.668	1.00
222_A	232_M	3.315	1.00
346_L	351_R	3.188	1.00
14_V	17_L	3.163	0.99
328_D	332_A	3.123	0.99
160_A	172_L	3.099	0.99
197_I	243_V	3.056	0.99
347_T	350_D	3.050	0.99
205_E	211_P	2.942	0.99
162_K	237_E	2.933	0.99
292_Q	340_F	2.898	0.99
16_A	19_S	2.857	0.99
155_K	159_D	2.832	0.99
204_Y	211_P	2.807	0.99
160_A	165_D	2.713	0.98
48_V	113_L	2.634	0.98
166_I	170_K	2.604	0.98
150_L	243_V	2.455	0.97
202_D	283_Y	2.432	0.97
79_R	88_Q	2.263	0.95
155_K	244_V	2.239	0.95
161_I	166_I	2.229	0.94
216_F	243_V	2.209	0.94
33_K	44_M	2.095	0.92
68_E	79_R	2.057	0.92
132_L	257_P	2.049	0.91
341_E	345_K	2.031	0.91
199_A	213_F	2.006	0.91
167_E	170_K	1.933	0.89
180_Y	216_F	1.916	0.88
196_S	238_Q	1.906	0.88
228_T	231_G	1.906	0.88
178_Q	293_A	1.854	0.87
155_K	240_Y	1.841	0.86
356_G	359_T	1.840	0.86
196_S	245_D	1.836	0.86
170_K	227_N	1.830	0.86
218_R	235_Y	1.823	0.86
12_L	17_L	1.819	0.86
69_I	94_L	1.810	0.85
180_Y	246_L	1.806	0.85
155_K	158_T	1.798	0.85
17_L	21_A	1.762	0.84
134_G	138_A	1.725	0.82
194_D	200_R	1.675	0.80
194_D	270_E	1.673	0.80
221_K	226_D	1.641	0.79
13_S	16_A	1.613	0.78
48_V	53_T	1.592	0.77
265_A	269_E	1.585	0.77
50_A	96_P	1.575	0.76
201_E	221_K	1.556	0.75
162_K	233_D	1.554	0.75
139_Y	297_G	1.547	0.75
214_T	242_D	1.539	0.74
154_T	243_V	1.536	0.74
257_P	305_L	1.523	0.74
180_Y	274_S	1.511	0.73
68_E	88_Q	1.504	0.73
300_K	304_L	1.501	0.72
15_A	20_S	1.487	0.72
38_D	62_Q	1.479	0.71
161_I	232_M	1.470	0.71
146_E	179_H	1.469	0.71
323_N	326_K	1.464	0.70
250_I	260_V	1.458	0.70
105_L	109_P	1.420	0.68
204_Y	282_R	1.413	0.68
180_Y	249_R	1.413	0.68
262_G	364_D	1.413	0.68
98_E	114_I	1.403	0.67
98_E	112_K	1.389	0.66
182_R	296_E	1.367	0.65
204_Y	213_F	1.360	0.65
132_L	305_L	1.346	0.64
104_G	109_P	1.345	0.64
46_I	111_G	1.344	0.64
153_D	179_H	1.344	0.64
309_L	368_L	1.339	0.63
335_R	340_F	1.337	0.63
299_Q	328_D	1.334	0.63
200_R	280_E	1.333	0.63
350_D	353_A	1.298	0.61
313_N	367_Q	1.292	0.61
196_S	242_D	1.289	0.60
325_K	329_T	1.278	0.60
213_F	221_K	1.275	0.59
151_V	247_Q	1.262	0.59
72_G	110_K	1.254	0.58
14_V	20_S	1.245	0.58
180_Y	197_I	1.230	0.57
163_A	168_K	1.228	0.57
36_V	68_E	1.227	0.56
261_V	369_R	1.223	0.56
327_V	361_L	1.223	0.56
16_A	20_S	1.223	0.56
198_D	287_D	1.223	0.56
180_Y	320_V	1.217	0.56
234_Q	314_P	1.208	0.55
284_S	294_N	1.200	0.55
177_R	290_D	1.200	0.55
57_I	108_N	1.197	0.55
332_A	335_R	1.191	0.54
303_D	335_R	1.187	0.54
150_L	216_F	1.186	0.54
352_N	359_T	1.186	0.54
292_Q	332_A	1.185	0.54
204_Y	207_K	1.184	0.54
131_S	311_K	1.175	0.53
100_D	112_K	1.167	0.53
