GREMLIN Database
YAIV - Uncharacterized protein YaiV
UniProt: P0AAP5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13607
Length: 207 (198)
Sequences: 238 (176)
Seq/√Len: 12.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
143_R167_H4.0201.00
139_Y203_L3.9180.99
49_E93_T3.4770.99
149_M178_A3.0820.97
139_Y187_G2.8940.95
167_H177_V2.7790.94
139_Y204_P2.7420.94
189_Y204_P2.7140.93
139_Y189_Y2.5470.91
53_S89_E2.3920.88
54_L200_I2.3260.86
146_L165_Y2.2360.84
126_L203_L2.2150.83
177_V183_A2.2120.83
87_I179_E2.1970.83
187_G204_P2.1150.80
36_S73_L2.0650.79
162_V188_G2.0490.78
142_I180_V2.0300.77
142_I192_M2.0300.77
149_M172_I1.9830.76
68_P157_R1.9780.75
161_G176_V1.9530.74
97_L115_A1.8900.72
162_V185_R1.8650.71
191_E199_A1.8630.71
26_E185_R1.8550.70
67_A116_F1.8420.70
88_S102_T1.8400.70
163_M178_A1.7980.68
101_Q105_L1.7580.66
60_V134_I1.7410.65
52_I87_I1.7340.65
161_G179_E1.6930.63
119_L126_L1.6750.62
18_L68_P1.6720.62
152_W176_V1.6440.61
22_G194_K1.6370.60
174_R181_L1.6200.60
14_L86_L1.6150.59
67_A138_S1.6030.59
25_F94_G1.5990.59
47_I138_S1.5380.55
166_I174_R1.4940.53
52_I82_I1.4730.52
19_S70_I1.4700.52
162_V192_M1.4520.51
166_I189_Y1.4490.51
112_W143_R1.3990.48
33_V156_L1.3760.47
143_R182_A1.3720.47
29_N93_T1.3270.45
107_E113_R1.3080.44
112_W139_Y1.3050.44
162_V181_L1.2940.43
152_W178_A1.2940.43
129_R152_W1.2840.42
176_V179_E1.2750.42
62_I100_K1.2390.40
11_F118_W1.2380.40
165_Y197_L1.2290.40
157_R178_A1.2260.40
18_L106_I1.2140.39
149_M162_V1.2100.39
143_R187_G1.2050.39
163_M167_H1.1910.38
150_I157_R1.1850.38
148_S167_H1.1850.38
112_W146_L1.1760.37
48_L95_Y1.1750.37
158_S177_V1.1740.37
10_E160_I1.1520.36
152_W165_Y1.1450.36
180_V193_N1.1150.34
92_C153_N1.1100.34
61_L183_A1.0920.33
12_G177_V1.0900.33
190_I204_P1.0840.33
45_F105_L1.0740.32
12_G59_N1.0600.32
87_I119_L1.0560.32
48_L150_I1.0550.32
64_I183_A1.0550.32
88_S203_L1.0510.31
111_L139_Y1.0480.31
94_G135_G1.0460.31
44_T118_W1.0440.31
14_L153_N1.0410.31
146_L184_L1.0350.31
138_S160_I1.0270.30
138_S155_E1.0230.30
29_N200_I1.0140.30
62_I193_N1.0130.30
47_I52_I1.0120.30
102_T161_G1.0070.30
108_Q119_L1.0040.29
158_S198_V1.0040.29
113_R202_R1.0020.29
162_V196_K1.0000.29
30_E102_T0.9950.29
97_L102_T0.9860.29
117_Y185_R0.9810.28
25_F143_R0.9810.28
128_L169_R0.9780.28
89_E186_K0.9780.28
62_I201_N0.9780.28
13_K17_C0.9750.28
135_G173_S0.9720.28
24_R92_C0.9710.28
130_D152_W0.9690.28
108_Q198_V0.9680.28
14_L18_L0.9660.28
44_T102_T0.9580.27
42_E88_S0.9570.27
84_Y162_V0.9560.27
120_A198_V0.9540.27
28_N31_K0.9520.27
70_I79_K0.9490.27
33_V41_N0.9450.27
163_M169_R0.9350.27
12_G16_K0.9330.26
183_A187_G0.9300.26
71_M88_S0.9250.26
20_R150_I0.9190.26
30_E138_S0.9120.26
20_R46_V0.9090.26
182_A192_M0.9060.25
145_T163_M0.8950.25
86_L202_R0.8910.25
127_E149_M0.8850.25
120_A129_R0.8760.24
181_L184_L0.8750.24
31_K179_E0.8740.24
149_M159_R0.8740.24
70_I104_T0.8710.24
161_G164_N0.8700.24
79_K190_I0.8520.23
135_G179_E0.8360.23
65_T123_N0.8350.23
56_R157_R0.8310.23
49_E101_Q0.8240.22
184_L197_L0.8220.22
145_T170_T0.8210.22
129_R162_V0.8210.22
49_E179_E0.8130.22
13_K114_D0.8130.22
19_S191_E0.8110.22
187_G190_I0.8050.22
56_R130_D0.8030.22
88_S161_G0.7990.21
119_L148_S0.7980.21
15_D206_E0.7920.21
47_I175_S0.7900.21
147_L203_L0.7890.21
165_Y169_R0.7860.21
