GREMLIN Database
YBHH - Putative isomerase YbhH
UniProt: P0AAV8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13664
Length: 350 (345)
Sequences: 1277 (770)
Seq/√Len: 41.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
202_P205_Y5.1231.00
121_I132_A4.5571.00
18_F99_G4.1691.00
202_P298_Q3.6161.00
19_L38_I3.2621.00
179_N182_D3.2341.00
68_D122_R3.1181.00
76_L124_V3.0841.00
175_F180_Q3.0771.00
183_Y188_P3.0381.00
63_I103_F2.8961.00
38_I347_V2.7631.00
148_R155_T2.7551.00
17_A38_I2.7181.00
122_R127_G2.6071.00
309_N316_A2.5701.00
56_L275_R2.4971.00
184_F233_Q2.4851.00
265_V277_L2.3641.00
20_L107_N2.3311.00
71_A129_F2.3271.00
208_K220_D2.2501.00
211_Y255_S2.2241.00
261_G311_E2.1951.00
22_E65_R2.1941.00
324_E331_L2.1520.99
181_I188_P2.1450.99
175_F294_T2.1410.99
54_N275_R2.1170.99
184_F234_A2.1160.99
201_I230_I2.1100.99
132_A161_L2.1070.99
147_A336_I2.0810.99
73_V101_G1.9520.99
117_T136_T1.9400.99
233_Q237_A1.9260.99
254_I296_T1.9060.99
255_S264_N1.9040.99
78_A87_V1.9010.99
180_Q294_T1.8880.99
18_F96_M1.8600.98
182_D237_A1.8590.98
218_D273_C1.8390.98
344_S348_Y1.8270.98
267_Y281_G1.8210.98
55_P269_M1.7880.98
15_R342_I1.7520.98
17_A50_I1.7500.98
191_C238_M1.7480.98
73_V110_I1.7350.97
184_F237_A1.7300.97
277_L285_I1.7270.97
175_F190_T1.7260.97
289_C296_T1.7220.97
105_I134_V1.6950.97
3_K346_E1.6900.97
4_I34_I1.6850.97
217_L268_F1.6850.97
188_P298_Q1.6650.97
199_V230_I1.6200.96
11_G99_G1.6180.96
208_K223_L1.6120.96
267_Y278_A1.5980.96
324_E327_D1.5910.96
213_L216_E1.5890.96
8_M50_I1.5760.95
158_P336_I1.5730.95
214_P275_R1.5700.95
78_A89_T1.5650.95
16_G96_M1.5560.95
61_A96_M1.5550.95
279_I335_V1.5510.95
181_I298_Q1.5510.95
107_N341_K1.5280.95
42_G83_H1.5160.94
106_E141_V1.5120.94
185_D233_Q1.5090.94
7_V341_K1.4950.94
209_T212_E1.4950.94
107_N344_S1.4910.94
7_V107_N1.4660.93
309_N318_D1.4600.93
32_D89_T1.4460.93
42_G85_Q1.4380.93
200_I254_I1.4150.92
106_E143_Y1.4120.92
211_Y258_Q1.3910.91
135_Q158_P1.3880.91
287_S330_T1.3800.91
185_D229_S1.3770.91
275_R343_F1.3690.91
41_S58_S1.3620.90
116_V133_D1.3580.90
92_N123_N1.3550.90
45_L54_N1.3490.90
167_A174_V1.3460.90
74_D122_R1.3430.90
66_S74_D1.3380.90
101_G134_V1.3330.90
106_E341_K1.3280.89
210_G255_S1.3260.89
133_D162_T1.3250.89
263_I310_I1.3200.89
67_S122_R1.3190.89
341_K348_Y1.3190.89
135_Q157_A1.3140.89
66_S69_P1.2970.88
206_L253_L1.2960.88
198_V284_A1.2950.88
92_N280_T1.2750.87
118_R131_E1.2530.86
166_A269_M1.2520.86
36_M85_Q1.2400.86
175_F291_L1.2370.86
35_L57_T1.2340.86
198_V252_V1.2330.85
291_L294_T1.2280.85
91_P247_V1.2260.85
200_I285_I1.2160.85
214_P276_A1.2150.85
201_I206_L1.2070.84
216_E220_D1.2060.84
3_K348_Y1.2030.84
78_A88_D1.1960.84
175_F192_I1.1950.84
70_R120_R1.1950.84
41_S83_H1.1950.84