56_I	87_S	1.165	0.53
168_K	171_A	1.164	0.52
292_Q	296_E	1.149	0.51
295_V	327_V	1.148	0.51
268_I	327_V	1.142	0.51
194_D	198_D	1.131	0.50
306_R	346_L	1.130	0.50
68_E	90_M	1.128	0.50
159_D	163_A	1.126	0.50
341_E	346_L	1.125	0.50
38_D	63_K	1.122	0.50
271_V	295_V	1.117	0.49
321_D	325_K	1.105	0.49
295_V	328_D	1.100	0.48
77_E	88_Q	1.097	0.48
219_L	235_Y	1.090	0.48
334_Y	350_D	1.087	0.48
106_L	109_P	1.084	0.47
235_Y	242_D	1.082	0.47
20_S	23_M	1.080	0.47
309_L	317_L	1.079	0.47
12_L	16_A	1.071	0.46
288_L	294_N	1.070	0.46
197_I	216_F	1.065	0.46
75_V	364_D	1.064	0.46
37_T	40_Q	1.062	0.46
291_F	343_Y	1.058	0.46
68_E	109_P	1.057	0.46
19_S	22_F	1.056	0.46
202_D	219_L	1.055	0.45
158_T	162_K	1.055	0.45
156_A	172_L	1.048	0.45
267_L	275_K	1.048	0.45
156_A	168_K	1.040	0.45
275_K	280_E	1.039	0.44
238_Q	245_D	1.036	0.44
271_V	364_D	1.031	0.44
252_E	350_D	1.026	0.44
82_I	353_A	1.018	0.43
11_Q	15_A	1.017	0.43
184_E	267_L	1.014	0.43
364_D	369_R	1.012	0.43
280_E	287_D	1.007	0.42
181_E	294_N	1.002	0.42
49_N	116_K	0.994	0.42
177_R	287_D	0.993	0.42
204_Y	214_T	0.990	0.41
322_A	326_K	0.987	0.41
276_I	301_I	0.982	0.41
132_L	308_Q	0.978	0.41
305_L	308_Q	0.978	0.41
334_Y	341_E	0.976	0.40
181_E	275_K	0.973	0.40
224_F	281_D	0.969	0.40
109_P	269_E	0.963	0.40
31_Q	56_I	0.960	0.40
270_E	275_K	0.959	0.39
335_R	338_D	0.958	0.39
192_D	249_R	0.958	0.39
82_I	90_M	0.943	0.38
320_V	358_I	0.942	0.38
336_T	345_K	0.940	0.38
13_S	329_T	0.938	0.38
228_T	233_D	0.922	0.37
73_V	129_L	0.921	0.37
296_E	328_D	0.911	0.37
322_A	349_A	0.911	0.37
219_L	237_E	0.908	0.36
173_Y	309_L	0.907	0.36
157_F	172_L	0.906	0.36
320_V	364_D	0.902	0.36
245_D	249_R	0.901	0.36
70_L	272_A	0.894	0.36
228_T	232_M	0.894	0.36
288_L	297_G	0.891	0.35
37_T	60_H	0.891	0.35
214_T	238_Q	0.889	0.35
136_I	256_P	0.888	0.35
202_D	213_F	0.888	0.35
48_V	69_I	0.886	0.35
142_Y	182_R	0.883	0.35
94_L	231_G	0.881	0.35
206_Q	211_P	0.880	0.35
326_K	357_P	0.880	0.35
217_H	284_S	0.879	0.35
14_V	21_A	0.879	0.35
191_S	369_R	0.878	0.35
277_S	284_S	0.876	0.34
323_N	372_L	0.874	0.34
176_T	255_F	0.874	0.34
271_V	291_F	0.871	0.34
275_K	290_D	0.871	0.34
171_A	335_R	0.871	0.34
48_V	57_I	0.862	0.34
222_A	228_T	0.861	0.34
289_W	342_T	0.856	0.33
114_I	120_T	0.856	0.33
298_S	302_V	0.855	0.33
347_T	351_R	0.852	0.33
53_T	75_V	0.851	0.33
140_K	253_L	0.848	0.33
55_F	246_L	0.847	0.33
259_K	347_T	0.845	0.33
213_F	282_R	0.841	0.32
134_G	137_T	0.840	0.32
41_C	51_G	0.838	0.32
299_Q	325_K	0.832	0.32
330_I	353_A	0.830	0.32
216_F	309_L	0.822	0.31
148_T	244_V	0.819	0.31
