GREMLIN Database
MCBA - Uncharacterized protein McbA
UniProt: P0AAX6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13318
Length: 86 (86)
Sequences: 466 (251)
Seq/√Len: 27.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_N83_T3.3201.00
68_V83_T2.6240.99
56_A60_R2.6070.99
21_Y25_P2.3820.99
48_L80_G2.2090.98
55_L82_A2.1600.97
74_G78_M2.1540.97
39_T70_N2.0050.96
42_A55_L1.7390.91
76_D84_I1.7370.91
47_N50_D1.7070.91
6_T10_A1.6590.89
51_L78_M1.6560.89
19_T62_Q1.5970.88
57_E60_R1.5220.85
16_I19_T1.5080.84
57_E61_E1.4830.83
70_N81_T1.4800.83
36_P83_T1.4770.83
27_S66_G1.4760.83
5_L13_L1.4750.83
38_G55_L1.4500.82
25_P67_Y1.4220.81
51_L74_G1.4060.80
24_Q37_A1.3810.79
42_A51_L1.3180.75
37_A45_A1.3120.75
7_L43_T1.3040.74
30_D76_D1.2850.73
65_K86_K1.2260.70
45_A51_L1.2240.69
73_G79_F1.2030.68
16_I21_Y1.2020.68
38_G41_S1.2020.68
26_M34_L1.2000.68
65_K68_V1.1930.67
24_Q27_S1.1820.67
44_G77_Q1.1490.64
55_L84_I1.1220.63
14_S18_L1.0850.60
41_S81_T1.0340.56
46_S51_L1.0330.56
35_R68_V1.0310.56
11_T62_Q0.9860.53
16_I86_K0.9780.52
51_L76_D0.9510.50
4_C36_P0.9460.50
40_V45_A0.9410.49
11_T36_P0.9200.48
38_G80_G0.9140.47
16_I79_F0.9090.47
50_D53_D0.9090.47
36_P39_T0.9060.47
11_T58_K0.8990.46
26_M68_V0.8990.46
22_A69_I0.8910.45
7_L30_D0.8910.45
48_L51_L0.8870.45
38_G48_L0.8850.45
6_T39_T0.8840.45
56_A84_I0.8790.45
16_I43_T0.8750.44
56_A83_T0.8680.44
30_D47_N0.8640.43
48_L72_A0.8610.43
43_T78_M0.8580.43
30_D66_G0.8560.43
42_A82_A0.8460.42
37_A44_G0.8430.42
52_E57_E0.8420.42
42_A80_G0.8320.41
7_L41_S0.8220.40
71_S81_T0.8210.40
38_G84_I0.8130.40
6_T11_T0.8050.39
13_L44_G0.7920.38
43_T46_S0.7860.38
71_S79_F0.7840.38
49_S84_I0.7820.38
67_Y71_S0.7750.37
7_L20_A0.7710.37
50_D61_E0.7680.37
69_I83_T0.7520.35
14_S85_Y0.7430.35
4_C20_A0.7300.34
25_P28_N0.7270.34
40_V60_R0.7200.33
10_A33_Q0.6920.31
11_T54_K0.6850.31
36_P84_I0.6740.30
75_N78_M0.6740.30
57_E66_G0.6710.30
12_V29_L0.6660.30
21_Y32_G0.6580.29
41_S85_Y0.6570.29
51_L80_G0.6420.28
55_L83_T0.6370.28
14_S19_T0.6370.28
3_K50_D0.6330.28
4_C8_L0.6260.27
45_A75_N0.6250.27
29_L40_V0.6190.27
54_K57_E0.6100.26
12_V15_G0.5880.25
52_E69_I0.5880.25
18_L31_S0.5880.25
56_A67_Y0.5860.25
13_L20_A0.5820.25
42_A46_S0.5740.24
16_I81_T0.5730.24
30_D34_L0.5730.24
14_S35_R0.5710.24
1_M81_T0.5660.24
16_I77_Q0.5570.23
40_V77_Q0.5560.23
15_G33_Q0.5530.23
48_L74_G0.5510.23
36_P50_D0.5460.23
49_S79_F0.5400.22
25_P35_R0.5340.22
13_L18_L0.5230.22
45_A61_E0.5230.22
29_L32_G0.5220.22
9_I15_G0.5150.21
42_A71_S0.5140.21
77_Q84_I0.5110.21
76_D86_K0.5080.21
47_N77_Q0.5060.21
45_A80_G0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nocA 1 0.9884 100 0.143 Contact Map
2jnaA 2 0.9884 100 0.163 Contact Map
2m2jA 1 0.7674 99.9 0.32 Contact Map
2ma4A 1 0.7442 99.8 0.34 Contact Map
4evuA 2 0.7558 99.8 0.391 Contact Map
4n4rB 1 0.6977 41.6 0.889 Contact Map
3layA 5 0.686 40.7 0.89 Contact Map
3b55A 1 0.5581 38.2 0.892 Contact Map
2qgmA 1 0.5698 24.4 0.902 Contact Map
4ivkA 4 0.6512 22 0.904 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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