GREMLIN Database
POTE - Putrescine-ornithine antiporter
UniProt: P0AAF1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10753
Length: 439 (411)
Sequences: 24546 (15546)
Seq/√Len: 766.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
136_T330_V4.4251.00
312_I324_Q4.3151.00
379_N383_S3.5251.00
365_I396_A3.2881.00
49_A235_A3.2441.00
373_I377_V3.1951.00
315_R324_Q3.1131.00
221_R225_I2.9761.00
10_G217_E2.9651.00
73_G306_E2.7511.00
216_V222_N2.7451.00
89_N303_S2.6541.00
304_S314_S2.5841.00
218_N221_R2.5261.00
168_G244_V2.5171.00
317_T323_V2.5011.00
312_I315_R2.4811.00
129_I334_S2.4771.00
166_I170_F2.4161.00
15_T229_G2.4061.00
11_V229_G2.3771.00
214_D305_D2.3571.00
368_M395_G2.3191.00
61_K375_Q2.3141.00
215_V298_Q2.2801.00
77_E85_N2.2281.00
393_F397_M2.1901.00
301_K305_D2.1431.00
11_V222_N2.1281.00
327_L331_I2.1261.00
137_V141_G2.1251.00
136_T326_M2.0941.00
80_F373_I2.0891.00
263_L266_A2.0881.00
11_V15_T2.0741.00
14_L216_V2.0651.00
144_R148_Q2.0491.00
140_F323_V2.0231.00
133_W334_S2.0111.00
225_I229_G2.0001.00
253_E267_Q1.9901.00
423_T427_L1.9561.00
10_G13_Q1.9561.00
128_T337_A1.9441.00
155_W159_I1.9361.00
129_I337_A1.8991.00
380_V383_S1.8781.00
272_E276_V1.8781.00
58_A368_M1.8711.00
313_F328_T1.8711.00
77_E82_K1.8701.00
93_G329_I1.8661.00
50_V54_A1.8461.00
307_G311_K1.8441.00
250_P253_E1.8341.00
379_N382_P1.8331.00
369_A396_A1.8201.00
80_F369_A1.8121.00
13_Q151_S1.7751.00
81_G84_G1.7731.00
139_N290_L1.7721.00
263_L267_Q1.7721.00
34_L41_S1.7711.00
317_T321_A1.7481.00
133_W330_V1.7421.00
218_N222_N1.7361.00
228_L232_L1.7161.00
76_A88_A1.7071.00
51_G398_Y1.7041.00
397_M401_Y1.7021.00
417_V421_G1.6531.00
104_A289_L1.6331.00
390_F394_V1.6331.00
319_V323_V1.6311.00
140_F327_L1.6201.00
18_T230_G1.6061.00
44_S195_S1.6001.00
373_I376_K1.5981.00
159_I163_G1.5951.00
132_L333_Q1.5841.00
88_A366_L1.5801.00
15_T233_G1.5711.00
123_Q126_L1.5711.00
40_I192_V1.5511.00
415_S419_F1.5301.00
111_G127_A1.5281.00
9_M13_Q1.5131.00
232_L236_V1.5001.00
182_N186_A1.4851.00
301_K316_V1.4821.00
178_V181_W1.4781.00
422_W426_G1.4721.00
266_A274_G1.4641.00
324_Q328_T1.4621.00
122_V126_L1.4511.00
48_T199_T1.4491.00
257_S263_L1.4491.00
212_N294_F1.4491.00
100_N333_Q1.4481.00
54_A394_V1.4471.00
300_F325_G1.4431.00
387_V391_V1.4421.00
56_A231_T1.4361.00
311_K314_S1.4291.00
160_P280_L1.4231.00
107_A131_V1.4231.00
107_A282_V1.4211.00
90_Y421_G1.4171.00
104_A132_L1.4171.00
136_T327_L1.4161.00
129_I133_W1.4111.00
6_S320_D1.4101.00
169_W244_V1.4061.00
369_A373_I1.4041.00
141_G319_V1.3921.00
218_N225_I1.3841.00
50_V394_V1.3831.00
158_I162_V1.3831.00
