FTSH - ECOLI - GREMLIN Contacts

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FTSH - ATP-dependent zinc metalloprotease FtsH

UniProt:	P0AAI3	Sequences: MAKNLILWLVIAVVLMSVFQSFGPSESNGRKVDYSTFLQEVNNDQVREARINGREINVTKKDSNRYTTYIPVQDPKLLDNLLTKNVKVVGEPPEEPSLLASIFISWFPMLLLIGVWIFFMRQMQGGGGKGAMSFGKSKARMLTEDQIKTTFADVAGCDEAKEEVAELVEYLREPSRFQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGVGASRVRDMFEQAKKAAPCIIFIDEIDAVGRQRGAGLGGGHDEREQTLNQMLVEMDGFEGNEGIIVIAATNRPDVLDPALLRPGRFDRQVVVGLPDVRGREQILKVHMRRVPLAPDIDAAIIARGTPGFSGADLANLVNEAALFAARGNKRVVSMVEFEKAKDKIMMGAERRSMVMTEAQKESTAYHEAGHAIIGRLVPEHDPVHKVTIIPRGRALGVTFFLPEGDAISASRQKLESQISTLYGGRLAEEIIYGPEHVSTGASNDIKVATNLARNMVTQWGFSEKLGPLLYAEEEGEVFLGRSVAKAKHMSDETARIIDQEVKALIERNYNRARQLLTDNMDILHAMKDALMKYETIDAPQIDDLMARRDVRPPAGWEEPGASNNSGDNGSPKAPRPVDEPRTPNPGNTMSEQLGDK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11506
Length:	644 (590)
Sequences:	4859 (2658)
Seq/√Len:	109.4

ECOLI - FTSH
BACSU - FTSH

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
568_M	572_H	5.829	1.00
562_Q	566_D	4.867	1.00
328_E	347_A	3.927	1.00
551_A	555_R	3.881	1.00
321_L	357_S	3.786	1.00
466_I	556_N	3.621	1.00
479_I	568_M	3.604	1.00
335_M	365_V	3.601	1.00
169_E	177_F	3.588	1.00
328_E	332_K	3.585	1.00
338_V	380_V	3.445	1.00
377_K	384_E	3.442	1.00
540_E	543_R	3.409	1.00
40_E	45_Q	3.359	1.00
424_L	563_L	3.250	1.00
238_E	242_K	3.238	1.00
512_K	544_I	3.208	1.00
335_M	346_A	3.187	1.00
331_L	361_L	3.145	1.00
581_Y	588_Q	3.080	1.00
477_E	561_R	3.065	1.00
572_H	576_D	3.029	1.00
365_V	385_F	2.965	1.00
504_V	552_L	2.906	1.00
421_I	467_S	2.869	1.00
561_R	565_T	2.864	1.00
478_I	564_L	2.835	1.00
424_L	567_N	2.808	1.00
479_I	571_L	2.804	1.00
460_Q	484_H	2.781	1.00
512_K	548_E	2.752	1.00
491_N	494_K	2.748	1.00
377_K	381_S	2.745	1.00
467_S	556_N	2.735	1.00
427_E	464_S	2.733	1.00
567_N	570_I	2.717	1.00
179_K	378_R	2.716	1.00
479_I	572_H	2.703	1.00
409_E	576_D	2.700	1.00
466_I	500_A	2.615	1.00
469_L	495_V	2.597	1.00
66_Y	71_P	2.585	1.00
416_A	574_M	2.521	1.00
477_E	557_Y	2.520	1.00
512_K	547_Q	2.481	1.00
496_A	553_I	2.427	1.00
550_K	554_E	2.417	1.00
411_T	456_S	2.416	1.00
466_I	552_L	2.403	1.00
381_S	384_E	2.398	1.00
422_G	448_F	2.371	1.00
467_S	560_A	2.345	1.00
175_S	179_K	2.336	1.00
474_L	561_R	2.327	1.00
115_V	119_F	2.319	1.00
375_G	387_K	2.265	1.00
183_K	362_A	2.256	1.00
558_N	562_Q	2.228	1.00
76_K	79_D	2.216	1.00
462_L	499_L	2.215	1.00
487_T	507_W	2.161	1.00
448_F	468_T	2.160	1.00
502_N	507_W	2.151	1.00
557_Y	561_R	2.123	1.00
435_T	583_T	2.114	1.00
510_S	548_E	2.077	1.00
375_G	384_E	2.059	1.00
33_D	36_T	2.054	1.00
422_G	468_T	2.050	1.00
491_N	495_V	2.041	1.00
164_V	205_I	2.025	1.00
425_V	464_S	2.020	1.00
214_F	243_A	1.998	1.00
