GREMLIN Database
SAPF - Peptide transport system ATP-binding protein SapF
UniProt: P0AAH8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12305
Length: 268 (226)
Sequences: 207290 (119924)
Seq/√Len: 7977.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_Q220_Q3.3411.00
44_A218_S3.1341.00
10_N32_P3.0941.00
7_E36_T3.0131.00
70_E77_P2.9161.00
9_R70_E2.9051.00
28_E31_K2.8801.00
89_R170_K2.8001.00
43_L222_L2.6561.00
143_H146_Y2.6091.00
220_Q232_R2.5571.00
38_R41_Q2.5531.00
31_K228_E2.5471.00
12_S32_P2.3181.00
7_E72_L2.3151.00
8_V11_L2.2491.00
14_T28_E2.1711.00
9_R72_L2.0151.00
12_S28_E2.0001.00
13_K59_M1.9971.00
135_R141_P1.9841.00
234_S237_D1.9701.00
233_G237_D1.9611.00
57_A207_V1.9011.00
222_L232_R1.9001.00
12_S68_S1.8931.00
105_Q109_Q1.8741.00
74_D170_K1.8591.00
168_R202_I1.8581.00
222_L229_V1.8561.00
195_E199_K1.8421.00
57_A173_I1.7941.00
39_E170_K1.7791.00
122_E125_Q1.7391.00
129_Q168_R1.6861.00
134_M144_V1.6351.00
131_I144_V1.6201.00
10_N34_S1.6171.00
194_L216_H1.6091.00
131_I135_R1.5751.00
108_S145_S1.5671.00
136_M200_Q1.5661.00
108_S112_D1.5291.00
208_T214_M1.4811.00
37_L43_L1.4691.00
41_Q219_D1.4691.00
14_T67_T1.4651.00
132_E136_M1.4631.00
16_R26_T1.4431.00
13_K67_T1.4411.00
107_I151_L1.4411.00
129_Q132_E1.4361.00
15_F29_A1.4321.00
35_F222_L1.4051.00
112_D126_R1.3931.00
13_K64_I1.3911.00
5_L74_D1.3521.00
58_K64_I1.3341.00
30_V59_M1.3241.00
146_Y150_M1.3231.00
56_L224_M1.3211.00
108_S144_V1.3151.00
233_G238_V1.3051.00
110_I163_R1.3011.00
12_S31_K1.2961.00
77_P80_F1.2781.00
8_V35_F1.2771.00
127_R131_I1.2691.00
136_M195_E1.2621.00
108_S130_I1.2441.00
62_G65_E1.2401.00
170_K202_I1.2351.00
15_F55_T1.2111.00
59_M66_P1.1901.00
8_V60_L1.1871.00
106_R109_Q1.1861.00
72_L77_P1.1831.00
128_K132_E1.1751.00
38_R220_Q1.1671.00
9_R36_T1.1651.00
197_Q219_D1.1601.00
43_L220_Q1.1601.00
215_K236_A1.1511.00
225_H230_V1.1411.00
108_S127_R1.1381.00
43_L232_R1.1361.00
133_T166_I1.1321.00
42_T197_Q1.1171.00
11_L66_P1.1131.00
197_Q204_Y1.1131.00
181_L189_L1.1071.00
44_A214_M1.1071.00
42_T218_S1.1021.00
91_R169_P1.0911.00
61_A92_M1.0901.00
168_R200_Q1.0831.00
74_D89_R1.0821.00
111_L166_I1.0781.00
42_T206_Y1.0691.00
122_E126_R1.0651.00
172_I202_I1.0631.00
187_S191_N1.0631.00
190_I213_M1.0371.00
196_L202_I1.0291.00
137_V162_A1.0271.00
125_Q128_K1.0251.00
115_L166_I1.0221.00
33_L56_L1.0211.00
174_A193_M1.0191.00
13_K55_T1.0181.00
83_Y87_S1.0171.00
42_T204_Y1.0081.00
9_R34_S1.0051.00
186_R213_M1.0021.00
