GREMLIN Database
ELYC - Envelope biogenesis factor ElyC
UniProt: P0AB01 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12166
Length: 259 (228)
Sequences: 2405 (1948)
Seq/√Len: 129.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
116_W155_Q4.1481.00
126_F146_A3.1761.00
163_K167_E3.1141.00
84_V112_G3.0801.00
169_A197_F3.0491.00
126_F156_I2.9951.00
111_E114_R2.9091.00
143_A153_R2.8911.00
185_T190_L2.8731.00
143_A147_Q2.8691.00
137_S140_E2.6861.00
143_A158_T2.5241.00
79_V182_L2.3881.00
127_T162_P2.3671.00
159_L168_E2.3631.00
140_E160_D2.3611.00
125_I172_V2.3441.00
190_L206_P2.2771.00
166_E170_A2.2251.00
116_W152_P2.2201.00
161_L171_A2.2141.00
139_A158_T2.1791.00
82_I184_V2.1641.00
113_I146_A2.1411.00
80_D180_P2.1381.00
126_F142_G2.1311.00
173_K177_G2.1311.00
194_M204_P2.1051.00
136_V144_R2.0181.00
53_L234_S2.0051.00
194_M206_P1.9221.00
70_Y194_M1.8971.00
159_L162_P1.8701.00
124_L146_A1.8451.00
162_P168_E1.8321.00
26_G39_G1.7571.00
110_N145_V1.7521.00
169_A200_E1.7491.00
164_D167_E1.7251.00
111_E209_A1.6931.00
81_Y176_I1.6921.00
123_K155_Q1.6621.00
168_E172_V1.6321.00
170_A174_Q1.6101.00
123_K157_I1.6091.00
194_M198_Q1.5771.00
140_E144_R1.5751.00
147_Q153_R1.5701.00
159_L171_A1.5311.00
111_E207_A1.5301.00
129_G138_T1.5131.00
112_G146_A1.5091.00
87_G105_S1.4651.00
82_I115_L1.4431.00
168_E171_A1.4061.00
109_L146_A1.4001.00
127_T172_V1.3991.00
152_P155_Q1.3821.00
137_S160_D1.3801.00
83_V181_F1.3691.00
115_L207_A1.3641.00
106_L110_N1.3481.00
159_L172_V1.3431.00
113_I117_R1.3431.00
36_Q40_K1.3321.00
187_A211_Q1.3231.00
188_S236_R1.3071.00
183_L197_F1.2971.00
140_E143_A1.2881.00
85_L193_A1.2711.00
129_G162_P1.2691.00
126_F158_T1.2521.00
181_F202_L1.2421.00
51_L55_L1.2391.00
109_L142_G1.2261.00
181_F204_P1.2261.00
166_E200_E1.2221.00
25_A29_L1.2130.99
140_E158_T1.2130.99
53_L231_L1.2050.99
165_T189_H1.1990.99
169_A183_L1.1950.99
137_S158_T1.1920.99
89_Y141_V1.1910.99
89_Y138_T1.1870.99
167_E171_A1.1830.99
190_L208_P1.1820.99
15_P19_M1.1820.99
186_S210_N1.1750.99
114_R118_E1.1620.99
55_L58_V1.1490.99
171_A174_Q1.1470.99
84_V146_A1.1370.99
87_G102_I1.1270.99
69_T191_P1.1210.99
109_L145_V1.1170.99
237_V241_T1.1160.99
23_I26_G1.1030.99
113_I149_L1.1020.99
187_A216_S1.0920.99
35_F38_T1.0910.99
151_V156_I1.0810.99
119_N122_S1.0700.99
87_G104_N1.0670.99
109_L126_F1.0670.99
80_D179_A1.0670.99
125_I176_I1.0590.99
101_L109_L1.0530.99
82_I121_G1.0420.98
116_W151_V1.0290.98
112_G124_L1.0230.98
65_P241_T1.0210.98
125_I175_A1.0170.98
