GREMLIN Database
FABF - 3-oxoacyl-[acyl-carrier-protein] synthase 2
UniProt: P0AAI5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12606
Length: 413 (395)
Sequences: 21144 (14008)
Seq/√Len: 704.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
281_A321_T3.2161.00
259_V411_K3.0581.00
20_T23_S2.9221.00
354_S394_T2.8321.00
100_R184_D2.7331.00
256_A355_I2.7221.00
26_K30_A2.7071.00
172_G261_F2.6991.00
225_K371_N2.6911.00
225_K374_E2.5791.00
393_Y411_K2.5341.00
362_A385_A2.4721.00
4_R245_E2.4351.00
255_Y359_R2.3521.00
88_D255_Y2.3331.00
85_A240_V2.2921.00
243_E246_H2.2511.00
223_W303_A2.2321.00
29_L362_A2.2311.00
27_A34_G2.1871.00
81_A236_A2.1251.00
27_A32_Q2.1021.00
222_P337_S2.0891.00
19_N23_S2.0871.00
178_I243_E2.0721.00
357_A364_P2.0651.00
297_Q393_Y2.0611.00
351_S410_F2.0411.00
104_A177_I2.0401.00
171_I351_S2.0371.00
242_E252_A1.9981.00
5_R259_V1.9831.00
281_A285_A1.9811.00
362_A387_Q1.9421.00
226_E371_N1.9381.00
176_R180_Y1.9371.00
107_S143_V1.9201.00
365_P385_A1.9121.00
294_E297_Q1.8951.00
331_L386_R1.8791.00
35_I52_G1.8611.00
83_V87_Q1.8321.00
217_Q228_D1.8101.00
82_G147_L1.8091.00
242_E250_R1.8081.00
63_I71_M1.8051.00
82_G187_V1.7901.00
102_G186_M1.7871.00
37_L50_F1.7811.00
293_I393_Y1.7621.00
380_F386_R1.7551.00
244_Y248_K1.7301.00
100_R286_N1.7301.00
15_S349_V1.7291.00
105_I238_M1.7171.00
237_G348_A1.6841.00
226_E370_D1.6801.00
363_V382_P1.6691.00
36_S55_K1.6671.00
356_L359_R1.6651.00
356_L360_D1.6641.00
246_H249_K1.6531.00
8_V351_S1.6521.00
175_A258_L1.6491.00
37_L49_K1.6441.00
281_A322_I1.6431.00
189_G238_M1.6271.00
24_T335_T1.6211.00
183_A186_M1.6111.00
233_G342_L1.5971.00
8_V355_I1.5951.00
351_S396_C1.5851.00
33_S219_A1.5801.00
175_A179_A1.5681.00
12_G81_A1.5681.00
239_L351_S1.5681.00
106_G166_S1.5591.00
253_K359_R1.5581.00
148_T157_S1.5581.00
335_T349_V1.5531.00
177_I183_A1.5421.00
176_R182_D1.5261.00
78_G147_L1.5141.00
301_V319_V1.5121.00
224_D369_L1.5041.00
187_V240_V1.5001.00
4_R243_E1.4991.00
331_L380_F1.4971.00
81_A238_M1.4891.00
259_V393_Y1.4871.00
264_S405_N1.4871.00
58_N61_D1.4831.00
78_G105_I1.4801.00
29_L385_A1.4721.00
169_H406_G1.4641.00
11_L21_V1.4621.00
162_T165_T1.4541.00
237_G352_I1.4481.00
24_T353_Y1.4451.00
73_A77_Y1.4431.00
47_A204_G1.4211.00
101_I185_V1.4071.00
88_D253_K1.4031.00
92_E95_E1.4021.00
83_V150_M1.3951.00
78_G238_M1.3871.00
185_V240_V1.3851.00
261_F408_L1.3831.00
235_G342_L1.3731.00
217_Q221_R1.3691.00
176_R179_A1.3651.00
102_G183_A1.3631.00
337_S367_I1.3621.00
