GREMLIN Database
SAPD - Peptide transport system ATP-binding protein SapD
UniProt: P0AAH4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12304
Length: 330 (266)
Sequences: 51007 (31444)
Seq/√Len: 1928.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_E228_K4.2081.00
90_N178_R3.5191.00
8_N25_R3.2661.00
5_D29_T3.2011.00
7_R67_R3.1331.00
21_K24_D2.9221.00
11_I52_A2.8721.00
36_R230_N2.8651.00
67_R74_D2.6031.00
37_G226_A2.5671.00
242_P245_E2.5081.00
71_D178_R2.5031.00
31_T34_E2.4831.00
228_K240_T2.4621.00
230_N237_T2.4111.00
12_E21_K2.4021.00
128_R131_W2.3781.00
151_A154_S2.3741.00
5_D69_R2.3251.00
24_D236_Q2.2571.00
10_T65_A2.2461.00
6_I9_L2.1901.00
10_T25_R2.1341.00
223_S244_K2.0961.00
50_A215_I2.0951.00
135_R138_E2.0931.00
32_E178_R2.0581.00
135_R176_Q2.0511.00
74_D77_R2.0421.00
139_L174_A1.9881.00
7_R69_R1.9761.00
241_A246_L1.9611.00
79_S82_E1.9371.00
13_F48_L1.9311.00
137_I152_M1.8471.00
106_E110_R1.8381.00
14_K19_W1.8191.00
10_T21_K1.7551.00
216_S222_L1.7371.00
50_A181_I1.7341.00
55_G83_R1.7311.00
230_N240_T1.7111.00
73_I82_E1.7091.00
37_G222_L1.7011.00
154_S158_E1.6781.00
13_F22_A1.6771.00
58_K63_V1.6641.00
113_M136_A1.6281.00
11_I57_N1.6261.00
12_E64_T1.6101.00
138_E142_R1.6091.00
241_A245_E1.5971.00
71_D90_N1.5911.00
6_I28_M1.5591.00
8_N27_S1.5521.00
12_E19_W1.5511.00
109_G153_R1.5481.00
113_M132_R1.5411.00
147_D150_D1.5281.00
245_E249_M1.5101.00
109_G152_M1.4991.00
9_L63_V1.4941.00
151_A159_L1.4911.00
137_I147_D1.4891.00
11_I64_T1.4781.00
202_T224_Q1.4541.00
117_P132_R1.4371.00
10_T24_D1.4111.00
78_L82_E1.3881.00
107_R110_R1.3691.00
146_K150_D1.3691.00
182_A212_I1.3591.00
133_K137_I1.3491.00
112_L140_L1.3341.00
109_G113_M1.3121.00
6_I53_I1.3031.00
35_I205_N1.2841.00
198_F221_M1.2811.00
99_Q164_C1.2761.00
34_E227_D1.2741.00
94_I182_A1.2691.00
28_M49_I1.2631.00
30_L36_R1.2551.00
7_R27_S1.2531.00
150_D154_S1.2511.00
73_I78_L1.2331.00
7_R29_T1.2291.00
28_M230_N1.2231.00
52_A63_V1.2071.00
110_R113_M1.2041.00
35_I212_I1.2041.00
134_R138_E1.2011.00
256_Q260_R1.1991.00
202_T205_N1.1951.00
201_L212_I1.1921.00
54_C93_M1.1871.00
38_L213_L1.1831.00
244_K248_T1.1761.00
133_K152_M1.1761.00
36_R240_T1.1751.00
159_L167_V1.1731.00
55_G58_K1.1701.00
121_Y127_Q1.1681.00
107_R153_R1.1661.00
69_R74_D1.1611.00
105_S157_Y1.1591.00
26_V49_I1.1521.00
140_L152_M1.1451.00
78_L83_R1.1441.00
36_R228_K1.1391.00
32_E71_D1.1041.00
129_F132_R1.1031.00
109_G133_K1.0961.00
109_G136_A1.0931.00
111_Q171_I1.0901.00
35_I226_A1.0821.00
31_T228_K1.0751.00
180_L210_T1.0701.00
112_L174_A1.0601.00
130_G134_R1.0551.00
131_W134_R1.0531.00
14_K18_E1.0221.00
138_E141_H1.0211.00
253_P256_Q1.0141.00
229_I243_S1.0111.00
113_M117_P1.0101.00
146_K151_A1.0051.00
189_M197_I0.9981.00
120_T127_Q0.9871.00
8_N65_A0.9871.00
132_R136_A0.9861.00
30_L179_L0.9741.00
144_G203_R0.9731.00
205_N212_I0.9721.00
176_Q210_T0.9711.00
