GREMLIN Database
HYCB - Formate hydrogenlyase subunit 2
UniProt: P0AAK1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10475
Length: 203 (170)
Sequences: 1432 (958)
Seq/√Len: 73.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
149_D157_R3.3821.00
5_V145_L3.3481.00
12_C18_C3.3191.00
15_C18_C3.1001.00
173_A178_R3.0791.00
68_I97_I3.0361.00
12_C15_C2.9121.00
153_P156_V2.8171.00
62_V87_L2.7661.00
43_E103_R2.6631.00
171_D174_R2.5471.00
12_C159_C2.4391.00
25_T148_F2.4251.00
6_I176_S2.3641.00
86_K99_F2.2861.00
15_C159_C2.2011.00
34_M37_L2.1321.00
69_T78_N2.1051.00
4_F169_N2.0981.00
135_G141_V1.9811.00
10_T183_T1.9741.00
175_V178_R1.9511.00
176_S179_K1.9321.00
18_C159_C1.9051.00
70_R75_V1.8941.00
62_V91_A1.8481.00
63_C88_C1.8201.00
165_H179_K1.7261.00
7_A164_L1.7221.00
23_S28_Q1.6901.00
175_V179_K1.6811.00
86_K89_G1.6551.00
37_L40_M1.6471.00
156_V164_L1.6331.00
178_R182_L1.6190.99
60_A140_A1.6100.99
63_C82_C1.6040.99
174_R177_K1.5990.99
79_E139_I1.5390.99
17_T21_A1.5170.99
98_E101_G1.5090.99
172_I177_K1.4810.99
82_C88_C1.4710.99
6_I179_K1.4680.99
93_P153_P1.4020.99
74_A150_E1.3720.98
7_A50_L1.3630.98
13_I161_T1.3570.98
86_K101_G1.3550.98
21_A158_M1.3040.98
63_C85_C1.2880.97
82_C85_C1.2740.97
153_P164_L1.2530.97
180_R184_F1.2470.97
84_S93_P1.2350.97
103_R106_D1.2240.96
122_A125_R1.2010.96
60_A70_R1.1910.96
177_K181_E1.1890.96
53_H75_V1.1860.96
5_V9_S1.1860.96
35_P39_V1.1800.96
68_I77_L1.1700.95
72_D147_S1.1450.95
85_C88_C1.1420.95
70_R73_G1.1330.95
168_D171_D1.1290.94
60_A75_V1.1260.94
71_V74_A1.1150.94
143_C146_C1.1140.94
87_L99_F1.1030.94
53_H73_G1.0890.93
37_L42_N1.0850.93
125_R128_T1.0700.93
100_S141_V1.0680.93
178_R181_E1.0630.92
86_K95_G1.0620.92
62_V84_S1.0570.92
62_V90_I1.0300.91
125_R134_P1.0170.91
47_A50_L0.9910.89
123_P127_S0.9860.89
162_K165_H0.9810.89
26_H29_H0.9630.88
87_L90_I0.9420.87
87_L91_A0.9380.87
179_K183_T0.9340.87
35_P42_N0.9200.86
139_I142_K0.9180.86
57_A70_R0.9150.85
57_A60_A0.9120.85
78_N81_L0.9090.85
142_K146_C0.9080.85
8_D178_R0.9070.85
3_R72_D0.9070.85
24_E158_M0.9060.85
14_G17_T0.9020.85
12_C160_P0.8990.84
49_Q52_H0.8950.84
172_I176_S0.8820.83
145_L166_L0.8790.83
14_G160_P0.8720.83
177_K180_R0.8680.82
61_V152_G0.8670.82
73_G93_P0.8620.82
50_L145_L0.8440.80
15_C20_A0.8440.80
13_I21_A0.8400.80
58_P93_P0.8390.80
27_R141_V0.8380.80
124_A127_S0.8370.80
149_D154_A0.8370.80
128_T131_D0.8360.80
154_A157_R0.8360.80
26_H84_S0.8310.79
172_I180_R0.8310.79
89_G140_A0.8120.78
12_C22_C0.8060.77
39_V181_E0.7970.76
52_H145_L0.7920.76
26_H148_F0.7780.75
61_V101_G0.7720.74
65_V83_V0.7700.74
135_G139_I0.7680.74
14_G18_C0.7660.74
179_K182_L0.7630.73
49_Q97_I0.7540.72
17_T166_L0.7460.72
83_V87_L0.7440.71
38_R105_L0.7430.71
16_H19_E0.7410.71
27_R135_G0.7340.70
65_V87_L0.7330.70
17_T158_M0.7320.70
14_G159_C0.7300.70
