GREMLIN Database
FRMR - Transcriptional repressor FrmR
UniProt: P0AAP3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13296
Length: 91 (90)
Sequences: 435 (285)
Seq/√Len: 30.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_I56_V4.6041.00
19_R23_D3.5301.00
45_V49_A2.9941.00
4_T8_K2.6421.00
18_I22_I2.5250.99
23_D27_R2.4000.99
8_K32_D2.0110.97
16_R26_E2.0090.97
49_A53_M1.8880.96
15_V29_L1.8880.96
79_V82_T1.8730.96
58_E62_R1.8240.95
53_M90_L1.8060.95
44_A53_M1.7180.93
24_A28_S1.7120.93
61_I82_T1.6400.91
24_A40_Q1.5890.90
2_P64_T1.5550.89
29_L50_N1.5450.89
34_E37_A1.5270.88
58_E83_I1.4220.84
11_V64_T1.4190.84
12_L16_R1.4030.83
54_A90_L1.3820.82
71_Y75_V1.3490.81
86_V90_L1.3380.80
25_L41_Q1.3370.80
62_R83_I1.3280.80
11_V85_L1.2900.78
15_V52_L1.2830.77
4_T11_V1.1870.71
39_L57_L1.1750.71
9_K13_T1.1570.69
2_P5_P1.1320.68
3_S64_T1.1010.65
25_L44_A1.0950.65
13_T17_R1.0860.64
19_R26_E1.0600.62
40_Q44_A1.0260.60
45_V90_L1.0150.59
3_S11_V1.0080.59
61_I86_V1.0000.58
27_R30_E0.9940.57
78_S91_K0.9940.57
57_L79_V0.9920.57
15_V26_E0.9750.56
61_I83_I0.9640.55
5_P32_D0.9600.55
7_E56_V0.9490.54
4_T59_S0.9350.53
71_Y74_E0.9320.53
28_S33_A0.9260.52
28_S57_L0.9150.51
73_R76_S0.9130.51
10_K23_D0.9110.51
61_I79_V0.9000.50
57_L66_D0.8940.50
63_E88_A0.8810.49
43_A87_R0.8750.48
42_I53_M0.8460.46
39_L50_N0.8320.45
10_K32_D0.8260.44
28_S31_G0.8100.43
72_S76_S0.8090.43
57_L62_R0.8050.43
4_T64_T0.8000.42
66_D79_V0.7950.42
78_S87_R0.7780.40
16_R87_R0.7780.40
59_S68_N0.7740.40
78_S85_L0.7660.40
18_I45_V0.7530.39
36_R46_R0.7520.38
22_I25_L0.7470.38
63_E67_R0.7460.38
54_A86_V0.7440.38
27_R46_R0.7300.37
27_R41_Q0.7290.37
49_A69_D0.7220.36
36_R81_D0.7140.36
3_S38_I0.7070.35
45_V79_V0.7020.35
55_E84_E0.6940.34
50_N89_Y0.6860.34
9_K40_Q0.6830.33
20_G48_A0.6830.33
41_Q48_A0.6710.33
8_K12_L0.6670.32
64_T85_L0.6660.32
10_K69_D0.6550.31
44_A48_A0.6480.31
56_V65_F0.6440.31
69_D76_S0.6440.31
5_P8_K0.6430.31
69_D72_S0.6410.31
4_T32_D0.6380.30
11_V80_D0.6340.30
2_P11_V0.6320.30
15_V38_I0.6290.30
19_R88_A0.6260.30
38_I76_S0.6230.29
13_T45_V0.6210.29
25_L32_D0.6190.29
7_E84_E0.6150.29
5_P59_S0.6100.28
59_S63_E0.6050.28
25_L59_S0.6000.28
51_G85_L0.5960.28
9_K41_Q0.5910.27
42_I52_L0.5860.27
35_C87_R0.5800.27
24_A49_A0.5780.26
43_A80_D0.5760.26
76_S80_D0.5730.26
74_E83_I0.5720.26
54_A79_V0.5700.26
57_L86_V0.5670.26
59_S84_E0.5660.26
50_N91_K0.5650.26
11_V59_S0.5640.26
10_K37_A0.5640.26
53_M68_N0.5550.25
10_K19_R0.5530.25
60_H64_T0.5440.24
37_A40_Q0.5440.24
13_T22_I0.5420.24
71_Y83_I0.5420.24
60_H66_D0.5390.24
14_R20_G0.5370.24
18_I91_K0.5260.23
59_S64_T0.5200.23
34_E38_I0.5160.23
23_D54_A0.5050.22
46_R54_A0.5010.22
12_L28_S0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4m1pA 3 0.989 99.9 0.328 Contact Map
2hh7A 3 0.9231 99.9 0.346 Contact Map
4adzA 4 0.967 99.9 0.369 Contact Map
3aaiA 3 0.8791 99.9 0.401 Contact Map
2okuA 2 0.5714 73.9 0.885 Contact Map
2fb5A 3 0.9011 35.2 0.909 Contact Map
2ffhA 4 0.4835 18.6 0.921 Contact Map
3dm5A 4 0.5275 14 0.925 Contact Map
2xxaA 1 0.4725 12.2 0.927 Contact Map
2p61A 1 0.5604 10.9 0.929 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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