245_E248_T0.9711.00
141_H147_D0.9691.00
106_E114_Q0.9671.00
116_I174_A0.9611.00
214_L225_W0.9611.00
12_E24_D0.9571.00
49_I232_L0.9551.00
137_I141_H0.9501.00
23_V52_A0.9491.00
237_T240_T0.9471.00
53_I213_L0.9431.00
180_L212_I0.9431.00
32_E209_N0.9381.00
51_K56_V0.9331.00
92_S172_A0.9281.00
139_L142_R0.9221.00
141_H146_K0.9221.00
38_L230_N0.9221.00
264_D267_S0.9121.00
228_K239_E0.9111.00
6_I68_M0.9101.00
142_R203_R0.9091.00
31_T211_T0.9081.00
194_Q218_D0.8981.00
54_C181_I0.8971.00
128_R132_R0.8961.00
38_L49_I0.8911.00
11_I48_L0.8891.00
129_F133_K0.8881.00
44_S232_L0.8851.00
22_A48_L0.8831.00
120_T135_R0.8811.00
91_V179_L0.8731.00
135_R139_L0.8731.00
3_L71_D0.8711.00
255_T259_I0.8671.00
92_S177_P0.8671.00
74_D78_L0.8601.00
247_V250_P0.8581.00
194_Q221_M0.8551.00
80_A83_R0.8541.00
253_P257_A0.8481.00
35_I202_T0.8451.00
202_T225_W0.8401.00
51_K57_N0.8391.00
102_L164_C0.8381.00
182_A201_L0.8371.00
246_L255_T0.8361.00
113_M133_K0.8331.00
106_E111_Q0.8331.00
116_I120_T0.8281.00
52_A68_M0.8261.00
108_V159_L0.8251.00
260_R276_N0.8241.00
3_L70_F0.8201.00
108_V167_V0.8191.00
119_W175_N0.8171.00
73_I90_N0.8161.00
94_I169_I0.8151.00
107_R155_F0.8151.00
155_F158_E0.8141.00
70_F90_N0.8101.00
23_V26_V0.8101.00
11_I23_V0.8101.00
275_L278_L0.8051.00
288_L291_G0.8051.00
280_G284_L0.8041.00
221_M225_W0.8041.00
133_K153_R0.8001.00
9_L52_A0.7991.00
139_L170_A0.7971.00
200_L203_R0.7971.00
52_A57_N0.7931.00
144_G196_Q0.7891.00
226_A229_I0.7881.00
39_V222_L0.7881.00
205_N227_D0.7871.00
233_Y238_V0.7841.00
8_N11_I0.7771.00
282_I285_L0.7731.00
159_L163_E0.7721.00
252_H255_T0.7721.00
284_L287_Q0.7711.00
243_S247_V0.7701.00
198_F224_Q0.7691.00
30_L211_T0.7691.00
136_A152_M0.7671.00
115_N171_I0.7671.00
83_R88_G0.7651.00
26_V237_T0.7631.00
25_R236_Q0.7601.00
184_E217_H0.7561.00
231_V250_P0.7541.00
147_D152_M0.7521.00
145_I151_A0.7421.00
257_A261_A0.7391.00
287_Q290_I0.7361.00
214_L226_A0.7331.00
103_D106_E0.7331.00
143_V170_A0.7321.00
115_N175_N0.7291.00
35_I225_W0.7291.00
289_P292_C0.7281.00
156_P167_V0.7251.00
4_L53_I0.7241.00
195_A199_R0.7241.00
30_L213_L0.7181.00
147_D151_A0.7141.00
272_K276_N0.7131.00
181_I213_L0.7071.00
219_L247_V0.7061.00
51_K93_M0.7051.00
130_G133_K0.7041.00
121_Y128_R0.7041.00
75_L91_V0.7041.00
139_L173_L0.7011.00
285_L288_L0.7001.00
199_R202_T0.6991.00
199_R224_Q0.6961.00
112_L136_A0.6961.00
94_I172_A0.6941.00
179_L211_T0.6851.00
204_L210_T0.6851.00
13_F57_N0.6841.00
280_G283_P0.6841.00
36_R213_L0.6831.00
117_P129_F0.6821.00
23_V49_I0.6821.00
67_R76_L0.6811.00
89_H120_T0.6791.00
274_R278_L0.6781.00
35_I227_D0.6721.00
281_A284_L0.6701.00
233_Y236_Q0.6681.00
179_L213_L0.6671.00
56_V95_F0.6661.00
151_A163_E0.6641.00
226_A243_S0.6561.00
266_G269_M0.6531.00
107_R111_Q0.6521.00
238_V252_H0.6521.00
69_R72_D0.6471.00
261_A264_D0.6471.00
70_F75_L0.6461.00
63_V76_L0.6451.00
