GREMLIN Database
ARAG - Arabinose import ATP-binding protein AraG
UniProt: P0AAF3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10058
Length: 504 (392)
Sequences: 2505 (1952)
Seq/√Len: 98.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_S70_E4.9511.00
34_Q212_A4.0741.00
12_G25_D4.0051.00
121_N138_D3.9371.00
262_R278_A3.9241.00
24_T220_R3.9121.00
125_G129_K3.5681.00
37_A210_S3.5441.00
36_H214_T3.5061.00
67_N163_K3.3531.00
312_Q319_P3.3171.00
300_K306_T3.2581.00
264_D312_Q3.2111.00
263_L277_L3.1221.00
259_E262_R3.0811.00
9_S29_D3.0801.00
383_I393_A3.0381.00
73_F82_A2.9101.00
262_R314_Y2.8881.00
35_V186_I2.8821.00
265_A274_P2.8471.00
119_L123_E2.8361.00
123_E126_L2.8331.00
12_G27_S2.8051.00
223_K239_A2.7951.00
238_Q244_D2.7461.00
11_R63_S2.6461.00
263_L266_V2.6291.00
226_T229_Q2.5971.00
21_K24_T2.5821.00
10_F53_L2.5441.00
187_R208_A2.5331.00
122_Y126_L2.5301.00
259_E278_A2.4761.00
16_T21_K2.4491.00
126_L130_H2.4461.00
17_F57_Y2.4321.00
210_S227_D2.4291.00
180_D208_A2.4281.00
370_I375_E2.4101.00
258_E281_S2.2791.00
139_T143_Y2.2361.00
9_S65_V2.2241.00
346_I357_I2.2001.00
87_I167_F2.1851.00
14_G21_K2.1731.00
10_F13_I2.1411.00
116_N119_L2.1361.00
11_R65_V2.0961.00
381_H385_S2.0561.00
66_I164_I2.0061.00
14_G25_D1.9971.00
16_T61_T1.9831.00
318_Q331_A1.9441.00
56_N88_Y1.8971.00
74_S78_A1.8781.00
65_V70_E1.8651.00
259_E280_R1.8571.00
279_V285_V1.8281.00
355_I388_I1.8131.00
30_C195_V1.8081.00
356_N375_E1.7991.00
100_A121_N1.7951.00
163_K194_R1.7901.00
383_I390_T1.7901.00
93_L141_L1.7601.00
267_K274_P1.7441.00
16_T60_T1.7411.00
99_V135_I1.7251.00
382_H388_I1.7201.00
30_C164_I1.7101.00
130_H192_E1.7081.00
7_Y195_V1.6951.00
129_K134_D1.6811.00
323_R327_H1.6581.00
50_L86_I1.6561.00
136_D139_T1.6401.00
8_L66_I1.5871.00
264_D314_Y1.5791.00
13_I52_I1.5771.00
380_D384_R1.5711.00
190_R211_D1.5671.00
12_G61_T1.5511.00
188_E191_K1.5091.00
52_I60_T1.5041.00
27_S221_Y1.4661.00
18_P21_K1.4631.00
69_Q82_A1.4591.00
214_T221_Y1.4541.00
118_S122_Y1.4521.00
36_H224_T1.4361.00
183_F209_L1.4351.00
315_I320_I1.4241.00
98_T101_E1.4221.00
301_G308_I1.4001.00
207_F236_L1.3910.99
130_H188_E1.3790.99
18_P391_P1.3760.99
235_A238_Q1.3360.99
225_F230_Q1.3180.99
376_E394_E1.3130.99
109_P115_V1.3070.99
32_A195_V1.3050.99
341_K347_P1.3050.99
277_L285_V1.3040.99
374_W377_N1.3020.99
50_L199_V1.3020.99
54_S86_I1.2990.99
350_S353_D1.2960.99
29_D212_A1.2880.99
269_P309_T1.2830.99
114_I369_V1.2770.99
96_E142_K1.2690.99
8_L53_L1.2630.99
