GREMLIN Database
CADB - Probable cadaverine/lysine antiporter
UniProt: P0AAE8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10132
Length: 444 (411)
Sequences: 24644 (15998)
Seq/√Len: 789.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
309_V321_K4.3981.00
133_T327_A4.3891.00
47_I232_G3.2551.00
312_E321_K3.0911.00
218_R222_L2.9671.00
8_G214_K2.8911.00
375_R379_V2.8421.00
367_F394_C2.8331.00
71_I303_D2.7041.00
213_V219_T2.6871.00
215_N218_R2.6761.00
86_G300_A2.6531.00
314_D320_K2.6491.00
165_G241_V2.5911.00
301_A311_G2.5271.00
309_V312_E2.4991.00
163_I167_H2.3831.00
13_T226_L2.3751.00
269_W273_L2.3711.00
211_G302_N2.3081.00
9_L226_L2.2981.00
212_M295_Q2.2441.00
260_I263_S2.2211.00
298_V302_N2.1741.00
370_C393_G2.1741.00
9_L219_T2.1621.00
75_G82_G2.1381.00
391_V395_V2.1241.00
421_M425_R2.1221.00
324_L328_V2.1111.00
134_F138_L2.0951.00
379_V383_N2.0751.00
12_C213_V2.0651.00
141_T145_R2.0501.00
9_L13_T2.0301.00
77_I375_R2.0161.00
222_L226_L2.0131.00
137_M320_K2.0131.00
250_V264_T1.9911.00
133_T323_L1.9861.00
75_G79_P1.9551.00
126_I335_I1.9431.00
152_V156_I1.9371.00
90_Y326_A1.9371.00
8_G11_A1.9201.00
56_V370_C1.9141.00
78_S81_F1.9121.00
310_Y325_L1.8981.00
260_I264_T1.8921.00
304_G308_K1.8851.00
48_I52_S1.8701.00
386_S390_S1.8691.00
395_V399_I1.8571.00
126_I332_A1.8381.00
77_I371_V1.8281.00
59_R377_E1.8191.00
247_P250_V1.8171.00
388_I392_L1.8151.00
338_T341_N1.7991.00
130_W327_A1.7851.00
32_L39_A1.7421.00
11_A148_T1.7411.00
136_N287_G1.7381.00
215_N219_T1.7341.00
375_R378_G1.7261.00
87_V419_I1.7241.00
74_A85_T1.7091.00
225_M229_G1.6711.00
16_V227_G1.6551.00
380_N383_N1.6491.00
42_G192_S1.6331.00
101_G286_L1.6081.00
49_G396_F1.6011.00
314_D318_I1.6011.00
415_V419_I1.5951.00
85_T368_Y1.5861.00
156_I160_M1.5811.00
108_L124_A1.5701.00
13_T230_L1.5701.00
377_E381_I1.5651.00
177_N180_T1.5621.00
385_V389_C1.5561.00
413_F417_L1.5521.00
137_M324_L1.5351.00
387_L391_V1.5301.00
321_K325_L1.5161.00
157_P277_F1.5131.00
254_S260_I1.5121.00
298_V313_V1.5101.00
263_S271_A1.5011.00
371_V394_C1.5001.00
7_I11_A1.4901.00
229_G233_I1.4891.00
420_L424_A1.4841.00
378_G381_I1.4601.00
371_V375_R1.4571.00
101_G129_V1.4541.00
209_S291_M1.4501.00
215_N222_L1.4491.00
297_G322_G1.4491.00
293_V326_A1.4471.00
399_I403_G1.4461.00
46_S196_C1.4441.00
104_A128_I1.4441.00
4_A317_G1.4281.00
308_K311_G1.4251.00
74_A368_Y1.4241.00
104_A279_A1.4171.00
166_W241_V1.4121.00
126_I130_W1.4081.00
54_A228_T1.4071.00
48_I392_L1.3961.00
406_S409_L1.3871.00
272_P276_A1.3861.00
133_T324_L1.3841.00
64_N76_E1.3771.00
120_P123_I1.3651.00
233_I237_A1.3631.00