39_M60_V1.1940.84
16_G99_G1.1840.83
27_D30_Q1.1840.83
278_A281_G1.1780.83
8_M17_A1.1760.83
197_P250_K1.1710.82
254_I299_I1.1610.82
118_R133_D1.1570.82
341_K344_S1.1560.82
6_C343_F1.1560.82
211_Y264_N1.1510.81
73_V119_V1.1480.81
30_Q34_I1.1250.80
201_I227_I1.1200.79
190_T284_A1.1170.79
19_L23_H1.1170.79
81_I84_E1.1150.79
250_K282_A1.1040.78
7_V344_S1.1040.78
56_L278_A1.0940.78
228_E271_H1.0840.77
187_V205_Y1.0820.77
123_N170_K1.0820.77
168_G172_G1.0710.76
90_T246_M1.0660.76
96_M99_G1.0650.76
20_L109_L1.0610.76
200_I296_T1.0570.75
53_G57_T1.0550.75
39_M347_V1.0530.75
47_I153_P1.0500.75
220_D223_L1.0400.74
192_I284_A1.0270.73
168_G171_T1.0230.73
64_S124_V1.0230.73
322_S331_L1.0210.73
177_T182_D1.0210.73
45_L53_G1.0180.72
21_A64_S1.0110.72
97_L161_L1.0080.72
194_M284_A1.0060.72
28_Q31_R1.0030.71
46_E58_S1.0020.71
36_M42_G1.0010.71
184_F189_V0.9960.71
114_S136_T0.9930.71
81_I86_R0.9840.70
3_K344_S0.9830.70
103_F107_N0.9780.69
68_D74_D0.9780.69
150_D312_H0.9770.69
195_A278_A0.9730.69
276_A321_L0.9730.69
286_S319_V0.9710.69
207_G210_G0.9710.69
137_P142_E0.9700.69
150_D316_A0.9670.69
8_M343_F0.9610.68
65_R111_A0.9590.68
198_V267_Y0.9560.68
101_G119_V0.9550.68
227_I268_F0.9550.68
162_T332_R0.9550.68
50_I347_V0.9540.67
50_I343_F0.9510.67
55_P332_R0.9500.67
203_A266_R0.9490.67
233_Q236_K0.9480.67
203_A207_G0.9480.67
97_L102_A0.9450.67
130_I280_T0.9370.66
162_T334_S0.9350.66
17_A96_M0.9320.66
180_Q293_G0.9150.64
265_V310_I0.9140.64
218_D272_S0.9140.64
257_A301_P0.9120.64
71_A74_D0.9080.64
223_L226_R0.9040.63
310_I329_T0.9040.63
54_N57_T0.8960.63
73_V100_V0.8950.62
123_N171_T0.8920.62
256_P299_I0.8910.62
234_A238_M0.8900.62
214_P218_D0.8880.62
208_K253_L0.8880.62
20_L103_F0.8870.62
33_K37_A0.8870.62
208_K212_E0.8870.62
34_I38_I0.8870.62
24_L31_R0.8840.62
18_F100_V0.8840.62
215_A219_A0.8840.62
91_P270_P0.8810.61
204_E256_P0.8800.61
342_I347_V0.8720.60
194_M283_I0.8650.60
8_M56_L0.8640.60
105_I117_T0.8630.60
55_P250_K0.8620.60
56_L269_M0.8600.59
209_T255_S0.8600.59
263_I289_C0.8550.59
43_N53_G0.8550.59
47_I57_T0.8510.59
43_N46_E0.8500.58
273_C343_F0.8470.58
171_T193_D0.8420.58
191_C234_A0.8350.57
319_V333_A0.8350.57
262_A311_E0.8320.57
105_I110_I0.8310.57
66_S122_R0.8310.57
63_I107_N0.8300.57
50_I342_I0.8290.57
200_I295_V0.8290.57
288_S296_T0.8280.56
116_V135_Q0.8230.56
123_N126_T0.8230.56
177_T191_C0.8230.56
169_T190_T0.8220.56
180_Q291_L0.8180.56
98_S284_A0.8130.55
195_A284_A0.8110.55
63_I96_M0.8100.55
254_I295_V0.8100.55
294_T297_R0.8090.55
183_Y186_D0.8080.55
197_P238_M0.8050.54
181_I295_V0.8010.54
122_R128_T0.7970.54
28_Q32_D0.7970.54
179_N237_A0.7910.53
250_K269_M0.7890.53
276_A314_S0.7890.53
7_V63_I0.7860.53
29_T32_D0.7850.52
159_V289_C0.7840.52
110_I120_R0.7840.52