331_L363_V1.3571.00
158_I173_H1.3531.00
298_I393_Y1.3501.00
300_Y363_V1.3451.00
154_R282_L1.3361.00
331_L382_P1.3311.00
361_Q392_E1.3291.00
42_D45_A1.3251.00
282_L286_N1.3211.00
221_R226_E1.3161.00
102_G156_P1.3141.00
169_H404_T1.3091.00
366_T369_L1.3071.00
6_V241_L1.3051.00
395_L409_I1.3041.00
5_R257_E1.3011.00
78_G143_V1.2941.00
388_V392_E1.2921.00
224_D371_N1.2881.00
177_I182_D1.2861.00
26_K32_Q1.2851.00
316_A332_V1.2821.00
4_R7_V1.2731.00
144_A159_S1.2721.00
39_D42_D1.2721.00
224_D370_D1.2711.00
97_N152_G1.2651.00
17_V34_G1.2641.00
6_V175_A1.2631.00
264_S283_A1.2601.00
337_S366_T1.2551.00
255_Y355_I1.2551.00
395_L407_S1.2471.00
23_S26_K1.2461.00
239_L348_A1.2431.00
300_Y333_S1.2391.00
26_K29_L1.2371.00
363_V388_V1.2371.00
145_G402_G1.2341.00
369_L372_P1.2321.00
358_L410_F1.2311.00
11_L352_I1.2241.00
184_D246_H1.2081.00
210_S228_D1.2041.00
397_N407_S1.1941.00
285_A289_R1.1811.00
339_T349_V1.1801.00
13_M21_V1.1801.00
262_G283_A1.1801.00
105_I189_G1.1611.00
169_H263_M1.1581.00
262_G287_A1.1551.00
342_L349_V1.1511.00
300_Y354_S1.1511.00
15_S237_G1.1481.00
239_L352_I1.1411.00
19_N55_K1.1371.00
171_I241_L1.1361.00
52_G233_G1.1311.00
373_D376_C1.1291.00
319_V332_V1.1261.00
10_G88_D1.1221.00
299_G392_E1.1221.00
216_P228_D1.1201.00
221_R228_D1.1181.00
82_G238_M1.1141.00
190_G348_A1.1101.00
85_A238_M1.1081.00
260_G290_D1.1081.00
283_A287_A1.1041.00
176_R290_D1.1031.00
35_I50_F1.1021.00
244_Y257_E1.1001.00
22_E88_D1.0931.00
168_V406_G1.0891.00
28_L353_Y1.0861.00
297_Q390_G1.0841.00
157_S265_S1.0811.00
369_L381_V1.0701.00
335_T339_T1.0681.00
33_S368_N1.0661.00
11_L255_Y1.0651.00
13_M352_I1.0631.00
286_N290_D1.0631.00
5_R244_Y1.0601.00
25_W360_D1.0591.00
338_M367_I1.0541.00
370_D383_H1.0521.00
354_S358_L1.0521.00
174_A188_A1.0511.00
316_A376_C1.0511.00
61_D83_V1.0501.00
288_L298_I1.0401.00
293_I297_Q1.0391.00
83_V151_Y1.0371.00
179_A290_D1.0341.00
284_M322_I1.0291.00
288_L295_A1.0271.00
13_M24_T1.0261.00
85_A187_V1.0211.00
148_T265_S1.0211.00
317_Q321_T1.0201.00
200_V232_L1.0171.00
171_I408_L1.0131.00
358_L361_Q1.0111.00
299_G388_V1.0051.00
296_S326_A1.0001.00
323_F395_L0.9901.00
178_I241_L0.9901.00
382_P386_R0.9891.00
218_A370_D0.9831.00
160_I173_H0.9831.00
372_P378_L0.9821.00
369_L383_H0.9821.00
86_M151_Y0.9821.00
184_D243_E0.9811.00
168_V408_L0.9811.00
284_M397_N0.9791.00
354_S396_C0.9781.00
81_A84_Q0.9771.00
309_P375_G0.9711.00
142_M272_S0.9671.00
284_M395_L0.9641.00
12_G85_A0.9621.00
25_W364_P0.9561.00
120_T123_M0.9561.00
