GREMLIN Database
YBDG - Miniconductance mechanosensitive channel YbdG
UniProt: P0AAT4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12620
Length: 415 (332)
Sequences: 1230 (954)
Seq/√Len: 52.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
274_I324_I7.8551.00
277_L281_E4.7171.00
167_I170_S4.5821.00
55_S60_L4.1321.00
112_L152_V4.0081.00
236_I254_G3.6291.00
332_N336_R3.5311.00
200_D203_K3.4501.00
275_R281_E3.4131.00
140_I193_G3.4101.00
209_E250_K3.2331.00
220_I230_R2.8881.00
186_P225_T2.7851.00
278_D281_E2.5911.00
37_H74_F2.5811.00
157_I168_L2.4421.00
301_E306_N2.4031.00
201_M238_T2.3481.00
201_M228_K2.3391.00
212_K247_D2.3021.00
285_L295_L2.2581.00
209_E232_W2.2521.00
277_L282_M2.2221.00
216_D264_K2.1501.00
342_R345_M2.1341.00
165_P170_S2.1181.00
317_N325_G2.0981.00
286_N296_T2.0201.00
277_L285_L1.9711.00
230_R234_N1.9531.00
231_N235_T1.9441.00
300_Q303_N1.9160.99
281_E285_L1.8790.99
203_K253_S1.8580.99
136_P142_Q1.8280.99
320_R323_N1.8230.99
174_A178_V1.8190.99
211_P214_G1.8160.99
322_T325_G1.7880.99
341_I347_L1.7660.99
135_L200_D1.7490.99
43_V47_T1.7420.99
303_N307_R1.7360.99
218_A234_N1.7160.99
36_V41_H1.7130.99
343_K347_L1.7080.99
78_G106_W1.6720.99
116_F149_A1.6470.98
199_N225_T1.6270.98
184_K188_L1.6210.98
184_K242_W1.5970.98
319_R325_G1.5950.98
300_Q304_E1.5940.98
35_V39_I1.5880.98
215_A237_T1.5850.98
108_M159_L1.5850.98
239_I248_S1.5700.98
139_G176_A1.5680.98
321_M326_T1.5600.98
37_H41_H1.5540.98
176_A200_D1.5410.97
29_I88_W1.5280.97
216_D232_W1.5250.97
59_W125_L1.5230.97
120_D145_K1.5220.97
306_N317_N1.4790.97
269_I278_D1.4750.97
286_N299_H1.4540.96
329_A333_E1.4480.96
154_I165_P1.4330.96
55_S61_Q1.4250.96
326_T329_A1.4210.96
271_V353_A1.4080.96
225_T249_F1.4080.96
108_M155_L1.4070.96
204_L234_N1.4010.96
170_S209_E1.3990.96
195_Q232_W1.3730.95
52_A55_S1.3690.95
174_A177_A1.3620.95
323_N327_F1.3590.95
195_Q227_V1.3580.95
154_I164_S1.3530.95
321_M325_G1.3490.95
132_A137_L1.3290.94
82_N100_T1.3240.94
223_G241_T1.3240.94
218_A232_W1.3130.94
32_T76_L1.2820.93
217_G229_V1.2800.93
161_I164_S1.2780.93
298_R301_E1.2690.93
201_M244_L1.2690.93
333_E337_N1.2640.92
154_I172_L1.2360.91
181_L187_I1.2330.91
189_G225_T1.2290.91
208_L244_L1.2240.91
155_L165_P1.2120.91
232_W252_W1.2110.91
339_P344_D1.2080.91
306_N325_G1.2070.90
138_K223_G1.2050.90
278_D282_M1.2040.90
140_I143_G1.2020.90
132_A171_G1.1930.90
133_S292_K1.1900.90
275_R278_D1.1870.90
202_L244_L1.1820.90
267_I331_L1.1780.89
74_F106_W1.1740.89
202_L249_F1.1740.89
306_N319_R1.1710.89
112_L153_G1.1660.89
288_A317_N1.1650.89
100_T168_L1.1650.89
21_S25_I1.1590.89
336_R343_K1.1550.88
283_Q287_K1.1530.88
230_R236_I1.1490.88