454_A	461_K	1.991	1.00
502_N	506_Q	1.988	1.00
577_A	584_I	1.984	1.00
423_R	590_D	1.979	1.00
463_E	555_R	1.968	1.00
44_D	84_K	1.958	1.00
257_G	307_L	1.952	1.00
37_F	41_V	1.945	1.00
478_I	565_T	1.922	1.00
329_Q	332_K	1.917	1.00
408_K	579_M	1.908	1.00
459_R	463_E	1.903	1.00
372_A	384_E	1.899	1.00
463_E	556_N	1.891	1.00
41_V	46_V	1.860	1.00
342_P	379_V	1.857	1.00
516_L	553_I	1.851	1.00
176_R	376_N	1.833	1.00
467_S	559_R	1.830	1.00
341_A	379_V	1.795	1.00
585_D	588_Q	1.782	1.00
410_S	480_Y	1.765	1.00
113_I	117_I	1.758	1.00
42_N	80_N	1.740	1.00
48_E	59_T	1.713	1.00
46_V	60_K	1.688	1.00
443_L	456_S	1.688	1.00
434_V	446_T	1.675	1.00
338_V	365_V	1.671	1.00
464_S	559_R	1.661	1.00
431_V	446_T	1.660	1.00
406_A	409_E	1.659	1.00
335_M	385_F	1.654	1.00
79_D	83_T	1.646	1.00
98_L	102_I	1.645	1.00
241_K	288_N	1.645	1.00
410_S	486_S	1.634	1.00
325_R	328_E	1.631	1.00
577_A	581_Y	1.630	1.00
554_E	558_N	1.628	1.00
167_L	188_V	1.626	1.00
68_T	71_P	1.607	1.00
109_M	113_I	1.593	1.00
110_L	114_G	1.585	1.00
158_D	326_G	1.585	1.00
518_Y	545_I	1.577	1.00
462_L	487_T	1.567	1.00
340_L	346_A	1.562	1.00
576_D	580_K	1.554	1.00
459_R	511_E	1.552	1.00
565_T	568_M	1.544	1.00
37_F	49_A	1.535	1.00
465_Q	495_V	1.516	1.00
420_I	574_M	1.509	1.00
201_L	319_V	1.505	1.00
69_Y	72_V	1.499	1.00
413_Y	572_H	1.493	1.00
48_E	87_K	1.478	1.00
341_A	381_S	1.475	1.00
543_R	547_Q	1.469	1.00
558_N	561_R	1.466	1.00
66_Y	69_Y	1.455	1.00
246_C	291_I	1.451	1.00
469_L	499_L	1.451	1.00
428_H	468_T	1.450	1.00
442_A	445_V	1.448	1.00
383_V	387_K	1.447	1.00
345_D	348_I	1.438	1.00
559_R	562_Q	1.431	1.00
474_L	557_Y	1.429	1.00
390_D	433_K	1.418	1.00
409_E	480_Y	1.417	1.00
114_G	118_F	1.402	1.00
413_Y	576_D	1.397	1.00
36_T	40_E	1.385	1.00
548_E	551_A	1.384	1.00
67_T	70_I	1.377	1.00
106_W	110_L	1.368	1.00
49_A	56_I	1.368	1.00
586_A	590_D	1.359	1.00
428_H	464_S	1.357	1.00
80_N	84_K	1.350	1.00
371_F	384_E	1.348	1.00
540_E	544_I	1.347	1.00
570_I	593_M	1.340	1.00
570_I	573_A	1.339	1.00
544_I	547_Q	1.338	1.00
458_S	486_S	1.337	1.00
493_I	517_L	1.331	1.00
428_H	448_F	1.325	0.99
32_V	58_V	1.315	0.99
40_E	60_K	1.305	0.99
478_I	561_R	1.303	0.99
498_N	502_N	1.299	0.99
67_T	71_P	1.289	0.99
420_I	571_L	1.287	0.99
77_L	81_L	1.280	0.99
500_A	552_L	1.278	0.99
36_T	39_Q	1.276	0.99
432_H	449_L	1.272	0.99
262_A	526_F	1.271	0.99
424_L	570_I	1.271	0.99
108_P	111_L	1.267	0.99
39_Q	43_N	1.266	0.99
473_R	489_A	1.265	0.99
117_I	121_R	1.259	0.99
526_F	529_R	1.257	0.99
474_L	565_T	1.254	0.99
463_E	467_S	1.253	0.99
67_T	72_V	1.243	0.99
537_M	542_A	1.243	0.99
421_I	560_A	1.243	0.99
82_L	88_V	1.236	0.99
480_Y	486_S	1.235	0.99
239_Q	242_K	1.230	0.99
240_A	248_I	1.220	0.99
573_A	595_R	1.220	0.99
149_T	203_K	1.212	0.99
136_K	139_A	1.209	0.99