88_Q	306_R	0.816	0.31
352_N	356_G	0.813	0.31
319_K	323_N	0.812	0.31
11_Q	14_V	0.811	0.31
118_E	295_V	0.810	0.31
270_E	294_N	0.806	0.31
348_D	352_N	0.806	0.31
173_Y	289_W	0.801	0.30
148_T	152_T	0.800	0.30
168_K	306_R	0.799	0.30
177_R	294_N	0.798	0.30
102_T	105_L	0.797	0.30
290_D	294_N	0.797	0.30
194_D	294_N	0.796	0.30
201_E	282_R	0.796	0.30
88_Q	282_R	0.795	0.30
281_D	286_T	0.794	0.30
98_E	322_A	0.793	0.30
340_F	343_Y	0.792	0.30
43_P	101_M	0.792	0.30
292_Q	328_D	0.790	0.30
32_V	45_T	0.790	0.30
199_A	202_D	0.790	0.30
163_A	170_K	0.789	0.30
117_G	243_V	0.785	0.29
213_F	306_R	0.783	0.29
284_S	290_D	0.783	0.29
181_E	290_D	0.781	0.29
230_K	349_A	0.781	0.29
35_T	56_I	0.776	0.29
267_L	280_E	0.775	0.29
18_F	21_A	0.774	0.29
75_V	302_V	0.773	0.29
79_R	90_M	0.771	0.29
279_E	294_N	0.771	0.29
271_V	365_L	0.769	0.29
188_E	267_L	0.769	0.29
162_K	219_L	0.767	0.28
162_K	352_N	0.762	0.28
67_W	101_M	0.762	0.28
35_T	60_H	0.759	0.28
181_E	284_S	0.759	0.28
285_H	344_D	0.757	0.28
327_V	358_I	0.757	0.28
160_A	264_A	0.757	0.28
85_G	160_A	0.756	0.28
199_A	309_L	0.756	0.28
229_T	232_M	0.755	0.28
334_Y	354_L	0.748	0.27
12_L	20_S	0.747	0.27
270_E	290_D	0.746	0.27
63_K	104_G	0.745	0.27
213_F	218_R	0.744	0.27
136_I	140_K	0.742	0.27
38_D	170_K	0.740	0.27
16_A	22_F	0.738	0.27
194_D	280_E	0.737	0.27
342_T	345_K	0.737	0.27
142_Y	200_R	0.735	0.27
149_Q	153_D	0.734	0.27
322_A	325_K	0.733	0.27
187_A	280_E	0.729	0.26
111_G	309_L	0.729	0.26
96_P	117_G	0.726	0.26
298_S	358_I	0.721	0.26
267_L	270_E	0.720	0.26
265_A	305_L	0.720	0.26
199_A	204_Y	0.719	0.26
96_P	118_E	0.716	0.26
184_E	290_D	0.715	0.26
184_E	187_A	0.714	0.26
46_I	113_L	0.711	0.26
333_K	353_A	0.711	0.26
270_E	279_E	0.709	0.26
161_I	222_A	0.708	0.25
276_I	281_D	0.706	0.25
67_W	105_L	0.705	0.25
141_A	145_A	0.705	0.25
263_G	290_D	0.704	0.25
275_K	287_D	0.703	0.25
219_L	245_D	0.701	0.25
65_L	69_I	0.701	0.25
28_D	31_Q	0.700	0.25
143_V	154_T	0.699	0.25
87_S	362_A	0.697	0.25
200_R	282_R	0.696	0.25
149_Q	179_H	0.696	0.25
77_E	92_A	0.694	0.25
50_A	117_G	0.694	0.25
199_A	203_D	0.694	0.25
271_V	275_K	0.693	0.25
305_L	372_L	0.692	0.25
306_R	317_L	0.692	0.25
213_F	255_F	0.692	0.25
266_G	363_E	0.691	0.25
159_D	240_Y	0.689	0.25
284_S	288_L	0.688	0.24
170_K	311_K	0.688	0.24
357_P	363_E	0.688	0.24
56_I	89_K	0.688	0.24
302_V	368_L	0.686	0.24
242_D	286_T	0.685	0.24
207_K	211_P	0.684	0.24
31_Q	295_V	0.683	0.24
12_L	23_M	0.680	0.24
200_R	279_E	0.679	0.24
150_L	309_L	0.678	0.24
264_A	301_I	0.676	0.24
57_I	77_E	0.674	0.24