296_I329_I1.3821.00
269_F273_V1.3631.00
275_K279_A1.3591.00
311_K315_R1.3541.00
219_P224_P1.3491.00
315_R323_V1.3471.00
132_L330_V1.3391.00
76_A366_L1.3391.00
69_S214_D1.3381.00
416_I420_L1.3371.00
13_Q147_G1.3331.00
172_F247_G1.3301.00
388_A392_A1.3201.00
421_G424_L1.3191.00
365_I400_F1.3011.00
56_A227_V1.2941.00
9_M14_L1.2941.00
297_A326_M1.2931.00
222_N225_I1.2851.00
165_C240_V1.2731.00
66_S78_Y1.2711.00
42_I243_N1.2681.00
266_A271_P1.2661.00
384_K387_V1.2661.00
79_A370_A1.2601.00
11_V225_I1.2551.00
401_Y405_S1.2531.00
236_V240_V1.2521.00
68_K74_G1.2481.00
57_W228_L1.2431.00
80_F84_G1.2401.00
103_I288_S1.2371.00
9_M147_G1.2341.00
125_G129_I1.2341.00
372_V393_F1.2281.00
55_L368_M1.2271.00
385_A388_A1.2261.00
135_C289_L1.2231.00
168_G248_I1.2171.00
300_F309_F1.2171.00
22_M234_A1.2111.00
58_A392_A1.2081.00
182_N185_H1.2081.00
74_G78_Y1.2051.00
83_S428_V1.2021.00
12_V16_I1.1961.00
164_L168_G1.1611.00
40_I185_H1.1601.00
68_K78_Y1.1591.00
14_L226_A1.1581.00
138_A149_I1.1551.00
217_E222_N1.1491.00
93_G300_F1.1471.00
59_F72_M1.1451.00
65_F381_P1.1381.00
419_F423_T1.1361.00
173_S176_L1.1291.00
424_L427_L1.1191.00
163_G167_I1.1181.00
389_N393_F1.1121.00
35_A41_S1.1081.00
29_M106_S1.1021.00
169_W173_S1.0961.00
63_G75_Y1.0951.00
78_Y378_A1.0941.00
8_K217_E1.0871.00
324_Q327_L1.0791.00
61_K64_M1.0741.00
390_F393_F1.0731.00
410_A414_G1.0701.00
17_L212_N1.0701.00
126_L130_G1.0671.00
316_V320_D1.0651.00
130_G134_I1.0621.00
188_F191_A1.0611.00
18_T209_A1.0571.00
305_D314_S1.0561.00
86_F90_Y1.0561.00
411_M415_S1.0511.00
185_H188_F1.0471.00
73_G302_S1.0461.00
395_G399_S1.0421.00
19_M233_G1.0401.00
414_G418_T1.0371.00
150_S290_L1.0341.00
170_F175_T1.0321.00
371_L392_A1.0281.00
149_I153_T1.0171.00
76_A84_G1.0171.00
108_V127_A1.0161.00
400_F404_Y1.0111.00
412_L415_S1.0091.00
257_S260_P1.0071.00
193_G401_Y1.0031.00
81_G85_N1.0031.00
148_Q152_I1.0031.00
136_T140_F1.0021.00
411_M414_G1.0011.00
133_W137_V0.9951.00
19_M234_A0.9951.00
170_F174_P0.9951.00
412_L416_I0.9941.00
413_Y416_I0.9931.00
162_V166_I0.9911.00
46_L239_I0.9901.00
189_F192_V0.9901.00
259_A263_L0.9831.00
183_P186_A0.9761.00
385_A389_N0.9741.00
376_K389_N0.9731.00
396_A400_F0.9721.00
111_G115_L0.9701.00
368_M396_A0.9681.00
331_I335_G0.9671.00
248_I264_A0.9661.00
134_I286_C0.9641.00
140_F321_A0.9591.00
143_A294_F0.9581.00
392_A396_A0.9571.00
372_V389_N0.9551.00
213_T223_V0.9531.00
54_A391_V0.9501.00
365_I399_S0.9471.00
250_P267_Q0.9451.00
385_A392_A0.9311.00
365_I369_A0.9301.00
42_I246_A0.9281.00
424_L428_V0.9261.00
207_E211_A0.9241.00
111_G282_V0.9221.00
140_F317_T0.9191.00
