GREMLIN Database
ARCD - Putative arginine/ornithine antiporter
UniProt: P0AAE5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13930
Length: 460 (406)
Sequences: 24651 (15798)
Seq/√Len: 784.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
142_H338_N4.3461.00
320_I332_A4.2541.00
47_G242_L3.1491.00
323_R332_A3.0881.00
228_R232_K3.0251.00
6_G225_R2.9141.00
59_I381_A2.7651.00
72_F314_H2.7271.00
224_A229_D2.7121.00
88_A311_A2.6431.00
325_N331_S2.6151.00
312_A322_A2.5301.00
174_A251_L2.4581.00
135_S342_Q2.4361.00
11_T236_L2.4171.00
172_V176_M2.4071.00
222_A313_T2.3981.00
280_W284_I2.3791.00
320_I323_R2.3721.00
415_L419_G2.3621.00
7_L236_L2.3201.00
223_R306_E2.2851.00
371_F394_C2.2571.00
76_R84_G2.2371.00
79_F379_K2.1761.00
335_W339_I2.1601.00
309_F313_T2.1291.00
399_W403_A2.1191.00
142_H334_L2.1101.00
143_F147_R2.1031.00
7_L229_D2.0831.00
150_Q154_S2.0511.00
7_L11_T2.0451.00
139_W342_Q2.0391.00
10_L224_A2.0231.00
134_A345_L1.9791.00
374_G393_A1.9661.00
146_L331_S1.9501.00
6_G9_A1.9411.00
161_L165_L1.9301.00
56_A374_G1.9291.00
383_R387_K1.9241.00
315_K319_R1.9201.00
135_S345_L1.9161.00
232_K236_L1.9151.00
92_W337_T1.8971.00
76_R81_E1.8901.00
321_F336_L1.8831.00
48_A52_L1.8821.00
30_M39_L1.8761.00
406_P409_L1.8661.00
391_V395_I1.8581.00
235_L239_L1.8301.00
79_F375_A1.8291.00
271_G274_V1.7931.00
257_A260_E1.7871.00
419_G422_V1.7831.00
405_G408_H1.7751.00
395_I399_W1.7391.00
393_A397_G1.7311.00
226_N229_D1.7261.00
260_E275_E1.7211.00
139_W338_N1.7141.00
103_L297_Y1.6931.00
9_A157_L1.6851.00
390_G393_A1.6721.00
145_I298_L1.6691.00
388_A392_G1.6631.00
421_L425_Y1.6611.00
87_S372_L1.6571.00
75_A87_S1.6481.00
14_V237_A1.6391.00
325_N329_A1.6351.00
42_G203_T1.6151.00
138_L341_V1.6121.00
146_L335_W1.6051.00
99_N341_V1.6051.00
166_P288_G1.5691.00
11_T240_S1.5671.00
399_W402_Y1.5551.00
165_L169_L1.5541.00
89_W419_G1.5531.00
129_Q132_V1.5471.00
5_L9_A1.5441.00
382_T385_L1.5381.00
424_L428_K1.5381.00
390_G394_C1.5241.00
110_L133_G1.5101.00
239_L243_G1.4941.00
220_V302_I1.4791.00
226_N232_K1.4671.00
164_L168_G1.4611.00
103_L138_L1.4611.00
404_S408_H1.4581.00
309_F324_Q1.4531.00
375_A379_K1.4501.00
308_P333_S1.4471.00
46_T207_T1.4321.00
68_D222_A1.4291.00
332_A336_L1.4261.00
54_A238_V1.4251.00
80_G83_I1.4241.00
413_V417_A1.3971.00
142_H335_W1.3941.00
37_A193_G1.3861.00
75_A372_L1.3861.00
175_M251_L1.3811.00
319_R323_R1.3791.00
138_L338_N1.3721.00
304_A337_T1.3721.00
106_V290_I1.3701.00
243_G247_L1.3651.00
319_R322_A1.3541.00
390_G402_Y1.3421.00
283_I287_A1.3411.00
393_A396_Y1.3361.00