176_A180_T1.3571.00
129_V331_T1.3541.00
308_K312_E1.3531.00
77_I81_F1.3461.00
52_S392_L1.3451.00
67_Q211_G1.3431.00
54_A224_T1.3411.00
409_L412_T1.3381.00
129_V327_A1.3371.00
385_V388_I1.3351.00
219_T222_L1.3331.00
169_F244_G1.3261.00
312_E320_K1.3241.00
216_P221_P1.3051.00
11_A144_S1.3031.00
266_L270_A1.2981.00
155_L159_V1.2971.00
162_A237_A1.2921.00
414_I418_I1.2881.00
40_I240_Q1.2871.00
294_G323_L1.2851.00
7_I12_C1.2791.00
170_D173_T1.2661.00
132_F286_L1.2561.00
100_I285_S1.2481.00
331_T334_M1.2411.00
169_F172_A1.2401.00
406_S410_A1.2331.00
55_Y225_M1.2301.00
90_Y297_G1.2231.00
393_G397_C1.2221.00
72_A76_E1.2141.00
59_R62_T1.2131.00
20_M231_A1.2071.00
419_I422_F1.2071.00
419_I423_Y1.2061.00
263_S268_N1.2061.00
9_L222_L1.2061.00
10_F14_G1.2051.00
122_G126_I1.1981.00
397_C400_A1.1981.00
385_V390_S1.1961.00
53_L370_C1.1941.00
165_G245_M1.1911.00
422_F425_R1.1881.00
80_A426_K1.1851.00
27_L103_T1.1831.00
56_V390_S1.1771.00
321_K324_L1.1731.00
297_G306_F1.1701.00
7_I144_S1.1601.00
63_K383_N1.1601.00
254_S257_P1.1551.00
388_I391_V1.1521.00
135_V146_L1.1511.00
57_Y70_P1.1371.00
409_L413_F1.1351.00
313_V317_G1.1291.00
66_Q72_A1.1291.00
161_T165_G1.1291.00
302_N311_G1.1281.00
83_F87_V1.1251.00
160_M164_V1.1241.00
398_F402_M1.1231.00
412_T416_S1.1221.00
105_V124_A1.1211.00
367_F398_F1.1151.00
125_C335_I1.1101.00
97_N331_T1.1071.00
214_K219_T1.1061.00
411_G414_I1.1041.00
417_L421_M1.1031.00
61_A73_Y1.0981.00
407_F410_A1.0941.00
12_C223_A1.0921.00
127_A131_V1.0811.00
74_A81_F1.0811.00
185_D188_A1.0761.00
374_I391_V1.0751.00
123_I127_A1.0691.00
17_A231_A1.0641.00
6_K214_K1.0641.00
147_T287_G1.0581.00
256_A260_I1.0561.00
145_R149_I1.0521.00
16_V206_A1.0501.00
174_Y244_G1.0491.00
15_V209_S1.0441.00
133_T137_M1.0391.00
407_F411_G1.0351.00
332_A335_I1.0331.00
17_A230_L1.0271.00
401_L404_A1.0241.00
33_A39_A1.0201.00
146_L150_G1.0191.00
384_F387_L1.0121.00
422_F426_K1.0101.00
21_M24_G1.0041.00
178_W183_T0.9961.00
140_G291_M0.9941.00
393_G396_F0.9911.00
247_P264_T0.9901.00
66_Q76_E0.9861.00
159_V163_I0.9831.00
119_V123_I0.9811.00
373_L390_S0.9791.00
131_V283_L0.9761.00
44_I236_I0.9731.00
71_I299_R0.9731.00
137_M318_I0.9661.00
414_I417_L0.9631.00
268_N272_P0.9631.00
394_C398_F0.9621.00
161_T262_A0.9571.00
390_S394_C0.9551.00
108_L112_F0.9541.00
377_E380_N0.9461.00
410_A413_F0.9431.00
190_I399_I0.9431.00
210_T220_V0.9381.00
150_G284_T0.9301.00
402_M405_S0.9291.00
374_I387_L0.9281.00
130_W134_F0.9281.00
240_Q244_G0.9271.00
6_K141_T0.9241.00
162_A241_V0.9231.00
99_A198_W0.9231.00
385_V404_A0.9141.00
201_V362_T0.9131.00
132_F287_G0.9131.00