478_I	568_M	1.209	0.99
352_G	389_K	1.208	0.99
193_P	320_G	1.208	0.99
414_H	418_H	1.204	0.99
151_F	168_V	1.198	0.99
574_M	592_L	1.197	0.99
386_E	432_H	1.197	0.99
41_V	84_K	1.191	0.99
405_E	409_E	1.189	0.99
513_L	518_Y	1.183	0.99
469_L	496_A	1.181	0.99
160_A	320_G	1.180	0.99
364_L	389_K	1.178	0.99
560_A	563_L	1.178	0.99
421_I	471_G	1.172	0.99
573_A	577_A	1.171	0.99
434_V	589_I	1.167	0.99
131_A	134_F	1.166	0.99
406_A	452_G	1.165	0.99
203_K	287_G	1.161	0.99
577_A	591_D	1.159	0.99
475_A	571_L	1.158	0.99
15_L	19_F	1.156	0.99
469_L	491_N	1.155	0.99
418_H	488_G	1.149	0.99
335_M	340_L	1.148	0.99
205_I	294_I	1.147	0.99
259_Q	529_R	1.141	0.98
328_E	346_A	1.133	0.98
220_D	277_Q	1.126	0.98
107_F	110_L	1.123	0.98
423_R	589_I	1.118	0.98
47_R	61_K	1.118	0.98
513_L	545_I	1.118	0.98
463_E	559_R	1.110	0.98
425_V	428_H	1.108	0.98
325_R	329_Q	1.105	0.98
587_P	591_D	1.104	0.98
137_S	235_D	1.104	0.98
264_L	527_L	1.103	0.98
591_D	596_R	1.100	0.98
389_K	394_M	1.096	0.98
421_I	563_L	1.095	0.98
34_Y	74_D	1.092	0.98
474_L	560_A	1.091	0.98
588_Q	591_D	1.087	0.98
512_K	551_A	1.085	0.98
81_L	86_V	1.083	0.98
457_A	461_K	1.080	0.98
387_K	397_E	1.076	0.98
32_V	40_E	1.075	0.98
347_A	351_R	1.073	0.98
356_F	364_L	1.072	0.98
564_L	571_L	1.070	0.98
591_D	595_R	1.068	0.98
158_D	329_Q	1.065	0.98
429_D	465_Q	1.064	0.98
144_E	147_I	1.058	0.98
8_W	12_A	1.058	0.98
416_A	575_K	1.056	0.97
493_I	516_L	1.052	0.97
10_V	17_S	1.050	0.97
448_F	469_L	1.047	0.97
481_G	484_H	1.043	0.97
412_A	579_M	1.040	0.97
108_P	123_M	1.040	0.97
180_L	373_A	1.037	0.97
419_A	584_I	1.035	0.97
323_D	326_G	1.035	0.97
466_I	496_A	1.032	0.97
14_V	18_V	1.031	0.97
394_M	401_M	1.028	0.97
331_L	349_I	1.025	0.97
410_S	456_S	1.024	0.97
573_A	592_L	1.022	0.97
222_V	270_E	1.021	0.97
246_C	290_G	1.021	0.97
407_Q	456_S	1.019	0.97
162_E	165_A	1.019	0.97
112_L	116_W	1.018	0.97
44_D	85_N	1.015	0.97
413_Y	479_I	1.006	0.97
535_K	539_D	1.002	0.97
8_W	22_F	1.002	0.97
188_V	292_I	0.997	0.96
348_I	386_E	0.991	0.96
574_M	589_I	0.990	0.96
467_S	563_L	0.989	0.96
416_A	420_I	0.978	0.96
167_L	205_I	0.977	0.96
118_F	122_Q	0.977	0.96
38_L	82_L	0.971	0.96
414_H	488_G	0.971	0.96
448_F	465_Q	0.968	0.96
413_Y	575_K	0.966	0.96
431_V	434_V	0.966	0.96
49_A	81_L	0.962	0.96
495_V	498_N	0.962	0.96
71_P	74_D	0.960	0.96
258_R	302_V	0.959	0.96
435_T	445_V	0.959	0.96
410_S	443_L	0.956	0.95
200_L	358_G	0.955	0.95
352_G	391_K	0.952	0.95
70_I	73_Q	0.951	0.95
104_I	108_P	0.950	0.95
33_D	87_K	0.949	0.95
544_I	550_K	0.948	0.95
577_A	580_K	0.945	0.95
331_L	346_A	0.944	0.95
405_E	408_K	0.940	0.95
494_K	498_N	0.940	0.95
565_T	569_D	0.937	0.95
255_A	280_V	0.936	0.95
47_R	59_T	0.935	0.95
574_M	584_I	0.932	0.95
62_D	65_R	0.931	0.95
139_A	142_L	0.931	0.95
390_D	445_V	0.926	0.95
