GREMLIN Database
NRFC - Protein NrfC
UniProt: P0AAK7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11946
Length: 223 (180)
Sequences: 2578 (1482)
Seq/√Len: 110.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
112_D115_S5.6801.00
59_V157_K3.0621.00
39_M154_F2.7091.00
166_P169_V2.7071.00
109_S140_R2.5791.00
78_G81_P2.4941.00
200_R203_L2.2931.00
101_V109_S2.2901.00
129_Q142_I2.2771.00
68_R71_I2.2061.00
132_I149_A2.0771.00
154_F211_L2.0081.00
40_V189_I1.9941.00
38_G182_L1.9871.00
98_A111_R1.9591.00
169_V177_L1.9381.00
35_V183_D1.8261.00
96_D210_K1.8171.00
112_D161_Q1.8061.00
103_V130_Y1.7441.00
36_R96_D1.7351.00
46_C52_C1.7331.00
35_V181_N1.7241.00
184_D187_S1.7121.00
46_C172_C1.6851.00
200_R208_K1.6511.00
91_S211_L1.6371.00
121_N124_L1.6361.00
46_C49_C1.6331.00
156_R161_Q1.6101.00
55_A171_A1.6051.00
187_S190_S1.5961.00
103_V134_A1.5821.00
186_N191_Q1.5811.00
129_Q132_I1.5621.00
60_N153_D1.5561.00
68_R150_D1.5281.00
41_H177_L1.5251.00
104_C125_C1.5241.00
60_N157_K1.5221.00
178_T192_L1.5201.00
104_C131_C1.5041.00
142_I149_A1.4971.00
49_C172_C1.4751.00
188_E191_Q1.4741.00
49_C52_C1.4661.00
99_P207_T1.4491.00
143_H150_D1.4391.00
159_N164_K1.4361.00
125_C131_C1.4341.00
47_I174_T1.4301.00
68_R72_I1.4161.00
40_V192_L1.3881.00
159_N170_E1.3721.00
109_S120_V1.3541.00
101_V111_R1.3471.00
52_C172_C1.3311.00
178_T188_E1.3281.00
188_E192_L1.2620.99
50_T53_M1.2520.99
112_D117_I1.2440.99
181_N184_D1.2380.99
44_S196_K1.2360.99
89_R177_L1.2160.99
98_A101_V1.2130.99
117_I160_L1.2040.99
193_L198_T1.2040.99
198_T214_V1.1960.99
59_V159_N1.1920.99
110_F121_N1.1830.99
41_H89_R1.1750.99
202_K205_L1.1660.99
191_Q195_Q1.1600.99
193_L212_Y1.1490.99
112_D119_D1.1380.99
36_R210_K1.1350.98
40_V214_V1.1300.98
90_K201_Y1.1300.98
190_S194_R1.1290.98
106_T109_S1.1190.98
69_L72_I1.1130.98
182_L186_N1.1030.98
41_H211_L1.0950.98
91_S177_L1.0880.98
51_A171_A1.0790.98
196_K214_V1.0630.98
44_S214_V1.0620.98
89_R213_R1.0590.98
38_G185_P1.0340.97
97_H102_D1.0310.97
111_R118_V1.0270.97
200_R205_L1.0260.97
144_P147_K1.0180.97
125_C128_C1.0160.97
96_D208_K1.0140.97
78_G82_D1.0090.97
141_F150_D1.0050.97
64_E67_S1.0000.97
164_K170_E0.9920.96
103_V109_S0.9840.96
111_R210_K0.9830.96
143_H146_T0.9820.96
79_E82_D0.9800.96
191_Q194_R0.9710.96
105_P131_C0.9690.96
110_F119_D0.9640.96
71_I75_E0.9620.96
38_G189_I0.9590.96
96_D111_R0.9560.96
200_R212_Y0.9430.95
119_D153_D0.9380.95
105_P125_C0.9330.95
122_P148_T0.9290.95
59_V167_A0.9130.94
104_C128_C0.9090.94
130_Y133_A0.9080.94
128_C131_C0.9070.94
160_L179_F0.9050.94
48_G71_I0.8850.93
41_H91_S0.8840.93
106_T126_V0.8760.93
185_P190_S0.8690.93
142_I147_K0.8610.92
51_A54_D0.8600.92
43_E89_R0.8570.92
189_I192_L0.8480.92
129_Q144_P0.8470.92
69_L177_L0.8430.92
112_D156_R0.8400.91
117_I154_F0.8390.91
76_P85_Y0.8370.91
57_R62_V0.8350.91
120_V149_A0.8300.91
187_S191_Q0.8270.91
69_L75_E0.8160.90
190_S193_L0.8150.90
55_A167_A0.8080.90
37_Y179_F0.8040.90
78_G83_V0.8040.90
97_H208_K0.8020.89
34_G183_D0.7850.88
71_I74_S0.7820.88
