GREMLIN Database
ADRA - Probable diguanylate cyclase AdrA
UniProt: P0AAP1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11257
Length: 371 (323)
Sequences: 13149 (12189)
Seq/√Len: 678.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
280_R283_D4.3151.00
251_H364_R4.0841.00
208_V212_R3.8351.00
245_L309_M3.4861.00
245_L333_V3.4251.00
228_L345_Y3.3911.00
359_A368_E3.2941.00
243_T337_P3.2911.00
219_Y223_H3.1451.00
224_W294_A2.9741.00
218_V272_T2.6871.00
317_N365_N2.6861.00
310_L313_H2.6161.00
249_I271_L2.5371.00
332_S359_A2.4541.00
224_W286_G2.4531.00
199_L203_K2.4491.00
218_V285_I2.4421.00
288_F294_A2.4031.00
243_T305_A2.3751.00
362_A368_E2.3631.00
266_E269_V2.3501.00
274_Q319_L2.3451.00
339_N342_M2.2821.00
262_D350_K2.2361.00
313_H367_T2.2221.00
231_E234_N2.1671.00
301_P304_S2.1561.00
275_L285_I2.1291.00
203_K206_L2.1251.00
223_H227_M2.0361.00
362_A366_R2.0071.00
267_A329_L1.9971.00
247_I333_V1.9961.00
358_K362_A1.9881.00
344_H347_E1.9831.00
316_L331_I1.9601.00
247_I331_I1.9471.00
255_I267_A1.9451.00
227_M230_N1.9271.00
216_T268_I1.9221.00
350_K354_L1.9121.00
313_H317_N1.8581.00
297_M308_A1.8211.00
359_A366_R1.8201.00
279_L285_I1.8021.00
250_D332_S1.7941.00
207_Q211_T1.7661.00
330_R365_N1.7521.00
246_I356_L1.7181.00
219_Y284_V1.7001.00
245_L297_M1.6951.00
271_L316_L1.6881.00
358_K368_E1.6801.00
242_A348_W1.6661.00
270_A273_R1.6641.00
192_S195_T1.6501.00
211_T226_T1.6311.00
249_I331_I1.6271.00
278_T311_R1.6261.00
273_R276_Q1.6231.00
255_I327_V1.6021.00
263_V266_E1.5991.00
196_A199_L1.5961.00
358_K361_K1.5921.00
246_I288_F1.5701.00
343_S351_S1.5511.00
221_R265_D1.5511.00
288_F349_L1.5431.00
195_T199_L1.5431.00
308_A311_R1.5271.00
310_L314_E1.5221.00
338_L348_W1.4931.00
242_A338_L1.4861.00
214_G222_R1.4821.00
278_T315_G1.4791.00
257_D357_Y1.4761.00
270_A274_Q1.4621.00
246_I349_L1.4581.00
227_M231_E1.4431.00
342_M351_S1.4371.00
227_M284_V1.4351.00
271_L275_L1.4241.00
270_A320_R1.4231.00
266_E270_A1.4101.00
253_K257_D1.3991.00
227_M286_G1.3821.00
211_T223_H1.3751.00
254_S258_T1.3401.00
306_I310_L1.3381.00
223_H284_V1.3321.00
202_H205_R1.3271.00
200_A203_K1.3211.00
353_D357_Y1.3201.00
305_A335_V1.3101.00
335_V367_T1.3001.00
192_S196_A1.3001.00
279_L295_V1.2981.00
240_R299_G1.2961.00
209_M222_R1.2881.00
199_L202_H1.2851.00
251_H254_S1.2801.00
261_H353_D1.2661.00
272_T285_I1.2621.00
313_H333_V1.2611.00
253_K357_Y1.2551.00
225_E346_R1.2501.00
314_E318_T1.2411.00
336_A348_W1.2381.00
225_E229_R1.2351.00
252_F268_I1.2311.00
279_L283_D1.2311.00
274_Q320_R1.2251.00
261_H357_Y1.2201.00
251_H291_D1.2201.00
351_S355_A1.2151.00
256_N264_G1.2031.00
