FDOH - ECOLI - GREMLIN Contacts

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FDOH - Formate dehydrogenase-O iron-sulfur subunit

UniProt:	P0AAJ5	Sequences: MAYQSQDIIRRSATNGLTPAPQARDFQEEVAKLIDVTTCIGCKACQVACSEWNDIRDTVGNNIGVYDNPNDLSAKSWTVMRFSEVEQNDKLEWLIRKDGCMHCSDPGCLKACPAEGAIIQYANGIVDFQSEQCIGCGYCIAGCPFDIPRLNPEDNRVYKCTLCVDRVVVGQEPACVKTCPTGAIHFGTKESMKTLASERVAELKTRGYDNAGLYDPAGVGGTHVMYVLHHADKPNLYHGLPENPEISETVKFWKGIWKPLAAVGFAATFAASIFHYVGVGPNRADEEENNLHEEKDEERK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11857
Length:	300 (246)
Sequences:	1227 (495)
Seq/√Len:	31.6

ECOLI - FDOH FDNH HYBA NRFC YDHX YNFG DMSB
HALSA - DMSB
SULSO - Q97V38 Q97XX9 Q97V75

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
176_V	184_I	5.035	1.00
117_A	120_Q	3.558	1.00
195_L	198_E	3.504	1.00
116_G	120_Q	3.328	1.00
46_Q	69_P	2.817	1.00
137_G	150_L	2.799	1.00
107_G	142_G	2.771	1.00
189_K	193_K	2.717	1.00
197_S	216_P	2.687	1.00
30_V	188_T	2.598	1.00
52_W	174_A	2.494	0.99
128_F	148_P	2.428	0.99
173_P	176_V	2.413	0.99
185_H	195_L	2.394	0.99
78_T	97_K	2.380	0.99
219_V	222_T	2.356	0.99
40_I	181_T	2.331	0.99
32_K	224_V	2.305	0.99
48_A	174_A	2.215	0.99
52_W	165_D	2.199	0.99
235_N	242_E	2.185	0.99
34_I	224_V	2.178	0.99
164_V	168_V	2.054	0.98
128_F	157_V	2.046	0.98
33_L	225_M	2.034	0.98
53_N	161_T	2.019	0.98
34_I	99_G	1.974	0.97
33_L	227_V	1.938	0.97
28_E	190_E	1.874	0.96
29_E	223_H	1.844	0.96
116_G	119_I	1.838	0.96
150_L	157_V	1.838	0.96
213_L	216_P	1.810	0.95
58_T	73_S	1.807	0.95
197_S	213_L	1.798	0.95
113_P	134_I	1.791	0.95
104_S	223_H	1.763	0.95
34_I	162_L	1.730	0.94
194_T	198_E	1.693	0.93
188_T	191_S	1.659	0.93
187_G	192_M	1.655	0.93
106_P	120_Q	1.643	0.92
71_D	149_R	1.630	0.92
105_D	110_K	1.625	0.92
192_M	225_M	1.621	0.92
31_A	192_M	1.605	0.92
109_L	118_I	1.596	0.91
257_W	261_A	1.575	0.91
130_S	141_A	1.570	0.91
151_N	154_D	1.559	0.90
125_I	167_V	1.553	0.90
200_V	203_L	1.551	0.90
171_Q	177_K	1.526	0.89
172_E	177_K	1.481	0.88
32_K	184_I	1.479	0.88
57_D	76_S	1.446	0.87
263_V	267_A	1.445	0.86
235_N	239_G	1.431	0.86
38_T	182_G	1.425	0.86
39_C	45_C	1.424	0.86
42_C	45_C	1.424	0.86
39_C	42_C	1.424	0.86
111_A	142_G	1.399	0.85
77_W	158_Y	1.376	0.84
29_E	104_S	1.365	0.83
30_V	186_F	1.364	0.83
121_Y	127_D	1.332	0.82
166_R	171_Q	1.329	0.81
261_A	264_G	1.326	0.81
166_R	177_K	1.301	0.80
52_W	166_R	1.301	0.80
267_A	270_A	1.288	0.79
34_I	226_Y	1.277	0.79
133_C	139_C	1.272	0.78