128_W132_V1.3341.00
323_R331_S1.3311.00
79_F83_I1.3301.00
397_G400_L1.3211.00
305_A334_L1.3201.00
229_D232_K1.3101.00
25_S105_I1.3071.00
264_I271_G1.3031.00
106_V137_L1.2961.00
274_V282_E1.2941.00
9_A153_A1.2931.00
53_L374_G1.2881.00
390_G397_G1.2771.00
64_R77_E1.2761.00
171_V247_L1.2711.00
135_S139_W1.2611.00
82_L426_A1.2591.00
54_A234_T1.2581.00
78_G376_F1.2531.00
5_L10_L1.2511.00
375_A394_C1.2481.00
40_L250_L1.2471.00
308_P317_F1.2451.00
7_L232_K1.2361.00
102_Y296_A1.2221.00
425_Y429_T1.2211.00
55_F235_L1.2191.00
49_G396_Y1.2171.00
271_G275_E1.2171.00
384_P387_K1.2081.00
419_G423_F1.2061.00
18_M241_A1.2051.00
73_T77_E1.2051.00
258_R261_L1.2011.00
396_Y399_W1.2001.00
264_I267_P1.1991.00
178_F254_G1.1961.00
5_L153_A1.1951.00
141_V297_Y1.1891.00
48_A392_G1.1891.00
393_A403_A1.1851.00
92_W308_P1.1751.00
59_I62_R1.1721.00
170_F174_A1.1701.00
398_L402_Y1.1621.00
31_A39_L1.1611.00
389_V393_A1.1591.00
8_S12_A1.1561.00
422_V426_A1.1541.00
411_L414_V1.1481.00
404_S409_L1.1481.00
420_L424_L1.1481.00
131_I135_S1.1481.00
174_A255_V1.1431.00
176_M181_D1.1411.00
397_G401_L1.1381.00
75_A83_I1.1301.00
191_A194_V1.1291.00
273_M278_G1.1271.00
188_T191_A1.1231.00
390_G396_Y1.1211.00
405_G409_L1.1191.00
313_T322_A1.1191.00
144_L155_I1.1191.00
225_R229_D1.1161.00
66_E73_T1.1151.00
175_M179_K1.1141.00
37_A200_V1.1131.00
404_S407_M1.1121.00
417_A421_L1.1101.00
10_L233_A1.1071.00
426_A429_T1.1071.00
132_V136_A1.1051.00
136_A140_I1.1001.00
61_T74_Y1.0981.00
169_L173_L1.0971.00
57_M71_I1.0961.00
414_V418_P1.0951.00
15_L240_S1.0941.00
13_L220_V1.0931.00
415_L422_V1.0881.00
155_I159_A1.0881.00
390_G400_L1.0821.00
422_V425_Y1.0791.00
4_K225_R1.0741.00
324_Q328_A1.0741.00
332_A335_W1.0621.00
394_C397_G1.0491.00
14_V217_A1.0481.00
339_I343_I1.0431.00
142_H146_L1.0401.00
52_L392_G1.0401.00
186_D189_G1.0371.00
44_G246_L1.0331.00
406_P410_L1.0331.00
407_M410_L1.0291.00
196_V199_Q1.0281.00
156_N298_L1.0281.00
107_F133_G1.0261.00
168_G172_V1.0241.00
277_M281_G1.0171.00
371_F398_L1.0161.00
85_F89_W1.0111.00
425_Y428_K1.0061.00
382_T387_K1.0041.00
146_L329_A1.0031.00
394_C398_L0.9991.00
154_S158_V0.9991.00
110_L290_I0.9891.00
212_I366_I0.9821.00
72_F310_L0.9811.00
139_W143_F0.9771.00
278_G281_G0.9701.00
389_V397_G0.9661.00
179_K182_T0.9661.00
190_L193_G0.9651.00
274_V279_P0.9621.00
110_L114_T0.9611.00
186_D190_L0.9581.00
149_V302_I0.9571.00
146_L325_N0.9561.00
66_E77_E0.9561.00
164_L244_V0.9561.00
179_K183_F0.9521.00
389_V403_A0.9501.00
412_S416_Y0.9481.00
388_A391_V0.9461.00
396_Y400_L0.9381.00
140_I294_C0.9381.00