320_R325_G1.1480.88
196_L201_M1.1440.88
243_S247_D1.1390.88
241_T245_V1.1370.88
313_E318_L1.1320.87
105_L156_M1.1310.87
130_P137_L1.1300.87
283_Q286_N1.1240.87
227_V249_F1.1210.87
29_I84_Q1.1210.87
291_L294_Y1.1210.87
221_D239_I1.1130.87
207_W261_R1.1100.86
136_P143_G1.1090.86
227_V241_T1.1070.86
174_A179_L1.0990.86
42_W76_L1.0970.86
336_R347_L1.0950.86
170_S223_G1.0930.86
180_M193_G1.0850.85
81_V103_A1.0830.85
234_N254_G1.0820.85
280_D283_Q1.0780.85
147_I151_L1.0680.84
135_L193_G1.0680.84
50_K54_A1.0680.84
37_H40_L1.0660.84
224_L262_R1.0510.83
220_I236_I1.0470.83
39_I292_K1.0450.83
234_N258_S1.0440.83
38_I42_W1.0370.82
126_A132_A1.0340.82
111_A151_L1.0310.82
231_N261_R1.0300.82
184_K196_L1.0220.81
193_G299_H1.0170.81
116_F196_L1.0100.81
65_Q124_N1.0080.81
79_I94_E1.0060.80
135_L197_S1.0050.80
302_I326_T1.0030.80
302_I306_N1.0010.80
137_L141_F1.0000.80
134_Q147_I0.9960.80
89_L225_T0.9960.80
151_L155_L0.9930.79
298_R302_I0.9880.79
324_I331_L0.9870.79
118_L122_I0.9840.79
63_I68_L0.9830.79
36_V76_L0.9800.79
120_D141_F0.9790.79
68_L121_V0.9700.78
111_A150_I0.9680.78
221_D228_K0.9620.77
28_I43_V0.9600.77
293_P297_S0.9530.77
76_L80_I0.9510.76
140_I225_T0.9480.76
30_F49_E0.9440.76
183_F273_S0.9370.75
192_A195_Q0.9320.75
217_G328_R0.9310.75
195_Q225_T0.9290.75
158_S271_V0.9260.75
189_G242_W0.9250.74
301_E305_W0.9240.74
77_Q143_G0.9180.74
327_F331_L0.9170.74
202_L245_V0.9170.74
202_L331_L0.9170.74
245_V248_S0.9160.74
258_S345_M0.9150.74
144_I333_E0.9130.73
25_I28_I0.9120.73
157_I161_I0.9100.73
135_L140_I0.9090.73
85_A88_W0.9080.73
266_S271_V0.9020.73
48_F110_Y0.8960.72
333_E336_R0.8940.72
177_A183_F0.8870.71
196_L331_L0.8840.71
161_I166_A0.8840.71
36_V279_E0.8820.71
212_K243_S0.8820.71
230_R254_G0.8820.71
143_G146_L0.8800.71
144_I297_S0.8790.71
138_K221_D0.8780.71
268_S271_V0.8730.70
338_H341_I0.8700.70
190_L197_S0.8690.70
201_M245_V0.8640.69
200_D223_G0.8620.69
295_L326_T0.8550.68
137_L143_G0.8540.68
193_G241_T0.8540.68
249_F252_W0.8520.68
28_I46_R0.8510.68
140_I200_D0.8480.68
36_V70_H0.8450.68
290_L294_Y0.8450.68
155_L158_S0.8410.67
281_E284_R0.8370.67
39_I202_L0.8370.67
231_N262_R0.8310.66
72_L284_R0.8260.66
45_L72_L0.8220.65
127_Q162_G0.8220.65
193_G270_D0.8210.65
186_P190_L0.8200.65
304_E307_R0.8170.65
94_E99_L0.8160.65
124_N284_R0.8150.65
67_K70_H0.8150.65
237_T247_D0.8150.65
317_N321_M0.8120.64
195_Q249_F0.8070.64
215_A243_S0.8060.64
320_R333_E0.8050.64
172_L185_D0.8050.64
54_A57_R0.8000.63
51_R110_Y0.8000.63
233_D252_W0.7980.63
216_D235_T0.7960.63
69_F78_G0.7940.63
304_E308_Q0.7940.63
180_M241_T0.7930.63
245_V250_K0.7920.63
22_M28_I0.7900.62
27_G39_I0.7890.62
280_D316_L0.7890.62