9_T242_E0.9551.00
299_G390_G0.9531.00
104_A186_M0.9531.00
172_G182_D0.9511.00
313_K317_Q0.9491.00
120_T124_N0.9481.00
245_E248_K0.9481.00
101_I153_L0.9451.00
171_I188_A0.9421.00
286_N289_R0.9381.00
11_L355_I0.9311.00
173_H176_R0.9291.00
355_I410_F0.9271.00
361_Q390_G0.9271.00
288_L323_F0.9251.00
378_L381_V0.9201.00
232_L343_L0.9171.00
175_A290_D0.9161.00
119_H123_M0.9131.00
257_E411_K0.9081.00
388_V391_M0.9071.00
379_D386_R0.9061.00
247_A254_I0.9041.00
29_L360_D0.9041.00
54_V77_Y0.9021.00
18_G27_A0.9011.00
172_G176_R0.9001.00
77_Y236_A0.8991.00
167_G348_A0.8981.00
174_A186_M0.8931.00
7_V257_E0.8921.00
22_E26_K0.8911.00
31_G365_P0.8871.00
303_A332_V0.8871.00
350_E396_C0.8851.00
15_S352_I0.8841.00
302_N350_E0.8801.00
235_G349_V0.8761.00
175_A261_F0.8751.00
20_T84_Q0.8741.00
78_G189_G0.8721.00
277_G317_Q0.8711.00
288_L293_I0.8691.00
278_A281_A0.8661.00
305_G311_G0.8601.00
162_T169_H0.8591.00
86_M187_V0.8581.00
7_V244_Y0.8581.00
31_G384_E0.8551.00
298_I323_F0.8551.00
167_G190_G0.8541.00
39_D53_L0.8531.00
380_F383_H0.8521.00
293_I409_I0.8491.00
118_N121_S0.8491.00
305_G334_S0.8471.00
358_L391_M0.8441.00
301_V395_L0.8431.00
154_R278_A0.8431.00
12_G84_Q0.8391.00
11_L88_D0.8391.00
316_A380_F0.8341.00
24_T339_T0.8341.00
287_A409_I0.8321.00
14_L84_Q0.8321.00
103_A153_L0.8291.00
110_G140_V0.8251.00
185_V188_A0.8241.00
210_S221_R0.8181.00
298_I409_I0.8171.00
287_A291_A0.8161.00
64_S67_E0.8151.00
25_W29_L0.8121.00
168_V347_G0.8091.00
11_L356_L0.8081.00
264_S282_L0.8071.00
57_F80_V0.8061.00
18_G34_G0.8061.00
243_E248_K0.8041.00
33_S367_I0.8011.00
34_G52_G0.8001.00
25_W356_L0.8001.00
284_M318_A0.7981.00
282_L285_A0.7971.00
187_V238_M0.7931.00
22_E360_D0.7901.00
246_H250_R0.7891.00
35_I231_V0.7891.00
280_A399_F0.7881.00
107_S140_V0.7861.00
271_T274_P0.7831.00
17_V27_A0.7811.00
334_S366_T0.7791.00
285_A321_T0.7791.00
316_A320_K0.7791.00
48_T204_G0.7781.00
354_S357_A0.7781.00
108_G344_G0.7761.00
47_A207_R0.7741.00
86_M240_V0.7731.00
14_L80_V0.7681.00
342_L345_A0.7651.00
145_G157_S0.7641.00
244_Y254_I0.7601.00
278_A282_L0.7601.00
323_F330_V0.7591.00
270_M274_P0.7581.00
82_G85_A0.7571.00
201_G204_G0.7561.00
304_H308_T0.7551.00
7_V254_I0.7551.00
104_A183_A0.7551.00
259_V293_I0.7501.00
284_M288_L0.7471.00
43_T49_K0.7471.00
299_G393_Y0.7471.00
382_P385_A0.7471.00
285_A322_I0.7431.00
188_A241_L0.7421.00
79_I150_M0.7421.00
36_S53_L0.7401.00
366_T381_V0.7401.00
135_V202_G0.7401.00
185_V246_H0.7391.00
23_S27_A0.7391.00
191_A236_A0.7371.00