277_L287_L1.2440.99
186_I209_L1.2420.99
91_L173_S1.2420.99
94_V105_L1.2390.99
264_D278_A1.2380.99
377_N381_H1.2370.99
153_E156_K1.2350.99
145_S148_Q1.2330.99
7_Y164_I1.2280.99
296_S338_E1.2260.99
78_A81_N1.2230.99
380_D393_A1.2230.99
119_L122_Y1.2120.99
225_F229_Q1.2070.99
187_R190_R1.2000.98
345_I397_I1.1970.98
101_E117_R1.1960.98
371_N374_W1.1960.98
95_P149_W1.1940.98
125_G137_P1.1920.98
351_V390_T1.1890.98
18_P22_A1.1750.98
32_A163_K1.1710.98
186_I198_Y1.1670.98
123_E161_N1.1470.98
268_A309_T1.1400.98
256_Y280_R1.1340.98
99_V144_L1.1290.98
39_M203_M1.1270.98
14_G61_T1.1220.98
268_A301_G1.1200.98
186_I196_I1.1170.98
71_M82_A1.1160.98
73_F78_A1.1120.97
339_D342_A1.1110.97
30_C197_L1.1080.97
110_H116_N1.0990.97
266_V301_G1.0860.97
221_Y224_T1.0840.97
162_A165_I1.0770.97
352_R376_E1.0740.97
225_F239_A1.0680.97
122_Y125_G1.0670.97
231_V235_A1.0650.97
260_R316_D1.0550.96
181_N184_R1.0540.96
39_M236_L1.0540.96
141_L152_V1.0530.96
7_Y66_I1.0530.96
300_K343_E1.0510.96
259_E264_D1.0480.96
314_Y319_P1.0460.96
131_L155_A1.0460.96
66_I163_K1.0410.96
75_D78_A1.0400.96
127_Q159_A1.0350.96
100_A137_P1.0310.96
204_E232_D1.0280.96
103_I152_V1.0230.96
10_F28_F1.0210.96
25_D220_R1.0100.96
85_A162_A1.0070.95
132_G188_E1.0050.95
236_L240_M0.9990.95
92_H167_F0.9970.95
188_E192_E0.9940.95
263_L302_M0.9930.95
31_Y212_A0.9870.95
91_L172_S0.9850.95
213_I227_D0.9840.95
51_K88_Y0.9790.95
25_D61_T0.9790.95
262_R317_Q0.9700.94
346_I349_H0.9690.94
391_P395_Q0.9680.94
99_V139_T0.9660.94
121_N125_G0.9660.94
73_F76_T0.9620.94
395_Q398_M0.9600.94
352_R394_E0.9600.94
179_I202_R0.9590.94
8_L164_I0.9590.94
226_T230_Q0.9590.94
128_L155_A0.9560.94
26_I216_F0.9500.94
7_Y30_C0.9450.94
348_V398_M0.9440.94
363_H378_N0.9430.94
47_S51_K0.9350.93
365_L368_C0.9340.93
214_T224_T0.9340.93
215_V239_A0.9330.93
173_S291_V0.9320.93
109_P120_L0.9290.93
167_F196_I0.9260.93
14_G24_T0.9170.93
326_S330_A0.9150.92
52_I59_P0.9110.92
240_M243_R0.9110.92
212_A226_T0.9110.92
53_L64_V0.9090.92
328_A333_M0.9060.92
128_L133_M0.9040.92
247_D250_G0.8910.91
7_Y67_N0.8880.91
236_L242_G0.8880.91
64_V73_F0.8860.91
140_P143_Y0.8840.91
237_V240_M0.8820.91
125_G138_D0.8820.91
352_R375_E0.8810.91
11_R27_S0.8790.91
18_P24_T0.8770.91
126_L129_K0.8770.91
268_A272_R0.8750.91
270_G273_T0.8740.91
261_L266_V0.8700.90
355_I378_N0.8670.90
109_P123_E0.8590.90
325_P328_A0.8570.90
35_V190_R0.8460.89
381_H384_R0.8450.89
133_M151_M0.8450.89
210_S213_I0.8410.89
364_V378_N0.8400.89