223_H226_T1.2011.00
231_E298_S1.1991.00
270_A319_L1.1931.00
291_D330_R1.1831.00
267_A320_R1.1791.00
212_R219_Y1.1781.00
294_A349_L1.1721.00
247_I275_L1.1671.00
221_R225_E1.1541.00
359_A363_G1.1521.00
211_T219_Y1.1441.00
224_W296_I1.1361.00
219_Y286_G1.1261.00
309_M333_V1.1241.00
279_L312_V1.1211.00
195_T200_A1.1201.00
345_Y349_L1.1141.00
267_A291_D1.1111.00
205_R209_M1.0991.00
290_G357_Y1.0921.00
319_L322_P1.0911.00
269_V272_T1.0861.00
229_R233_D1.0861.00
228_L296_I1.0831.00
271_L329_L1.0791.00
286_G294_A1.0771.00
203_K207_Q1.0741.00
245_L295_V1.0741.00
309_M367_T1.0641.00
71_L75_G1.0621.00
347_E350_K1.0541.00
269_V273_R1.0511.00
271_L331_I1.0451.00
305_A309_M1.0311.00
223_H286_G1.0251.00
313_H365_N1.0231.00
205_R208_V1.0211.00
309_M335_V1.0181.00
277_I315_G1.0181.00
229_R345_Y1.0151.00
110_G114_G1.0101.00
306_I367_T1.0041.00
302_A337_P0.9971.00
300_T304_S0.9941.00
224_W228_L0.9911.00
204_R207_Q0.9901.00
315_G318_T0.9901.00
247_I295_V0.9901.00
249_I330_R0.9851.00
283_D311_R0.9731.00
336_A351_S0.9731.00
292_E353_D0.9711.00
248_D360_K0.9641.00
270_A321_L0.9611.00
231_E242_A0.9601.00
275_L295_V0.9551.00
244_L349_L0.9531.00
243_T335_V0.9521.00
226_T230_N0.9481.00
235_C338_L0.9351.00
273_R277_I0.9341.00
336_A352_A0.9311.00
196_A200_A0.9301.00
253_K261_H0.9231.00
197_T200_A0.9221.00
355_A359_A0.9101.00
249_I268_I0.9091.00
215_M221_R0.9091.00
302_A306_I0.9051.00
252_F267_A0.9021.00
195_T198_K0.8991.00
275_L279_L0.8981.00
262_D266_E0.8921.00
193_Y197_T0.8901.00
289_G357_Y0.8881.00
274_Q315_G0.8861.00
245_L335_V0.8861.00
343_S347_E0.8841.00
248_D357_Y0.8841.00
246_I294_A0.8821.00
241_D340_P0.8801.00
253_K353_D0.8751.00
250_D364_R0.8741.00
285_I295_V0.8731.00
193_Y199_L0.8721.00
263_V327_V0.8711.00
210_S220_N0.8671.00
253_K256_N0.8641.00
280_R311_R0.8641.00
232_F338_L0.8611.00
72_V75_G0.8601.00
227_M296_I0.8571.00
215_M268_I0.8531.00
192_S197_T0.8521.00
248_D261_H0.8461.00
244_L348_W0.8451.00
289_G353_D0.8441.00
228_L232_F0.8441.00
339_N351_S0.8421.00
323_N326_Q0.8421.00
289_G292_E0.8421.00
280_R300_T0.8411.00
276_Q285_I0.8341.00
308_A312_V0.8341.00
322_P327_V0.8331.00
330_R363_G0.8331.00
120_V124_T0.8311.00
336_A355_A0.8301.00
280_R308_A0.8281.00
279_L308_A0.8271.00
314_E317_N0.8251.00
261_H292_E0.8241.00
303_E306_I0.8231.00
256_N290_G0.8221.00
297_M305_A0.8181.00
234_N298_S0.8181.00
255_I263_V0.8141.00
78_F81_P0.8001.00
253_K290_G0.7951.00
333_V367_T0.7951.00
309_M313_H0.7931.00
221_R288_F0.7931.00
257_D353_D0.7921.00
262_D288_F0.7901.00
341_Q351_S0.7901.00
224_W288_F0.7851.00
283_D308_A0.7831.00
198_K201_E0.7821.00
193_Y196_A0.7801.00
143_F146_G0.7751.00