159_A295_G0.9321.00
171_V251_L0.9261.00
407_M411_L0.9261.00
107_F134_A0.9251.00
377_L381_A0.9181.00
364_E412_S0.9161.00
390_G403_A0.9161.00
423_F426_A0.9141.00
197_W200_V0.9131.00
15_L241_A0.9121.00
397_G403_A0.9081.00
101_S209_W0.9011.00
19_L22_G0.9001.00
408_H411_L0.8991.00
176_M180_L0.8951.00
89_W317_F0.8941.00
301_T338_N0.8901.00
393_A400_L0.8901.00
40_L253_L0.8901.00
141_V298_L0.8891.00
4_K150_Q0.8881.00
82_L86_C0.8861.00
221_S230_V0.8841.00
236_L240_S0.8821.00
393_A402_Y0.8781.00
414_V417_A0.8771.00
107_F130_S0.8751.00
412_S415_L0.8741.00
215_E219_V0.8741.00
242_L246_L0.8731.00
101_S359_L0.8731.00
323_R326_A0.8711.00
226_N231_G0.8691.00
69_G73_T0.8651.00
371_F375_A0.8641.00
44_G48_A0.8601.00
250_L254_G0.8571.00
163_K292_S0.8571.00
76_R314_H0.8561.00
279_P283_I0.8531.00
321_F332_A0.8511.00
171_V175_M0.8481.00
190_L194_V0.8411.00
422_V428_K0.8401.00
180_L183_F0.8401.00
133_G136_A0.8351.00
271_G277_M0.8351.00
69_G72_F0.8341.00
12_A157_L0.8341.00
82_L420_L0.8331.00
47_G211_F0.8301.00
36_P253_L0.8221.00
216_G303_M0.8211.00
106_V294_C0.8181.00
338_N342_Q0.8151.00
51_L55_F0.8111.00
9_A154_S0.8101.00
98_A362_A0.8061.00
197_W201_K0.8061.00
60_L377_L0.8051.00
273_M276_M0.8041.00
317_F321_F0.8031.00
202_N206_I0.8031.00
80_G427_R0.8021.00
271_G278_G0.8011.00
423_F427_R0.8001.00
83_I372_L0.7991.00
378_L391_V0.7991.00
75_A376_F0.7991.00
331_S335_W0.7981.00
400_L403_A0.7971.00
410_L414_V0.7971.00
187_F190_L0.7971.00
51_L235_L0.7921.00
79_F376_F0.7911.00
106_V293_V0.7911.00
8_S157_L0.7901.00
393_A401_L0.7881.00
131_I345_L0.7881.00
143_F146_L0.7871.00
376_F380_I0.7871.00
41_I200_V0.7871.00
141_V301_T0.7851.00
273_M277_M0.7841.00
111_S130_S0.7831.00
193_G200_V0.7831.00
175_M247_L0.7811.00
18_M237_A0.7761.00
391_V401_L0.7721.00
396_Y403_A0.7711.00
326_A331_S0.7711.00
52_L56_A0.7701.00
418_P422_V0.7681.00
390_G401_L0.7661.00
410_L413_V0.7621.00
263_E266_N0.7601.00
339_I342_Q0.7581.00
19_L24_F0.7541.00
154_S157_L0.7531.00
257_A275_E0.7471.00
40_L44_G0.7471.00
201_K399_W0.7471.00
231_G234_T0.7471.00
176_M179_K0.7461.00
19_L163_K0.7451.00
23_V248_V0.7431.00
8_S154_S0.7411.00
138_L345_L0.7401.00
188_T193_G0.7351.00
306_E309_F0.7331.00
388_A396_Y0.7331.00
7_L233_A0.7271.00
420_L423_F0.7271.00
59_I63_I0.7251.00
56_A390_G0.7231.00
272_L275_E0.7221.00
193_G196_V0.7221.00
178_F181_D0.7211.00
413_V416_Y0.7191.00
236_L239_L0.7181.00
374_G394_C0.7161.00
415_L418_P0.7151.00
147_R151_T0.7151.00
60_L74_Y0.7151.00
271_G276_M0.7121.00
11_T233_A0.7101.00
418_P421_L0.7101.00
212_I370_Y0.7071.00
72_F76_R0.7051.00
