GREMLIN Database
TUSE - Sulfurtransferase TusE
UniProt: P0AB18 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12876
Length: 109 (106)
Sequences: 770 (417)
Seq/√Len: 40.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_E22_Q6.0821.00
85_Y109_I3.9481.00
25_E48_R3.6831.00
39_L47_V2.8461.00
35_E98_K2.8171.00
28_A99_I2.7631.00
50_V96_A2.4311.00
35_E99_I2.4041.00
4_F27_L2.3321.00
31_I99_I2.2801.00
24_S27_L2.1410.99
63_I91_G2.0030.99
82_R85_Y1.9160.99
5_E26_P1.8550.98
91_G97_T1.7820.98
46_V96_A1.7790.98
7_K24_S1.7700.98
30_V33_E1.6530.96
26_P29_V1.6140.96
37_I99_I1.6000.96
82_R86_R1.5900.95
45_E78_K1.5390.95
52_D73_K1.5030.94
52_D55_L1.3950.91
94_K98_K1.3730.90
4_F30_V1.3310.89
30_V34_N1.3270.89
71_A76_E1.3000.88
49_F69_A1.2820.87
66_L93_A1.2370.85
106_V109_I1.2350.85
43_H87_L1.2080.84
50_V106_V1.1890.83
11_T31_I1.1750.82
59_T106_V1.1610.81
44_W47_V1.1360.80
28_A44_W1.1300.79
85_Y91_G1.1200.79
25_E29_V1.0900.77
9_I30_V1.0850.76
41_P45_E1.0840.76
75_G79_G1.0780.76
12_D66_L1.0430.73
62_A66_L1.0380.73
9_I27_L1.0340.73
14_E104_K1.0230.72
79_G83_Y1.0220.72
41_P51_R1.0200.72
31_I98_K1.0100.71
85_Y92_P1.0090.71
82_R107_K0.9950.70
45_E79_G0.9930.70
31_I34_N0.9880.69
60_S93_A0.9760.68
9_I31_I0.9750.68
11_T34_N0.9680.68
16_Y95_Q0.9580.67
63_I66_L0.9460.66
42_E83_Y0.9390.65
16_Y20_S0.9360.65
47_V99_I0.9120.63
23_W28_A0.9010.62
40_S43_H0.8930.61
48_R55_L0.8810.60
10_E26_P0.8550.58
53_F97_T0.8500.58
56_E73_K0.8310.56
46_V70_M0.8310.56
103_P108_C0.8280.56
14_E31_I0.8240.55
105_P108_C0.8230.55
54_Y61_P0.8220.55
70_M74_F0.8220.55
32_A44_W0.7720.50
51_R55_L0.7700.50
53_F57_F0.7680.50
12_D18_K0.7670.50
45_E83_Y0.7670.50
17_L102_L0.7490.48
32_A51_R0.7470.48
35_E95_Q0.7460.48
8_E19_E0.7330.47
92_P103_P0.7320.47
93_A96_A0.7270.46
46_V76_E0.7230.46
57_F66_L0.7030.44
18_K38_S0.7030.44
7_K38_S0.7000.44
4_F9_I0.6980.44
15_G54_Y0.6980.44
50_V59_T0.6940.43
49_F65_M0.6820.42
63_I67_V0.6780.42
65_M97_T0.6780.42
50_V102_L0.6770.42
14_E36_G0.6760.42
24_S29_V0.6730.41
63_I85_Y0.6630.40
20_S24_S0.6610.40
20_S51_R0.6580.40
53_F60_S0.6570.40
60_S106_V0.6540.40
48_R76_E0.6520.39
42_E67_V0.6510.39
97_T106_V0.6390.38
90_K95_Q0.6330.38
81_S91_G0.6320.38
59_T66_L0.6290.37
49_F80_N0.6270.37
18_K47_V0.6240.37
10_E22_Q0.6220.37
85_Y89_P0.6210.37
75_G78_K0.6210.37
50_V107_K0.6180.37
29_V73_K0.6070.36
63_I93_A0.6060.36
37_I43_H0.6050.35
18_K98_K0.5990.35
56_E59_T0.5980.35
7_K33_E0.5960.35
27_L31_I0.5900.34
32_A99_I0.5840.34
29_V41_P0.5750.33
104_K108_C0.5730.33
18_K40_S0.5710.33
37_I87_L0.5700.33
14_E58_N0.5690.32
5_E8_E0.5680.32
49_F91_G0.5660.32
19_E29_V0.5630.32
21_S38_S0.5620.32
42_E45_E0.5610.32
58_N106_V0.5600.32
93_A105_P0.5580.32
39_L99_I0.5530.31
31_I35_E0.5530.31
19_E55_L0.5510.31
26_P52_D0.5420.30
61_P66_L0.5360.30
85_Y107_K0.5330.30
64_R94_K0.5330.30
63_I107_K0.5320.30
65_M91_G0.5300.29
10_E13_T0.5280.29
77_E80_N0.5230.29
33_E39_L0.5230.29
12_D93_A0.5230.29
28_A71_A0.5210.29
62_A69_A0.5160.28
48_R52_D0.5160.28
81_S92_P0.5150.28
50_V91_G0.5120.28
12_D53_F0.5120.28
34_N37_I0.5100.28
17_L84_L0.5080.28
59_T97_T0.5060.28
5_E11_T0.5060.28
27_L99_I0.5010.27
19_E38_S0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yx3A 1 1 100 0.023 Contact Map
1sauA 1 0.9908 100 0.072 Contact Map
1ji8A 1 0.9358 100 0.157 Contact Map
3or1C 1 0.9358 100 0.172 Contact Map
3k2zA 2 0.633 64.8 0.913 Contact Map
3rixA 1 0 33.1 0.929 Contact Map
2vs7A 1 0.7982 27.1 0.931 Contact Map
1jhfA 2 0.633 23.7 0.933 Contact Map
2d1sA 1 0.8165 22.8 0.934 Contact Map
1y13A 5 0.8807 18.8 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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