15_A	19_S	0.674	0.24
151_V	155_K	0.674	0.24
104_G	205_E	0.672	0.24
20_S	25_N	0.670	0.24
29_V	338_D	0.669	0.24
94_L	330_I	0.669	0.24
40_Q	155_K	0.669	0.24
321_D	346_L	0.668	0.24
66_E	84_P	0.666	0.23
70_L	368_L	0.665	0.23
263_G	275_K	0.665	0.23
312_A	338_D	0.664	0.23
184_E	270_E	0.663	0.23
275_K	294_N	0.662	0.23
234_Q	238_Q	0.659	0.23
83_A	87_S	0.658	0.23
200_R	287_D	0.658	0.23
79_R	109_P	0.657	0.23
300_K	303_D	0.656	0.23
216_F	284_S	0.656	0.23
254_A	259_K	0.656	0.23
218_R	232_M	0.656	0.23
268_I	358_I	0.651	0.23
163_A	251_S	0.651	0.23
25_N	28_D	0.651	0.23
153_D	156_A	0.650	0.23
33_K	155_K	0.649	0.23
310_Q	365_L	0.648	0.23
177_R	279_E	0.648	0.23
186_I	298_S	0.646	0.23
281_D	351_R	0.645	0.23
270_E	280_E	0.641	0.22
174_A	183_I	0.641	0.22
281_D	284_S	0.639	0.22
140_K	191_S	0.639	0.22
331_L	346_L	0.639	0.22
89_K	314_P	0.638	0.22
216_F	298_S	0.635	0.22
43_P	68_E	0.632	0.22
184_E	275_K	0.632	0.22
83_A	189_L	0.629	0.22
191_S	262_G	0.629	0.22
78_E	84_P	0.628	0.22
49_N	243_V	0.627	0.22
177_R	288_L	0.626	0.22
162_K	240_Y	0.625	0.22
323_N	360_A	0.622	0.21
230_K	322_A	0.621	0.21
263_G	267_L	0.620	0.21
150_L	368_L	0.619	0.21
45_T	113_L	0.619	0.21
61_S	67_W	0.619	0.21
197_I	219_L	0.618	0.21
177_R	343_Y	0.616	0.21
65_L	68_E	0.614	0.21
271_V	280_E	0.613	0.21
352_N	367_Q	0.612	0.21
279_E	287_D	0.612	0.21
53_T	94_L	0.608	0.21
35_T	69_I	0.607	0.21
151_V	244_V	0.607	0.21
192_D	214_T	0.606	0.21
13_S	17_L	0.606	0.21
298_S	365_L	0.604	0.21
241_T	310_Q	0.603	0.21
260_V	307_P	0.602	0.21
231_G	234_Q	0.602	0.21
13_S	28_D	0.602	0.21
202_D	351_R	0.601	0.21
250_I	342_T	0.600	0.21
281_D	293_A	0.598	0.20
40_Q	322_A	0.596	0.20
58_Q	69_I	0.595	0.20
68_E	81_N	0.594	0.20
322_A	339_G	0.593	0.20
31_Q	89_K	0.593	0.20
229_T	233_D	0.591	0.20
92_A	202_D	0.591	0.20
166_I	229_T	0.591	0.20
151_V	156_A	0.590	0.20
96_P	156_A	0.586	0.20
310_Q	317_L	0.586	0.20
75_V	191_S	0.586	0.20
126_S	130_L	0.585	0.20
334_Y	346_L	0.584	0.20
198_D	270_E	0.584	0.20
183_I	271_V	0.584	0.20
346_L	350_D	0.583	0.20
262_G	369_R	0.583	0.20
88_Q	346_L	0.582	0.20
153_D	296_E	0.581	0.20
127_D	134_G	0.580	0.20
187_A	267_L	0.580	0.20
225_G	283_Y	0.579	0.20
259_K	309_L	0.579	0.20
30_P	110_K	0.578	0.20
158_T	237_E	0.578	0.20
206_Q	219_L	0.578	0.20
290_D	297_G	0.578	0.20
36_V	109_P	0.576	0.20
161_I	307_P	0.575	0.20
311_K	322_A	0.575	0.20
117_G	197_I	0.575	0.20
314_P	318_A	0.575	0.20
61_S	102_T	0.574	0.19
181_E	194_D	0.574	0.19
331_L	363_E	0.572	0.19
330_I	363_E	0.572	0.19
267_L	290_D	0.572	0.19
151_V	168_K	0.570	0.19
