GREMLIN Database
HYDN - Electron transport protein HydN
UniProt: P0AAK4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11552
Length: 175 (150)
Sequences: 4025 (2466)
Seq/√Len: 201.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_A75_I3.0651.00
93_K106_V2.7591.00
69_V98_A2.6741.00
25_S136_H2.4661.00
75_I84_V2.4601.00
141_P144_M2.2391.00
16_R19_E2.2231.00
96_V128_A2.1661.00
75_I104_M2.1361.00
26_H132_D2.1191.00
137_R145_A2.1081.00
63_D68_N2.0801.00
144_M152_L2.0431.00
4_F157_R1.9361.00
76_S83_H1.9321.00
135_N139_D1.9321.00
81_F133_L1.9161.00
21_A146_A1.8931.00
76_S85_M1.8701.00
15_C18_C1.8651.00
153_I163_L1.8051.00
64_A77_R1.7981.00
93_K96_V1.7821.00
69_V94_T1.7531.00
13_I149_T1.7281.00
163_L166_E1.7221.00
5_I133_L1.7091.00
107_V129_N1.7041.00
67_A77_R1.6081.00
89_C95_C1.5541.00
44_I47_I1.5291.00
70_C95_C1.5211.00
106_V128_A1.4831.00
8_D11_K1.4711.00
84_V128_A1.4511.00
7_A152_L1.4471.00
159_K162_Q1.4331.00
83_H135_N1.4221.00
163_L167_K1.4181.00
12_C15_C1.4151.00
70_C89_C1.4101.00
12_C18_C1.3981.00
85_M88_R1.3891.00
93_K108_V1.3861.00
104_M128_A1.3781.00
37_P41_L1.3771.00
157_R161_E1.3671.00
72_N75_I1.3391.00
7_A55_A1.3131.00
137_R142_A1.3091.00
156_D159_K1.3041.00
25_S142_A1.2951.00
64_A67_A1.2891.00
6_I164_S1.2841.00
34_S129_N1.2791.00
12_C147_C1.2731.00
81_F138_E1.2691.00
74_A88_R1.2641.00
107_V125_K1.2611.00
72_N90_I1.2521.00
89_C92_C1.2501.00
15_C147_C1.2471.00
93_K128_A1.2451.00
26_H136_H1.2321.00
5_I144_M1.2271.00
38_E42_P1.2221.00
77_R82_V1.1901.00
25_S137_R1.1641.00
79_K139_D1.1571.00
92_C95_C1.1571.00
153_I167_K1.1461.00
37_P40_F1.1301.00
44_I48_K1.0981.00
155_V159_K1.0931.00
161_E166_E1.0711.00
94_T97_V1.0601.00
32_C35_L1.0561.00
36_T40_F1.0521.00
38_E41_L1.0511.00
86_Q127_E1.0311.00
37_P42_P1.0291.00
162_Q165_A1.0211.00
70_C92_C1.0091.00
133_L154_C1.0051.00
107_V126_A1.0041.00
3_R156_D0.9751.00
71_P90_I0.9741.00
153_I164_S0.9680.99
6_I167_K0.9650.99
18_C147_C0.9630.99
8_D153_I0.9610.99
108_V124_D0.9570.99
57_V152_L0.9300.99
17_T146_A0.9290.99
17_T20_V0.9260.99
40_F43_R0.9220.99
161_E165_A0.9160.99
3_R154_C0.9110.99
60_Q82_V0.9090.99
86_Q125_K0.9040.99
96_V106_V0.9030.99
164_S167_K0.8990.99
7_A57_V0.8970.99
162_Q166_E0.8790.99
138_E154_C0.8750.99
11_K151_A0.8570.99
79_K83_H0.8430.99
55_A152_L0.8400.99
65_P98_A0.8150.98
77_R81_F0.8140.98
106_V126_A0.8140.98
60_Q138_E0.8130.98
79_K135_N0.8100.98
133_L138_E0.8060.98
28_E34_S0.7980.98
45_H50_V0.7890.98
107_V124_D0.7870.98
39_T43_R0.7830.98
37_P44_I0.7650.97