107_P209_A1.0120.98
81_Y181_F1.0020.98
79_V119_N0.9980.98
9_I13_L0.9960.98
110_N149_L0.9950.98
50_L54_S0.9890.98
62_L65_P0.9780.98
170_A200_E0.9770.98
79_V205_L0.9690.97
138_T168_E0.9670.97
82_I122_S0.9610.97
121_G155_Q0.9600.97
136_V140_E0.9580.97
84_V126_F0.9570.97
116_W124_L0.9550.97
143_A156_I0.9540.97
172_V176_I0.9450.97
176_I181_F0.9370.97
19_M49_A0.9320.97
139_A159_L0.9260.97
195_I198_Q0.9160.96
66_I241_T0.9130.96
33_S36_Q0.9120.96
164_D226_P0.9100.96
161_L174_Q0.8960.96
22_I26_G0.8940.96
185_T193_A0.8920.96
162_P171_A0.8640.95
83_V172_V0.8630.95
60_D64_R0.8620.95
144_R147_Q0.8610.95
19_M23_I0.8590.95
26_G29_L0.8540.95
190_L193_A0.8430.94
92_N135_T0.8430.94
166_E196_F0.8410.94
62_L237_V0.8390.94
12_M19_M0.8380.94
38_T42_F0.8380.94
234_S238_G0.8340.94
91_W135_T0.8330.94
16_L235_D0.8240.94
222_E225_I0.8220.94
180_P203_N0.8210.94
138_T159_L0.8200.93
231_L235_D0.8180.93
178_D202_L0.8090.93
65_P237_V0.8030.93
157_I175_A0.8000.93
26_G46_G0.7950.92
60_D63_L0.7910.92
195_I199_Q0.7910.92
173_K202_L0.7900.92
102_I145_V0.7880.92
146_A156_I0.7870.92
185_T189_H0.7860.92
198_Q204_P0.7830.92
23_I27_L0.7830.92
173_K200_E0.7780.92
147_Q156_I0.7780.92
231_L234_S0.7690.91
182_L205_L0.7690.91
115_L184_V0.7690.91
10_G239_Y0.7680.91
198_Q203_N0.7670.91
101_L141_V0.7660.91
58_V61_R0.7590.91
112_G126_F0.7500.90
136_V141_V0.7490.90
146_A168_E0.7440.90
187_A208_P0.7430.90
37_K40_K0.7410.90
138_T162_P0.7400.89
129_G159_L0.7380.89
25_A28_A0.7380.89
38_T41_I0.7360.89
84_V142_G0.7340.89
227_S230_W0.7290.89
43_I47_W0.7200.88
234_S237_V0.7180.88
101_L106_L0.7180.88
129_G139_A0.7140.88
130_V134_N0.7110.88
183_L205_L0.7100.87
129_G168_E0.6980.87
114_R148_S0.6900.86
22_I25_A0.6890.86
56_Q230_W0.6850.86
54_S231_L0.6820.85
128_G165_T0.6810.85
52_L58_V0.6800.85
127_T159_L0.6780.85
63_L237_V0.6760.85
67_E211_Q0.6760.85
190_L194_M0.6740.85
130_V137_S0.6720.84
19_M26_G0.6710.84
180_P205_L0.6700.84
183_L206_P0.6690.84
169_A202_L0.6650.84
35_F39_G0.6630.84
53_L61_R0.6590.83
12_M15_P0.6590.83
23_I47_W0.6580.83
151_V155_Q0.6580.83
113_I151_V0.6570.83
188_S212_L0.6560.83
107_P186_S0.6530.83
196_F200_E0.6530.83
208_P211_Q0.6480.82
101_L105_S0.6470.82
113_I126_F0.6460.82
86_G127_T0.6430.82
168_E189_H0.6410.82
223_R226_P0.6410.82
110_N113_I0.6380.81
54_S234_S0.6380.81
64_R67_E0.6380.81
78_K180_P0.6340.81
11_N15_P0.6330.81
91_W134_N0.6290.80
44_S47_W0.6260.80
14_L17_P0.6250.80
116_W120_P0.6250.80
164_D196_F0.6230.80
57_P61_R0.6220.80
59_A62_L0.6190.79