241_V245_I0.8330.88
257_G281_S0.8320.88
77_T81_N0.8270.88
265_A310_A0.8270.88
237_V242_G0.8260.88
251_W254_R0.8250.88
365_L371_N0.8240.88
396_L399_N0.8220.88
110_H113_G0.8210.88
299_M335_L0.8170.88
324_K327_H0.8160.87
225_F235_A0.8150.87
104_Y120_L0.8100.87
80_L160_R0.8100.87
198_Y202_R0.8090.87
22_A391_P0.8050.87
180_D184_R0.8040.87
230_Q235_A0.8020.87
90_E341_K0.7990.86
390_T395_Q0.7960.86
303_F335_L0.7950.86
58_A72_S0.7930.86
206_I227_D0.7930.86
322_I327_H0.7930.86
268_A271_V0.7920.86
212_A224_T0.7900.86
322_I328_A0.7840.85
237_V241_V0.7820.85
146_I173_S0.7820.85
198_Y206_I0.7770.85
93_L149_W0.7770.85
103_I124_A0.7740.85
32_A67_N0.7720.84
298_L302_M0.7690.84
204_E208_A0.7680.84
121_N137_P0.7670.84
18_P390_T0.7600.83
39_M215_V0.7590.83
337_P343_E0.7570.83
16_T19_G0.7550.83
28_F197_L0.7540.83
171_T182_L0.7510.83
29_D65_V0.7490.83
265_A276_S0.7480.82
100_A104_Y0.7470.82
78_A82_A0.7450.82
16_T22_A0.7390.82
267_K310_A0.7390.82
49_L216_F0.7380.82
229_Q232_D0.7370.82
300_K305_G0.7350.81
277_L298_L0.7340.81
28_F36_H0.7320.81
207_F210_S0.7310.81
93_L152_V0.7290.81
260_R281_S0.7290.81
355_I379_A0.7280.81
207_F213_I0.7280.81
376_E380_D0.7280.81
187_R191_K0.7270.81
287_L299_M0.7270.81
359_A363_H0.7260.81
230_Q233_H0.7250.80
99_V152_V0.7250.80
257_G280_R0.7220.80
22_A52_I0.7200.80
329_I358_S0.7190.80
245_I250_G0.7170.80
124_A128_L0.7100.79
20_V44_A0.7090.79
366_G371_N0.7090.79
223_K226_T0.7040.79
262_R312_Q0.7040.79
91_L146_I0.7030.78
259_E314_Y0.7020.78
59_P72_S0.7020.78
353_D372_N0.7020.78
98_T140_P0.7020.78
164_I195_V0.7000.78
380_D383_I0.6990.78
392_G395_Q0.6990.78
66_I82_A0.6970.78
157_A167_F0.6960.78
240_M245_I0.6950.78
149_W172_S0.6940.78
207_F231_V0.6870.77
325_P335_L0.6860.77
308_I321_D0.6850.77
225_F228_M0.6840.76
139_T148_Q0.6810.76
349_H353_D0.6800.76
100_A120_L0.6800.76
265_A314_Y0.6790.76
156_K339_D0.6790.76
373_G377_N0.6770.76
31_Y195_V0.6770.76
256_Y259_E0.6770.76
287_L298_L0.6770.76
64_V71_M0.6750.76
51_K56_N0.6750.76
30_C36_H0.6740.75
137_P140_P0.6730.75
147_G151_M0.6720.75
290_L293_A0.6720.75
35_V187_R0.6710.75
87_I149_W0.6690.75
242_G245_I0.6690.75
23_L52_I0.6680.75
232_D235_A0.6680.75
223_K229_Q0.6670.75
295_R338_E0.6670.75
200_S210_S0.6650.74
235_A239_A0.6650.74
54_S80_L0.6650.74
383_I388_I0.6650.74
207_F227_D0.6630.74
393_A396_L0.6620.74
28_F38_L0.6620.74
10_F27_S0.6610.74
267_K276_S0.6610.74
144_L148_Q0.6590.74
327_H330_A0.6580.74
167_F182_L0.6540.73
175_S178_E0.6530.73