9_A54_T0.7590.97
56_T59_R0.7470.97
39_T44_I0.7460.97
5_I57_V0.7430.97
160_L164_S0.7410.97
14_G53_S0.7380.97
60_Q130_K0.7350.97
14_G17_T0.7340.97
132_D136_H0.7330.97
26_H142_A0.7300.96
40_F44_I0.7290.96
13_I148_P0.7270.96
129_N132_D0.7240.96
156_D162_Q0.7210.96
90_I94_T0.7110.96
29_N32_C0.7090.96
17_T148_P0.7060.96
96_V108_V0.7060.96
160_L165_A0.7030.96
74_A77_R0.7020.96
83_H132_D0.6960.95
42_P46_V0.6940.95
4_F160_L0.6860.95
75_I128_A0.6840.95
31_D34_S0.6800.95
43_R47_I0.6790.95
38_E43_R0.6790.95
69_V97_V0.6780.95
155_V160_L0.6710.94
150_H153_I0.6690.94
44_I49_G0.6660.94
40_F46_V0.6640.94
160_L163_L0.6630.94
42_P47_I0.6590.94
62_E77_R0.6580.94
71_P95_C0.6540.94
43_R50_V0.6530.94
84_V104_M0.6520.93
20_V24_V0.6520.93
94_T98_A0.6510.93
9_A55_A0.6500.93
31_D35_L0.6500.93
25_S132_D0.6480.93
10_S167_K0.6340.93
10_S94_T0.6300.92
38_E46_V0.6300.92
42_P45_H0.6280.92
36_T46_V0.6260.92
6_I153_I0.6240.92
17_T149_T0.6230.92
55_A59_R0.6200.92
105_E129_N0.6190.92
5_I154_C0.6170.92
72_N76_S0.6140.91
5_I59_R0.6130.91
18_C22_C0.6120.91
14_G18_C0.6030.91
39_T45_H0.6020.90
36_T39_T0.5930.90
136_H139_D0.5840.89
84_V103_A0.5820.89
57_V133_L0.5800.89
108_V125_K0.5780.89
8_D167_K0.5700.88
43_R46_V0.5680.88
27_Q30_Q0.5630.87
11_K150_H0.5630.87
67_A76_S0.5620.87
40_F51_N0.5620.87
86_Q129_N0.5610.87
133_L157_R0.5550.87
98_A103_A0.5540.87
17_T24_V0.5530.86
78_D81_F0.5530.86
108_V126_A0.5520.86
71_P89_C0.5490.86
5_I55_A0.5460.86
20_V30_Q0.5430.85
146_A149_T0.5390.85
159_K164_S0.5390.85
37_P43_R0.5390.85
11_K167_K0.5380.85
93_K97_V0.5370.85
21_A25_S0.5350.85
36_T41_L0.5350.85
157_R160_L0.5340.84
35_L152_L0.5320.84
41_L44_I0.5320.84
81_F135_N0.5320.84
28_E32_C0.5280.84
42_P51_N0.5260.84
73_G88_R0.5240.83
36_T42_P0.5220.83
160_L167_K0.5220.83
106_V125_K0.5220.83
15_C22_C0.5190.83
142_A146_A0.5190.83
40_F47_I0.5190.83
4_F164_S0.5190.83
45_H48_K0.5130.82
30_Q33_A0.5100.82
7_A59_R0.5080.81
59_R103_A0.5020.81
21_A142_A0.5010.81
72_N92_C0.5000.80
13_I16_R0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ivfB 1 0.9143 100 0.336 Contact Map
1ti6B 2 0.8914 100 0.343 Contact Map
1h0hB 1 0.9086 100 0.349 Contact Map
1kqfB 3 0.9143 100 0.358 Contact Map
2vpzB 2 0.9029 100 0.382 Contact Map
1q16B 2 0.9143 100 0.473 Contact Map
4z3xE 2 0.8457 100 0.495 Contact Map
3mm5B 2 0.8571 99.7 0.644 Contact Map
1jnrB 1 0.7143 99.4 0.729 Contact Map
3gyxB 1 0.7257 99.3 0.733 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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