27_P249_T0.7051.00
104_V358_L0.7031.00
247_L251_L0.7021.00
320_I336_L0.7021.00
419_G426_A0.7021.00
135_S346_V0.6991.00
361_I365_M0.6981.00
178_F182_T0.6971.00
391_V394_C0.6971.00
393_A399_W0.6951.00
145_I302_I0.6941.00
409_L412_S0.6941.00
41_I44_G0.6931.00
96_V340_C0.6931.00
145_I334_L0.6921.00
230_V234_T0.6891.00
389_V396_Y0.6881.00
391_V403_A0.6881.00
416_Y420_L0.6851.00
240_S244_V0.6831.00
424_L427_R0.6831.00
308_P336_L0.6831.00
327_Q331_S0.6831.00
41_I45_I0.6821.00
68_D309_F0.6821.00
410_L415_L0.6771.00
178_F251_L0.6771.00
301_T305_A0.6761.00
173_L278_G0.6751.00
222_A309_F0.6741.00
141_V294_C0.6741.00
97_I361_I0.6701.00
11_T14_V0.6701.00
415_L420_L0.6691.00
78_G379_K0.6681.00
419_G428_K0.6671.00
109_A289_L0.6671.00
396_Y401_L0.6671.00
151_T154_S0.6641.00
280_W283_I0.6631.00
411_L415_L0.6621.00
110_L137_L0.6621.00
16_S160_T0.6621.00
98_A101_S0.6611.00
394_C403_A0.6611.00
153_A157_L0.6581.00
354_D357_T0.6581.00
416_Y419_G0.6561.00
218_V234_T0.6561.00
57_M373_V0.6561.00
395_I398_L0.6561.00
4_K149_V0.6541.00
223_R324_Q0.6501.00
59_I384_P0.6491.00
272_L276_M0.6491.00
312_A321_F0.6481.00
139_W142_H0.6481.00
50_I214_V0.6481.00
183_F254_G0.6481.00
127_T130_S0.6461.00
19_L244_V0.6451.00
391_V399_W0.6451.00
184_K188_T0.6451.00
131_I134_A0.6441.00
94_C366_I0.6441.00
72_F88_A0.6441.00
255_V272_L0.6441.00
415_L423_F0.6431.00
171_V248_V0.6401.00
100_V344_C0.6401.00
245_Y249_T0.6361.00
40_L246_L0.6351.00
142_H301_T0.6331.00
91_Y95_A0.6321.00
321_F333_S0.6311.00
389_V392_G0.6301.00
419_G427_R0.6291.00
365_M369_P0.6281.00
78_G380_I0.6281.00
305_A333_S0.6261.00
102_Y297_Y0.6241.00
325_N328_A0.6231.00
248_V252_S0.6221.00
61_T230_V0.6221.00
52_L389_V0.6221.00
392_G396_Y0.6201.00
398_L401_L0.6201.00
149_V220_V0.6191.00
356_N359_L0.6191.00
113_F287_A0.6171.00
390_G399_W0.6171.00
137_L297_Y0.6171.00
39_L249_T0.6161.00
228_R231_G0.6151.00
146_L334_L0.6141.00
173_L177_M0.6131.00
408_H412_S0.6131.00
58_L62_R0.6121.00
406_P412_S0.6111.00
100_V358_L0.6091.00
90_G369_P0.6081.00
36_P40_L0.6071.00
71_I215_E0.6071.00
63_I380_I0.6061.00
34_A37_A0.6051.00
112_F286_A0.6041.00
20_G245_Y0.6041.00
151_T155_I0.6031.00
20_G24_F0.6021.00
391_V402_Y0.6021.00
170_F273_M0.6021.00
422_V427_R0.6011.00
388_A393_A0.6011.00
55_F389_V0.6011.00
70_G218_V0.6011.00
107_F110_L0.6001.00
153_A298_L0.5971.00
414_V421_L0.5941.00
43_W210_V0.5941.00
98_A102_Y0.5941.00
405_G411_L0.5921.00
162_A288_G0.5911.00
61_T218_V0.5901.00
45_I204_M0.5891.00
388_A399_W0.5881.00
388_A402_Y0.5881.00
266_N271_G0.5871.00
199_Q202_N0.5861.00
391_V397_G0.5841.00
