GREMLIN Database
FDNH - Formate dehydrogenase, nitrate-inducible, iron-sulfur subunit
UniProt: P0AAJ3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11228
Length: 294 (254)
Sequences: 855 (484)
Seq/√Len: 30.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
176_V184_I5.0831.00
197_E216_P3.2681.00
117_A120_Q3.2281.00
235_E242_K3.1071.00
30_V188_T3.0641.00
189_K193_L3.0601.00
185_H195_L2.9421.00
46_Q69_P2.8921.00
195_L198_Q2.8071.00
78_T97_K2.6851.00
116_G120_Q2.6321.00
107_G142_G2.5641.00
219_V222_T2.5450.99
52_W165_D2.4940.99
31_A192_M2.4420.99
137_G150_L2.2830.99
150_L157_V2.2780.99
197_E213_V2.2460.99
164_V168_S2.2200.99
32_K224_V2.2120.99
71_D149_R2.2040.98
106_P120_Q2.1370.98
40_I181_T2.1340.98
104_E223_H2.0540.98
52_W174_A2.0260.97
34_I224_V1.9860.97
33_L225_M1.9630.97
172_E177_K1.9240.96
33_L227_V1.9090.96
194_E197_E1.8880.96
112_C133_C1.8720.96
28_A190_K1.8690.96
23_V26_Y1.8690.96
112_C139_C1.8590.96
133_C139_C1.8520.96
228_L234_P1.8250.95
194_E198_Q1.8160.95
29_E223_H1.7630.94
53_N161_T1.7610.94
37_S231_A1.7480.94
276_Y280_G1.7230.93
198_Q201_A1.6930.93
105_D110_K1.6820.93
275_H280_G1.6410.92
215_N218_G1.6360.91
203_L207_G1.6310.91
267_A270_A1.6190.91
193_L216_P1.6060.91
257_L271_G1.6050.91
192_M225_M1.6010.91
42_C45_C1.5930.90
39_C45_C1.5930.90
39_C42_C1.5930.90
109_L118_I1.5760.90
57_D76_S1.5620.89
193_L213_V1.5510.89
262_A266_I1.5030.87
58_E73_S1.4950.87
198_Q202_K1.4930.87
188_T191_E1.4780.87
189_K225_M1.4630.86
260_L266_I1.4560.86
24_R27_K1.4540.86
113_P134_I1.4330.85
77_W158_Y1.4100.84
165_D174_A1.4090.84
52_W166_R1.4000.83
187_G192_M1.3990.83
271_G274_F1.3970.83
31_A162_L1.3930.83
121_Y127_D1.3650.82
29_E104_E1.3530.81
38_T182_G1.3480.81
34_I162_L1.3390.81
129_Q132_N1.3340.80
204_K207_G1.3250.80
267_A271_G1.2970.78
28_A188_T1.2830.78
130_S141_A1.2670.77
99_G224_V1.2640.76
116_G119_I1.2550.76
137_G140_I1.2500.76
145_F222_T1.2500.76
257_L260_L1.2350.75
166_R177_K1.2330.75
261_A267_A1.2270.74
30_V186_F1.2240.74
57_D60_G1.2050.73
32_K184_I1.2030.73
172_E182_G1.2020.73
195_L201_A1.1760.71
105_D273_I1.1650.70
40_I44_A1.1590.70
266_I269_F1.1510.69
193_L197_E1.1480.69
151_N154_D1.1420.69
171_Q177_K1.1410.69
34_I226_Y1.1320.68
205_A209_E1.1210.67
166_R171_Q1.1210.67
256_A266_I1.1190.67
46_Q68_N1.1190.67
146_N184_I1.1130.67
116_G123_N1.1130.67
78_T99_G1.1110.67
34_I99_G1.1020.66
125_I167_V1.0980.66
112_C135_G1.0930.65
200_V227_V1.0740.64
269_F278_G1.0670.63
33_L192_M1.0630.63
135_G139_C1.0580.63
197_E201_A1.0480.62
80_M125_I1.0470.62
146_N176_V1.0400.61
189_K222_T1.0290.61
172_E272_L1.0260.60
182_G225_M1.0240.60
200_V203_L1.0210.60
68_N82_F1.0130.59
154_D158_Y1.0080.59
265_F269_F1.0050.59
213_V216_P1.0030.59
36_V226_Y1.0030.59
128_F148_P0.9990.58
173_P176_V0.9950.58