60_L205_I1.0021.00
231_E242_P1.0021.00
132_E135_R1.0001.00
231_E243_L0.9941.00
131_I141_P0.9941.00
35_F56_L0.9931.00
10_N68_S0.9891.00
108_S131_I0.9881.00
112_D130_I0.9801.00
14_T29_A0.9791.00
45_I56_L0.9781.00
5_L39_E0.9741.00
8_V71_L0.9701.00
124_E128_K0.9691.00
11_L59_M0.9671.00
151_L159_L0.9671.00
61_A173_I0.9581.00
39_E74_D0.9581.00
123_P127_R0.9571.00
237_D241_S0.9561.00
231_E241_S0.9541.00
130_I133_T0.9471.00
192_L195_E0.9461.00
14_T26_T0.9391.00
133_T162_A0.9371.00
186_R210_H0.9341.00
136_M199_K0.9341.00
45_I222_L0.9321.00
221_V235_T0.9321.00
194_L197_Q0.9301.00
176_E209_Q0.9271.00
5_L38_R0.9211.00
115_L120_D0.9161.00
109_Q112_D0.9141.00
93_I174_A0.9121.00
123_P126_R0.9091.00
82_D85_F0.9061.00
59_M71_L0.9031.00
230_V244_H0.9001.00
93_I161_L0.9001.00
37_L205_I0.8991.00
32_P228_E0.8961.00
30_V33_L0.8911.00
5_L36_T0.8881.00
8_V56_L0.8821.00
129_Q133_T0.8801.00
141_P144_V0.8701.00
48_E225_H0.8651.00
37_L203_S0.8531.00
174_A204_Y0.8521.00
118_N167_L0.8521.00
101_L156_K0.8491.00
91_R164_A0.8491.00
172_I204_Y0.8451.00
106_R147_Y0.8441.00
43_L205_I0.8421.00
147_Y150_M0.8421.00
191_N195_E0.8381.00
143_H151_L0.8231.00
76_H89_R0.8161.00
236_A240_A0.8071.00
125_Q129_Q0.8011.00
85_F88_Q0.7961.00
122_E131_I0.7901.00
6_L73_I0.7891.00
188_Q191_N0.7861.00
126_R131_I0.7841.00
45_I205_I0.7841.00
95_Q153_P0.7831.00
107_I159_L0.7821.00
157_Q180_S0.7791.00
191_N194_L0.7791.00
153_P158_R0.7781.00
225_H244_H0.7741.00
139_L142_D0.7731.00
41_Q232_R0.7711.00
115_L126_R0.7691.00
115_L118_N0.7691.00
126_R130_I0.7691.00
138_G188_Q0.7691.00
49_N185_M0.7601.00
51_S224_M0.7591.00
42_T194_L0.7591.00
121_L126_R0.7581.00
65_E79_H0.7541.00
178_L189_L0.7531.00
42_T217_I0.7531.00
143_H155_Q0.7491.00
190_I216_H0.7461.00
46_I223_V0.7431.00
133_T137_V0.7421.00
116_R126_R0.7411.00
77_P81_G0.7401.00
229_V232_R0.7381.00
112_D127_R0.7361.00
102_N113_F0.7351.00
195_E200_Q0.7331.00
93_I164_A0.7251.00
66_P79_H0.7151.00
59_M64_I0.7101.00
173_I205_I0.7091.00
46_I214_M0.7071.00
6_L171_V0.7031.00
106_R145_S0.7011.00
39_E203_S0.6981.00
121_L125_Q0.6961.00
15_F64_I0.6961.00
193_M204_Y0.6961.00
97_P160_G0.6951.00
127_R130_I0.6941.00
231_E238_V0.6911.00
46_I211_I0.6901.00
104_R149_H0.6901.00
28_E32_P0.6821.00
132_E168_R0.6801.00
30_V56_L0.6791.00
191_N216_H0.6781.00
98_S156_K0.6781.00
101_L148_P0.6761.00
5_L73_I0.6731.00
14_T68_S0.6701.00
148_P159_L0.6701.00
72_L75_D0.6691.00
6_L60_L0.6691.00
237_D240_A0.6681.00