54_A58_L0.5831.00
306_E324_Q0.5801.00
304_A308_P0.5801.00
184_K187_F0.5791.00
287_A291_V0.5791.00
54_A214_V0.5791.00
21_A209_W0.5791.00
25_S28_Q0.5781.00
14_V18_M0.5761.00
186_D192_L0.5751.00
13_L16_S0.5741.00
160_T163_K0.5701.00
113_F286_A0.5701.00
26_L359_L0.5701.00
415_L427_R0.5691.00
95_A300_W0.5691.00
240_S243_G0.5681.00
140_I144_L0.5681.00
263_E267_P0.5661.00
219_V303_M0.5631.00
90_G368_V0.5631.00
147_R327_Q0.5631.00
138_L342_Q0.5621.00
184_K189_G0.5621.00
212_I215_E0.5621.00
17_S300_W0.5621.00
224_A230_V0.5611.00
148_G151_T0.5591.00
72_F84_G0.5581.00
405_G410_L0.5571.00
178_F255_V0.5571.00
46_T211_F0.5571.00
408_H415_L0.5561.00
406_P413_V0.5561.00
8_S11_T0.5551.00
223_R330_P0.5551.00
292_S295_G0.5551.00
15_L160_T0.5531.00
162_A166_P0.5531.00
46_T208_L0.5531.00
43_W249_T0.5531.00
366_I369_P0.5511.00
29_N32_A0.5501.00
306_E330_P0.5491.00
251_L254_G0.5491.00
75_A84_G0.5491.00
178_F183_F0.5471.00
413_V428_K0.5461.00
166_P284_I0.5451.00
284_I288_G0.5441.00
152_A302_I0.5421.00
423_F429_T0.5421.00
331_S334_L0.5411.00
421_L424_L0.5401.00
36_P258_R0.5401.00
128_W133_G0.5401.00
417_A420_L0.5401.00
105_I109_A0.5401.00
23_V167_L0.5391.00
100_V341_V0.5381.00
17_S299_S0.5371.00
80_G84_G0.5351.00
137_L294_C0.5351.00
19_L26_L0.5351.00
130_S134_A0.5351.00
136_A139_W0.5351.00
71_I219_V0.5341.00
10_L220_V0.5331.00
212_I362_A0.5331.00
103_L107_F0.5321.00
96_V337_T0.5311.00
355_Y359_L0.5301.00
60_L78_G0.5301.00
4_K8_S0.5281.00
193_G197_W0.5281.00
406_P415_L0.5271.00
183_F253_L0.5261.00
96_V344_C0.5261.00
308_P312_A0.5251.00
258_R262_A0.5251.00
330_P333_S0.5241.00
240_S247_L0.5231.00
108_S130_S0.5231.00
418_P426_A0.5211.00
343_I346_V0.5201.00
139_W335_W0.5201.00
353_S356_N0.5181.00
412_S419_G0.5181.00
184_K191_A0.5181.00
29_N33_V0.5171.00
94_C365_M0.5171.00
58_L234_T0.5161.00
224_A233_A0.5141.00
416_Y422_V0.5131.00
97_I362_A0.5131.00
423_F428_K0.5111.00
24_F167_L0.5101.00
30_M203_T0.5101.00
90_G94_C0.5101.00
301_T334_L0.5091.00
420_L428_K0.5081.00
174_A178_F0.5051.00
165_L168_G0.5031.00
413_V422_V0.5011.00
37_A192_L0.5001.00
29_N356_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.9 100 0.29 Contact Map
3giaA 1 0.9152 100 0.346 Contact Map
4djkA 2 0.8826 100 0.393 Contact Map
2jlnA 1 0.8848 99.1 0.842 Contact Map
3dh4A 3 0.9261 99 0.85 Contact Map
2xq2A 2 0.9239 98.9 0.853 Contact Map
4wgvA 2 0.7913 97.7 0.897 Contact Map
4xp4A 1 0.9326 96.8 0.911 Contact Map
2a65A 2 0.9022 96.1 0.917 Contact Map
4c7rA 3 0.8739 95 0.924 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0139 seconds.