GREMLIN Database
FDOH - Formate dehydrogenase-O iron-sulfur subunit
UniProt: P0AAJ5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11857
Length: 300 (246)
Sequences: 1227 (495)
Seq/√Len: 31.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
176_V184_I5.0351.00
117_A120_Q3.5581.00
195_L198_E3.5041.00
116_G120_Q3.3281.00
46_Q69_P2.8171.00
137_G150_L2.7991.00
107_G142_G2.7711.00
189_K193_K2.7171.00
197_S216_P2.6871.00
30_V188_T2.5981.00
52_W174_A2.4940.99
128_F148_P2.4280.99
173_P176_V2.4130.99
185_H195_L2.3940.99
78_T97_K2.3800.99
219_V222_T2.3560.99
40_I181_T2.3310.99
32_K224_V2.3050.99
48_A174_A2.2150.99
52_W165_D2.1990.99
235_N242_E2.1850.99
34_I224_V2.1780.99
164_V168_V2.0540.98
128_F157_V2.0460.98
33_L225_M2.0340.98
53_N161_T2.0190.98
34_I99_G1.9740.97
33_L227_V1.9380.97
28_E190_E1.8740.96
29_E223_H1.8440.96
116_G119_I1.8380.96
150_L157_V1.8380.96
213_L216_P1.8100.95
58_T73_S1.8070.95
197_S213_L1.7980.95
113_P134_I1.7910.95
104_S223_H1.7630.95
34_I162_L1.7300.94
194_T198_E1.6930.93
188_T191_S1.6590.93
187_G192_M1.6550.93
106_P120_Q1.6430.92
71_D149_R1.6300.92
105_D110_K1.6250.92
192_M225_M1.6210.92
31_A192_M1.6050.92
109_L118_I1.5960.91
257_W261_A1.5750.91
130_S141_A1.5700.91
151_N154_D1.5590.90
125_I167_V1.5530.90
200_V203_L1.5510.90
171_Q177_K1.5260.89
172_E177_K1.4810.88
32_K184_I1.4790.88
57_D76_S1.4460.87
263_V267_A1.4450.86
235_N239_G1.4310.86
38_T182_G1.4250.86
39_C45_C1.4240.86
42_C45_C1.4240.86
39_C42_C1.4240.86
111_A142_G1.3990.85
77_W158_Y1.3760.84
29_E104_S1.3650.83
30_V186_F1.3640.83
121_Y127_D1.3320.82
166_R171_Q1.3290.81
261_A264_G1.3260.81
166_R177_K1.3010.80
52_W166_R1.3010.80
267_A270_A1.2880.79
34_I226_Y1.2770.79
133_C139_C1.2720.78
112_C139_C1.2720.78
198_E202_E1.2620.78
203_L207_G1.2600.78
112_C133_C1.2590.78
266_A269_F1.2430.77
258_K265_F1.2360.76
36_V40_I1.2310.76
40_I44_A1.2200.75
193_K216_P1.2150.75
36_V94_L1.2120.75
114_A136_C1.2010.74
137_G140_I1.2010.74
54_D168_V1.1920.74
44_A104_S1.1800.73
37_T229_H1.1750.73
204_K207_G1.1730.72
32_K162_L1.1670.72
208_Y212_G1.1520.71
193_K213_L1.1420.70
257_W260_L1.1370.70
145_F222_T1.1270.69
194_T272_S1.1260.69
196_A199_R1.1260.69
228_L235_N1.1230.69
140_I157_V1.1210.69
31_A162_L1.1140.68
120_Q123_N1.1130.68
189_K225_M1.1080.68
198_E201_A1.1000.67
244_P247_S1.0940.67
119_I129_Q1.0940.67
47_V178_T1.0910.67
218_G221_G1.0910.67
229_H234_P1.0860.66
106_P123_N1.0860.66
78_T99_G1.0850.66
116_G123_N1.0840.66
140_I151_N1.0760.66
46_Q68_N1.0720.65
32_K176_V1.0660.65
146_D184_I1.0660.65
74_A153_E1.0660.65
232_D235_N1.0650.65
56_R158_Y1.0640.65
34_I101_M1.0630.65
215_D218_G1.0570.64
84_E165_D1.0510.64
189_K216_P1.0510.64