51_K92_H0.6520.73
377_N380_D0.6520.73
291_V295_R0.6520.73
157_A165_I0.6500.73
111_K116_N0.6490.73
28_F195_V0.6460.72
121_N124_A0.6460.72
23_L128_L0.6430.72
100_A109_P0.6400.72
289_G292_G0.6400.72
351_V383_I0.6380.71
359_A362_K0.6360.71
103_I159_A0.6360.71
100_A138_D0.6340.71
175_S349_H0.6330.71
11_R29_D0.6300.70
125_G134_D0.6290.70
243_R249_Y0.6290.70
245_I249_Y0.6280.70
30_C66_I0.6270.70
239_A242_G0.6260.70
261_L279_V0.6250.70
53_L166_A0.6250.70
54_S87_I0.6250.70
16_T27_S0.6230.70
393_A397_I0.6230.70
226_T233_H0.6230.70
289_G340_R0.6230.70
41_E243_R0.6200.69
52_I57_Y0.6180.69
41_E175_S0.6180.69
135_I155_A0.6180.69
128_L131_L0.6170.69
10_F166_A0.6160.69
190_R209_L0.6140.69
91_L153_E0.6130.68
207_F232_D0.6120.68
290_L295_R0.6100.68
145_S175_S0.6090.68
51_K157_A0.6090.68
100_A124_A0.6090.68
352_R379_A0.6080.68
184_R188_E0.6060.67
200_S206_I0.6060.67
111_K114_I0.6060.67
292_G354_N0.6050.67
153_E199_V0.6010.67
339_D345_I0.6010.67
33_G38_L0.6010.67
376_E393_A0.6000.67
93_L165_I0.6000.67
31_Y226_T0.6000.67
96_E140_P0.5990.67
271_V309_T0.5990.67
206_I213_I0.5980.66
281_S316_D0.5970.66
66_I71_M0.5960.66
218_D389_K0.5950.66
128_L137_P0.5900.65
108_L120_L0.5860.65
169_E201_H0.5850.65
90_E153_E0.5840.65
15_K60_T0.5840.65
258_E316_D0.5840.65
7_Y34_Q0.5820.64
315_I331_A0.5820.64
10_F50_L0.5820.64
221_Y239_A0.5810.64
107_Q160_R0.5800.64
156_K160_R0.5790.64
269_P275_I0.5780.64
301_G306_T0.5770.64
296_S335_L0.5770.64
50_L166_A0.5770.64
131_L185_V0.5770.64
340_R344_G0.5760.64
8_L179_I0.5750.63
147_G291_V0.5740.63
283_E292_G0.5730.63
184_R208_A0.5730.63
191_K367_G0.5730.63
41_E241_V0.5720.63
40_G43_G0.5720.63
31_Y34_Q0.5700.63
303_F358_S0.5700.63
93_L158_L0.5700.63
92_H155_A0.5690.63
287_L309_T0.5680.63
31_Y35_V0.5670.62
203_M236_L0.5670.62
103_I127_Q0.5660.62
251_W279_V0.5650.62
14_G22_A0.5650.62
127_Q131_L0.5650.62
73_F84_V0.5640.62
314_Y317_Q0.5640.62
150_Q170_P0.5630.62
289_G294_G0.5630.62
38_L50_L0.5630.62
128_L136_D0.5620.62
285_V310_A0.5620.62
150_Q202_R0.5610.62
106_G206_I0.5600.61
337_P342_A0.5590.61
23_L90_E0.5580.61
183_F216_F0.5570.61
260_R266_V0.5570.61
38_L354_N0.5560.61
272_R301_G0.5560.61
132_G184_R0.5560.61
337_P344_G0.5550.61
391_P399_N0.5550.61
330_A361_R0.5540.61
263_L313_V0.5540.61
45_G62_G0.5530.60
282_G292_G0.5520.60
13_I50_L0.5520.60
286_G289_G0.5510.60
167_F198_Y0.5500.60
338_E344_G0.5490.60
260_R279_V0.5490.60
309_T312_Q0.5480.60
41_E153_E0.5480.60
135_I139_T0.5480.60
206_I221_Y0.5470.60