387_L390_S0.9121.00
290_M327_A0.9111.00
40_I243_S0.9091.00
14_G148_T0.9081.00
176_A179_N0.9081.00
137_M314_D0.9071.00
378_G387_L0.9051.00
245_M261_S0.9031.00
410_A414_I0.9031.00
105_V125_C0.9021.00
226_L230_L0.9011.00
387_L404_A0.8991.00
360_L412_T0.8991.00
386_S389_C0.8981.00
155_L234_V0.8961.00
204_E208_V0.8951.00
367_F371_V0.8921.00
186_G189_I0.8911.00
174_Y177_N0.8851.00
162_A166_W0.8821.00
179_N183_T0.8821.00
87_V306_F0.8811.00
68_G72_A0.8791.00
379_V382_R0.8791.00
76_E380_N0.8761.00
130_W332_A0.8761.00
312_E315_S0.8741.00
232_G236_I0.8741.00
134_F137_M0.8691.00
390_S404_A0.8661.00
154_V281_A0.8611.00
418_I422_F0.8601.00
367_F397_C0.8601.00
205_S292_L0.8561.00
306_F310_Y0.8541.00
124_A127_A0.8531.00
52_S389_C0.8511.00
41_W45_I0.8491.00
378_G382_R0.8481.00
178_W182_D0.8481.00
191_K195_L0.8451.00
384_F388_I0.8441.00
406_S419_I0.8441.00
99_A355_T0.8431.00
75_G303_D0.8411.00
399_I402_M0.8411.00
9_L223_A0.8401.00
310_Y321_K0.8341.00
320_K324_L0.8321.00
68_G71_I0.8311.00
370_C394_C0.8311.00
11_A145_R0.8261.00
80_A84_Q0.8221.00
51_M55_Y0.8191.00
334_M338_T0.8191.00
145_R148_T0.8181.00
315_S320_K0.8171.00
400_A404_A0.8161.00
166_W170_D0.8111.00
80_A420_L0.8071.00
47_I200_F0.8071.00
186_G190_I0.8051.00
44_I48_I0.8031.00
390_S397_C0.8021.00
174_Y178_W0.7981.00
41_W189_I0.7971.00
418_I421_M0.7971.00
104_A283_L0.7961.00
384_F390_S0.7961.00
167_H171_A0.7961.00
408_E411_G0.7961.00
108_L279_A0.7901.00
357_I361_L0.7881.00
60_L373_L0.7841.00
408_E412_T0.7801.00
166_W237_A0.7781.00
167_H170_D0.7781.00
78_S427_M0.7771.00
238_A258_F0.7771.00
178_W181_A0.7761.00
331_T335_I0.7741.00
177_N182_D0.7741.00
51_M225_M0.7671.00
104_A282_C0.7661.00
221_P224_T0.7661.00
81_F368_Y0.7621.00
22_G26_A0.7621.00
52_S56_V0.7621.00
393_G404_A0.7561.00
10_F145_R0.7561.00
138_L142_W0.7551.00
63_K381_I0.7551.00
267_G270_A0.7531.00
10_F148_T0.7531.00
13_T16_V0.7521.00
96_G358_A0.7511.00
384_F404_A0.7511.00
413_F419_I0.7511.00
397_C404_A0.7491.00
177_N183_T0.7441.00
132_F290_M0.7431.00
176_A181_A0.7431.00
294_G322_G0.7361.00
256_A259_A0.7331.00
53_L397_C0.7331.00
162_A238_A0.7331.00
60_L73_Y0.7281.00
407_F412_T0.7261.00
174_Y179_N0.7261.00
295_Q298_V0.7231.00
167_H172_A0.7211.00
415_V418_I0.7211.00
201_V366_Y0.7201.00
71_I75_G0.7191.00
13_T223_A0.7161.00
144_S148_T0.7141.00
237_A241_V0.7131.00
372_D376_F0.7091.00
176_A183_T0.7091.00
395_V398_F0.7091.00
6_K140_G0.7081.00
29_P239_T0.7061.00
78_S82_G0.7051.00
416_S419_I0.7041.00
136_N323_L0.7041.00
390_S405_S0.7031.00
290_M294_G0.7011.00
74_A372_D0.6991.00
21_M26_A0.6981.00
67_Q298_V0.6971.00
215_N221_P0.6971.00