117_A132_Q1.0500.64
43_K67_D1.0470.64
227_V231_A1.0430.63
267_A271_A1.0420.63
38_T185_H1.0360.63
268_T273_I1.0240.62
99_G224_V1.0210.62
34_I183_A1.0190.61
257_W263_V1.0190.61
165_D174_A1.0020.60
264_G267_A0.9890.59
182_G225_M0.9750.58
80_M125_I0.9700.58
57_D60_G0.9610.57
72_L161_T0.9570.57
256_I261_A0.9560.56
253_W259_P0.9480.56
151_N156_R0.9390.55
196_A214_Y0.9390.55
28_E188_T0.9310.54
258_K264_G0.9290.54
121_Y125_I0.9230.54
37_T231_A0.9210.54
86_E89_D0.9210.54
194_T197_S0.9200.54
53_N162_L0.9170.53
74_A154_D0.9140.53
43_K46_Q0.9060.52
248_E267_A0.9060.52
34_I134_I0.9020.52
205_T209_D0.9020.52
52_W84_E0.9000.52
262_A266_A0.8980.52
113_P116_G0.8940.51
106_P121_Y0.8930.51
234_P237_Y0.8890.51
245_E269_F0.8800.50
189_K215_D0.8800.50
162_L167_V0.8770.50
167_V186_F0.8750.50
187_G191_S0.8720.50
257_W271_A0.8670.49
44_A178_T0.8630.49
238_H242_E0.8600.49
99_G140_I0.8570.48
33_L221_G0.8490.48
118_I128_F0.8430.47
71_D81_R0.8430.47
47_V52_W0.8410.47
189_K222_T0.8390.47
89_D92_E0.8350.47
263_V270_A0.8340.47
68_N82_F0.8220.46
203_L211_A0.8210.46
35_D45_C0.8120.45
35_D42_C0.8120.45
35_D39_C0.8120.45
80_M95_I0.8120.45
193_K197_S0.8110.45
138_Y162_L0.8090.45
162_L224_V0.8090.45
34_I97_K0.8080.44
256_I260_L0.8060.44
261_A267_A0.8040.44
87_Q198_E0.8010.44
262_A265_F0.8000.44
253_W261_A0.7990.44
242_E248_E0.7940.43
35_D173_P0.7870.43
106_P223_H0.7750.42
259_P264_G0.7720.42
234_P239_G0.7720.42
231_A234_P0.7720.42
104_S243_N0.7710.42
185_H201_A0.7650.41
235_N238_H0.7630.41
48_A173_P0.7570.40
154_D158_Y0.7540.40
265_F273_I0.7480.40
223_H226_Y0.7450.39
107_G246_I0.7410.39
245_E256_I0.7410.39
52_W173_P0.7400.39
117_A121_Y0.7370.39
80_M121_Y0.7370.39
150_L194_T0.7350.39
33_L192_M0.7340.39
47_V51_E0.7330.39
195_L201_A0.7300.38
31_A225_M0.7250.38
47_V171_Q0.7220.38
203_L206_R0.7150.37
106_P148_P0.7150.37
212_G231_A0.7130.37
73_S227_V0.7100.37
71_D148_P0.7090.37
84_E93_W0.7070.37
67_D79_V0.7060.36
34_I173_P0.7040.36
40_I111_A0.7030.36
37_T271_A0.6990.36
260_L270_A0.6980.36
197_S215_D0.6980.36
236_L242_E0.6970.36
196_A215_D0.6960.36
132_Q156_R0.6940.36
258_K262_A0.6930.36
215_D220_G0.6930.36
137_G154_D0.6930.36
36_V228_L0.6910.35
43_K181_T0.6890.35
52_W82_F0.6840.35
132_Q273_I0.6830.35
97_K224_V0.6770.34
46_Q64_G0.6740.34
260_L263_V0.6730.34
146_D176_V0.6730.34
35_D196_A0.6720.34
31_A146_D0.6700.34
63_I68_N0.6700.34
190_E194_T0.6660.34
98_D151_N0.6650.33
253_W258_K0.6640.33
90_K242_E0.6640.33
27_Q155_N0.6610.33
116_G122_A0.6590.33
264_G272_S0.6580.33
50_S76_S0.6570.33
34_I165_D0.6570.33
33_L222_T0.6550.33
38_T129_Q0.6540.33
200_V225_M0.6530.33
205_T270_A0.6510.32
252_F255_G0.6490.32
239_G248_E0.6480.32
122_A132_Q0.6480.32