316_L320_R0.7711.00
304_S307_T0.7601.00
232_F345_Y0.7591.00
134_L138_G0.7591.00
309_M331_I0.7491.00
275_L312_V0.7491.00
51_G54_L0.7471.00
291_D359_A0.7461.00
235_C242_A0.7451.00
211_T222_R0.7451.00
84_A88_A0.7451.00
295_V312_V0.7441.00
310_L367_T0.7441.00
71_L74_V0.7431.00
246_I352_A0.7411.00
214_G225_E0.7391.00
254_S291_D0.7361.00
249_I252_F0.7331.00
82_H86_Q0.7271.00
86_Q90_R0.7261.00
290_G353_D0.7241.00
55_P59_T0.7221.00
212_R218_V0.7221.00
321_L326_Q0.7211.00
75_G79_V0.7201.00
248_D291_D0.7201.00
257_D261_H0.7191.00
196_A203_K0.7181.00
292_E357_Y0.7161.00
351_S354_L0.7161.00
54_L58_S0.7151.00
302_A305_A0.7141.00
142_L146_G0.7141.00
81_P84_A0.7131.00
217_G269_V0.7131.00
316_L329_L0.7131.00
262_D346_R0.7111.00
347_E351_S0.7081.00
202_H209_M0.7061.00
225_E228_L0.7041.00
266_E323_N0.6961.00
332_S357_Y0.6951.00
259_W327_V0.6951.00
65_P68_W0.6911.00
218_V286_G0.6901.00
244_L294_A0.6891.00
313_H330_R0.6881.00
206_L209_M0.6871.00
320_R328_T0.6861.00
242_A296_I0.6851.00
212_R276_Q0.6841.00
225_E286_G0.6821.00
338_L342_M0.6811.00
250_D363_G0.6771.00
151_V154_C0.6751.00
232_F242_A0.6721.00
200_A204_R0.6681.00
238_H299_G0.6671.00
155_L159_E0.6651.00
274_Q322_P0.6641.00
261_H291_D0.6641.00
101_N105_D0.6631.00
283_D297_M0.6631.00
256_N360_K0.6621.00
206_L211_T0.6581.00
356_L364_R0.6581.00
307_T311_R0.6571.00
324_T327_V0.6571.00
152_V156_V0.6561.00
173_E177_S0.6551.00
272_T275_L0.6541.00
257_D292_E0.6541.00
252_F291_D0.6521.00
306_I335_V0.6511.00
228_L242_A0.6501.00
300_T305_A0.6481.00
188_F191_V0.6441.00
256_N291_D0.6431.00
237_R282_S0.6411.00
259_W263_V0.6411.00
211_T214_G0.6401.00
291_D360_K0.6401.00
267_A321_L0.6401.00
332_S363_G0.6391.00
248_D256_N0.6391.00
58_S62_S0.6371.00
291_D363_G0.6341.00
253_K292_E0.6311.00
284_V296_I0.6301.00
192_S199_L0.6291.00
237_R280_R0.6271.00
222_R225_E0.6271.00
218_V275_L0.6241.00
225_E345_Y0.6231.00
85_W89_S0.6221.00
224_W345_Y0.6211.00
305_A337_P0.6191.00
53_F57_A0.6181.00
251_H356_L0.6181.00
288_F291_D0.6181.00
69_W72_V0.6171.00
274_Q278_T0.6171.00
271_L320_R0.6161.00
90_R94_P0.6151.00
69_W80_W0.6131.00
197_T201_E0.6131.00
209_M214_G0.6131.00
135_M139_G0.6111.00
261_H360_K0.6111.00
118_V121_L0.6091.00
195_T203_K0.6081.00
275_L293_F0.6071.00
261_H290_G0.6061.00
117_G124_T0.6061.00
55_P58_S0.6061.00
339_N343_S0.6061.00
121_L124_T0.6051.00
113_V116_M0.6041.00
356_L359_A0.6021.00
115_V118_V0.6021.00
248_D264_G0.6021.00
231_E296_I0.6011.00
135_M138_G0.6001.00
99_I102_L0.5981.00
264_G291_D0.5971.00
100_Y103_K0.5971.00
224_W349_L0.5971.00
250_D356_L0.5961.00
59_T62_S0.5931.00
357_Y360_K0.5931.00
125_A129_I0.5921.00