556_N	559_R	0.923	0.95
184_I	292_I	0.923	0.95
202_A	358_G	0.923	0.95
406_A	410_S	0.922	0.94
98_L	104_I	0.921	0.94
79_D	82_L	0.920	0.94
515_P	554_E	0.910	0.94
163_E	391_K	0.910	0.94
348_I	382_M	0.909	0.94
500_A	549_V	0.904	0.94
74_D	77_L	0.903	0.94
109_M	114_G	0.902	0.94
17_S	21_S	0.901	0.94
69_Y	73_Q	0.898	0.94
594_A	597_D	0.894	0.94
562_Q	565_T	0.894	0.94
169_E	173_E	0.891	0.93
423_R	593_M	0.890	0.93
510_S	551_A	0.890	0.93
461_K	465_Q	0.889	0.93
577_A	588_Q	0.884	0.93
32_V	36_T	0.884	0.93
37_F	58_V	0.882	0.93
157_C	326_G	0.880	0.93
569_D	573_A	0.876	0.93
505_T	545_I	0.873	0.93
300_P	527_L	0.873	0.93
462_L	507_W	0.873	0.93
590_D	594_A	0.867	0.92
102_I	106_W	0.867	0.92
38_L	80_N	0.866	0.92
464_S	467_S	0.865	0.92
19_F	23_G	0.860	0.92
16_M	20_Q	0.859	0.92
188_V	317_V	0.858	0.92
391_K	394_M	0.858	0.92
107_F	114_G	0.857	0.92
443_L	455_I	0.857	0.92
163_E	396_A	0.857	0.92
465_Q	469_L	0.855	0.92
214_F	239_Q	0.854	0.92
349_I	361_L	0.851	0.92
547_Q	551_A	0.851	0.92
132_M	135_G	0.850	0.92
349_I	385_F	0.849	0.92
544_I	548_E	0.849	0.92
109_M	115_V	0.849	0.92
78_L	88_V	0.848	0.92
116_W	120_M	0.847	0.92
324_V	347_A	0.845	0.92
434_V	584_I	0.843	0.91
108_P	121_R	0.841	0.91
460_Q	464_S	0.840	0.91
190_M	370_L	0.839	0.91
513_L	544_I	0.837	0.91
164_V	167_L	0.837	0.91
40_E	58_V	0.836	0.91
37_F	56_I	0.836	0.91
8_W	20_Q	0.835	0.91
66_Y	70_I	0.833	0.91
240_A	291_I	0.833	0.91
595_R	598_V	0.831	0.91
109_M	116_W	0.831	0.91
235_D	239_Q	0.830	0.91
157_C	160_A	0.830	0.91
264_L	529_R	0.829	0.91
50_R	57_N	0.829	0.91
268_H	271_R	0.828	0.91
419_A	434_V	0.827	0.91
539_D	543_R	0.825	0.91
113_I	116_W	0.823	0.90
244_A	290_G	0.821	0.90
513_L	541_T	0.821	0.90
409_E	413_Y	0.810	0.90
18_V	22_F	0.809	0.90
338_V	385_F	0.807	0.90
427_E	460_Q	0.806	0.89
368_A	385_F	0.806	0.89
397_E	445_V	0.803	0.89
243_A	246_C	0.802	0.89
504_V	549_V	0.802	0.89
433_K	583_T	0.801	0.89
125_G	130_G	0.801	0.89
32_V	37_F	0.801	0.89
573_A	576_D	0.800	0.89
465_Q	499_L	0.799	0.89
30_R	36_T	0.799	0.89
286_E	289_E	0.795	0.89
169_E	176_R	0.794	0.89
572_H	575_K	0.794	0.89
13_V	17_S	0.789	0.88
480_Y	485_V	0.789	0.88
352_G	390_D	0.788	0.88
109_M	112_L	0.788	0.88
552_L	556_N	0.786	0.88
175_S	178_Q	0.786	0.88
390_D	447_F	0.785	0.88
348_I	351_R	0.784	0.88
591_D	599_R	0.784	0.88
38_L	46_V	0.783	0.88
106_W	109_M	0.783	0.88
434_V	445_V	0.780	0.88
34_Y	37_F	0.780	0.88
571_L	575_K	0.780	0.88
108_P	112_L	0.779	0.88
264_L	526_F	0.776	0.88
12_A	20_Q	0.775	0.88
165_A	169_E	0.775	0.88
262_A	528_G	0.773	0.87
403_M	408_K	0.772	0.87
42_N	84_K	0.770	0.87
78_L	82_L	0.770	0.87
58_V	66_Y	0.770	0.87
112_L	115_V	0.767	0.87
69_Y	74_D	0.767	0.87
14_V	17_S	0.765	0.87
403_M	411_T	0.763	0.87
129_K	167_L	0.761	0.87
410_S	484_H	0.760	0.87
