GREMLIN Database
FABD - Malonyl CoA-acyl carrier protein transacylase
UniProt: P0AAI9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11317
Length: 309 (284)
Sequences: 15396 (11522)
Seq/√Len: 683.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
157_S203_A3.7831.00
256_Q259_K3.3111.00
133_A180_G3.0751.00
177_E193_P2.5651.00
75_R78_Q2.5011.00
37_S43_D2.4691.00
106_D109_D2.4201.00
8_F74_Y2.4121.00
123_E211_K2.3541.00
249_R253_N2.3531.00
139_D142_S2.3221.00
258_T262_E2.3211.00
116_M119_K2.3121.00
146_A186_A2.2551.00
74_Y101_C2.1851.00
140_D144_A2.1841.00
206_K252_Y2.1221.00
213_A245_D2.0661.00
46_A50_Q1.9711.00
67_L110_A1.9391.00
78_Q84_A1.9151.00
170_A202_C1.8781.00
23_A34_A1.8771.00
60_W122_Q1.8531.00
5_A269_V1.8241.00
169_I179_A1.8191.00
172_H204_L1.8031.00
180_G193_P1.7991.00
36_A107_F1.7971.00
33_F68_T1.7821.00
213_A248_V1.7791.00
182_A186_A1.7761.00
155_V172_H1.7631.00
131_A176_V1.7591.00
173_K193_P1.7481.00
32_T35_E1.7441.00
32_T75_R1.7371.00
231_N260_S1.7371.00
245_D249_R1.7321.00
28_I79_Q1.7231.00
116_M215_E1.7061.00
104_V224_P1.7021.00
180_G184_K1.6811.00
100_V110_A1.6761.00
7_V285_T1.6741.00
235_K263_Y1.6701.00
172_H175_A1.6681.00
156_V179_A1.6631.00
58_K122_Q1.6411.00
265_A289_V1.6251.00
71_V100_V1.6061.00
229_V263_Y1.6021.00
173_K177_E1.5951.00
26_Y76_V1.5811.00
89_A260_S1.5711.00
229_V236_C1.5561.00
70_S97_S1.5531.00
180_G191_A1.5441.00
33_F48_T1.5421.00
146_A183_C1.5371.00
131_A173_K1.5321.00
5_A264_M1.5301.00
87_M269_V1.5291.00
142_S145_K1.5121.00
35_E108_A1.5081.00
39_A108_A1.5041.00
133_A176_V1.5021.00
155_V175_A1.4991.00
113_L216_L1.4931.00
261_V285_T1.4881.00
30_E34_A1.4801.00
88_M226_V1.4711.00
20_A24_A1.4691.00
263_Y267_Q1.4681.00
39_A111_V1.4451.00
159_V170_A1.4371.00
34_A45_W1.4271.00
14_Q18_M1.4101.00
115_E119_K1.3941.00
19_L69_A1.3811.00
37_S45_W1.3761.00
213_A217_A1.3601.00
33_F72_A1.3601.00
138_L188_A1.3571.00
140_D256_Q1.3541.00
43_D46_A1.3511.00
211_K214_V1.3421.00
8_F101_C1.3361.00
216_L221_F1.3331.00
140_D161_F1.3291.00
149_E182_A1.3151.00
144_A148_E1.2971.00
227_P236_C1.2951.00
177_E181_A1.2931.00
6_F85_P1.2891.00
26_Y80_Q1.2831.00
142_S186_A1.2741.00
183_C188_A1.2741.00
89_A264_M1.2691.00
4_F86_A1.2651.00
4_F271_H1.2591.00
161_F258_T1.2531.00
138_L143_I1.2521.00
229_V260_S1.2341.00
150_A182_A1.2211.00
209_A213_A1.2181.00
177_E180_G1.2121.00
261_V288_I1.2081.00
131_A193_P1.2041.00
135_I143_I1.1901.00
161_F167_V1.1871.00
40_L115_E1.1661.00
35_E75_R1.1531.00
211_K215_E1.1511.00
53_A57_N1.1471.00
214_V217_A1.1371.00
55_E58_K1.1341.00
6_F275_V1.1301.00
181_A184_K1.1291.00
47_L50_Q1.1281.00
223_A240_G1.1271.00
206_K209_A1.1251.00
120_F211_K1.1191.00
87_M264_M1.1181.00
229_V267_Q1.1171.00
272_L285_T1.1151.00
182_A185_A1.1121.00
223_A239_N1.1071.00
181_A185_A1.1061.00
146_A182_A1.0971.00
163_S284_L1.0941.00
215_E218_K1.0921.00
31_E35_E1.0851.00
119_K123_E1.0831.00
21_D25_S1.0781.00
7_V89_A1.0771.00
116_M120_F1.0771.00
137_G190_R1.0751.00
36_A68_T1.0741.00
209_A248_V1.0701.00
133_A191_A1.0701.00
209_A252_Y1.0701.00