50_A203_V0.6951.00
137_M323_L0.6931.00
397_C401_L0.6931.00
310_Y322_G0.6921.00
20_M227_G0.6921.00
211_G298_V0.6921.00
39_A239_T0.6901.00
400_A403_G0.6871.00
179_N182_D0.6871.00
108_L128_I0.6871.00
109_S113_P0.6871.00
301_A310_Y0.6861.00
421_M424_A0.6861.00
57_Y369_S0.6851.00
80_A423_Y0.6851.00
132_F283_L0.6841.00
413_F416_S0.6831.00
332_A336_L0.6821.00
101_G105_V0.6821.00
21_M154_V0.6811.00
25_I238_A0.6771.00
153_L277_F0.6761.00
164_V168_W0.6711.00
309_V325_L0.6701.00
43_W199_A0.6681.00
316_N320_K0.6661.00
133_T290_M0.6661.00
94_W326_A0.6651.00
35_I191_K0.6651.00
102_I354_L0.6641.00
226_L229_G0.6641.00
88_L365_P0.6641.00
100_I103_T0.6631.00
269_W272_P0.6631.00
164_V266_L0.6631.00
59_R63_K0.6621.00
361_L365_P0.6621.00
71_I86_G0.6591.00
32_L36_G0.6571.00
41_W44_I0.6561.00
58_A62_T0.6531.00
94_W329_K0.6511.00
262_A267_G0.6511.00
314_D317_G0.6481.00
77_I82_G0.6481.00
401_L405_S0.6451.00
98_L354_L0.6451.00
38_I243_S0.6451.00
328_V333_L0.6421.00
230_L234_V0.6421.00
297_G325_L0.6411.00
142_W145_R0.6401.00
18_G151_L0.6391.00
384_F389_C0.6381.00
81_F84_Q0.6381.00
31_N352_G0.6361.00
111_F275_S0.6361.00
31_N34_S0.6351.00
335_I338_T0.6351.00
40_I44_I0.6341.00
207_A224_T0.6341.00
386_S401_L0.6331.00
262_A270_A0.6331.00
6_K10_F0.6331.00
394_C397_C0.6311.00
415_V422_F0.6301.00
109_S121_A0.6301.00
136_N291_M0.6301.00
406_S413_F0.6291.00
45_I193_I0.6281.00
19_N289_W0.6271.00
95_I357_I0.6261.00
377_E382_R0.6261.00
386_S393_G0.6251.00
325_L329_K0.6251.00
35_I38_I0.6251.00
139_G142_W0.6251.00
416_S420_L0.6241.00
212_M313_V0.6241.00
89_Y93_N0.6231.00
19_N288_S0.6231.00
128_I286_L0.6221.00
96_G99_A0.6211.00
138_L316_N0.6211.00
61_A207_A0.6191.00
16_V20_M0.6191.00
293_V297_G0.6171.00
212_M319_P0.6171.00
54_A203_V0.6161.00
373_L377_E0.6161.00
396_F400_A0.6161.00
130_W133_T0.6151.00
54_A58_A0.6141.00
406_S412_T0.6121.00
248_S251_M0.6111.00
105_V108_L0.6101.00
61_A220_V0.6091.00
208_V292_L0.6081.00
216_P219_T0.6081.00
77_I372_D0.6071.00
220_V224_T0.6061.00
112_F118_P0.6061.00
390_S400_A0.6061.00
70_P204_E0.6041.00
230_L233_I0.6041.00
42_G189_I0.6031.00
169_F173_T0.6031.00
92_A362_T0.6011.00
103_T107_Y0.6011.00
396_F399_I0.6011.00
105_V121_A0.5991.00
31_N35_I0.5991.00
201_V204_E0.5981.00
143_V291_M0.5971.00
176_A182_D0.5921.00
360_L401_L0.5921.00
408_E415_V0.5901.00
71_I82_G0.5901.00
93_N289_W0.5891.00
374_I378_G0.5881.00
113_P118_P0.5871.00
257_P262_A0.5871.00
412_T423_Y0.5861.00
52_S393_G0.5861.00
238_A242_L0.5861.00
180_T183_T0.5861.00
107_Y278_T0.5841.00
169_F245_M0.5831.00
386_S404_A0.5791.00
21_M234_V0.5791.00
188_A191_K0.5781.00