291_A409_I0.7361.00
324_G327_A0.7361.00
363_V391_M0.7351.00
372_P381_V0.7351.00
99_T184_D0.7341.00
355_I358_L0.7331.00
121_S125_G0.7331.00
107_S159_S0.7321.00
168_V396_C0.7321.00
263_M406_G0.7321.00
171_I348_A0.7301.00
89_S240_V0.7291.00
156_P183_A0.7271.00
301_V330_V0.7261.00
14_L81_A0.7231.00
104_A158_I0.7231.00
82_G151_Y0.7201.00
182_D290_D0.7201.00
284_M319_V0.7191.00
27_A30_A0.7191.00
256_A410_F0.7141.00
264_S286_N0.7111.00
285_A325_E0.7091.00
308_T311_G0.7081.00
288_L409_I0.7061.00
21_V356_L0.7041.00
19_N56_D0.7041.00
96_E101_I0.7011.00
74_F191_A0.7001.00
99_T154_R0.7001.00
302_N353_Y0.6981.00
277_G318_A0.6971.00
130_I201_G0.6951.00
171_I239_L0.6951.00
171_I258_L0.6941.00
208_A230_F0.6921.00
38_I53_L0.6921.00
10_G85_A0.6911.00
38_I41_F0.6871.00
39_D43_T0.6851.00
50_F219_A0.6811.00
300_Y394_T0.6781.00
17_V36_S0.6781.00
40_H73_A0.6781.00
103_A147_L0.6771.00
277_G281_A0.6731.00
248_K254_I0.6711.00
355_I359_R0.6701.00
168_V398_S0.6681.00
283_A407_S0.6681.00
310_A314_A0.6661.00
313_K375_G0.6651.00
153_L187_V0.6631.00
317_Q375_G0.6631.00
320_K377_D0.6571.00
335_T353_Y0.6561.00
38_I200_V0.6551.00
21_V88_D0.6551.00
28_L356_L0.6541.00
320_K324_G0.6541.00
258_L408_L0.6531.00
203_F208_A0.6521.00
5_R179_A0.6501.00
245_E249_K0.6491.00
326_A329_R0.6481.00
299_G391_M0.6471.00
73_A76_Q0.6431.00
185_V242_E0.6411.00
75_I142_M0.6391.00
38_I51_A0.6371.00
320_K378_L0.6371.00
220_S230_F0.6361.00
98_A152_G0.6361.00
192_E343_L0.6351.00
86_M153_L0.6341.00
51_A200_V0.6341.00
316_A378_L0.6311.00
260_G287_A0.6301.00
84_Q88_D0.6301.00
16_P342_L0.6271.00
141_N163_A0.6271.00
361_Q387_Q0.6271.00
274_P310_A0.6251.00
24_T349_V0.6241.00
278_A321_T0.6231.00
24_T28_L0.6221.00
339_T342_L0.6221.00
391_M411_K0.6221.00
158_I162_T0.6221.00
142_M401_F0.6191.00
203_F401_F0.6181.00
357_A388_V0.6181.00
188_A239_L0.6161.00
230_F343_L0.6141.00
75_I143_V0.6141.00
86_M96_E0.6131.00
277_G314_A0.6121.00
227_R373_D0.6121.00
329_R380_F0.6121.00
177_I186_M0.6111.00
242_E246_H0.6101.00
238_M348_A0.6091.00
139_I142_M0.6061.00
363_V386_R0.6061.00
264_S279_G0.6051.00
78_G82_G0.6041.00
102_G177_I0.6031.00
80_V84_Q0.6021.00
221_R370_D0.6011.00
281_A318_A0.6011.00
18_G55_K0.6001.00
293_I298_I0.6001.00
180_Y290_D0.5981.00
331_L388_V0.5951.00
118_N122_L0.5941.00
173_H177_I0.5921.00
105_I144_A0.5921.00
221_R368_N0.5911.00
9_T252_A0.5901.00
263_M404_T0.5891.00
358_L394_T0.5881.00
17_V24_T0.5871.00
6_V243_E0.5861.00
188_A348_A0.5851.00
21_V24_T0.5851.00
210_S217_Q0.5841.00
