FABD - ECOLI - GREMLIN Contacts

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FABD - Malonyl CoA-acyl carrier protein transacylase

UniProt:	P0AAI9	Sequences: MTQFAFVFPGQGSQTVGMLADMAASYPIVEETFAEASAALGYDLWALTQQGPAEELNKTWQTQPALLTASVALYRVWQQQGGKAPAMMAGHSLGEYSALVCAGVIDFADAVRLVEMRGKFMQEAVPEGTGAMAAIIGLDDASIAKACEEAAEGQVVSPVNFNSPGQVVIAGHKEAVERAGAACKAAGAKRALPLPVSVPSHCALMKPAADKLAVELAKITFNAPTVPVVNNVDVKCETNGDAIRDALVRQLYNPVQWTKSVEYMAAQGVEHLYEVGPGKVLTGLTKRIVDTLTASALNEPSAMAAALEL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11317
Length:	309 (284)
Sequences:	15396 (11522)
Seq/√Len:	683.7

ECOLI - FABD
BACSU - FABD PKSD PKSC PKSE

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
157_S	203_A	3.783	1.00
256_Q	259_K	3.311	1.00
133_A	180_G	3.075	1.00
177_E	193_P	2.565	1.00
75_R	78_Q	2.501	1.00
37_S	43_D	2.469	1.00
106_D	109_D	2.420	1.00
8_F	74_Y	2.412	1.00
123_E	211_K	2.354	1.00
249_R	253_N	2.353	1.00
139_D	142_S	2.322	1.00
258_T	262_E	2.321	1.00
116_M	119_K	2.312	1.00
146_A	186_A	2.255	1.00
74_Y	101_C	2.185	1.00
140_D	144_A	2.184	1.00
206_K	252_Y	2.122	1.00
213_A	245_D	2.066	1.00
46_A	50_Q	1.971	1.00
67_L	110_A	1.939	1.00
78_Q	84_A	1.915	1.00
170_A	202_C	1.878	1.00
23_A	34_A	1.877	1.00
60_W	122_Q	1.853	1.00
5_A	269_V	1.824	1.00
169_I	179_A	1.819	1.00
172_H	204_L	1.803	1.00
180_G	193_P	1.799	1.00
36_A	107_F	1.797	1.00
33_F	68_T	1.782	1.00
213_A	248_V	1.779	1.00
182_A	186_A	1.776	1.00
155_V	172_H	1.763	1.00
131_A	176_V	1.759	1.00
173_K	193_P	1.748	1.00
32_T	35_E	1.744	1.00
32_T	75_R	1.737	1.00
231_N	260_S	1.737	1.00
245_D	249_R	1.732	1.00
28_I	79_Q	1.723	1.00
116_M	215_E	1.706	1.00
104_V	224_P	1.702	1.00
180_G	184_K	1.681	1.00
100_V	110_A	1.676	1.00
7_V	285_T	1.674	1.00
235_K	263_Y	1.670	1.00
172_H	175_A	1.668	1.00
156_V	179_A	1.663	1.00
58_K	122_Q	1.641	1.00
265_A	289_V	1.625	1.00
71_V	100_V	1.606	1.00
229_V	263_Y	1.602	1.00
173_K	177_E	1.595	1.00
26_Y	76_V	1.581	1.00
89_A	260_S	1.571	1.00
229_V	236_C	1.556	1.00
70_S	97_S	1.553	1.00
180_G	191_A	1.544	1.00
33_F	48_T	1.542	1.00
146_A	183_C	1.537	1.00
131_A	173_K	1.532	1.00
5_A	264_M	1.530	1.00
87_M	269_V	1.529	1.00
142_S	145_K	1.512	1.00
35_E	108_A	1.508	1.00
39_A	108_A	1.504	1.00
133_A	176_V	1.502	1.00
155_V	175_A	1.499	1.00
113_L	216_L	1.493	1.00
261_V	285_T	1.488	1.00
30_E	34_A	1.480	1.00
88_M	226_V	1.471	1.00
20_A	24_A	1.469	1.00
263_Y	267_Q	1.468	1.00
39_A	111_V	1.445	1.00
159_V	170_A	1.437	1.00
34_A	45_W	1.427	1.00
14_Q	18_M	1.410	1.00
115_E	119_K	1.394	1.00
19_L	69_A	1.381	1.00
37_S	45_W	1.376	1.00
213_A	217_A	1.360	1.00
33_F	72_A	1.360	1.00
138_L	188_A	1.357	1.00
140_D	256_Q	1.354	1.00
43_D	46_A	1.351	1.00
211_K	214_V	1.342	1.00
8_F	101_C	1.336	1.00
216_L	221_F	1.333	1.00