142_I146_T0.7800.88
129_Q149_A0.7790.88
99_P134_A0.7790.88
159_N167_A0.7780.88
69_L73_R0.7720.88
144_P150_D0.7710.88
153_D157_K0.7670.87
120_V140_R0.7650.87
70_T73_R0.7570.87
71_I76_P0.7560.87
105_P126_V0.7520.86
140_R149_A0.7430.86
39_M169_V0.7420.85
37_Y181_N0.7420.85
51_A174_T0.7400.85
165_L169_V0.7380.85
180_G184_D0.7350.85
117_I156_R0.7350.85
56_C152_C0.7340.85
72_I76_P0.7310.85
103_V133_A0.7270.84
186_N190_S0.7270.84
106_T128_C0.7270.84
51_A58_E0.7250.84
106_T124_L0.7210.84
62_V68_R0.7210.84
104_C127_G0.7200.84
165_L170_E0.7200.84
192_L196_K0.7160.83
45_L192_L0.7150.83
67_S70_T0.7140.83
108_A124_L0.7130.83
36_R182_L0.7130.83
200_R210_K0.7090.83
61_K150_D0.7030.82
132_I142_I0.7010.82
36_R183_D0.6970.82
175_K178_T0.6930.81
152_C155_C0.6910.81
45_L175_K0.6860.81
56_C155_C0.6780.80
185_P189_I0.6780.80
206_G209_P0.6750.80
166_P177_L0.6730.79
127_G131_C0.6690.79
193_L197_P0.6670.79
119_D156_R0.6640.79
181_N185_P0.6620.78
201_Y205_L0.6610.78
71_I77_Q0.6570.78
91_S154_F0.6570.78
181_N187_S0.6520.77
70_T77_Q0.6520.77
143_H147_K0.6380.76
184_D189_I0.6370.76
37_Y117_I0.6350.75
68_R73_R0.6330.75
48_G176_A0.6330.75
69_L76_P0.6240.74
39_M211_L0.6200.74
122_P142_I0.6190.74
137_Y209_P0.6170.73
163_G193_L0.6170.73
40_V193_L0.6170.73
58_E171_A0.6160.73
93_Q139_V0.6160.73
58_E170_E0.6140.73
106_T120_V0.6120.73
126_V131_C0.6070.72
70_T90_K0.6060.72
38_G210_K0.6040.72
68_R141_F0.6030.72
129_Q150_D0.6020.71
78_G84_K0.5990.71
122_P146_T0.5970.71
77_Q84_K0.5970.71
115_S161_Q0.5960.71
70_T74_S0.5950.71
74_S77_Q0.5930.70
205_L210_K0.5890.70
37_Y160_L0.5880.70
90_K93_Q0.5840.69
47_I173_P0.5820.69
98_A118_V0.5810.69
201_Y207_T0.5810.69
48_G139_V0.5810.69
57_R85_Y0.5780.68
53_M173_P0.5750.68
42_D214_V0.5750.68
200_R204_A0.5740.68
39_M179_F0.5720.68
102_D130_Y0.5700.67
175_K192_L0.5690.67
75_E78_G0.5690.67
40_V91_S0.5670.67
153_D156_R0.5670.67
39_M89_R0.5640.67
69_L91_S0.5620.66
43_E88_F0.5570.66
101_V105_P0.5570.66
93_Q140_R0.5560.65
182_L190_S0.5540.65
118_V134_A0.5520.65
48_G172_C0.5520.65
110_F124_L0.5480.64
137_Y207_T0.5430.64
154_F160_L0.5370.63
45_L178_T0.5360.63
115_S156_R0.5350.63
193_L196_K0.5270.61
140_R177_L0.5250.61
44_S212_Y0.5220.61
126_V130_Y0.5210.60
48_G52_C0.5180.60
138_R141_F0.5170.60
44_S192_L0.5120.59
209_P213_R0.5120.59
98_A140_R0.5120.59
68_R75_E0.5120.59
41_H213_R0.5110.59
80_F83_V0.5090.59
37_Y115_S0.5090.59
132_I144_P0.5080.59
137_Y180_G0.5070.58
106_T110_F0.5020.58
38_G212_Y0.5000.57
192_L195_Q0.5000.57
59_V170_E0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ivfB 1 0.8475 100 0.401 Contact Map
1ti6B 2 0.8251 100 0.423 Contact Map
1kqfB 3 0.9372 100 0.453 Contact Map
1h0hB 1 0.8386 100 0.46 Contact Map
2vpzB 2 0.8341 100 0.483 Contact Map
1q16B 2 0.861 100 0.513 Contact Map
4z3xE 2 0.7309 100 0.632 Contact Map
3mm5B 2 0.991 99.8 0.726 Contact Map
1jnrB 1 0.6368 99.5 0.792 Contact Map
3gyxB 1 0.435 99.5 0.797 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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