258_Q264_N0.7800.52
159_V339_T0.7800.52
109_L282_A0.7730.51
338_T345_G0.7710.51
254_I288_S0.7710.51
58_S77_F0.7660.51
29_T33_K0.7630.50
110_I117_T0.7610.50
18_F63_I0.7590.50
34_I37_A0.7580.50
195_A277_L0.7580.50
254_I306_G0.7570.50
91_P246_M0.7540.50
283_I342_I0.7530.49
320_H332_R0.7490.49
323_N330_T0.7480.49
67_S111_A0.7480.49
166_A280_T0.7440.49
134_V141_V0.7410.48
277_L317_L0.7380.48
31_R35_L0.7370.48
71_A122_R0.7330.48
131_E162_T0.7300.47
303_V306_G0.7240.47
36_M53_G0.7240.47
114_S138_N0.7220.47
61_A75_Y0.7220.47
147_A158_P0.7190.46
209_T258_Q0.7170.46
154_G338_T0.7160.46
187_V201_I0.7150.46
324_E329_T0.7130.46
6_C17_A0.7120.46
219_A324_E0.7060.45
88_D91_P0.6990.44
91_P284_A0.6980.44
123_N280_T0.6980.44
260_G311_E0.6980.44
254_I298_Q0.6970.44
196_M279_I0.6940.44
121_I347_V0.6940.44
15_R96_M0.6930.44
277_L282_A0.6930.44
138_N304_G0.6920.44
203_A255_S0.6920.44
188_P205_Y0.6920.44
307_N318_D0.6910.44
130_I194_M0.6900.44
205_Y298_Q0.6880.43
16_G35_L0.6870.43
56_L271_H0.6870.43
250_K270_P0.6860.43
52_G79_Q0.6850.43
168_G193_D0.6840.43
91_P235_G0.6840.43
64_S122_R0.6840.43
53_G84_E0.6840.43
228_E232_L0.6830.43
56_L166_A0.6830.43
244_S256_P0.6820.43
166_A283_I0.6790.43
132_A157_A0.6780.43
181_I263_I0.6770.42
269_M280_T0.6750.42
149_I152_V0.6740.42
134_V159_V0.6730.42
180_Q308_I0.6730.42
135_Q142_E0.6720.42
135_Q223_L0.6710.42
194_M287_S0.6700.42
220_D225_A0.6700.42
42_G46_E0.6680.42
92_N103_F0.6630.41
10_R14_S0.6630.41
88_D247_V0.6620.41
99_G155_T0.6600.41
195_A280_T0.6590.41
16_G25_P0.6590.41
301_P329_T0.6560.41
55_P333_A0.6560.41
169_T173_K0.6550.40
67_S326_Q0.6550.40
169_T248_I0.6550.40
101_G132_A0.6540.40
289_C300_V0.6530.40
90_T170_K0.6530.40
9_M341_K0.6500.40
131_E164_L0.6490.40
120_R164_L0.6490.40
21_A31_R0.6470.40
8_M276_A0.6470.40
117_T134_V0.6460.40
91_P196_M0.6460.40
24_L32_D0.6450.40
89_T123_N0.6420.39
139_G145_G0.6400.39
191_C197_P0.6390.39
130_I163_F0.6390.39
97_L341_K0.6380.39
86_R237_A0.6370.39
252_V265_V0.6360.39
57_T283_I0.6350.39
16_G343_F0.6320.38
300_V303_V0.6300.38
62_I78_A0.6300.38
327_D331_L0.6280.38
268_F311_E0.6280.38
68_D71_A0.6260.38
96_M195_A0.6250.38
102_A157_A0.6250.38
102_A134_V0.6230.38
295_V336_I0.6220.38
65_R109_L0.6210.37
92_N167_A0.6180.37
67_S110_I0.6170.37
101_G110_I0.6150.37
56_L279_I0.6140.37
123_N278_A0.6140.37
79_Q313_P0.6120.37
278_A283_I0.6080.36
173_K291_L0.6070.36
209_T216_E0.6070.36
73_V121_I0.6030.36
10_R13_T0.6020.36
130_I161_L0.6000.36
148_R154_G0.5990.36
126_T154_G0.5990.36
140_V204_E0.5980.35
182_D187_V0.5970.35
247_V250_K0.5960.35
218_D290_A0.5920.35
190_T271_H0.5920.35
67_S229_S0.5920.35
267_Y280_T0.5910.35
55_P166_A0.5900.35
130_I269_M0.5890.35
302_S306_G0.5890.35
241_G244_S0.5890.35