106_R110_I0.6681.00
76_H85_F0.6621.00
14_T31_K0.6611.00
10_N13_K0.6601.00
139_L143_H0.6591.00
235_T239_L0.6561.00
32_P68_S0.6531.00
125_Q134_M0.6521.00
151_L155_Q0.6511.00
33_L229_V0.6461.00
7_E75_D0.6451.00
187_S216_H0.6441.00
111_L134_M0.6441.00
39_E201_G0.6411.00
171_V203_S0.6401.00
70_E79_H0.6401.00
73_I171_V0.6381.00
76_H81_G0.6311.00
133_T165_L0.6271.00
60_L71_L0.6241.00
190_I217_I0.6241.00
115_L167_L0.6211.00
108_S141_P0.6201.00
38_R203_S0.6181.00
208_T213_M0.6131.00
218_S235_T0.6131.00
49_N209_Q0.6111.00
185_M188_Q0.6101.00
206_Y217_I0.6081.00
84_S88_Q0.6061.00
36_T232_R0.6061.00
108_S111_L0.6041.00
125_Q131_I0.6031.00
5_L171_V0.6031.00
60_L173_I0.6031.00
5_L203_S0.6011.00
49_N158_R0.5991.00
133_T136_M0.5981.00
85_F89_R0.5971.00
94_F97_P0.5961.00
214_M218_S0.5951.00
96_D156_K0.5951.00
111_L125_Q0.5931.00
182_D185_M0.5921.00
112_D116_R0.5901.00
14_T27_V0.5881.00
110_I148_P0.5871.00
91_R167_L0.5811.00
215_K239_L0.5801.00
59_M67_T0.5781.00
120_D166_I0.5761.00
35_F43_L0.5751.00
53_K176_E0.5751.00
54_S58_K0.5741.00
40_G203_S0.5721.00
152_A155_Q0.5721.00
103_P156_K0.5711.00
45_I207_V0.5711.00
142_D146_Y0.5701.00
90_I171_V0.5691.00
215_K235_T0.5681.00
97_P156_K0.5661.00
13_K29_A0.5661.00
196_L200_Q0.5621.00
213_M217_I0.5601.00
105_Q113_F0.5591.00
53_K175_D0.5551.00
49_N176_E0.5541.00
225_H228_E0.5501.00
223_V238_V0.5481.00
102_N110_I0.5471.00
31_K226_Q0.5451.00
105_Q110_I0.5391.00
197_Q202_I0.5381.00
74_D171_V0.5361.00
13_K30_V0.5341.00
86_R90_I0.5341.00
83_Y86_R0.5331.00
142_D155_Q0.5331.00
53_K209_Q0.5321.00
137_V192_L0.5311.00
28_E68_S0.5301.00
16_R28_E0.5281.00
210_H213_M0.5271.00
231_E237_D0.5251.00
214_M235_T0.5221.00
128_K131_I0.5211.00
6_L205_I0.5211.00
111_L159_L0.5191.00
161_L189_L0.5181.00
54_S175_D0.5141.00
189_L192_L0.5121.00
235_T238_V0.5111.00
165_L202_I0.5061.00
206_Y218_S0.5061.00
13_K16_R0.5051.00
95_Q179_A0.5051.00
214_M221_V0.5041.00
51_S226_Q0.5021.00
158_R188_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tuiC 2 0.9552 100 0.077 Contact Map
4f4cA 1 0.8545 100 0.09 Contact Map
4ry2A 2 0.8881 100 0.093 Contact Map
1g291 4 0.944 100 0.096 Contact Map
2yyzA 1 0.9328 100 0.099 Contact Map
4mkiB 2 0.9664 100 0.1 Contact Map
2it1A 1 0.9366 100 0.1 Contact Map
1v43A 2 0.9142 100 0.101 Contact Map
3rlfA 2 0.9328 100 0.102 Contact Map
3fvqA 2 0.944 100 0.103 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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