165_C244_V0.9181.00
358_V414_G0.9091.00
108_V128_T0.9081.00
204_L360_N0.9051.00
251_N254_L0.9051.00
404_Y408_E0.9041.00
153_T287_G0.9041.00
235_A239_I0.9031.00
421_G425_Y0.9001.00
293_Q330_V0.8971.00
164_L265_F0.8951.00
70_G74_G0.8951.00
229_G233_G0.8931.00
387_V390_F0.8811.00
165_C169_W0.8731.00
43_I192_V0.8731.00
102_A201_W0.8711.00
157_V284_S0.8701.00
70_G73_G0.8661.00
189_F193_G0.8651.00
16_I151_S0.8601.00
158_I237_I0.8601.00
243_N247_G0.8591.00
49_A203_F0.8521.00
330_V334_S0.8501.00
270_T273_V0.8491.00
135_C290_L0.8471.00
90_Y309_F0.8461.00
102_A353_V0.8451.00
77_E306_E0.8431.00
107_A286_C0.8421.00
62_C371_L0.8421.00
11_V226_A0.8411.00
208_S295_T0.8401.00
416_I419_F0.8341.00
13_Q148_Q0.8321.00
384_K389_N0.8321.00
372_V392_A0.8321.00
8_K144_R0.8281.00
84_G366_L0.8281.00
410_A413_Y0.8241.00
317_T320_D0.8221.00
309_F313_F0.8211.00
127_A130_G0.8211.00
98_I101_V0.8201.00
392_A406_S0.8131.00
137_V140_F0.8101.00
403_L406_S0.8071.00
53_M57_W0.8051.00
194_S198_M0.8041.00
172_F175_T0.8001.00
389_N392_A0.7991.00
385_A391_V0.7961.00
83_S87_M0.7961.00
83_S422_W0.7941.00
313_F324_Q0.7921.00
414_G417_V0.7921.00
23_M26_G0.7921.00
55_L399_S0.7891.00
169_W240_V0.7881.00
425_Y429_S0.7871.00
107_A285_C0.7861.00
401_Y404_Y0.7861.00
420_L424_L0.7851.00
323_V327_L0.7841.00
148_Q151_S0.7791.00
22_M230_G0.7791.00
112_T124_I0.7781.00
53_M228_L0.7781.00
411_M424_L0.7751.00
15_T226_A0.7711.00
386_K389_N0.7701.00
132_L337_A0.7651.00
417_V424_L0.7641.00
12_V151_S0.7641.00
410_A421_G0.7571.00
135_C293_Q0.7571.00
185_H192_V0.7561.00
139_N326_M0.7551.00
399_S402_A0.7541.00
141_G145_I0.7541.00
355_L359_T0.7511.00
125_G337_A0.7491.00
371_L375_Q0.7481.00
57_W391_V0.7471.00
54_A58_A0.7461.00
174_P177_Y0.7451.00
410_A415_S0.7441.00
170_F173_S0.7421.00
76_A370_A0.7421.00
46_L50_V0.7421.00
388_A391_V0.7391.00
411_M421_G0.7381.00
80_F370_A0.7371.00
386_K390_F0.7361.00
410_A417_V0.7361.00
224_P227_V0.7351.00
331_I334_S0.7331.00
318_K323_V0.7321.00
43_I46_L0.7301.00
108_V124_I0.7291.00
395_G398_Y0.7271.00
97_L101_V0.7241.00
426_G429_S0.7231.00
147_G151_S0.7221.00
298_Q301_K0.7221.00
417_V420_L0.7211.00
105_I352_L0.7211.00
411_M425_Y0.7191.00
92_Y96_L0.7181.00
204_L364_Y0.7161.00
62_C75_Y0.7141.00
129_I338_L0.7121.00
122_V125_G0.7111.00
297_A325_G0.7101.00
139_N294_F0.7101.00
358_V403_L0.7081.00
218_N224_P0.7071.00
372_V376_K0.7071.00
172_F176_L0.7061.00
313_F325_G0.7051.00
73_G77_E0.7051.00
418_T422_W0.7011.00
27_I241_S0.7001.00
69_S301_K0.7001.00
220_E382_P0.6991.00
412_L428_V0.6981.00
423_T426_G0.6971.00
165_C241_S0.6961.00
140_F319_V0.6961.00