253_P256_Y0.5460.60
258_E384_R0.5450.59
282_G290_L0.5450.59
82_A164_I0.5420.59
99_V186_I0.5420.59
213_I236_L0.5420.59
351_V388_I0.5420.59
14_G27_S0.5400.59
146_I175_S0.5390.59
7_Y32_A0.5380.58
85_A91_L0.5370.58
143_Y148_Q0.5360.58
39_M216_F0.5360.58
200_S209_L0.5360.58
115_V360_R0.5350.58
104_Y160_R0.5340.58
236_L239_A0.5330.58
107_Q159_A0.5330.58
124_A137_P0.5330.58
156_K195_V0.5330.58
100_A125_G0.5330.58
109_P113_G0.5320.58
237_V243_R0.5320.58
20_V391_P0.5310.57
80_L88_Y0.5310.57
71_M74_S0.5310.57
372_N375_E0.5310.57
38_L178_E0.5310.57
104_Y123_E0.5300.57
141_L165_I0.5300.57
197_L213_I0.5290.57
227_D230_Q0.5290.57
104_Y124_A0.5280.57
98_T105_L0.5270.57
270_G309_T0.5270.57
263_L276_S0.5260.57
32_A191_K0.5260.57
73_F79_A0.5260.57
91_L151_M0.5250.57
41_E202_R0.5240.56
167_F179_I0.5240.56
80_L107_Q0.5230.56
23_L216_F0.5220.56
258_E262_R0.5210.56
11_R25_D0.5210.56
147_G150_Q0.5200.56
303_F334_M0.5190.56
186_I346_I0.5190.56
91_L341_K0.5180.56
359_A385_S0.5180.56
86_I160_R0.5170.55
39_M291_V0.5170.55
335_L386_L0.5170.55
146_I172_S0.5160.55
11_R84_V0.5160.55
236_L241_V0.5140.55
233_H244_D0.5140.55
276_S311_G0.5130.55
91_L141_L0.5130.55
263_L268_A0.5130.55
40_G45_G0.5120.55
284_I287_L0.5120.55
162_A178_E0.5120.55
182_L186_I0.5120.55
283_E289_G0.5110.55
66_I85_A0.5110.55
44_A153_E0.5110.55
170_P178_E0.5110.55
327_H331_A0.5110.55
341_K345_I0.5110.55
183_F210_S0.5100.54
257_G262_R0.5100.54
282_G289_G0.5100.54
292_G304_G0.5090.54
40_G46_K0.5090.54
254_R257_G0.5090.54
124_A127_Q0.5090.54
81_N111_K0.5080.54
67_N70_E0.5080.54
21_K61_T0.5070.54
23_L26_I0.5070.54
288_F292_G0.5070.54
54_S88_Y0.5070.54
120_L131_L0.5070.54
54_S147_G0.5070.54
288_F294_G0.5060.54
51_K57_Y0.5060.54
149_W165_I0.5060.54
222_V225_F0.5050.54
124_A159_A0.5040.54
17_F178_E0.5040.54
92_H160_R0.5030.53
54_S57_Y0.5030.53
64_V181_N0.5020.53
289_G304_G0.5020.53
312_Q321_D0.5010.53
40_G62_G0.5010.53
34_Q68_G0.5010.53
30_C60_T0.5010.53
10_F26_I0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q9hA 1 0.9603 100 0.408 Contact Map
4finA 2 0.8929 100 0.442 Contact Map
4f4cA 1 0.9484 100 0.446 Contact Map
3ux8A 2 0.8591 100 0.474 Contact Map
1yqtA 1 0.9028 100 0.476 Contact Map
3bk7A 1 0.9226 100 0.488 Contact Map
3ozxA 1 0.8909 100 0.496 Contact Map
2iw3A 2 0.8948 100 0.499 Contact Map
3j16B 1 0.9107 100 0.517 Contact Map
3tuiC 2 0.631 100 0.517 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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