112_C	139_C	1.272	0.78
198_E	202_E	1.262	0.78
203_L	207_G	1.260	0.78
112_C	133_C	1.259	0.78
266_A	269_F	1.243	0.77
258_K	265_F	1.236	0.76
36_V	40_I	1.231	0.76
40_I	44_A	1.220	0.75
193_K	216_P	1.215	0.75
36_V	94_L	1.212	0.75
114_A	136_C	1.201	0.74
137_G	140_I	1.201	0.74
54_D	168_V	1.192	0.74
44_A	104_S	1.180	0.73
37_T	229_H	1.175	0.73
204_K	207_G	1.173	0.72
32_K	162_L	1.167	0.72
208_Y	212_G	1.152	0.71
193_K	213_L	1.142	0.70
257_W	260_L	1.137	0.70
145_F	222_T	1.127	0.69
194_T	272_S	1.126	0.69
196_A	199_R	1.126	0.69
228_L	235_N	1.123	0.69
140_I	157_V	1.121	0.69
31_A	162_L	1.114	0.68
120_Q	123_N	1.113	0.68
189_K	225_M	1.108	0.68
198_E	201_A	1.100	0.67
244_P	247_S	1.094	0.67
119_I	129_Q	1.094	0.67
47_V	178_T	1.091	0.67
218_G	221_G	1.091	0.67
229_H	234_P	1.086	0.66
106_P	123_N	1.086	0.66
78_T	99_G	1.085	0.66
116_G	123_N	1.084	0.66
140_I	151_N	1.076	0.66
46_Q	68_N	1.072	0.65
32_K	176_V	1.066	0.65
146_D	184_I	1.066	0.65
74_A	153_E	1.066	0.65
232_D	235_N	1.065	0.65
56_R	158_Y	1.064	0.65
34_I	101_M	1.063	0.65
215_D	218_G	1.057	0.64
84_E	165_D	1.051	0.64
189_K	216_P	1.051	0.64
117_A	132_Q	1.050	0.64
43_K	67_D	1.047	0.64
227_V	231_A	1.043	0.63
267_A	271_A	1.042	0.63
38_T	185_H	1.036	0.63
268_T	273_I	1.024	0.62
99_G	224_V	1.021	0.62
34_I	183_A	1.019	0.61
257_W	263_V	1.019	0.61
165_D	174_A	1.002	0.60
264_G	267_A	0.989	0.59
182_G	225_M	0.975	0.58
80_M	125_I	0.970	0.58
57_D	60_G	0.961	0.57
72_L	161_T	0.957	0.57
256_I	261_A	0.956	0.56
253_W	259_P	0.948	0.56
151_N	156_R	0.939	0.55
196_A	214_Y	0.939	0.55
28_E	188_T	0.931	0.54
258_K	264_G	0.929	0.54
121_Y	125_I	0.923	0.54
37_T	231_A	0.921	0.54
86_E	89_D	0.921	0.54
194_T	197_S	0.920	0.54
53_N	162_L	0.917	0.53
74_A	154_D	0.914	0.53
43_K	46_Q	0.906	0.52
248_E	267_A	0.906	0.52
34_I	134_I	0.902	0.52
205_T	209_D	0.902	0.52
52_W	84_E	0.900	0.52
262_A	266_A	0.898	0.52
113_P	116_G	0.894	0.51
106_P	121_Y	0.893	0.51
234_P	237_Y	0.889	0.51
245_E	269_F	0.880	0.50
189_K	215_D	0.880	0.50
162_L	167_V	0.877	0.50
167_V	186_F	0.875	0.50
187_G	191_S	0.872	0.50
257_W	271_A	0.867	0.49
44_A	178_T	0.863	0.49
238_H	242_E	0.860	0.49
99_G	140_I	0.857	0.48
33_L	221_G	0.849	0.48
118_I	128_F	0.843	0.47
71_D	81_R	0.843	0.47
47_V	52_W	0.841	0.47
189_K	222_T	0.839	0.47
89_D	92_E	0.835	0.47
263_V	270_A	0.834	0.47
68_N	82_F	0.822	0.46
203_L	211_A	0.821	0.46
35_D	45_C	0.812	0.45
35_D	42_C	0.812	0.45
35_D	39_C	0.812	0.45
80_M	95_I	0.812	0.45