21_A154_A0.7260.70
36_R45_E0.7220.69
24_E161_T0.7220.69
90_I100_S0.7210.69
45_E182_L0.7200.69
14_G46_S0.7180.69
174_R178_R0.7170.69
11_L165_H0.7160.68
13_I19_E0.7140.68
17_T168_D0.7050.67
37_L41_L0.7050.67
13_I160_P0.7030.67
50_L94_F0.7020.67
77_L97_I0.7020.67
122_A181_E0.7010.67
142_K168_D0.6990.67
21_A157_R0.6920.66
58_P84_S0.6860.65
18_C160_P0.6850.65
5_V50_L0.6840.65
65_V68_I0.6830.65
57_A160_P0.6810.65
21_A84_S0.6760.64
106_D109_A0.6740.64
64_P88_C0.6720.64
10_T44_K0.6700.63
11_L131_D0.6660.63
25_T149_D0.6650.63
14_G19_E0.6570.62
99_F137_R0.6550.62
21_A25_T0.6550.62
48_P73_G0.6530.61
11_L107_I0.6520.61
64_P93_P0.6520.61
165_H176_S0.6460.61
12_C16_H0.6420.60
79_E100_S0.6400.60
135_G138_A0.6360.59
84_S99_F0.6360.59
83_V88_C0.6340.59
13_I179_K0.6320.59
62_V65_V0.6300.59
89_G100_S0.6290.58
71_V76_Q0.6260.58
36_R55_E0.6250.58
171_D176_S0.6220.58
125_R170_T0.6210.58
149_D153_P0.6180.57
20_A101_G0.6150.57
6_I156_V0.6120.56
84_S94_F0.6110.56
83_V149_D0.6100.56
74_A93_P0.6100.56
79_E132_W0.6100.56
73_G84_S0.6080.56
21_A140_A0.6080.56
10_T162_K0.6070.56
173_A177_K0.6040.55
4_F7_A0.6030.55
89_G99_F0.5990.55
73_G168_D0.5980.55
29_H132_W0.5970.55
72_D151_Q0.5960.54
69_T81_L0.5950.54
5_V8_D0.5930.54
141_V144_D0.5920.54
77_L104_P0.5920.54
64_P82_C0.5880.53
13_I158_M0.5880.53
26_H144_D0.5870.53
140_A166_L0.5870.53
53_H76_Q0.5820.53
124_A128_T0.5800.52
48_P163_A0.5780.52
20_A30_G0.5770.52
7_A56_D0.5760.52
10_T78_N0.5750.52
13_I18_C0.5740.52
20_A69_T0.5730.52
76_Q147_S0.5700.51
165_H175_V0.5670.51
24_E127_S0.5660.51
41_L173_A0.5660.51
101_G104_P0.5640.50
72_D109_A0.5570.50
63_C84_S0.5560.49
84_S88_C0.5540.49
80_S138_A0.5520.49
41_L182_L0.5500.49
76_Q144_D0.5490.49
75_V84_S0.5490.49
87_L101_G0.5480.49
109_A125_R0.5390.47
65_V138_A0.5360.47
10_T33_S0.5360.47
148_F157_R0.5350.47
180_R183_T0.5340.47
34_M42_N0.5340.47
62_V66_N0.5330.47
39_V42_N0.5320.47
86_K91_A0.5300.46
171_D178_R0.5260.46
75_V154_A0.5210.45
12_C163_A0.5210.45
122_A127_S0.5180.45
97_I100_S0.5120.44
93_P142_K0.5100.44
10_T43_E0.5090.44
38_R56_D0.5090.44
76_Q151_Q0.5080.44
65_V148_F0.5070.43
85_C140_A0.5040.43
48_P74_A0.5020.43
51_C59_C0.5000.43
51_C155_C0.5000.43
51_C54_C0.5000.43
59_C155_C0.5000.43
54_C59_C0.5000.43
54_C155_C0.5000.43
100_S135_G0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ivfB 1 0.8325 100 0.442 Contact Map
1ti6B 2 0.8177 100 0.451 Contact Map
1kqfB 3 0.8325 100 0.489 Contact Map
1h0hB 1 0.8177 100 0.494 Contact Map
2vpzB 2 0.8227 100 0.508 Contact Map
1q16B 2 0.8128 100 0.567 Contact Map
4z3xE 2 0.7783 99.9 0.614 Contact Map
3mm5B 2 0.8128 99.7 0.715 Contact Map
3gyxB 1 0.7291 99.4 0.776 Contact Map
1jnrB 1 0.7143 99.4 0.78 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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