12_G108_Q0.7840.21
91_N161_G0.7830.21
87_I161_G0.7810.21
187_G200_I0.7800.21
56_R111_L0.7780.21
9_Q109_N0.7750.21
50_G197_L0.7720.21
52_I66_Q0.7700.20
59_N116_F0.7690.20
46_V64_I0.7680.20
173_S203_L0.7620.20
41_N88_S0.7620.20
143_R204_P0.7590.20
77_L192_M0.7580.20
27_F86_L0.7580.20
95_Y145_T0.7570.20
118_W172_I0.7510.20
94_G172_I0.7500.20
27_F71_M0.7490.20
48_L142_I0.7400.19
54_L60_V0.7370.19
151_D154_E0.7340.19
27_F100_K0.7330.19
48_L165_Y0.7320.19
35_F71_M0.7300.19
84_Y129_R0.7200.19
143_R147_L0.7150.19
46_V102_T0.7150.19
14_L143_R0.7130.19
86_L192_M0.7120.19
101_Q104_T0.7110.19
30_E49_E0.7090.19
45_F108_Q0.7060.18
185_R202_R0.7040.18
56_R121_W0.6980.18
30_E47_I0.6920.18
18_L36_S0.6920.18
116_F189_Y0.6880.18
17_C109_N0.6760.18
7_P11_F0.6740.17
139_Y146_L0.6720.17
16_K206_E0.6690.17
116_F172_I0.6680.17
58_E61_L0.6680.17
17_C97_L0.6640.17
41_N73_L0.6610.17
180_V183_A0.6580.17
188_G195_G0.6570.17
117_Y153_N0.6560.17
24_R41_N0.6550.17
59_N94_G0.6490.17
109_N191_E0.6440.17
84_Y192_M0.6440.17
90_G113_R0.6420.17
127_E141_Q0.6420.17
56_R112_W0.6410.17
198_V203_L0.6390.16
95_Y136_H0.6380.16
142_I190_I0.6350.16
50_G175_S0.6310.16
183_A196_K0.6270.16
25_F118_W0.6260.16
90_G108_Q0.6260.16
111_L160_I0.6260.16
46_V63_G0.6220.16
32_Q186_K0.6220.16
60_V164_N0.6210.16
17_C142_I0.6200.16
149_M169_R0.6200.16
43_D71_M0.6190.16
47_I65_T0.6190.16
105_L186_K0.6180.16
21_Y165_Y0.6170.16
121_W169_R0.6160.16
14_L68_P0.6160.16
109_N199_A0.6130.16
166_I181_L0.6110.16
121_W129_R0.6080.16
15_D200_I0.6080.16
195_G204_P0.6030.15
184_L189_Y0.6030.15
159_R178_A0.6020.15
149_M170_T0.6010.15
142_I187_G0.5990.15
84_Y119_L0.5970.15
44_T161_G0.5930.15
14_L118_W0.5920.15
85_K108_Q0.5860.15
99_A119_L0.5820.15
140_E165_Y0.5820.15
9_Q104_T0.5820.15
97_L134_I0.5800.15
53_S157_R0.5780.15
154_E157_R0.5780.15
44_T115_A0.5760.15
21_Y33_V0.5760.15
26_E203_L0.5740.15
102_T115_A0.5700.15
158_S188_G0.5660.14
53_S74_A0.5640.14
26_E45_F0.5630.14
112_W148_S0.5600.14
106_I126_L0.5560.14
7_P121_W0.5560.14
174_R184_L0.5540.14
90_G107_E0.5540.14
29_N48_L0.5480.14
46_V68_P0.5480.14
34_I63_G0.5480.14
74_A133_L0.5460.14
112_W187_G0.5450.14
111_L157_R0.5440.14
98_P101_Q0.5400.14
197_L204_P0.5370.14
121_W125_I0.5350.14
98_P132_Q0.5350.14
68_P153_N0.5320.14
22_G201_N0.5310.14
184_L204_P0.5310.14
16_K62_I0.5310.14
62_I136_H0.5300.14
60_V203_L0.5290.14
54_L121_W0.5280.14
89_E167_H0.5270.14
22_G47_I0.5270.14
69_Y90_G0.5240.13
45_F135_G0.5220.13
150_I165_Y0.5180.13
35_F82_I0.5170.13
40_N101_Q0.5170.13
127_E161_G0.5150.13
146_L187_G0.5150.13
172_I177_V0.5100.13
82_I137_N0.5090.13
68_P173_S0.5090.13
114_D118_W0.5090.13
33_V154_E0.5090.13
8_L97_L0.5080.13
176_V192_M0.5050.13
28_N40_N0.5050.13
149_M196_K0.5000.13
77_L120_A0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kccA 2 0.9034 99.7 0.733 Contact Map
4r8hA 2 0.913 99.6 0.74 Contact Map
2oz6A 2 0.9082 99.6 0.743 Contact Map
3iwzA 2 0.9227 99.6 0.745 Contact Map
3e6cC 2 0.9758 99.6 0.745 Contact Map
3dv8A 2 0.9807 99.6 0.747 Contact Map
1zybA 2 0.9758 99.6 0.747 Contact Map
4i2oA 2 0.8841 99.6 0.747 Contact Map
2gauA 2 0.971 99.6 0.748 Contact Map
1o5lA 2 0.5942 99.6 0.748 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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