193_K	197_S	0.811	0.45
138_Y	162_L	0.809	0.45
162_L	224_V	0.809	0.45
34_I	97_K	0.808	0.44
256_I	260_L	0.806	0.44
261_A	267_A	0.804	0.44
87_Q	198_E	0.801	0.44
262_A	265_F	0.800	0.44
253_W	261_A	0.799	0.44
242_E	248_E	0.794	0.43
35_D	173_P	0.787	0.43
106_P	223_H	0.775	0.42
259_P	264_G	0.772	0.42
234_P	239_G	0.772	0.42
231_A	234_P	0.772	0.42
104_S	243_N	0.771	0.42
185_H	201_A	0.765	0.41
235_N	238_H	0.763	0.41
48_A	173_P	0.757	0.40
154_D	158_Y	0.754	0.40
265_F	273_I	0.748	0.40
223_H	226_Y	0.745	0.39
107_G	246_I	0.741	0.39
245_E	256_I	0.741	0.39
52_W	173_P	0.740	0.39
117_A	121_Y	0.737	0.39
80_M	121_Y	0.737	0.39
150_L	194_T	0.735	0.39
33_L	192_M	0.734	0.39
47_V	51_E	0.733	0.39
195_L	201_A	0.730	0.38
31_A	225_M	0.725	0.38
47_V	171_Q	0.722	0.38
203_L	206_R	0.715	0.37
106_P	148_P	0.715	0.37
212_G	231_A	0.713	0.37
73_S	227_V	0.710	0.37
71_D	148_P	0.709	0.37
84_E	93_W	0.707	0.37
67_D	79_V	0.706	0.36
34_I	173_P	0.704	0.36
40_I	111_A	0.703	0.36
37_T	271_A	0.699	0.36
260_L	270_A	0.698	0.36
197_S	215_D	0.698	0.36
236_L	242_E	0.697	0.36
196_A	215_D	0.696	0.36
132_Q	156_R	0.694	0.36
258_K	262_A	0.693	0.36
215_D	220_G	0.693	0.36
137_G	154_D	0.693	0.36
36_V	228_L	0.691	0.35
43_K	181_T	0.689	0.35
52_W	82_F	0.684	0.35
132_Q	273_I	0.683	0.35
97_K	224_V	0.677	0.34
46_Q	64_G	0.674	0.34
260_L	263_V	0.673	0.34
146_D	176_V	0.673	0.34
35_D	196_A	0.672	0.34
31_A	146_D	0.670	0.34
63_I	68_N	0.670	0.34
190_E	194_T	0.666	0.34
98_D	151_N	0.665	0.33
253_W	258_K	0.664	0.33
90_K	242_E	0.664	0.33
27_Q	155_N	0.661	0.33
116_G	122_A	0.659	0.33
264_G	272_S	0.658	0.33
50_S	76_S	0.657	0.33
34_I	165_D	0.657	0.33
33_L	222_T	0.655	0.33
38_T	129_Q	0.654	0.33
200_V	225_M	0.653	0.33
205_T	270_A	0.651	0.32
252_F	255_G	0.649	0.32
239_G	248_E	0.648	0.32
122_A	132_Q	0.648	0.32
259_P	267_A	0.639	0.32
82_F	93_W	0.638	0.32
75_K	153_E	0.638	0.32
172_E	176_V	0.637	0.31
51_E	177_K	0.636	0.31
259_P	263_V	0.634	0.31
129_Q	132_Q	0.634	0.31
99_G	183_A	0.634	0.31
196_A	225_M	0.634	0.31
230_H	234_P	0.632	0.31
213_L	217_A	0.631	0.31
90_K	266_A	0.628	0.31
191_S	232_D	0.626	0.31
263_V	272_S	0.626	0.31
152_P	235_N	0.624	0.31
126_V	165_D	0.623	0.30
27_Q	51_E	0.619	0.30
135_G	226_Y	0.618	0.30
214_Y	240_L	0.616	0.30
156_R	191_S	0.616	0.30
113_P	267_A	0.615	0.30
193_K	215_D	0.614	0.30
270_A	273_I	0.613	0.30
40_I	208_Y	0.610	0.30
211_A	228_L	0.608	0.29
215_D	222_T	0.605	0.29
40_I	69_P	0.604	0.29
36_V	226_Y	0.600	0.29