286_E289_P0.6431.00
39_V231_V0.6431.00
4_L179_L0.6401.00
186_T221_M0.6401.00
243_S254_Y0.6401.00
285_L289_P0.6401.00
54_C91_V0.6381.00
12_E65_A0.6371.00
115_N118_A0.6361.00
121_Y132_R0.6341.00
257_A260_R0.6301.00
233_Y257_A0.6291.00
283_P289_P0.6271.00
8_N66_D0.6231.00
254_Y258_L0.6231.00
173_L210_T0.6221.00
67_R77_R0.6201.00
278_L281_A0.6141.00
6_I49_I0.6121.00
131_W135_R0.6111.00
282_I286_E0.6111.00
25_R65_A0.6101.00
249_M252_H0.6091.00
3_L179_L0.6091.00
278_L282_I0.6091.00
202_T206_Q0.6081.00
102_L167_V0.6061.00
279_P292_C0.6061.00
280_G285_L0.6051.00
199_R203_R0.6051.00
231_V246_L0.6041.00
287_Q291_G0.6041.00
283_P291_G0.6031.00
53_I68_M0.6031.00
79_S83_R0.6021.00
120_T176_Q0.5971.00
47_S51_K0.5971.00
284_L288_L0.5971.00
254_Y257_A0.5951.00
109_G112_L0.5881.00
275_L279_P0.5871.00
245_E251_H0.5861.00
283_P287_Q0.5861.00
154_S159_L0.5851.00
57_N63_V0.5851.00
41_E233_Y0.5841.00
277_T281_A0.5831.00
102_L111_Q0.5801.00
111_Q156_P0.5791.00
68_M76_L0.5781.00
256_Q259_I0.5781.00
33_G211_T0.5761.00
169_I197_I0.5751.00
145_I163_E0.5731.00
281_A285_L0.5721.00
135_R142_R0.5701.00
134_R141_H0.5681.00
41_E44_S0.5661.00
52_A64_T0.5661.00
246_L250_P0.5651.00
113_M152_M0.5641.00
134_R137_I0.5621.00
261_A265_F0.5621.00
32_E211_T0.5611.00
281_A286_E0.5591.00
109_G137_I0.5591.00
70_F179_L0.5561.00
283_P288_L0.5551.00
116_I127_Q0.5551.00
273_S276_N0.5531.00
288_L292_C0.5511.00
285_L291_G0.5511.00
284_L289_P0.5491.00
116_I121_Y0.5461.00
4_L70_F0.5411.00
165_Q188_S0.5411.00
3_L211_T0.5411.00
10_T64_T0.5401.00
275_L282_I0.5401.00
75_L78_L0.5381.00
113_M121_Y0.5371.00
278_L285_L0.5361.00
243_S246_L0.5361.00
279_P282_I0.5361.00
276_N291_G0.5361.00
265_F269_M0.5351.00
121_Y131_W0.5321.00
284_L291_G0.5321.00
127_Q131_W0.5311.00
282_I288_L0.5281.00
262_I265_F0.5281.00
222_L229_I0.5271.00
282_I291_G0.5271.00
11_I63_V0.5231.00
178_R210_T0.5231.00
272_K275_L0.5221.00
186_T197_I0.5201.00
127_Q132_R0.5191.00
255_T258_L0.5191.00
241_A250_P0.5161.00
116_I175_N0.5151.00
161_E166_K0.5141.00
35_I214_L0.5141.00
238_V253_P0.5141.00
285_L290_I0.5121.00
29_T240_T0.5111.00
264_D269_M0.5111.00
12_E22_A0.5101.00
140_L151_A0.5091.00
116_I119_W0.5081.00
241_A247_V0.5071.00
34_E240_T0.5061.00
114_Q118_A0.5051.00
283_P290_I0.5051.00
285_L292_C0.5041.00
198_F225_W0.5031.00
222_L226_A0.5021.00
286_E290_I0.5011.00
220_Q224_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tuiC 2 0.9485 100 0.227 Contact Map
4fwiB 1 0.9212 100 0.233 Contact Map
2yyzA 1 0.9212 100 0.247 Contact Map
2it1A 1 0.9242 100 0.247 Contact Map
1g291 4 0.8667 100 0.248 Contact Map
1v43A 2 0.8121 100 0.251 Contact Map
4u00A 1 0.7273 100 0.252 Contact Map
4ry2A 2 0.7303 100 0.253 Contact Map
2oljA 2 0.7273 100 0.253 Contact Map
1oxxK 1 0.9152 100 0.254 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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