203_L211_A0.9890.57
128_F157_V0.9860.57
257_L263_A0.9860.57
212_G231_A0.9800.57
104_E119_I0.9750.56
24_R28_A0.9730.56
270_A273_I0.9640.56
36_V94_L0.9550.55
72_L178_T0.9450.54
198_Q248_T0.9370.53
193_L225_M0.9330.53
255_G259_P0.9320.53
106_P123_N0.9230.52
80_M95_I0.9220.52
120_Q123_N0.9220.52
117_A121_Y0.9180.52
234_P239_G0.9130.51
43_K67_D0.9120.51
27_K88_N0.9060.51
176_V183_A0.9030.51
71_D81_R0.9020.51
44_A178_T0.9000.50
87_Q90_K0.8900.50
114_S136_C0.8900.50
38_T185_H0.8860.49
193_L215_N0.8850.49
71_D148_P0.8820.49
23_V27_K0.8810.49
47_V178_T0.8760.49
32_K176_V0.8710.48
260_L263_A0.8710.48
47_V52_W0.8700.48
52_W82_F0.8690.48
77_W151_N0.8570.47
262_A269_F0.8570.47
156_R252_L0.8570.47
121_Y125_I0.8560.47
67_D79_V0.8550.47
34_I134_I0.8540.47
117_A132_N0.8540.47
126_V165_D0.8530.47
218_G221_G0.8530.47
256_A259_P0.8500.46
84_E165_D0.8490.46
74_A153_E0.8490.46
136_C142_G0.8460.46
272_L279_I0.8440.46
198_Q269_F0.8440.46
89_G233_Q0.8410.46
254_K259_P0.8410.46
43_K46_Q0.8390.46
106_P148_P0.8380.45
250_V253_W0.8340.45
118_I128_F0.8300.45
113_P133_C0.8190.44
35_D199_R0.8170.44
207_G211_A0.8110.43
260_L279_I0.7990.42
259_P273_I0.7970.42
65_V68_N0.7970.42
189_K216_P0.7950.42
119_I129_Q0.7920.42
140_I157_V0.7900.42
30_V125_I0.7880.42
44_A51_E0.7870.41
64_G72_L0.7860.41
201_A206_R0.7830.41
235_E241_P0.7800.41
113_P139_C0.7800.41
51_E177_K0.7750.41
31_A188_T0.7740.40
167_V276_Y0.7660.40
213_V227_V0.7660.40
215_N220_G0.7620.40
97_K226_Y0.7620.40
234_P237_Y0.7620.40
172_E176_V0.7610.39
265_F271_G0.7610.39
97_K224_V0.7550.39
142_G224_V0.7540.39
241_P244_P0.7510.39
86_E90_K0.7460.38
60_G69_P0.7450.38
35_D42_C0.7450.38
35_D45_C0.7450.38
35_D39_C0.7450.38
54_D168_S0.7450.38
162_L167_V0.7430.38
138_Y142_G0.7390.38
43_K69_P0.7390.38
58_E142_G0.7330.37
90_K208_Y0.7310.37
61_H264_G0.7300.37
273_I276_Y0.7280.37
156_R206_R0.7270.37
257_L261_A0.7250.37
202_K205_A0.7220.37
211_A228_L0.7220.37
192_M208_Y0.7190.36
34_I97_K0.7160.36
55_I77_W0.7150.36
232_D237_Y0.7140.36
82_F93_W0.7120.36
56_R158_Y0.7090.36
256_A263_A0.7090.36
84_E93_W0.7070.35
43_K82_F0.7070.35
266_I274_F0.6990.35
140_I151_N0.6990.35
187_G191_E0.6950.35
136_C139_C0.6940.34
114_S137_G0.6920.34
37_S212_G0.6920.34
130_S156_R0.6920.34
60_G151_N0.6910.34
101_M226_Y0.6900.34
113_P116_G0.6900.34
72_L161_T0.6880.34
67_D70_A0.6870.34
145_F214_Y0.6850.34
185_H201_A0.6850.34
214_Y221_G0.6840.34
227_V248_T0.6810.34
257_L264_G0.6760.33
110_K223_H0.6730.33
125_I147_I0.6720.33
43_K181_T0.6710.33
80_M121_Y0.6700.33
44_A104_E0.6690.33
106_P121_Y0.6670.33
253_W259_P0.6610.32
95_I183_A0.6590.32
37_S199_R0.6570.32
190_K194_E0.6560.32
36_V228_L0.6510.31
130_S158_Y0.6490.31
34_I184_I0.6490.31
137_G154_D0.6460.31
43_K95_I0.6430.31
233_Q236_L0.6400.31
46_Q116_G0.6400.31