470_Y	560_A	0.760	0.87
249_F	296_A	0.759	0.86
217_S	280_V	0.758	0.86
50_R	91_E	0.757	0.86
189_L	316_Q	0.757	0.86
48_E	89_V	0.756	0.86
13_V	16_M	0.754	0.86
555_R	562_Q	0.754	0.86
111_L	115_V	0.752	0.86
80_N	83_T	0.751	0.86
403_M	443_L	0.750	0.86
404_T	452_G	0.749	0.86
480_Y	579_M	0.749	0.86
17_S	22_F	0.749	0.86
178_Q	290_G	0.749	0.86
137_S	140_R	0.748	0.86
76_K	80_N	0.748	0.86
587_P	590_D	0.748	0.86
466_I	553_I	0.747	0.86
97_S	101_S	0.746	0.86
136_K	140_R	0.745	0.85
338_V	443_L	0.743	0.85
554_E	557_Y	0.741	0.85
570_I	592_L	0.739	0.85
134_F	228_V	0.738	0.85
334_H	362_A	0.737	0.85
222_V	271_R	0.734	0.85
420_I	424_L	0.734	0.85
191_V	300_P	0.733	0.85
40_E	43_N	0.731	0.84
41_V	86_V	0.731	0.84
56_I	60_K	0.731	0.84
41_V	81_L	0.729	0.84
44_D	61_K	0.727	0.84
456_S	486_S	0.727	0.84
380_V	385_F	0.726	0.84
132_M	136_K	0.724	0.84
166_E	374_R	0.723	0.84
11_I	20_Q	0.723	0.84
520_E	536_H	0.723	0.84
371_F	387_K	0.722	0.84
535_K	542_A	0.720	0.83
409_E	579_M	0.719	0.83
421_I	424_L	0.719	0.83
539_D	542_A	0.718	0.83
180_L	372_A	0.718	0.83
170_Y	184_I	0.718	0.83
496_A	560_A	0.718	0.83
46_V	58_V	0.717	0.83
157_C	205_I	0.717	0.83
108_P	118_F	0.717	0.83
422_G	447_F	0.717	0.83
114_G	117_I	0.716	0.83
152_A	329_Q	0.715	0.83
191_V	317_V	0.715	0.83
506_Q	517_L	0.715	0.83
514_G	557_Y	0.714	0.83
170_Y	285_F	0.714	0.83
426_P	464_S	0.713	0.83
11_I	14_V	0.712	0.83
147_I	150_T	0.711	0.83
480_Y	575_K	0.711	0.83
191_V	316_Q	0.711	0.83
354_P	449_L	0.710	0.83
352_G	386_E	0.710	0.83
109_M	123_M	0.709	0.83
317_V	391_K	0.708	0.82
116_W	123_M	0.707	0.82
263_G	266_G	0.707	0.82
127_G	130_G	0.705	0.82
108_P	116_W	0.704	0.82
224_M	228_V	0.703	0.82
188_V	294_I	0.699	0.82
389_K	445_V	0.697	0.81
190_M	588_Q	0.696	0.81
500_A	504_V	0.696	0.81
130_G	133_S	0.696	0.81
8_W	15_L	0.694	0.81
97_S	100_A	0.694	0.81
8_W	16_M	0.693	0.81
586_A	589_I	0.692	0.81
460_Q	481_G	0.690	0.81
425_V	467_S	0.690	0.81
258_R	269_D	0.688	0.81
180_L	584_I	0.687	0.80
418_H	492_D	0.687	0.80
105_S	112_L	0.686	0.80
107_F	111_L	0.686	0.80
407_Q	454_A	0.685	0.80
398_R	411_T	0.685	0.80
514_G	550_K	0.683	0.80
340_L	344_I	0.683	0.80
146_Q	210_K	0.681	0.80
581_Y	595_R	0.680	0.80
421_I	431_V	0.679	0.80
316_Q	441_R	0.678	0.80
386_E	390_D	0.675	0.79
470_Y	496_A	0.674	0.79
37_F	81_L	0.673	0.79
333_V	362_A	0.673	0.79
34_Y	38_L	0.669	0.79
159_E	323_D	0.667	0.79
570_I	596_R	0.667	0.79
415_E	418_H	0.667	0.79
72_V	77_L	0.666	0.78
411_T	455_I	0.665	0.78
386_E	592_L	0.665	0.78
480_Y	571_L	0.664	0.78
38_L	42_N	0.664	0.78
424_L	593_M	0.664	0.78
73_Q	76_K	0.663	0.78
152_A	336_R	0.663	0.78
20_Q	24_P	0.663	0.78
401_M	507_W	0.663	0.78
340_L	365_V	0.663	0.78
458_S	484_H	0.661	0.78
123_M	126_G	0.659	0.78
153_D	336_R	0.659	0.78
8_W	18_V	0.658	0.78
