GREMLIN Database
HYPC - Hydrogenase isoenzymes formation protein HypC
UniProt: P0AAM3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10485
Length: 90 (74)
Sequences: 646 (400)
Seq/√Len: 46.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_D69_D3.2801.00
17_A30_L2.9341.00
61_E65_R2.9291.00
9_I42_P2.6761.00
10_R25_Q2.2131.00
52_V55_A1.9640.99
7_G21_V1.9570.99
65_R69_D1.9000.99
7_G50_V1.8720.99
62_A66_D1.8570.99
40_G58_V1.6770.98
46_Q58_V1.6380.97
49_L59_I1.6120.97
21_V50_V1.6100.97
43_R46_Q1.5800.97
19_V50_V1.5270.96
8_Q20_D1.5080.96
9_I17_A1.4990.96
11_T18_K1.4780.95
26_R49_L1.3900.94
11_T25_Q1.3750.93
69_D72_Q1.3370.92
13_D18_K1.3000.91
28_V31_T1.2520.89
22_C49_L1.2050.87
20_D25_Q1.1840.87
63_E66_D1.1720.86
20_D56_M1.1560.85
28_V50_V1.1510.85
16_Q27_D1.1510.85
24_I59_I1.1160.83
22_C72_Q1.0940.82
65_R73_N1.0850.81
3_I46_Q1.0820.81
15_N31_T1.0820.81
7_G20_D1.0640.80
30_L42_P1.0570.80
49_L60_N1.0450.79
4_G32_L1.0380.78
8_Q58_V1.0120.77
67_T71_L1.0090.76
16_Q49_L0.9970.75
32_L40_G0.9940.75
4_G26_R0.9300.70
56_M59_I0.9270.70
18_K25_Q0.9030.68
9_I12_I0.8890.67
21_V71_L0.8880.67
18_K27_D0.8840.66
16_Q21_V0.8620.64
7_G19_V0.8520.63
57_S71_L0.8430.63
4_G47_W0.8310.61
11_T62_A0.8200.60
17_A55_A0.8130.60
4_G57_S0.7960.58
11_T42_P0.7930.58
33_V78_E0.7740.56
5_V52_V0.7700.56
13_D17_A0.7680.55
21_V32_L0.7580.54
70_A73_N0.7530.54
33_V75_F0.7520.54
75_F80_D0.7350.52
3_I24_I0.7340.52
46_Q73_N0.7320.52
57_S63_E0.7300.52
7_G71_L0.7300.52
29_D32_L0.7280.51
26_R54_F0.7140.50
72_Q79_P0.6960.48
52_V57_S0.6870.47
26_R71_L0.6820.47
10_R44_V0.6800.47
21_V67_T0.6740.46
13_D27_D0.6730.46
12_I44_V0.6700.46
33_V57_S0.6680.46
30_L33_V0.6570.44
50_V55_A0.6560.44
11_T76_D0.6540.44
40_G43_R0.6460.43
31_T52_V0.6450.43
15_N32_L0.6430.43
33_V40_G0.6330.42
33_V55_A0.6240.41
45_G66_D0.6150.40
8_Q27_D0.5990.39
15_N30_L0.5950.39
50_V77_V0.5830.37
69_D74_M0.5790.37
3_I54_F0.5770.37
28_V55_A0.5590.35
21_V26_R0.5570.35
9_I55_A0.5560.35
52_V63_E0.5550.35
28_V76_D0.5520.35
10_R30_L0.5440.34
62_A76_D0.5380.33
42_P58_V0.5370.33
23_G60_N0.5360.33
45_G59_I0.5340.33
28_V52_V0.5330.33
68_L71_L0.5260.32
43_R58_V0.5240.32
4_G67_T0.5210.32
8_Q45_G0.5140.31
73_N78_E0.5130.31
4_G48_V0.5050.30
48_V56_M0.5000.30
44_V62_A0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ot2A 1 1 100 0.157 Contact Map
2z1cA 1 0.8222 100 0.213 Contact Map
3d3rA 4 0.8111 100 0.217 Contact Map
3w1eA 1 0.5778 31.4 0.907 Contact Map
4wjwA 2 0.7444 30.2 0.908 Contact Map
3m9bA 3 0.7 12.9 0.922 Contact Map
2wfwA 3 0.9111 11.4 0.924 Contact Map
2rcnA 2 0.9 10.7 0.925 Contact Map
4r7yA 3 0.9667 8.1 0.929 Contact Map
2ztdA 4 0.9556 7.5 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.005 seconds.