195_L199_R0.6390.31
43_K207_G0.6390.31
48_A174_A0.6330.30
25_D122_A0.6330.30
256_A271_G0.6290.30
34_I183_A0.6270.30
204_K209_E0.6260.30
87_Q198_Q0.6230.30
31_A225_M0.6200.29
73_S227_V0.6190.29
243_D246_I0.6180.29
260_L274_F0.6170.29
263_A267_A0.6160.29
100_C143_C0.6160.29
100_C108_C0.6160.29
103_C179_C0.6160.29
108_C143_C0.6160.29
103_C108_C0.6160.29
100_C103_C0.6160.29
143_C179_C0.6160.29
103_C143_C0.6160.29
100_C179_C0.6160.29
108_C179_C0.6160.29
41_G222_T0.6110.29
96_R254_K0.6100.29
143_C175_C0.6090.29
103_C175_C0.6090.29
108_C175_C0.6090.29
175_C179_C0.6090.29
100_C175_C0.6090.29
188_T192_M0.6070.29
90_K169_V0.6060.28
34_I165_D0.6050.28
182_G217_E0.6040.28
116_G121_Y0.6040.28
135_G222_T0.6030.28
40_I69_P0.6020.28
196_A199_R0.6010.28
256_A269_F0.6010.28
86_E89_G0.6010.28
168_S271_G0.6000.28
119_I127_D0.5980.28
31_A54_D0.5970.28
275_H279_I0.5950.28
34_I113_P0.5940.28
189_K196_A0.5930.28
123_N127_D0.5840.27
234_P240_L0.5830.27
111_A142_G0.5810.27
32_K162_L0.5810.27
265_F277_I0.5800.27
189_K215_N0.5780.27
57_D171_Q0.5750.26
40_I111_A0.5710.26
213_V261_A0.5710.26
200_V212_G0.5680.26
214_Y244_P0.5680.26
257_L268_T0.5660.26
148_P196_A0.5650.26
122_A236_L0.5650.26
182_G192_M0.5610.26
85_T263_A0.5600.26
41_G80_M0.5600.26
112_C136_C0.5590.25
129_Q194_E0.5590.25
151_N156_R0.5580.25
56_R166_R0.5580.25
106_P195_L0.5570.25
110_K232_D0.5550.25
273_I277_I0.5550.25
169_V251_S0.5540.25
40_I180_P0.5530.25
185_H198_Q0.5520.25
39_C49_C0.5510.25
42_C49_C0.5510.25
45_C49_C0.5510.25
72_L149_R0.5510.25
50_S76_S0.5500.25
52_W84_E0.5480.25
200_V225_M0.5460.25
33_L221_G0.5450.25
260_L280_G0.5450.25
36_V40_I0.5440.25
242_K246_I0.5410.24
99_G183_A0.5400.24
133_C136_C0.5400.24
118_I165_D0.5380.24
127_D164_V0.5360.24
99_G140_I0.5300.24
111_A267_A0.5290.24
44_A95_I0.5270.24
174_A240_L0.5260.24
40_I113_P0.5250.23
265_F268_T0.5250.23
196_A225_M0.5230.23
265_F278_G0.5230.23
260_L264_G0.5210.23
257_L266_I0.5200.23
46_Q80_M0.5180.23
158_Y222_T0.5170.23
50_S262_A0.5170.23
245_K269_F0.5160.23
38_T129_Q0.5150.23
218_G222_T0.5150.23
164_V249_S0.5140.23
258_K262_A0.5140.23
258_K261_A0.5130.23
84_E91_L0.5130.23
189_K221_G0.5120.23
41_G239_G0.5070.22
109_L120_Q0.5060.22
252_L255_G0.5050.22
86_E170_G0.5000.22
166_R174_A0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kqfB 3 0.983 100 0.398 Contact Map
1h0hB 1 0.7075 100 0.542 Contact Map
2ivfB 1 0.8707 100 0.585 Contact Map
1ti6B 2 0.8401 100 0.606 Contact Map
2vpzB 2 0.6565 100 0.643 Contact Map
1q16B 2 0.898 100 0.674 Contact Map
4z3xE 2 0.5782 100 0.735 Contact Map
3mm5B 2 0.8469 99.8 0.808 Contact Map
1jnrB 1 0.5 99.4 0.858 Contact Map
2fgoA 1 0.2517 99.4 0.858 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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