299_Q	303_D	0.570	0.19
46_I	244_V	0.570	0.19
147_T	352_N	0.569	0.19
267_L	294_N	0.569	0.19
361_L	372_L	0.569	0.19
12_L	28_D	0.567	0.19
177_R	275_K	0.566	0.19
22_F	25_N	0.565	0.19
241_T	328_D	0.565	0.19
101_M	113_L	0.564	0.19
214_T	218_R	0.563	0.19
272_A	362_A	0.563	0.19
61_S	65_L	0.560	0.19
37_T	337_K	0.559	0.19
97_G	103_C	0.556	0.19
127_D	176_T	0.556	0.19
196_S	249_R	0.555	0.19
270_E	274_S	0.554	0.19
280_E	343_Y	0.553	0.19
271_V	324_F	0.551	0.19
163_A	172_L	0.550	0.19
86_F	259_K	0.550	0.19
19_S	332_A	0.550	0.19
153_D	176_T	0.550	0.19
77_E	90_M	0.549	0.18
37_T	62_Q	0.546	0.18
159_D	349_A	0.545	0.18
70_L	73_V	0.545	0.18
69_I	355_K	0.543	0.18
24_A	47_T	0.541	0.18
194_D	284_S	0.541	0.18
342_T	351_R	0.540	0.18
131_S	307_P	0.540	0.18
147_T	309_L	0.540	0.18
29_V	147_T	0.539	0.18
177_R	184_E	0.538	0.18
12_L	19_S	0.537	0.18
154_T	368_L	0.536	0.18
15_A	311_K	0.536	0.18
20_S	315_E	0.535	0.18
54_Q	261_V	0.534	0.18
280_E	294_N	0.533	0.18
199_A	335_R	0.531	0.18
322_A	372_L	0.530	0.18
73_V	110_K	0.530	0.18
18_F	22_F	0.529	0.18
177_R	291_F	0.529	0.18
232_M	283_Y	0.528	0.18
73_V	300_K	0.528	0.18
144_M	161_I	0.527	0.18
206_Q	212_K	0.527	0.18
83_A	100_D	0.525	0.18
181_E	217_H	0.523	0.18
87_S	118_E	0.523	0.18
201_E	331_L	0.522	0.17
270_E	287_D	0.522	0.17
180_Y	265_A	0.521	0.17
294_N	354_L	0.521	0.17
203_D	274_S	0.520	0.17
75_V	317_L	0.518	0.17
86_F	307_P	0.517	0.17
77_E	117_G	0.516	0.17
90_M	256_P	0.514	0.17
62_Q	90_M	0.514	0.17
30_P	235_Y	0.512	0.17
194_D	268_I	0.512	0.17
281_D	298_S	0.511	0.17
71_K	161_I	0.511	0.17
263_G	270_E	0.511	0.17
140_K	246_L	0.511	0.17
83_A	243_V	0.510	0.17
83_A	370_G	0.510	0.17
286_T	289_W	0.509	0.17
87_S	163_A	0.508	0.17
200_R	270_E	0.508	0.17
251_S	336_T	0.507	0.17
199_A	266_G	0.507	0.17
244_V	247_Q	0.506	0.17
146_E	356_G	0.506	0.17
274_S	363_E	0.505	0.17
114_I	345_K	0.503	0.17
325_K	328_D	0.503	0.17
177_R	263_G	0.503	0.17
183_I	246_L	0.502	0.17
138_A	257_P	0.501	0.17
140_K	255_F	0.501	0.17
206_Q	329_T	0.500	0.17

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3wscA	2	0.664	100	0.56	Contact Map
4bgoA	1	0.6667	100	0.588	Contact Map
3pf0A	1	0.6747	100	0.721	Contact Map
4ecgA	1	0.6827	100	0.722	Contact Map
3oyvA	1	0.4533	99.9	0.831	Contact Map
3ay2A	1	0.2373	98.8	0.914	Contact Map
3c75A	1	0.2533	98.7	0.917	Contact Map
1cuoA	1	0.24	98.6	0.919	Contact Map
1qhqA	3	0.2747	98.2	0.927	Contact Map
2ccwA	1	0.24	98.2	0.928	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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