109_A112_W0.5901.00
235_C238_H0.5901.00
70_W73_L0.5901.00
74_V78_F0.5901.00
253_K360_K0.5891.00
110_G113_V0.5891.00
247_I285_I0.5881.00
114_G117_G0.5871.00
243_T309_M0.5841.00
157_T161_T0.5811.00
111_M114_G0.5811.00
202_H206_L0.5811.00
112_W116_M0.5801.00
88_A91_A0.5791.00
60_L64_P0.5771.00
116_M120_V0.5771.00
291_D331_I0.5761.00
250_D330_R0.5761.00
177_S181_I0.5761.00
88_A92_V0.5751.00
263_V325_P0.5741.00
116_M119_N0.5731.00
52_M59_T0.5701.00
119_N122_P0.5701.00
120_V123_S0.5691.00
109_A113_V0.5691.00
346_R350_K0.5671.00
291_D357_Y0.5671.00
241_D301_P0.5661.00
267_A270_A0.5631.00
53_F58_S0.5601.00
98_E101_N0.5601.00
172_L175_W0.5601.00
79_V83_L0.5601.00
291_D365_N0.5591.00
312_V331_I0.5591.00
129_I132_L0.5581.00
253_K264_G0.5571.00
146_G149_L0.5561.00
212_R223_H0.5561.00
53_F59_T0.5561.00
207_Q226_T0.5551.00
63_H66_P0.5551.00
133_N138_G0.5551.00
262_D349_L0.5541.00
214_G288_F0.5541.00
278_T283_D0.5501.00
236_R338_L0.5481.00
227_M298_S0.5481.00
255_I322_P0.5471.00
236_R343_S0.5461.00
57_A61_V0.5451.00
228_L244_L0.5441.00
156_V159_E0.5441.00
241_D337_P0.5421.00
153_S157_T0.5381.00
119_N123_S0.5381.00
252_F359_A0.5371.00
244_L352_A0.5361.00
148_V152_V0.5351.00
136_G139_G0.5341.00
240_R298_S0.5331.00
252_F256_N0.5331.00
98_E102_L0.5321.00
204_R208_V0.5291.00
207_Q210_S0.5291.00
292_E332_S0.5281.00
234_N238_H0.5281.00
131_C138_G0.5261.00
320_R327_V0.5261.00
51_G55_P0.5261.00
58_S63_H0.5251.00
221_R224_W0.5231.00
206_L210_S0.5231.00
248_D289_G0.5210.99
51_G58_S0.5210.99
315_G319_L0.5200.99
248_D292_E0.5190.99
72_V79_V0.5180.99
133_N137_A0.5160.99
218_V276_Q0.5150.99
243_T297_M0.5150.99
271_L319_L0.5140.99
145_A148_V0.5130.99
117_G121_L0.5130.99
101_N104_T0.5130.99
174_W177_S0.5120.99
142_L145_A0.5120.99
317_N328_T0.5100.99
83_L86_Q0.5100.99
208_V211_T0.5100.99
203_K209_M0.5090.99
53_F56_I0.5080.99
141_R144_V0.5060.99
52_M58_S0.5050.99
52_M55_P0.5050.99
261_H289_G0.5050.99
311_R315_G0.5050.99
174_W178_L0.5040.99
255_I328_T0.5040.99
112_W115_V0.5030.99
208_V217_G0.5020.99
297_M300_T0.5010.99
130_M133_N0.5000.99
312_V315_G0.5000.99
198_K202_H0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w25A 2 0.6307 100 0.458 Contact Map
4j40A 2 0 100 0.464 Contact Map
3pjxA 1 0.4771 100 0.479 Contact Map
4rnhA 2 0.4232 100 0.481 Contact Map
3ignA 1 0.4447 100 0.487 Contact Map
3ezuA 2 0.8571 100 0.49 Contact Map
3mtkA 2 0.4259 100 0.497 Contact Map
3hvaA 1 0.434 100 0.508 Contact Map
3i5cA 2 0.5148 100 0.509 Contact Map
4urgA 1 0.4232 100 0.51 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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