71_V97_S1.0681.00
135_I183_C1.0651.00
6_F74_Y1.0631.00
20_A49_Q1.0631.00
120_F215_E1.0561.00
143_I167_V1.0561.00
31_E34_A1.0561.00
178_R182_A1.0481.00
208_A251_L1.0411.00
158_P167_V1.0411.00
212_L251_L1.0381.00
55_E61_Q1.0351.00
135_I169_I1.0321.00
157_S202_C1.0231.00
158_P161_F1.0221.00
161_F254_P1.0191.00
32_T72_A1.0141.00
7_V272_L1.0121.00
263_Y266_A1.0081.00
145_K149_E1.0051.00
45_W49_Q1.0041.00
74_Y78_Q1.0031.00
77_W275_V0.9991.00
120_F208_A0.9991.00
23_A49_Q0.9961.00
60_W118_G0.9911.00
149_E153_G0.9881.00
176_V193_P0.9821.00
129_T173_K0.9811.00
29_V72_A0.9801.00
17_G20_A0.9791.00
161_F256_Q0.9771.00
5_A272_L0.9751.00
238_T241_D0.9701.00
236_C263_Y0.9681.00
142_S188_A0.9661.00
112_R218_K0.9641.00
40_L111_V0.9611.00
28_I32_T0.9611.00
161_F259_K0.9541.00
57_N195_P0.9521.00
231_N250_Q0.9491.00
36_A111_V0.9481.00
88_M228_V0.9471.00
91_H162_N0.9451.00
178_R181_A0.9391.00
6_F83_K0.9341.00
145_K148_E0.9241.00
76_V80_Q0.9201.00
210_D213_A0.9181.00
96_Y114_V0.9151.00
133_A193_P0.9141.00
27_P31_E0.9081.00
228_V242_A0.9081.00
265_A272_L0.9031.00
88_M101_C0.8981.00
75_R100_V0.8981.00
146_A179_A0.8971.00
5_A87_M0.8951.00
60_W119_K0.8941.00
67_L100_V0.8901.00
9_P70_S0.8901.00
87_M229_V0.8871.00
232_V253_N0.8851.00
150_A178_R0.8831.00
76_V79_Q0.8811.00
165_G287_R0.8751.00
67_L71_V0.8731.00
149_E186_A0.8721.00
175_A178_R0.8711.00
156_V175_A0.8631.00
87_M267_Q0.8621.00
262_E266_A0.8621.00
210_D214_V0.8481.00
163_S287_R0.8451.00
99_L247_L0.8451.00
140_D167_V0.8381.00
93_L114_V0.8371.00
206_K248_V0.8361.00
109_D112_R0.8281.00
258_T288_I0.8261.00
164_P288_I0.8251.00
75_R107_F0.8211.00
35_E39_A0.8211.00
67_L114_V0.8201.00
32_T36_A0.8171.00
34_A38_A0.8171.00
217_A244_R0.8141.00
95_E231_N0.8081.00
23_A30_E0.8051.00
257_W285_T0.8041.00
143_I169_I0.8031.00
54_E57_N0.8031.00
33_F45_W0.8031.00
138_L142_S0.8001.00
24_A49_Q0.7981.00
237_E242_A0.7931.00
137_G165_G0.7881.00
184_K191_A0.7811.00
114_V118_G0.7751.00
103_G225_T0.7751.00
206_K210_D0.7721.00
141_A144_A0.7711.00
262_E288_I0.7681.00
109_D219_I0.7661.00
29_V69_A0.7631.00
66_L70_S0.7621.00
59_T200_S0.7611.00
112_R215_E0.7601.00
28_I31_E0.7601.00
105_I221_F0.7581.00
265_A270_E0.7571.00
179_A183_C0.7531.00
19_L29_V0.7491.00
42_Y61_Q0.7461.00
143_I147_C0.7461.00
112_R116_M0.7451.00
104_V221_F0.7431.00
233_D249_R0.7421.00
234_V259_K0.7371.00
109_D222_N0.7361.00
140_D259_K0.7301.00
47_L61_Q0.7281.00
84_A225_T0.7261.00
196_V200_S0.7261.00
133_A169_I0.7261.00
234_V260_S0.7241.00
137_G188_A0.7231.00
40_L64_P0.7191.00
29_V32_T0.7141.00
259_K262_E0.7131.00
262_E292_L0.7071.00
265_A290_D0.7041.00
105_I113_L0.7041.00
106_D222_N0.7041.00
125_V129_T0.7031.00
37_S44_L0.7011.00
142_S165_G0.7001.00
13_S66_L0.6991.00
228_V237_E0.6921.00
4_F273_Y0.6921.00
279_K283_G0.6871.00
96_Y216_L0.6871.00
229_V264_M0.6871.00
272_L292_L0.6851.00
146_A150_A0.6851.00
48_T69_A0.6801.00
113_L219_I0.6791.00
265_A292_L0.6781.00
230_N246_A0.6761.00
261_V272_L0.6761.00
100_V107_F0.6741.00
154_Q172_H0.6731.00
214_V218_K0.6721.00
89_A257_W0.6641.00