413_Y417_V0.6941.00
271_P275_K0.6911.00
43_I47_V0.6901.00
214_D301_K0.6891.00
293_Q297_A0.6861.00
12_V148_Q0.6861.00
39_T246_A0.6861.00
99_A356_A0.6851.00
312_I328_T0.6851.00
8_K143_A0.6841.00
387_V392_A0.6831.00
52_S206_L0.6831.00
42_I46_L0.6801.00
322_P325_G0.6771.00
370_A374_I0.6741.00
383_S386_K0.6741.00
15_T18_T0.6731.00
108_V111_G0.6711.00
21_N291_G0.6701.00
99_A102_A0.6701.00
420_L423_T0.6691.00
348_Q351_V0.6691.00
415_S418_T0.6681.00
378_A381_P0.6681.00
97_L332_I0.6681.00
388_A393_F0.6671.00
54_A395_G0.6661.00
111_G131_V0.6651.00
23_M157_V0.6651.00
63_G223_V0.6641.00
8_K12_V0.6621.00
304_S313_F0.6611.00
79_A373_I0.6601.00
260_P264_A0.6591.00
215_V316_V0.6591.00
425_Y428_V0.6551.00
73_G89_N0.6501.00
233_G237_I0.6491.00
95_S360_N0.6491.00
145_I148_Q0.6481.00
29_M32_T0.6471.00
33_K350_N0.6451.00
172_F244_V0.6451.00
59_F367_S0.6451.00
411_M418_T0.6441.00
173_S177_Y0.6431.00
65_F379_N0.6401.00
27_I30_L0.6381.00
241_S261_F0.6371.00
131_V289_L0.6371.00
415_S422_W0.6361.00
215_V322_P0.6351.00
107_A111_G0.6351.00
56_A206_L0.6331.00
45_W202_A0.6331.00
135_C286_C0.6331.00
79_A374_I0.6311.00
20_V154_V0.6301.00
374_I378_A0.6291.00
397_M400_F0.6291.00
58_A385_A0.6281.00
97_L329_I0.6281.00
284_S287_G0.6271.00
41_S242_T0.6251.00
417_V425_Y0.6251.00
81_G429_S0.6241.00
229_G232_L0.6231.00
359_T363_P0.6231.00
23_M28_I0.6231.00
133_W136_T0.6221.00
219_P222_N0.6221.00
33_K36_E0.6211.00
27_I31_P0.6211.00
34_L37_V0.6211.00
106_S110_Y0.6201.00
60_A64_M0.6171.00
393_F396_A0.6161.00
300_F328_T0.6151.00
298_Q316_V0.6151.00
140_F326_M0.6131.00
19_M22_M0.6131.00
383_S389_N0.6111.00
104_A108_V0.6101.00
42_I239_I0.6081.00
136_T293_Q0.6081.00
421_G426_G0.6061.00
412_L425_Y0.6051.00
72_M207_E0.6031.00
167_I171_W0.6021.00
31_P242_T0.6021.00
103_I289_L0.6021.00
404_Y407_G0.6011.00
143_A212_N0.6011.00
411_M417_V0.6001.00
260_P265_F0.5991.00
216_V223_V0.5991.00
276_V280_L0.5981.00
414_G423_T0.5981.00
125_G128_T0.5971.00
132_L334_S0.5971.00
113_E278_M0.5971.00
19_M154_V0.5951.00
417_V422_W0.5941.00
23_M237_I0.5931.00
233_G236_V0.5921.00
350_N353_V0.5921.00
372_V396_A0.5911.00
73_G85_N0.5911.00
410_A425_Y0.5901.00
414_G419_F0.5901.00
58_A395_G0.5901.00
399_S403_L0.5891.00
114_L279_A0.5891.00
259_A262_G0.5881.00
156_G280_L0.5881.00
142_G145_I0.5881.00
63_G210_C0.5871.00
402_A407_G0.5851.00
91_T363_P0.5851.00
411_M428_V0.5841.00
12_V15_T0.5841.00
296_I300_F0.5831.00
211_A295_T0.5831.00
241_S245_I0.5821.00
61_K65_F0.5811.00
402_A406_S0.5811.00
56_A60_A0.5811.00
398_Y402_A0.5801.00
244_V247_G0.5791.00
416_I427_L0.5781.00
160_P276_V0.5781.00
91_T362_I0.5771.00