294_T321_L0.5860.34
15_R37_A0.5860.34
290_A321_L0.5860.34
88_D228_E0.5860.34
197_P248_I0.5850.34
210_G266_R0.5840.34
76_L123_N0.5840.34
185_D258_Q0.5830.34
9_M99_G0.5830.34
89_T135_Q0.5830.34
123_N310_I0.5820.34
252_V284_A0.5820.34
88_D252_V0.5810.34
128_T314_S0.5800.34
238_M250_K0.5790.34
150_D156_A0.5780.34
228_E312_H0.5760.34
257_A299_I0.5760.34
199_V234_A0.5750.34
57_T278_A0.5740.33
165_N329_T0.5720.33
53_G85_Q0.5710.33
112_A115_P0.5690.33
34_I90_T0.5690.33
252_V267_Y0.5690.33
30_Q342_I0.5680.33
127_G219_A0.5680.33
223_L253_L0.5680.33
24_L34_I0.5670.33
257_A264_N0.5650.33
169_T240_L0.5640.33
218_D224_L0.5630.33
262_A309_N0.5620.32
286_S291_L0.5610.32
41_S46_E0.5600.32
217_L273_C0.5600.32
96_M126_T0.5580.32
121_I131_E0.5570.32
229_S233_Q0.5560.32
71_A120_R0.5560.32
123_N128_T0.5550.32
56_L276_A0.5550.32
227_I251_P0.5550.32
236_K241_G0.5540.32
128_T170_K0.5540.32
247_V270_P0.5540.32
149_I338_T0.5520.32
73_V105_I0.5520.32
74_D124_V0.5520.32
160_A336_I0.5520.32
159_V331_L0.5490.31
13_T39_M0.5490.31
225_A229_S0.5470.31
265_V269_M0.5460.31
97_L267_Y0.5440.31
215_A259_K0.5440.31
148_R308_I0.5440.31
146_S183_Y0.5440.31
31_R62_I0.5420.31
169_T284_A0.5420.31
232_L271_H0.5400.31
277_L310_I0.5380.31
214_P273_C0.5370.30
190_T287_S0.5370.30
102_A145_G0.5370.30
42_G45_L0.5350.30
4_I33_K0.5350.30
140_V189_V0.5340.30
214_P230_I0.5340.30
189_V305_Y0.5300.30
189_V237_A0.5290.30
146_S165_N0.5290.30
312_H345_G0.5280.30
16_G270_P0.5270.30
55_P267_Y0.5270.30
48_D340_R0.5270.30
172_G179_N0.5250.29
166_A194_M0.5240.29
23_H109_L0.5230.29
194_M280_T0.5220.29
177_T234_A0.5220.29
31_R279_I0.5220.29
91_P269_M0.5200.29
199_V251_P0.5190.29
170_K198_V0.5190.29
117_T137_P0.5190.29
6_C314_S0.5170.29
235_G243_V0.5160.29
8_M15_R0.5160.29
99_G103_F0.5160.29
46_E55_P0.5150.29
153_P338_T0.5150.29
282_A335_V0.5140.29
80_V105_I0.5130.29
26_E185_D0.5130.29
28_Q34_I0.5120.28
38_I88_D0.5120.28
184_F191_C0.5110.28
123_N195_A0.5110.28
256_P301_P0.5110.28
310_I335_V0.5110.28
30_Q33_K0.5110.28
141_V157_A0.5100.28
16_G345_G0.5090.28
48_D282_A0.5070.28
15_R70_R0.5060.28
16_G24_L0.5050.28
212_E266_R0.5050.28
282_A317_L0.5040.28
96_M267_Y0.5030.28
116_V227_I0.5010.28
107_N144_E0.5000.28
99_G181_I0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pw0A 2 0.9914 100 0.164 Contact Map
3g7kA 3 0.9943 100 0.336 Contact Map
1w61A 2 0.8771 99.9 0.817 Contact Map
4lb0A 2 0.8686 99.8 0.855 Contact Map
4k8lA 2 0.7886 99.8 0.855 Contact Map
3ednA 2 0.7971 98 0.936 Contact Map
4jbdA 2 0.7943 98 0.937 Contact Map
2otnA 2 0.7886 97.9 0.939 Contact Map
4juuA 2 0.8257 97.8 0.94 Contact Map
1xubA 2 0.7486 97.7 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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