140_D	161_F	1.329	1.00
149_E	182_A	1.315	1.00
144_A	148_E	1.297	1.00
227_P	236_C	1.295	1.00
177_E	181_A	1.293	1.00
6_F	85_P	1.289	1.00
26_Y	80_Q	1.283	1.00
142_S	186_A	1.274	1.00
183_C	188_A	1.274	1.00
89_A	264_M	1.269	1.00
4_F	86_A	1.265	1.00
4_F	271_H	1.259	1.00
161_F	258_T	1.253	1.00
138_L	143_I	1.252	1.00
229_V	260_S	1.234	1.00
150_A	182_A	1.221	1.00
209_A	213_A	1.218	1.00
177_E	180_G	1.212	1.00
261_V	288_I	1.208	1.00
131_A	193_P	1.204	1.00
135_I	143_I	1.190	1.00
161_F	167_V	1.187	1.00
40_L	115_E	1.166	1.00
35_E	75_R	1.153	1.00
211_K	215_E	1.151	1.00
53_A	57_N	1.147	1.00
214_V	217_A	1.137	1.00
55_E	58_K	1.134	1.00
6_F	275_V	1.130	1.00
181_A	184_K	1.129	1.00
47_L	50_Q	1.128	1.00
223_A	240_G	1.127	1.00
206_K	209_A	1.125	1.00
120_F	211_K	1.119	1.00
87_M	264_M	1.118	1.00
229_V	267_Q	1.117	1.00
272_L	285_T	1.115	1.00
182_A	185_A	1.112	1.00
223_A	239_N	1.107	1.00
181_A	185_A	1.106	1.00
146_A	182_A	1.097	1.00
163_S	284_L	1.094	1.00
215_E	218_K	1.092	1.00
31_E	35_E	1.085	1.00
119_K	123_E	1.083	1.00
21_D	25_S	1.078	1.00
7_V	89_A	1.077	1.00
116_M	120_F	1.077	1.00
137_G	190_R	1.075	1.00
36_A	68_T	1.074	1.00
209_A	248_V	1.070	1.00
133_A	191_A	1.070	1.00
209_A	252_Y	1.070	1.00
71_V	97_S	1.068	1.00
135_I	183_C	1.065	1.00
6_F	74_Y	1.063	1.00
20_A	49_Q	1.063	1.00
120_F	215_E	1.056	1.00
143_I	167_V	1.056	1.00
31_E	34_A	1.056	1.00
178_R	182_A	1.048	1.00
208_A	251_L	1.041	1.00
158_P	167_V	1.041	1.00
212_L	251_L	1.038	1.00
55_E	61_Q	1.035	1.00
135_I	169_I	1.032	1.00
157_S	202_C	1.023	1.00
158_P	161_F	1.022	1.00
161_F	254_P	1.019	1.00
32_T	72_A	1.014	1.00
7_V	272_L	1.012	1.00
263_Y	266_A	1.008	1.00
145_K	149_E	1.005	1.00
45_W	49_Q	1.004	1.00
74_Y	78_Q	1.003	1.00
77_W	275_V	0.999	1.00
120_F	208_A	0.999	1.00
23_A	49_Q	0.996	1.00
60_W	118_G	0.991	1.00
149_E	153_G	0.988	1.00
176_V	193_P	0.982	1.00
129_T	173_K	0.981	1.00
29_V	72_A	0.980	1.00
17_G	20_A	0.979	1.00
161_F	256_Q	0.977	1.00
5_A	272_L	0.975	1.00
238_T	241_D	0.970	1.00
236_C	263_Y	0.968	1.00
142_S	188_A	0.966	1.00
112_R	218_K	0.964	1.00
40_L	111_V	0.961	1.00
28_I	32_T	0.961	1.00
161_F	259_K	0.954	1.00
57_N	195_P	0.952	1.00
231_N	250_Q	0.949	1.00
36_A	111_V	0.948	1.00
88_M	228_V	0.947	1.00
91_H	162_N	0.945	1.00
178_R	181_A	0.939	1.00
6_F	83_K	0.934	1.00
145_K	148_E	0.924	1.00
76_V	80_Q	0.920	1.00
210_D	213_A	0.918	1.00
96_Y	114_V	0.915	1.00
133_A	193_P	0.914	1.00
27_P	31_E	0.908	1.00
228_V	242_A	0.908	1.00
265_A	272_L	0.903	1.00
88_M	101_C	0.898	1.00
75_R	100_V	0.898	1.00
146_A	179_A	0.897	1.00
5_A	87_M	0.895	1.00
60_W	119_K	0.894	1.00
67_L	100_V	0.890	1.00
9_P	70_S	0.890	1.00
87_M	229_V	0.887	1.00
232_V	253_N	0.885	1.00
150_A	178_R	0.883	1.00
76_V	79_Q	0.881	1.00
165_G	287_R	0.875	1.00