412_T422_F0.5771.00
111_F276_A0.5761.00
43_W239_T0.5741.00
140_G209_S0.5711.00
122_G125_C0.5711.00
391_V394_C0.5691.00
295_Q313_V0.5691.00
334_M341_N0.5691.00
406_S416_S0.5691.00
19_N205_S0.5681.00
100_I286_L0.5671.00
157_P273_L0.5631.00
213_V220_V0.5631.00
63_K376_F0.5621.00
142_W146_L0.5611.00
407_F419_I0.5611.00
389_C403_G0.5611.00
352_G355_T0.5601.00
8_G141_T0.5591.00
70_P208_V0.5581.00
127_A130_W0.5561.00
46_S200_F0.5561.00
46_S197_L0.5551.00
281_A284_T0.5551.00
319_P322_G0.5551.00
190_I403_G0.5551.00
144_S287_G0.5541.00
38_I248_S0.5541.00
389_C393_G0.5541.00
175_A179_N0.5541.00
362_T365_P0.5521.00
110_T113_P0.5521.00
378_G383_N0.5511.00
17_A151_L0.5511.00
276_A280_F0.5511.00
262_A266_L0.5511.00
98_L101_G0.5481.00
10_F13_T0.5481.00
156_I159_V0.5471.00
148_T152_V0.5471.00
59_R384_F0.5461.00
295_Q319_P0.5461.00
151_L154_V0.5461.00
394_C405_S0.5461.00
12_C209_S0.5451.00
401_L409_L0.5441.00
230_L237_A0.5441.00
164_V267_G0.5431.00
242_L258_F0.5411.00
177_N181_A0.5411.00
386_S391_V0.5401.00
400_A405_S0.5381.00
409_L416_S0.5381.00
241_V244_G0.5371.00
159_V162_A0.5371.00
129_V335_I0.5351.00
392_L396_F0.5351.00
218_R221_P0.5351.00
119_V122_G0.5301.00
327_A332_A0.5291.00
32_L192_S0.5291.00
415_V423_Y0.5271.00
110_T275_S0.5261.00
273_L277_F0.5251.00
309_V313_V0.5251.00
23_S198_W0.5241.00
40_I236_I0.5231.00
408_E419_I0.5231.00
128_I132_F0.5221.00
217_K222_L0.5211.00
286_L289_W0.5211.00
100_I282_C0.5191.00
336_L339_L0.5191.00
320_K323_L0.5191.00
92_A95_I0.5181.00
201_V358_A0.5151.00
390_S393_G0.5151.00
394_C404_A0.5151.00
29_P33_A0.5141.00
69_G207_A0.5131.00
28_L355_T0.5131.00
5_K214_K0.5131.00
25_I158_V0.5131.00
74_A82_G0.5131.00
107_Y259_A0.5121.00
416_S423_Y0.5121.00
377_E386_S0.5101.00
351_F355_T0.5101.00
365_P369_S0.5091.00
410_A415_V0.5071.00
393_G400_A0.5061.00
128_I283_L0.5061.00
208_V296_A0.5051.00
391_V401_L0.5051.00
53_L204_E0.5051.00
149_I153_L0.5051.00
82_G86_G0.5041.00
32_L196_C0.5041.00
85_T365_P0.5021.00
213_V223_A0.5021.00
66_Q211_G0.5011.00
36_G42_G0.5011.00
88_L92_A0.5001.00
153_L157_P0.5001.00
406_S423_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.9459 100 0.221 Contact Map
3giaA 1 0.9572 100 0.302 Contact Map
4djkA 2 0.9189 100 0.371 Contact Map
3dh4A 3 0.9347 99 0.847 Contact Map
2xq2A 2 0.9347 98.9 0.85 Contact Map
2jlnA 1 0.9167 98.7 0.86 Contact Map
2a65A 2 0.9189 97.2 0.904 Contact Map
4wgvA 2 0.8108 97.1 0.905 Contact Map
4xp4A 1 0.9482 96.4 0.913 Contact Map
4us3A 1 0.8739 94.8 0.922 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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