457_A	499_L	0.658	0.78
562_Q	567_N	0.656	0.77
555_R	559_R	0.656	0.77
31_K	36_T	0.656	0.77
511_E	551_A	0.656	0.77
135_G	231_S	0.654	0.77
541_T	544_I	0.651	0.77
85_N	88_V	0.651	0.77
256_V	301_D	0.651	0.77
130_G	134_F	0.650	0.77
318_V	441_R	0.650	0.77
160_A	433_K	0.648	0.77
12_A	22_F	0.647	0.76
36_T	87_K	0.646	0.76
268_H	529_R	0.646	0.76
145_D	148_K	0.645	0.76
105_S	116_W	0.643	0.76
8_W	17_S	0.643	0.76
500_A	553_I	0.643	0.76
488_G	492_D	0.642	0.76
10_V	13_V	0.641	0.76
371_F	396_A	0.639	0.76
36_T	47_R	0.639	0.76
406_A	484_H	0.638	0.75
263_G	269_D	0.637	0.75
226_V	285_F	0.637	0.75
12_A	16_M	0.636	0.75
18_V	21_S	0.636	0.75
493_I	515_P	0.636	0.75
230_A	273_Q	0.635	0.75
524_E	530_S	0.635	0.75
412_A	504_V	0.634	0.75
409_E	572_H	0.634	0.75
558_N	565_T	0.633	0.75
463_E	552_L	0.633	0.75
222_V	230_A	0.632	0.75
338_V	362_A	0.632	0.75
150_T	200_L	0.632	0.75
58_V	68_T	0.631	0.75
76_K	82_L	0.631	0.75
49_A	86_V	0.630	0.74
407_Q	455_I	0.630	0.74
343_D	381_S	0.629	0.74
398_R	401_M	0.629	0.74
356_F	393_M	0.628	0.74
142_L	145_D	0.628	0.74
8_W	19_F	0.627	0.74
436_I	443_L	0.627	0.74
45_Q	61_K	0.626	0.74
324_V	328_E	0.626	0.74
530_S	536_H	0.624	0.74
222_V	269_D	0.624	0.74
570_I	595_R	0.622	0.74
516_L	545_I	0.622	0.74
417_G	488_G	0.621	0.73
10_V	14_V	0.621	0.73
387_K	439_R	0.620	0.73
103_F	107_F	0.620	0.73
555_R	558_N	0.619	0.73
390_D	456_S	0.619	0.73
50_R	59_T	0.619	0.73
573_A	580_K	0.619	0.73
186_K	290_G	0.616	0.73
425_V	563_L	0.616	0.73
241_K	339_P	0.616	0.73
161_K	168_V	0.615	0.73
151_F	164_V	0.614	0.73
11_I	19_F	0.614	0.73
538_S	543_R	0.614	0.73
160_A	398_R	0.613	0.72
96_P	100_A	0.612	0.72
337_R	380_V	0.609	0.72
403_M	410_S	0.609	0.72
214_F	236_M	0.609	0.72
75_P	78_L	0.608	0.72
186_K	362_A	0.608	0.72
126_G	225_F	0.607	0.72
414_H	417_G	0.606	0.72
516_L	549_V	0.605	0.72
528_G	531_V	0.605	0.72
487_T	491_N	0.604	0.71
49_A	58_V	0.603	0.71
19_F	22_F	0.602	0.71
446_T	471_G	0.602	0.71
527_L	533_K	0.602	0.71
321_L	441_R	0.602	0.71
343_D	382_M	0.601	0.71
475_A	479_I	0.600	0.71
324_V	351_R	0.600	0.71
118_F	121_R	0.600	0.71
291_I	533_K	0.599	0.71
498_N	520_E	0.599	0.71
326_G	357_S	0.599	0.71
244_A	291_I	0.598	0.71
9_L	16_M	0.597	0.71
394_M	461_K	0.597	0.71
437_I	584_I	0.597	0.71
34_Y	77_L	0.597	0.71
157_C	329_Q	0.596	0.70
105_S	113_I	0.596	0.70
44_D	86_V	0.596	0.70
263_G	301_D	0.596	0.70
10_V	19_F	0.595	0.70
527_L	531_V	0.595	0.70
431_V	445_V	0.595	0.70
262_A	529_R	0.594	0.70
106_W	112_L	0.593	0.70
58_V	67_T	0.593	0.70
96_P	101_S	0.592	0.70
77_L	88_V	0.592	0.70
334_H	337_R	0.592	0.70
178_Q	182_G	0.592	0.70
339_P	379_V	0.592	0.70
400_S	403_M	0.591	0.70
462_L	502_N	0.591	0.70
45_Q	62_D	0.590	0.70
429_D	450_P	0.589	0.69
105_S	108_P	0.589	0.69
135_G	139_A	0.588	0.69
277_Q	281_E	0.588	0.69