67_L	71_V	0.873	1.00
149_E	186_A	0.872	1.00
175_A	178_R	0.871	1.00
156_V	175_A	0.863	1.00
87_M	267_Q	0.862	1.00
262_E	266_A	0.862	1.00
210_D	214_V	0.848	1.00
163_S	287_R	0.845	1.00
99_L	247_L	0.845	1.00
140_D	167_V	0.838	1.00
93_L	114_V	0.837	1.00
206_K	248_V	0.836	1.00
109_D	112_R	0.828	1.00
258_T	288_I	0.826	1.00
164_P	288_I	0.825	1.00
75_R	107_F	0.821	1.00
35_E	39_A	0.821	1.00
67_L	114_V	0.820	1.00
32_T	36_A	0.817	1.00
34_A	38_A	0.817	1.00
217_A	244_R	0.814	1.00
95_E	231_N	0.808	1.00
23_A	30_E	0.805	1.00
257_W	285_T	0.804	1.00
143_I	169_I	0.803	1.00
54_E	57_N	0.803	1.00
33_F	45_W	0.803	1.00
138_L	142_S	0.800	1.00
24_A	49_Q	0.798	1.00
237_E	242_A	0.793	1.00
137_G	165_G	0.788	1.00
184_K	191_A	0.781	1.00
114_V	118_G	0.775	1.00
103_G	225_T	0.775	1.00
206_K	210_D	0.772	1.00
141_A	144_A	0.771	1.00
262_E	288_I	0.768	1.00
109_D	219_I	0.766	1.00
29_V	69_A	0.763	1.00
66_L	70_S	0.762	1.00
59_T	200_S	0.761	1.00
112_R	215_E	0.760	1.00
28_I	31_E	0.760	1.00
105_I	221_F	0.758	1.00
265_A	270_E	0.757	1.00
179_A	183_C	0.753	1.00
19_L	29_V	0.749	1.00
42_Y	61_Q	0.746	1.00
143_I	147_C	0.746	1.00
112_R	116_M	0.745	1.00
104_V	221_F	0.743	1.00
233_D	249_R	0.742	1.00
234_V	259_K	0.737	1.00
109_D	222_N	0.736	1.00
140_D	259_K	0.730	1.00
47_L	61_Q	0.728	1.00
84_A	225_T	0.726	1.00
196_V	200_S	0.726	1.00
133_A	169_I	0.726	1.00
234_V	260_S	0.724	1.00
137_G	188_A	0.723	1.00
40_L	64_P	0.719	1.00
29_V	32_T	0.714	1.00
259_K	262_E	0.713	1.00
262_E	292_L	0.707	1.00
265_A	290_D	0.704	1.00
105_I	113_L	0.704	1.00
106_D	222_N	0.704	1.00
125_V	129_T	0.703	1.00
37_S	44_L	0.701	1.00
142_S	165_G	0.700	1.00
13_S	66_L	0.699	1.00
228_V	237_E	0.692	1.00
4_F	273_Y	0.692	1.00
279_K	283_G	0.687	1.00
96_Y	216_L	0.687	1.00
229_V	264_M	0.687	1.00
272_L	292_L	0.685	1.00
146_A	150_A	0.685	1.00
48_T	69_A	0.680	1.00
113_L	219_I	0.679	1.00
265_A	292_L	0.678	1.00
230_N	246_A	0.676	1.00
261_V	272_L	0.676	1.00
100_V	107_F	0.674	1.00
154_Q	172_H	0.673	1.00
214_V	218_K	0.672	1.00
89_A	257_W	0.664	1.00
233_D	246_A	0.658	1.00
71_V	101_C	0.657	1.00
233_D	237_E	0.649	1.00
39_A	112_R	0.649	1.00
123_E	208_A	0.648	1.00
27_P	30_E	0.646	1.00
11_Q	196_V	0.646	1.00
71_V	75_R	0.645	1.00
262_E	265_A	0.641	1.00
60_W	64_P	0.638	1.00
23_A	33_F	0.633	1.00
51_G	55_E	0.632	1.00
68_T	111_V	0.628	1.00
203_A	206_K	0.627	1.00
46_A	55_E	0.625	1.00
239_N	242_A	0.625	1.00
200_S	251_L	0.624	1.00
205_M	251_L	0.624	1.00
283_G	286_K	0.622	1.00
135_I	191_A	0.622	1.00
35_E	107_F	0.622	1.00
67_L	97_S	0.619	1.00
9_P	276_G	0.618	1.00
73_L	275_V	0.618	1.00
44_L	68_T	0.617	1.00
145_K	186_A	0.616	1.00
62_T	66_L	0.615	1.00
113_L	212_L	0.612	1.00
87_M	236_C	0.611	1.00
29_V	76_V	0.609	1.00
96_Y	219_I	0.608	1.00
67_L	111_V	0.607	1.00