8_V410_F0.5841.00
280_A318_A0.5831.00
42_D46_Y0.5831.00
100_R282_L0.5811.00
163_A401_F0.5791.00
288_L407_S0.5791.00
6_V178_I0.5791.00
302_N354_S0.5791.00
333_S364_P0.5781.00
331_L381_V0.5761.00
98_A154_R0.5731.00
154_R279_G0.5731.00
74_F143_V0.5721.00
208_A401_F0.5711.00
71_M146_H0.5691.00
178_I246_H0.5691.00
303_A334_S0.5671.00
84_Q87_Q0.5661.00
40_H53_L0.5661.00
9_T185_V0.5651.00
104_A173_H0.5641.00
258_L410_F0.5621.00
37_L43_T0.5621.00
237_G345_A0.5621.00
51_A54_V0.5601.00
94_T97_N0.5601.00
63_I80_V0.5601.00
18_G23_S0.5601.00
388_V394_T0.5591.00
91_L240_V0.5581.00
61_D87_Q0.5571.00
41_F200_V0.5571.00
169_H173_H0.5531.00
62_I80_V0.5511.00
318_A322_I0.5491.00
303_A319_V0.5491.00
357_A394_T0.5491.00
4_R179_A0.5481.00
320_K328_S0.5481.00
297_Q392_E0.5461.00
85_A89_S0.5451.00
43_T46_Y0.5441.00
220_S231_V0.5381.00
57_F62_I0.5381.00
107_S110_G0.5381.00
351_S355_I0.5371.00
133_F136_P0.5371.00
276_N279_G0.5361.00
220_S307_S0.5351.00
354_S410_F0.5351.00
21_V352_I0.5331.00
311_G314_A0.5331.00
338_M365_P0.5331.00
91_L185_V0.5331.00
166_S170_N0.5311.00
174_A241_L0.5291.00
396_C410_F0.5291.00
19_N84_Q0.5281.00
224_D368_N0.5271.00
217_Q231_V0.5271.00
181_G243_E0.5271.00
300_Y357_A0.5261.00
172_G263_M0.5261.00
177_I180_Y0.5241.00
16_P52_G0.5241.00
222_P230_F0.5241.00
41_F44_S0.5211.00
372_P377_D0.5211.00
14_L77_Y0.5211.00
309_P313_K0.5201.00
226_E369_L0.5201.00
266_D269_H0.5181.00
225_K373_D0.5171.00
333_S363_V0.5161.00
122_L125_G0.5161.00
97_N101_I0.5161.00
16_P233_G0.5161.00
15_S342_L0.5141.00
346_A398_S0.5131.00
91_L242_E0.5120.99
144_A157_S0.5120.99
358_L392_E0.5110.99
396_C408_L0.5110.99
352_I356_L0.5100.99
10_G253_K0.5100.99
178_I181_G0.5090.99
188_A238_M0.5090.99
156_P177_I0.5080.99
46_Y201_G0.5070.99
5_R245_E0.5050.99
15_S24_T0.5050.99
193_K234_D0.5040.99
127_P130_I0.5040.99
132_P202_G0.5040.99
75_I146_H0.5030.99
348_A352_I0.5030.99
15_S18_G0.5030.99
93_I97_N0.5010.99
77_Y193_K0.5000.99
274_P278_A0.5000.99
201_G205_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vz8A 2 0.954 100 0.049 Contact Map
4na1A 2 0.9685 100 0.115 Contact Map
4jrmD 2 0.9952 100 0.131 Contact Map
4tktA 1 0.9661 100 0.132 Contact Map
4qyrA 2 0.9588 100 0.134 Contact Map
1e5mA 2 0.9927 100 0.134 Contact Map
2hg4A 2 0.9685 100 0.135 Contact Map
1ox0A 2 0.9879 100 0.136 Contact Map
4mz0A 2 0.9685 100 0.137 Contact Map
2gqdA 2 0.9879 100 0.139 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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