79_I83_I0.7860.62
301_E317_N0.7840.62
169_I239_I0.7820.62
157_I160_L0.7820.62
261_R264_K0.7770.61
332_N335_L0.7750.61
43_V56_S0.7710.60
36_V99_L0.7690.60
176_A203_K0.7680.60
109_M169_I0.7670.60
278_D286_N0.7670.60
158_S165_P0.7660.60
189_G223_G0.7660.60
189_G245_V0.7650.60
331_L348_M0.7630.60
96_A99_L0.7630.60
320_R327_F0.7620.60
181_L188_L0.7610.59
200_D225_T0.7600.59
327_F330_Y0.7580.59
318_L324_I0.7540.59
101_T162_G0.7540.59
35_V109_M0.7530.59
302_I340_R0.7500.58
284_R287_K0.7500.58
94_E151_L0.7480.58
201_M243_S0.7480.58
234_N346_T0.7440.58
85_A96_A0.7430.58
329_A332_N0.7420.57
308_Q311_S0.7420.57
180_M187_I0.7400.57
32_T297_S0.7390.57
146_L218_A0.7380.57
23_V122_I0.7380.57
123_L271_V0.7360.57
122_I299_H0.7350.57
262_R330_Y0.7340.57
212_K343_K0.7330.57
192_A252_W0.7320.56
314_S319_R0.7300.56
35_V161_I0.7290.56
57_R60_L0.7240.56
101_T245_V0.7210.55
317_N326_T0.7200.55
52_A64_T0.7190.55
211_P221_D0.7170.55
323_N334_Y0.7170.55
142_Q227_V0.7090.54
29_I81_V0.7090.54
201_M226_T0.7060.54
330_Y334_Y0.7060.54
305_W318_L0.7050.54
151_L214_G0.7050.54
207_W252_W0.7040.54
185_D261_R0.7040.54
139_G168_L0.7030.53
193_G225_T0.7030.53
133_S136_P0.7030.53
331_L334_Y0.7020.53
43_V332_N0.7000.53
288_A316_L0.7000.53
176_A184_K0.6980.53
339_P343_K0.6970.53
146_L179_L0.6970.53
75_T110_Y0.6960.53
96_A267_I0.6960.53
186_P241_T0.6920.52
88_W115_V0.6880.52
233_D264_K0.6880.52
223_G326_T0.6880.52
231_N328_R0.6860.52
340_R344_D0.6860.52
71_R117_S0.6850.52
169_I204_L0.6840.51
102_C113_L0.6830.51
323_N326_T0.6820.51
172_L244_L0.6820.51
294_Y298_R0.6760.51
346_T351_Q0.6760.51
345_M348_M0.6730.50
189_G201_M0.6720.50
60_L63_I0.6690.50
317_N329_A0.6650.49
193_G217_G0.6630.49
46_R54_A0.6610.49
118_L347_L0.6610.49
282_M321_M0.6590.49
57_R61_Q0.6570.49
182_V253_S0.6560.49
32_T38_I0.6560.49
281_E291_L0.6540.48
30_F83_I0.6530.48
233_D261_R0.6530.48
78_G175_M0.6520.48
142_Q183_F0.6510.48
48_F51_R0.6490.48
32_T97_D0.6470.48
300_Q309_Q0.6420.47
177_A323_N0.6420.47
287_K311_S0.6410.47
156_M159_L0.6410.47
187_I190_L0.6400.47
274_I278_D0.6400.47
165_P171_G0.6380.47
258_S342_R0.6370.47
260_G345_M0.6350.46
78_G127_Q0.6340.46
215_A249_F0.6340.46
196_L271_V0.6290.46
153_G173_G0.6290.46
224_L263_I0.6280.46
158_S161_I0.6250.45
158_S169_I0.6250.45
274_I289_H0.6230.45
150_I172_L0.6190.45
228_K238_T0.6170.44
189_G243_S0.6170.44
30_F55_S0.6150.44
116_F145_K0.6130.44
263_I322_T0.6120.44
263_I341_I0.6100.44
56_S125_L0.6090.44
44_V55_S0.6060.43
28_I129_F0.6040.43
289_H292_K0.6040.43
74_F246_S0.6040.43
113_L222_I0.6030.43
193_G196_L0.5970.42
24_M56_S0.5960.42
41_H74_F0.5960.42
242_W246_S0.5960.42
50_K76_L0.5940.42
120_D238_T0.5940.42