485_V	557_Y	0.587	0.69
389_K	393_M	0.587	0.69
407_Q	461_K	0.587	0.69
236_M	248_I	0.587	0.69
418_H	444_G	0.586	0.69
270_E	367_E	0.586	0.69
125_G	129_K	0.586	0.69
259_Q	305_P	0.585	0.69
510_S	514_G	0.585	0.69
447_F	457_A	0.585	0.69
179_K	339_P	0.585	0.69
321_L	326_G	0.585	0.69
220_D	280_V	0.584	0.69
214_F	399_R	0.584	0.69
526_F	531_V	0.583	0.69
74_D	90_G	0.581	0.68
300_P	319_V	0.581	0.68
472_G	492_D	0.581	0.68
52_N	57_N	0.581	0.68
104_I	107_F	0.580	0.68
33_D	39_Q	0.580	0.68
447_F	574_M	0.580	0.68
172_R	210_K	0.579	0.68
186_K	293_V	0.578	0.68
393_M	447_F	0.578	0.68
241_K	286_E	0.577	0.68
100_A	103_F	0.577	0.68
278_M	316_Q	0.576	0.68
73_Q	78_L	0.576	0.68
59_T	63_S	0.575	0.68
446_T	493_I	0.575	0.68
133_S	136_K	0.574	0.68
456_S	507_W	0.574	0.68
501_R	549_V	0.574	0.68
112_L	117_I	0.572	0.67
247_I	402_V	0.572	0.67
375_G	383_V	0.571	0.67
9_L	14_V	0.570	0.67
256_V	295_A	0.568	0.67
394_M	432_H	0.567	0.67
594_A	598_V	0.567	0.67
446_T	589_I	0.566	0.66
112_L	119_F	0.566	0.66
428_H	493_I	0.565	0.66
310_P	392_I	0.565	0.66
365_V	368_A	0.565	0.66
13_V	20_Q	0.565	0.66
300_P	318_V	0.564	0.66
401_M	445_V	0.564	0.66
535_K	541_T	0.563	0.66
173_E	176_R	0.563	0.66
224_M	235_D	0.562	0.66
470_Y	553_I	0.562	0.66
540_E	547_Q	0.562	0.66
143_T	148_K	0.562	0.66
467_S	474_L	0.560	0.66
521_E	531_V	0.559	0.65
335_M	361_L	0.559	0.65
529_R	536_H	0.559	0.65
493_I	496_A	0.558	0.65
159_E	326_G	0.558	0.65
414_H	492_D	0.557	0.65
390_D	422_G	0.557	0.65
70_I	74_D	0.556	0.65
333_V	585_D	0.555	0.65
121_R	125_G	0.555	0.65
530_S	533_K	0.555	0.65
11_I	18_V	0.554	0.65
163_E	440_G	0.554	0.65
189_L	300_P	0.553	0.65
13_V	19_F	0.552	0.65
519_A	536_H	0.551	0.64
481_G	485_V	0.551	0.64
390_D	435_T	0.550	0.64
10_V	125_G	0.550	0.64
445_V	448_F	0.549	0.64
523_G	527_L	0.548	0.64
81_L	88_V	0.548	0.64
77_L	80_N	0.547	0.64
597_D	600_P	0.547	0.64
351_R	580_K	0.546	0.64
117_I	120_M	0.546	0.64
11_I	15_L	0.545	0.64
88_V	92_P	0.544	0.63
15_L	22_F	0.544	0.63
431_V	468_T	0.544	0.63
109_M	119_F	0.544	0.63
418_H	489_A	0.543	0.63
382_M	386_E	0.543	0.63
31_K	89_V	0.543	0.63
158_D	325_R	0.543	0.63
109_M	121_R	0.542	0.63
409_E	479_I	0.542	0.63
530_S	537_M	0.542	0.63
576_D	579_M	0.542	0.63
9_L	13_V	0.541	0.63
100_A	104_I	0.541	0.63
556_N	560_A	0.540	0.63
125_G	128_G	0.540	0.63
178_Q	186_K	0.539	0.63
111_L	114_G	0.538	0.63
9_L	17_S	0.538	0.63
42_N	87_K	0.538	0.63
501_R	536_H	0.537	0.62
406_A	461_K	0.537	0.62
573_A	597_D	0.537	0.62
416_A	589_I	0.537	0.62
515_P	557_Y	0.536	0.62
423_R	586_A	0.535	0.62
438_P	473_R	0.535	0.62
136_K	235_D	0.535	0.62
402_V	410_S	0.534	0.62
74_D	78_L	0.534	0.62
15_L	23_G	0.533	0.62
9_L	12_A	0.532	0.62
460_Q	463_E	0.531	0.62
9_L	18_V	0.531	0.62
229_G	274_T	0.531	0.62
258_R	261_G	0.531	0.62