11_N14_L0.6150.79
29_L198_Q0.6120.78
13_L17_P0.6110.78
87_G239_Y0.6100.78
46_G61_R0.6100.78
122_S155_Q0.6100.78
67_E187_A0.6090.78
81_Y125_I0.6080.78
191_P195_I0.6070.78
89_Y186_S0.6060.78
92_N136_V0.6020.77
27_L47_W0.5990.77
183_L204_P0.5970.77
107_P210_N0.5960.77
208_P214_I0.5950.77
86_G138_T0.5910.76
15_P25_A0.5900.76
10_G164_D0.5900.76
162_P172_V0.5890.76
144_R148_S0.5870.76
63_L188_S0.5850.75
131_A163_K0.5840.75
83_V176_I0.5840.75
60_D67_E0.5840.75
102_I110_N0.5810.75
130_V135_T0.5800.75
64_R68_S0.5780.74
130_V133_T0.5780.74
70_Y191_P0.5780.74
19_M27_L0.5770.74
23_I28_A0.5750.74
14_L20_L0.5750.74
101_L104_N0.5730.74
28_A32_F0.5730.74
59_A230_W0.5710.74
12_M17_P0.5710.74
15_P26_G0.5710.74
223_R242_L0.5710.74
116_W121_G0.5700.73
193_A230_W0.5670.73
85_L189_H0.5660.73
165_T185_T0.5650.73
80_D176_I0.5650.73
16_L19_M0.5640.73
162_P167_E0.5630.73
87_G189_H0.5620.72
182_L207_A0.5620.72
89_Y129_G0.5600.72
81_Y157_I0.5580.72
147_Q150_G0.5550.71
230_W233_H0.5540.71
139_A162_P0.5540.71
188_S239_Y0.5540.71
222_E226_P0.5510.71
79_V115_L0.5490.71
61_R65_P0.5470.70
219_N224_A0.5470.70
229_V232_M0.5450.70
146_A151_V0.5450.70
34_R40_K0.5450.70
81_Y123_K0.5430.70
36_Q39_G0.5420.70
81_Y179_A0.5420.70
79_V122_S0.5420.70
60_D65_P0.5400.69
187_A191_P0.5400.69
61_R64_R0.5400.69
191_P194_M0.5400.69
124_L151_V0.5380.69
176_I179_A0.5380.69
128_G162_P0.5380.69
10_G14_L0.5380.69
116_W122_S0.5370.69
127_T171_A0.5350.69
105_S142_G0.5340.69
106_L145_V0.5340.69
57_P224_A0.5330.68
74_N78_K0.5290.68
141_V223_R0.5280.68
174_Q177_G0.5250.67
127_T236_R0.5240.67
153_R156_I0.5220.67
89_Y168_E0.5220.67
128_G189_H0.5200.67
87_G90_T0.5170.66
21_L25_A0.5150.66
83_V177_G0.5150.66
44_S54_S0.5140.66
116_W119_N0.5120.65
150_G155_Q0.5100.65
124_L156_I0.5080.65
41_I77_Q0.5060.64
133_T217_P0.5050.64
28_A37_K0.5050.64
51_L54_S0.5050.64
154_E157_I0.5040.64
82_I112_G0.5040.64
233_H239_Y0.5040.64
125_I157_I0.5020.64
51_L56_Q0.5010.64
102_I106_L0.5000.64
89_Y105_S0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ca8A 1 0.7529 100 0.497 Contact Map
2hqsH 1 0.3707 81.7 0.93 Contact Map
2kgwA 1 0.4402 80.9 0.931 Contact Map
1r1mA 1 0.4286 77.9 0.933 Contact Map
4g4xA 1 0.3784 77.3 0.933 Contact Map
4pwtA 1 0.4556 73 0.935 Contact Map
3oonA 2 0.3977 71.4 0.936 Contact Map
2aizP 1 0.4479 67.3 0.938 Contact Map
4rhaA 2 0.4054 66.5 0.938 Contact Map
3td3A 2 0.4093 65.1 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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