259_P267_A0.6390.32
82_F93_W0.6380.32
75_K153_E0.6380.32
172_E176_V0.6370.31
51_E177_K0.6360.31
259_P263_V0.6340.31
129_Q132_Q0.6340.31
99_G183_A0.6340.31
196_A225_M0.6340.31
230_H234_P0.6320.31
213_L217_A0.6310.31
90_K266_A0.6280.31
191_S232_D0.6260.31
263_V272_S0.6260.31
152_P235_N0.6240.31
126_V165_D0.6230.30
27_Q51_E0.6190.30
135_G226_Y0.6180.30
214_Y240_L0.6160.30
156_R191_S0.6160.30
113_P267_A0.6150.30
193_K215_D0.6140.30
270_A273_I0.6130.30
40_I208_Y0.6100.30
211_A228_L0.6080.29
215_D222_T0.6050.29
40_I69_P0.6040.29
36_V226_Y0.6000.29
43_K82_F0.5980.29
186_F205_T0.5980.29
105_D221_G0.5930.28
41_G155_N0.5920.28
176_V183_A0.5920.28
197_S264_G0.5920.28
195_L227_V0.5860.28
37_T203_L0.5860.28
46_Q73_S0.5860.28
109_L114_A0.5850.28
43_K69_P0.5850.28
85_V92_E0.5840.28
129_Q172_E0.5820.28
34_I184_I0.5800.28
99_G184_I0.5800.28
106_P146_D0.5790.28
177_K203_L0.5780.27
148_P220_G0.5770.27
67_D70_N0.5770.27
77_W151_N0.5770.27
52_W161_T0.5760.27
178_T270_A0.5750.27
258_K269_F0.5720.27
157_V218_G0.5720.27
172_E182_G0.5700.27
37_T199_R0.5670.27
72_L149_R0.5670.27
254_K264_G0.5650.27
252_F267_A0.5630.27
261_A271_A0.5630.27
259_P273_I0.5580.26
153_E178_T0.5570.26
58_T142_G0.5570.26
31_A188_T0.5570.26
168_V171_Q0.5560.26
211_A237_Y0.5550.26
202_E205_T0.5520.26
32_K97_K0.5510.26
36_V262_A0.5450.25
259_P268_T0.5450.25
229_H235_N0.5450.25
193_K225_M0.5410.25
266_A273_I0.5400.25
69_P262_A0.5380.25
118_I165_D0.5370.25
37_T257_W0.5360.25
145_F214_Y0.5350.25
235_N243_N0.5320.25
156_R206_R0.5300.24
80_M149_R0.5290.24
106_P239_G0.5280.24
264_G268_T0.5260.24
259_P266_A0.5250.24
188_T192_M0.5240.24
127_D255_G0.5230.24
123_N127_D0.5230.24
104_S120_Q0.5220.24
162_L225_M0.5220.24
40_I113_P0.5210.24
48_A177_K0.5210.24
56_R169_V0.5200.24
109_L121_Y0.5190.24
119_I127_D0.5190.24
199_R205_T0.5180.24
189_K197_S0.5160.24
79_V178_T0.5160.24
99_G173_P0.5140.24
148_P183_A0.5130.23
199_R229_H0.5100.23
230_H235_N0.5070.23
254_K259_P0.5070.23
50_S58_T0.5060.23
68_N75_K0.5060.23
150_L155_N0.5040.23
80_M224_V0.5030.23
46_Q116_G0.5020.23
85_V88_N0.5010.23
254_K268_T0.5000.23
47_V77_W0.5000.23
143_C175_C0.5000.23
108_C175_C0.5000.23
175_C179_C0.5000.23
103_C175_C0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kqfB 3 0.9633 100 0.399 Contact Map
1h0hB 1 0.6933 100 0.552 Contact Map
2ivfB 1 0.8633 100 0.583 Contact Map
1ti6B 2 0.84 100 0.609 Contact Map
2vpzB 2 0.6433 100 0.644 Contact Map
1q16B 2 0.9 100 0.673 Contact Map
4z3xE 2 0.5633 100 0.737 Contact Map
3mm5B 2 0.8367 99.8 0.809 Contact Map
2fgoA 1 0.2467 99.4 0.857 Contact Map
1jnrB 1 0.49 99.4 0.859 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0091 seconds.