419_A	589_I	0.530	0.61
374_R	391_K	0.530	0.61
42_N	82_L	0.530	0.61
240_A	505_T	0.529	0.61
352_G	449_L	0.529	0.61
444_G	508_G	0.529	0.61
305_P	528_G	0.529	0.61
49_A	88_V	0.528	0.61
516_L	550_K	0.528	0.61
253_I	333_V	0.528	0.61
51_I	90_G	0.528	0.61
155_A	333_V	0.528	0.61
188_V	453_D	0.528	0.61
47_R	62_D	0.528	0.61
477_E	481_G	0.528	0.61
398_R	445_V	0.527	0.61
444_G	488_G	0.527	0.61
577_A	592_L	0.527	0.61
14_V	22_F	0.526	0.61
17_S	20_Q	0.526	0.61
531_V	536_H	0.524	0.61
182_G	380_V	0.524	0.61
448_F	464_S	0.522	0.60
15_L	30_R	0.522	0.60
471_G	493_I	0.521	0.60
265_G	529_R	0.521	0.60
353_T	361_L	0.521	0.60
53_G	74_D	0.521	0.60
564_L	574_M	0.521	0.60
415_E	444_G	0.520	0.60
241_K	289_E	0.519	0.60
148_K	203_K	0.519	0.60
59_T	62_D	0.518	0.60
379_V	593_M	0.518	0.60
432_H	447_F	0.518	0.60
501_R	505_T	0.517	0.60
489_A	492_D	0.517	0.60
19_F	106_W	0.517	0.60
458_S	461_K	0.517	0.60
300_P	441_R	0.517	0.60
217_S	269_D	0.516	0.59
104_I	109_M	0.516	0.59
365_V	380_V	0.516	0.59
137_S	141_M	0.515	0.59
183_K	454_A	0.515	0.59
38_L	88_V	0.515	0.59
182_G	583_T	0.514	0.59
324_V	402_V	0.514	0.59
323_D	401_M	0.514	0.59
183_K	337_R	0.512	0.59
70_I	92_P	0.512	0.59
523_G	530_S	0.512	0.59
66_Y	72_V	0.512	0.59
9_L	20_Q	0.511	0.59
9_L	22_F	0.511	0.59
406_A	427_E	0.511	0.59
592_L	595_R	0.511	0.59
108_P	114_G	0.511	0.59
164_V	188_V	0.511	0.59
67_T	73_Q	0.511	0.59
394_M	421_I	0.510	0.59
422_G	433_K	0.509	0.58
348_I	352_G	0.509	0.58
411_T	469_L	0.509	0.58
20_Q	23_G	0.509	0.58
437_I	553_I	0.509	0.58
11_I	16_M	0.509	0.58
435_T	446_T	0.509	0.58
377_K	383_V	0.508	0.58
371_F	388_A	0.508	0.58
387_K	396_A	0.508	0.58
74_D	81_L	0.507	0.58
69_Y	75_P	0.507	0.58
408_K	437_I	0.506	0.58
435_T	438_P	0.505	0.58
164_V	292_I	0.505	0.58
435_T	495_V	0.505	0.58
39_Q	83_T	0.505	0.58
72_V	75_P	0.504	0.58
99_L	102_I	0.504	0.58
397_E	443_L	0.504	0.58
413_Y	480_Y	0.504	0.58
41_V	80_N	0.504	0.58
538_S	541_T	0.503	0.57
97_S	102_I	0.503	0.57
415_E	473_R	0.502	0.57
16_M	21_S	0.502	0.57
414_H	444_G	0.502	0.57
261_G	264_L	0.501	0.57
112_L	121_R	0.501	0.57
527_L	536_H	0.501	0.57
35_S	88_V	0.501	0.57
397_E	437_I	0.501	0.57
376_N	458_S	0.501	0.57
50_R	75_P	0.501	0.57
98_L	101_S	0.501	0.57
259_Q	264_L	0.500	0.57

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ce7A	3	0.6661	100	0.399	Contact Map
4ww0A	4	0.6724	100	0.407	Contact Map
2dhrA	5	0.7112	100	0.442	Contact Map
4cr2J	1	0.5637	100	0.664	Contact Map
4cr2I	1	0.5606	100	0.682	Contact Map
4cr2K	1	0.573	100	0.694	Contact Map
4cr2L	1	0.5466	100	0.697	Contact Map
4cr2M	1	0.5512	100	0.7	Contact Map
4cr2H	1	0.5404	100	0.703	Contact Map
3cf2A	3	0.5047	100	0.705	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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