43_K	82_F	0.598	0.29
186_F	205_T	0.598	0.29
105_D	221_G	0.593	0.28
41_G	155_N	0.592	0.28
176_V	183_A	0.592	0.28
197_S	264_G	0.592	0.28
195_L	227_V	0.586	0.28
37_T	203_L	0.586	0.28
46_Q	73_S	0.586	0.28
109_L	114_A	0.585	0.28
43_K	69_P	0.585	0.28
85_V	92_E	0.584	0.28
129_Q	172_E	0.582	0.28
34_I	184_I	0.580	0.28
99_G	184_I	0.580	0.28
106_P	146_D	0.579	0.28
177_K	203_L	0.578	0.27
148_P	220_G	0.577	0.27
67_D	70_N	0.577	0.27
77_W	151_N	0.577	0.27
52_W	161_T	0.576	0.27
178_T	270_A	0.575	0.27
258_K	269_F	0.572	0.27
157_V	218_G	0.572	0.27
172_E	182_G	0.570	0.27
37_T	199_R	0.567	0.27
72_L	149_R	0.567	0.27
254_K	264_G	0.565	0.27
252_F	267_A	0.563	0.27
261_A	271_A	0.563	0.27
259_P	273_I	0.558	0.26
153_E	178_T	0.557	0.26
58_T	142_G	0.557	0.26
31_A	188_T	0.557	0.26
168_V	171_Q	0.556	0.26
211_A	237_Y	0.555	0.26
202_E	205_T	0.552	0.26
32_K	97_K	0.551	0.26
36_V	262_A	0.545	0.25
259_P	268_T	0.545	0.25
229_H	235_N	0.545	0.25
193_K	225_M	0.541	0.25
266_A	273_I	0.540	0.25
69_P	262_A	0.538	0.25
118_I	165_D	0.537	0.25
37_T	257_W	0.536	0.25
145_F	214_Y	0.535	0.25
235_N	243_N	0.532	0.25
156_R	206_R	0.530	0.24
80_M	149_R	0.529	0.24
106_P	239_G	0.528	0.24
264_G	268_T	0.526	0.24
259_P	266_A	0.525	0.24
188_T	192_M	0.524	0.24
127_D	255_G	0.523	0.24
123_N	127_D	0.523	0.24
104_S	120_Q	0.522	0.24
162_L	225_M	0.522	0.24
40_I	113_P	0.521	0.24
48_A	177_K	0.521	0.24
56_R	169_V	0.520	0.24
109_L	121_Y	0.519	0.24
119_I	127_D	0.519	0.24
199_R	205_T	0.518	0.24
189_K	197_S	0.516	0.24
79_V	178_T	0.516	0.24
99_G	173_P	0.514	0.24
148_P	183_A	0.513	0.23
199_R	229_H	0.510	0.23
230_H	235_N	0.507	0.23
254_K	259_P	0.507	0.23
50_S	58_T	0.506	0.23
68_N	75_K	0.506	0.23
150_L	155_N	0.504	0.23
80_M	224_V	0.503	0.23
46_Q	116_G	0.502	0.23
85_V	88_N	0.501	0.23
254_K	268_T	0.500	0.23
47_V	77_W	0.500	0.23
143_C	175_C	0.500	0.23
108_C	175_C	0.500	0.23
175_C	179_C	0.500	0.23
103_C	175_C	0.500	0.23

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1kqfB	3	0.9633	100	0.399	Contact Map
1h0hB	1	0.6933	100	0.552	Contact Map
2ivfB	1	0.8633	100	0.583	Contact Map
1ti6B	2	0.84	100	0.609	Contact Map
2vpzB	2	0.6433	100	0.644	Contact Map
1q16B	2	0.9	100	0.673	Contact Map
4z3xE	2	0.5633	100	0.737	Contact Map
3mm5B	2	0.8367	99.8	0.809	Contact Map
2fgoA	1	0.2467	99.4	0.857	Contact Map
1jnrB	1	0.49	99.4	0.859	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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