GREMLIN Database
YCCF - Inner membrane protein YccF
UniProt: P0AB12 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12306
Length: 148 (120)
Sequences: 533 (317)
Seq/√Len: 28.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
98_G115_F5.0461.00
18_T49_L5.0071.00
102_C111_G3.8671.00
29_I35_L2.9061.00
29_I38_T2.7621.00
98_G111_G2.6221.00
22_L45_T2.6110.99
3_T7_I2.5680.99
40_S125_V2.5540.99
94_H114_N2.4020.99
111_G115_F2.3970.99
10_F50_V2.3390.99
83_L122_L2.2530.98
10_F18_T1.9720.96
40_S43_E1.8950.95
58_H127_R1.8530.95
26_L30_V1.7920.94
98_G102_C1.6840.92
81_F85_F1.6760.91
28_S37_L1.6710.91
76_T80_I1.6350.90
30_V103_I1.6050.90
94_H117_I1.5510.88
11_V15_F1.4880.86
21_W90_L1.4720.85
10_F49_L1.4520.84
57_I130_V1.4490.84
43_E125_V1.4420.84
20_G88_W1.4280.83
28_S86_F1.3670.80
25_T38_T1.3570.80
20_G93_M1.3500.79
97_T101_Q1.3410.79
5_L8_L1.3380.79
25_T42_W1.3350.79
13_G16_A1.3190.78
22_L49_L1.2930.76
18_T22_L1.2880.76
102_C115_F1.2310.73
83_L123_W1.2080.71
113_A116_K1.2060.71
37_L78_L1.2060.71
96_A100_A1.2010.71
48_S94_H1.1850.70
12_L101_Q1.1830.70
92_L96_A1.1730.69
37_L86_F1.0980.64
31_L34_T1.0950.63
35_L38_T1.0680.62
88_W92_L0.9950.56
39_R125_V0.9930.56
56_A120_I0.9710.54
85_F89_W0.9620.53
25_T29_I0.9590.53
86_F89_W0.9580.53
10_F15_F0.9500.53
29_I125_V0.9380.52
74_G78_L0.9330.51
19_L33_F0.9280.51
25_T41_C0.9100.49
29_I40_S0.8980.48
17_T89_W0.8920.48
108_I111_G0.8860.48
97_T114_N0.8790.47
47_L120_I0.8750.47
86_F90_L0.8750.47
81_F90_L0.8720.46
57_I128_R0.8650.46
84_I88_W0.8490.45
17_T112_I0.8380.44
77_V92_L0.8360.44
17_T114_N0.8360.44
80_I105_I0.8350.44
21_W41_C0.8320.43
24_A86_F0.8300.43
24_A90_L0.8230.43
71_L125_V0.8210.43
76_T92_L0.8060.41
17_T97_T0.8040.41
102_C108_I0.8030.41
1_M5_L0.7930.40
29_I43_E0.7910.40
2_R50_V0.7790.39
8_L88_W0.7780.39
77_V103_I0.7760.39
93_M97_T0.7740.39
22_L26_L0.7730.39
80_I123_W0.7670.38
5_L113_A0.7530.37
75_G125_V0.7500.37
3_T88_W0.7440.37
19_L31_L0.7440.37
95_I129_V0.7400.36
11_V117_I0.7330.36
54_N129_V0.7270.36
103_I122_L0.7260.35
44_I129_V0.7240.35
31_L43_E0.7220.35
84_I103_I0.7140.35
79_N126_G0.7050.34
32_I39_R0.7010.34
29_I39_R0.6990.34
53_G82_W0.6920.33
2_R112_I0.6890.33
31_L110_V0.6830.32
47_L113_A0.6820.32
8_L114_N0.6790.32
19_L78_L0.6750.32
44_I101_Q0.6730.32
37_L127_R0.6680.31
57_I103_I0.6670.31
99_I111_G0.6670.31
71_L75_G0.6640.31
106_I119_A0.6630.31
92_L97_T0.6610.31
55_E122_L0.6550.31
13_G48_S0.6530.30
24_A30_V0.6520.30
38_T43_E0.6510.30
28_S48_S0.6470.30
44_I94_H0.6470.30
21_W44_I0.6460.30
86_F123_W0.6420.30
41_C55_E0.6350.29
54_N113_A0.6340.29
83_L90_L0.6280.29
24_A85_F0.6270.29
21_W118_A0.6250.29
7_I11_V0.6160.28
102_C112_I0.6150.28
71_L121_A0.6130.28
13_G114_N0.6120.28
48_S81_F0.6110.28
101_Q114_N0.6110.28
1_M7_I0.6040.27
34_T79_N0.6030.27
119_A130_V0.6010.27
35_L125_V0.5970.27
38_T125_V0.5950.27
17_T93_M0.5920.27
50_V131_S0.5880.26
33_F56_A0.5880.26
9_N25_T0.5850.26
39_R43_E0.5840.26
28_S32_I0.5790.26
41_C54_N0.5760.26
110_V113_A0.5730.25
15_F50_V0.5700.25
30_V96_A0.5670.25
24_A94_H0.5670.25
84_I89_W0.5630.25
17_T78_L0.5590.25
83_L86_F0.5550.24
43_E102_C0.5530.24
99_I122_L0.5520.24
12_L39_R0.5460.24
23_L96_A0.5460.24
72_N122_L0.5350.23
34_T110_V0.5330.23
70_L75_G0.5310.23
73_T97_T0.5290.23
19_L93_M0.5250.23
44_I88_W0.5250.23
45_T123_W0.5250.23
19_L80_I0.5240.23
95_I130_V0.5200.22
9_N31_L0.5160.22
2_R22_L0.5130.22
70_L86_F0.5130.22
32_I128_R0.5130.22
30_V95_I0.5110.22
11_V111_G0.5110.22
85_F99_I0.5100.22
20_G24_A0.5100.22
16_A97_T0.5090.22
8_L113_A0.5080.22
90_L121_A0.5040.22
104_S107_G0.5010.21
19_L22_L0.5010.21
16_A24_A0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4il3A 1 0.8446 5.8 0.959 Contact Map
3tx3A 2 0.8986 3.2 0.964 Contact Map
3ondA 4 0.3378 2.8 0.965 Contact Map
1lxnA 4 0.223 2.5 0.966 Contact Map
3b4rA 2 0.9459 2.2 0.967 Contact Map
4aw6A 2 0.8446 2.1 0.967 Contact Map
2c9kA 1 0.3919 1.7 0.969 Contact Map
2kncB 1 0.3851 1.7 0.969 Contact Map
1ji6A 1 0.3919 1.5 0.97 Contact Map
2epiA 4 0.2297 1.4 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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