233_D246_A0.6581.00
71_V101_C0.6571.00
233_D237_E0.6491.00
39_A112_R0.6491.00
123_E208_A0.6481.00
27_P30_E0.6461.00
11_Q196_V0.6461.00
71_V75_R0.6451.00
262_E265_A0.6411.00
60_W64_P0.6381.00
23_A33_F0.6331.00
51_G55_E0.6321.00
68_T111_V0.6281.00
203_A206_K0.6271.00
46_A55_E0.6251.00
239_N242_A0.6251.00
200_S251_L0.6241.00
205_M251_L0.6241.00
283_G286_K0.6221.00
135_I191_A0.6221.00
35_E107_F0.6221.00
67_L97_S0.6191.00
9_P276_G0.6181.00
73_L275_V0.6181.00
44_L68_T0.6171.00
145_K186_A0.6161.00
62_T66_L0.6151.00
113_L212_L0.6121.00
87_M236_C0.6111.00
29_V76_V0.6091.00
96_Y219_I0.6081.00
67_L111_V0.6071.00
142_S146_A0.6041.00
139_D143_I0.5991.00
121_M205_M0.5981.00
23_A45_W0.5951.00
150_A154_Q0.5921.00
141_A145_K0.5921.00
290_D293_T0.5921.00
121_M198_V0.5901.00
28_I75_R0.5891.00
235_K241_D0.5891.00
129_T172_H0.5891.00
121_M125_V0.5881.00
164_P258_T0.5871.00
260_S263_Y0.5871.00
120_F123_E0.5851.00
230_N237_E0.5841.00
139_D165_G0.5821.00
124_A205_M0.5811.00
135_I138_L0.5811.00
232_V249_R0.5811.00
192_L195_P0.5801.00
28_I76_V0.5791.00
50_Q54_E0.5791.00
155_V203_A0.5761.00
30_E45_W0.5751.00
47_L55_E0.5731.00
34_A37_S0.5721.00
132_M196_V0.5711.00
57_N62_T0.5711.00
144_A161_F0.5681.00
208_A212_L0.5661.00
204_L207_P0.5661.00
97_S100_V0.5641.00
35_E38_A0.5631.00
174_E177_E0.5601.00
93_L200_S0.5581.00
207_P210_D0.5561.00
107_F111_V0.5561.00
147_C158_P0.5551.00
100_V105_I0.5551.00
156_V169_I0.5541.00
134_A166_Q0.5541.00
32_T107_F0.5531.00
61_Q64_P0.5531.00
236_C267_Q0.5531.00
237_E241_D0.5501.00
78_Q225_T0.5481.00
71_V111_V0.5481.00
70_S275_V0.5471.00
248_V252_Y0.5461.00
150_A155_V0.5451.00
64_P118_G0.5441.00
155_V178_R0.5431.00
74_Y77_W0.5431.00
274_E281_L0.5421.00
63_Q117_R0.5411.00
264_M269_V0.5411.00
116_M211_K0.5411.00
11_Q63_Q0.5411.00
132_M170_A0.5391.00
140_D158_P0.5391.00
235_K259_K0.5391.00
5_A270_E0.5371.00
129_T207_P0.5361.00
95_E230_N0.5361.00
91_H255_V0.5351.00
32_T71_V0.5341.00
199_P204_L0.5311.00
26_Y79_Q0.5301.00
105_I110_A0.5301.00
131_A177_E0.5281.00
122_Q125_V0.5271.00
108_A112_R0.5271.00
221_F244_R0.5271.00
74_Y275_V0.5271.00
163_S166_Q0.5261.00
160_N168_V0.5241.00
11_Q200_S0.5221.00
99_L104_V0.5211.00
134_A137_G0.5211.00
230_N233_D0.5200.99
102_A228_V0.5190.99
144_A254_P0.5160.99
72_A76_V0.5160.99
96_Y113_L0.5140.99
289_V292_L0.5120.99
42_Y55_E0.5110.99
199_P205_M0.5110.99
183_C186_A0.5110.99
209_A249_R0.5100.99
46_A51_G0.5090.99
222_N225_T0.5080.99
150_A179_A0.5060.99
120_F212_L0.5060.99
46_A49_Q0.5050.99
200_S205_M0.5000.99
52_P55_E0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ptwA 1 0.9903 100 0.058 Contact Map
1mlaA 1 0.9871 100 0.059 Contact Map
3tqeA 1 1 100 0.068 Contact Map
3ezoA 1 0.9903 100 0.069 Contact Map
3k89A 1 0.9968 100 0.07 Contact Map
3qatA 2 0.9935 100 0.071 Contact Map
3im8A 1 0.9838 100 0.073 Contact Map
4mz0A 2 0.9579 100 0.082 Contact Map
2h1yA 1 0.9709 100 0.084 Contact Map
4rr5A 1 0.9482 100 0.085 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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