142_S	146_A	0.604	1.00
139_D	143_I	0.599	1.00
121_M	205_M	0.598	1.00
23_A	45_W	0.595	1.00
150_A	154_Q	0.592	1.00
141_A	145_K	0.592	1.00
290_D	293_T	0.592	1.00
121_M	198_V	0.590	1.00
28_I	75_R	0.589	1.00
235_K	241_D	0.589	1.00
129_T	172_H	0.589	1.00
121_M	125_V	0.588	1.00
164_P	258_T	0.587	1.00
260_S	263_Y	0.587	1.00
120_F	123_E	0.585	1.00
230_N	237_E	0.584	1.00
139_D	165_G	0.582	1.00
124_A	205_M	0.581	1.00
135_I	138_L	0.581	1.00
232_V	249_R	0.581	1.00
192_L	195_P	0.580	1.00
28_I	76_V	0.579	1.00
50_Q	54_E	0.579	1.00
155_V	203_A	0.576	1.00
30_E	45_W	0.575	1.00
47_L	55_E	0.573	1.00
34_A	37_S	0.572	1.00
132_M	196_V	0.571	1.00
57_N	62_T	0.571	1.00
144_A	161_F	0.568	1.00
208_A	212_L	0.566	1.00
204_L	207_P	0.566	1.00
97_S	100_V	0.564	1.00
35_E	38_A	0.563	1.00
174_E	177_E	0.560	1.00
93_L	200_S	0.558	1.00
207_P	210_D	0.556	1.00
107_F	111_V	0.556	1.00
147_C	158_P	0.555	1.00
100_V	105_I	0.555	1.00
156_V	169_I	0.554	1.00
134_A	166_Q	0.554	1.00
32_T	107_F	0.553	1.00
61_Q	64_P	0.553	1.00
236_C	267_Q	0.553	1.00
237_E	241_D	0.550	1.00
78_Q	225_T	0.548	1.00
71_V	111_V	0.548	1.00
70_S	275_V	0.547	1.00
248_V	252_Y	0.546	1.00
150_A	155_V	0.545	1.00
64_P	118_G	0.544	1.00
155_V	178_R	0.543	1.00
74_Y	77_W	0.543	1.00
274_E	281_L	0.542	1.00
63_Q	117_R	0.541	1.00
264_M	269_V	0.541	1.00
116_M	211_K	0.541	1.00
11_Q	63_Q	0.541	1.00
132_M	170_A	0.539	1.00
140_D	158_P	0.539	1.00
235_K	259_K	0.539	1.00
5_A	270_E	0.537	1.00
129_T	207_P	0.536	1.00
95_E	230_N	0.536	1.00
91_H	255_V	0.535	1.00
32_T	71_V	0.534	1.00
199_P	204_L	0.531	1.00
26_Y	79_Q	0.530	1.00
105_I	110_A	0.530	1.00
131_A	177_E	0.528	1.00
122_Q	125_V	0.527	1.00
108_A	112_R	0.527	1.00
221_F	244_R	0.527	1.00
74_Y	275_V	0.527	1.00
163_S	166_Q	0.526	1.00
160_N	168_V	0.524	1.00
11_Q	200_S	0.522	1.00
99_L	104_V	0.521	1.00
134_A	137_G	0.521	1.00
230_N	233_D	0.520	0.99
102_A	228_V	0.519	0.99
144_A	254_P	0.516	0.99
72_A	76_V	0.516	0.99
96_Y	113_L	0.514	0.99
289_V	292_L	0.512	0.99
42_Y	55_E	0.511	0.99
199_P	205_M	0.511	0.99
183_C	186_A	0.511	0.99
209_A	249_R	0.510	0.99
46_A	51_G	0.509	0.99
222_N	225_T	0.508	0.99
150_A	179_A	0.506	0.99
120_F	212_L	0.506	0.99
46_A	49_Q	0.505	0.99
200_S	205_M	0.500	0.99
52_P	55_E	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ptwA	1	0.9903	100	0.058	Contact Map
1mlaA	1	0.9871	100	0.059	Contact Map
3tqeA	1	1	100	0.068	Contact Map
3ezoA	1	0.9903	100	0.069	Contact Map
3k89A	1	0.9968	100	0.07	Contact Map
3qatA	2	0.9935	100	0.071	Contact Map
3im8A	1	0.9838	100	0.073	Contact Map
4mz0A	2	0.9579	100	0.082	Contact Map
2h1yA	1	0.9709	100	0.084	Contact Map
4rr5A	1	0.9482	100	0.085	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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