23_V27_G0.5930.42
112_L148_G0.5930.42
207_W231_N0.5920.42
30_F62_I0.5920.42
192_A245_V0.5900.42
81_V107_I0.5900.42
207_W233_D0.5890.42
192_A249_F0.5870.41
24_M28_I0.5860.41
35_V42_W0.5860.41
165_P176_A0.5860.41
260_G265_R0.5850.41
107_I111_A0.5850.41
131_A193_G0.5830.41
197_S346_T0.5790.41
24_M32_T0.5780.40
20_T35_V0.5760.40
174_A193_G0.5760.40
275_R332_N0.5750.40
54_A61_Q0.5740.40
137_L140_I0.5740.40
39_I59_W0.5720.40
192_A232_W0.5720.40
195_Q252_W0.5720.40
347_L353_A0.5710.40
196_L223_G0.5700.40
164_S170_S0.5690.40
161_I167_I0.5680.39
200_D253_S0.5680.39
142_Q191_V0.5680.39
161_I168_L0.5680.39
269_I352_L0.5660.39
60_L149_A0.5660.39
189_G238_T0.5660.39
63_I149_A0.5650.39
31_L59_W0.5640.39
135_L142_Q0.5640.39
216_D231_N0.5620.39
59_W69_F0.5610.39
303_N316_L0.5610.39
50_K115_V0.5610.39
190_L302_I0.5610.39
119_L133_S0.5600.39
294_Y326_T0.5590.39
174_A183_F0.5580.38
41_H45_L0.5570.38
98_I144_I0.5570.38
167_I184_K0.5570.38
167_I345_M0.5570.38
47_T81_V0.5540.38
65_Q68_L0.5510.38
282_M296_T0.5480.37
108_M190_L0.5440.37
84_Q91_K0.5420.37
37_H110_Y0.5420.37
126_A137_L0.5410.37
285_L290_L0.5400.37
155_L159_L0.5400.37
103_A147_I0.5390.37
43_V81_V0.5380.36
25_I71_R0.5380.36
114_S223_G0.5370.36
53_I147_I0.5370.36
36_V81_V0.5370.36
51_R55_S0.5370.36
262_R265_R0.5340.36
89_L189_G0.5330.36
159_L245_V0.5330.36
177_A241_T0.5320.36
53_I148_G0.5320.36
180_M184_K0.5310.36
294_Y319_R0.5300.36
216_D250_K0.5300.36
179_L239_I0.5300.36
295_L317_N0.5290.36
36_V80_I0.5280.36
182_V225_T0.5280.36
58_L61_Q0.5270.35
207_W216_D0.5250.35
317_N327_F0.5250.35
205_G219_V0.5240.35
199_N228_K0.5240.35
97_D101_T0.5230.35
46_R144_I0.5210.35
289_H318_L0.5200.35
334_Y338_H0.5180.35
208_L219_V0.5170.34
74_F77_Q0.5170.34
21_S81_V0.5150.34
111_A280_D0.5140.34
201_M247_D0.5140.34
59_W62_I0.5130.34
147_I267_I0.5130.34
59_W196_L0.5120.34
28_I31_L0.5120.34
52_A60_L0.5100.34
135_L139_G0.5100.34
24_M31_L0.5090.34
283_Q300_Q0.5080.34
177_A235_T0.5080.34
294_Y325_G0.5070.34
58_L269_I0.5040.33
51_R78_G0.5030.33
253_S327_F0.5030.33
53_I108_M0.5020.33
186_P200_D0.5020.33
88_W267_I0.5020.33
35_V147_I0.5010.33
59_W129_F0.5000.33
275_R284_R0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5ajiA 3 0.6337 100 0.613 Contact Map
3udcA 3 0.6241 100 0.614 Contact Map
4hw9A 3 0.6096 100 0.62 Contact Map
3mlqE 1 0.0964 63.9 0.963 Contact Map
4l5gA 1 0.3349 46.8 0.967 Contact Map
2lt1A 1 0.1542 30.3 0.97 Contact Map
2lt4A 1 0.1494 25.4 0.971 Contact Map
4kbmB 1 0.3301 20.2 0.972 Contact Map
3udfA 2 0.1012 19.3 0.973 Contact Map
2lwjA 1 0.3422 14.3 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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