204_L207_E0.5761.00
419_F422_W0.5761.00
416_I421_G0.5761.00
62_C79_A0.5761.00
269_F272_E0.5751.00
240_V244_V0.5751.00
412_L419_F0.5741.00
265_F269_F0.5731.00
101_V352_L0.5731.00
96_L292_W0.5701.00
98_I355_L0.5691.00
24_G238_Y0.5691.00
47_V196_I0.5681.00
103_I106_S0.5681.00
328_T332_I0.5661.00
145_I149_I0.5661.00
39_T251_N0.5661.00
147_G290_L0.5651.00
48_T203_F0.5631.00
14_L212_N0.5611.00
210_C227_V0.5611.00
298_Q322_P0.5601.00
110_Y281_M0.5601.00
375_Q388_A0.5591.00
110_Y262_G0.5581.00
349_F353_V0.5581.00
191_A194_S0.5581.00
48_T200_L0.5531.00
31_P34_L0.5531.00
416_I423_T0.5521.00
223_V227_V0.5511.00
72_M211_A0.5501.00
167_I269_F0.5501.00
335_G338_L0.5491.00
361_I399_S0.5481.00
421_G429_S0.5471.00
365_I403_L0.5461.00
25_S201_W0.5461.00
159_I162_V0.5441.00
413_Y425_Y0.5441.00
380_V384_K0.5381.00
24_G31_P0.5351.00
156_G160_P0.5351.00
412_L417_V0.5341.00
209_A223_V0.5341.00
39_T42_I0.5341.00
193_G405_S0.5341.00
30_L353_V0.5331.00
422_W425_Y0.5321.00
7_N217_E0.5311.00
42_I45_W0.5311.00
133_W327_L0.5301.00
151_S155_W0.5301.00
34_L199_T0.5291.00
131_V286_C0.5281.00
219_P223_V0.5281.00
216_V226_A0.5271.00
413_Y419_F0.5261.00
265_F270_T0.5261.00
200_L402_A0.5261.00
424_L429_S0.5251.00
18_T22_M0.5251.00
414_G428_V0.5231.00
410_A426_G0.5231.00
204_L356_A0.5221.00
392_A399_S0.5211.00
272_E275_K0.5211.00
21_N292_W0.5211.00
134_I138_A0.5201.00
91_T95_S0.5201.00
154_V157_V0.5201.00
184_H187_P0.5191.00
316_V319_V0.5181.00
146_T294_F0.5181.00
279_A283_M0.5171.00
418_T421_G0.5161.00
29_M33_K0.5161.00
114_L282_V0.5151.00
44_S192_V0.5141.00
76_A85_N0.5131.00
171_W268_M0.5131.00
415_S421_G0.5121.00
265_F273_V0.5111.00
45_W242_T0.5111.00
245_I261_F0.5101.00
312_I316_V0.5091.00
18_T226_A0.5081.00
24_G28_I0.5071.00
122_V127_A0.5071.00
293_Q326_M0.5071.00
172_F248_I0.5061.00
114_L278_M0.5061.00
87_M91_T0.5041.00
410_A419_F0.5041.00
88_A363_P0.5031.00
21_N208_S0.5031.00
396_A399_S0.5031.00
300_F304_S0.5031.00
55_L207_E0.5031.00
413_Y421_G0.5021.00
233_G240_V0.5021.00
150_S287_G0.5011.00
10_G144_R0.5011.00
60_A227_V0.5001.00
80_F85_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.959 100 0.221 Contact Map
3giaA 1 0.959 100 0.312 Contact Map
4djkA 2 0.9294 100 0.331 Contact Map
3dh4A 3 0.9339 98.7 0.862 Contact Map
2jlnA 1 0.918 98.7 0.864 Contact Map
2xq2A 2 0.9317 98.7 0.865 Contact Map
4wgvA 2 0.8405 98.1 0.886 Contact Map
2a65A 2 0.9476 98 0.889 Contact Map
4us3A 1 0.8815 97 0.908 Contact Map
4xp4A 1 0.9544 96.8 0.91 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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