PROY - ECOLI - GREMLIN Contacts

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PROY - Proline-specific permease ProY

UniProt:	P0AAE2	Sequences: MESKNKLKRGLSTRHIRFMALGSAIGTGLFYGSADAIKMAGPSVLLAYIIGGIAAYIIMRALGEMSVHNPAASSFSRYAQENLGPLAGYITGWTYCFEILIVAIADVTAFGIYMGVWFPTVPHWIWVLSVVLIICAVNLMSVKVFGELEFWFSFFKVATIIIMIVAGFGIIIWGIGNGGQPTGIHNLWSNGGFFSNGWLGMVMSLQMVMFAYGGIEIIGITAGEAKDPEKSIPRAINSVPMRILVFYVGTLFVIMSIYPWNQVGTAGSPFVLTFQHMGITFAASILNFVVLTASLSAINSDVFGVGRMLHGMAEQGSAPKIFSKTSRRGIPWVTVLVMTTALLFAVYLNYIMPENVFLVIASLATFATVWVWIMILLSQIAFRRRLPPEEVKALKFKVPGGVATTIGGLIFLLFIIGLIGYHPDTRISLYVGFAWIVVLLIGWMFKRRHDRQLAENQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13609
Length:	457 (417)
Sequences:	24719 (15764)
Seq/√Len:	772.0

ECOLI - PROY AROP YIFK ANSP GABP LYSP MMUP PHEP CYCA FRLA PLAP PUUP POTE ADIC YCAM GADC YGJI YBAT YJEM ARCD CADB YJEH TNAB
BACSU - GABP YTNA YBXG YDGF ROCC YBGF YVBW AAPA HUTM ASPP ROCE YBEC YHDG YCGH STET YFNA ARCD YECA YDAO GERBB GERAB YNDE GERKB
HALSA - Q9HHU7 Q9HQB3 Q9HSL5
SULSO - Q97U05 Q97X49 Q97WS3 Q7LXI7 Q97XM0 Q97Z63 Q97ZB5 Q97VA6 Q97U33 Q97WD4 Q97VR4 Q97VA8 Q97Y76 Q97YN3 Q97YX9 Q97U39

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
135_C	339_T	4.343	1.00
321_I	333_V	4.309	1.00
381_A	385_R	3.300	1.00
52_G	244_L	3.173	1.00
373_I	409_L	3.155	1.00
324_K	333_V	3.063	1.00
230_K	234_R	2.986	1.00
12_S	226_K	2.817	1.00
225_A	231_S	2.737	1.00
76_S	315_Q	2.677	1.00
313_A	323_S	2.611	1.00
92_G	312_M	2.602	1.00
227_D	230_K	2.600	1.00
167_G	253_V	2.546	1.00
17_R	238_S	2.509	1.00
128_L	343_L	2.487	1.00
326_S	332_W	2.470	1.00
321_I	324_K	2.448	1.00
281_F	285_I	2.419	1.00
432_G	436_I	2.377	1.00
13_T	238_S	2.352	1.00
223_G	314_E	2.329	1.00
165_V	169_G	2.279	1.00
376_L	408_G	2.273	1.00
80_Q	88_G	2.174	1.00
64_E	383_R	2.173	1.00
136_A	140_M	2.143	1.00
224_E	307_R	2.143	1.00
336_L	340_T	2.121	1.00
310_H	314_E	2.121	1.00
16_I	225_A	2.055	1.00
436_I	439_L	2.050	1.00
13_T	17_R	2.041	1.00
143_K	147_E	2.041	1.00
13_T	231_S	2.040	1.00
234_R	238_S	2.031	1.00
135_C	335_V	2.031	1.00
132_L	343_L	2.027	1.00
139_L	332_W	1.986	1.00
272_L	275_Q	1.985	1.00
438_V	442_G	1.982	1.00
127_V	346_V	1.962	1.00
154_F	158_A	1.954	1.00
83_L	381_A	1.949	1.00
406_I	410_I	1.944	1.00
17_R	242_R	1.920	1.00
61_A	376_L	1.907	1.00
80_Q	85_P	1.906	1.00
96_C	338_M	1.900	1.00
316_G	320_K	1.883	1.00
322_F	337_V	1.882	1.00
36_A	44_V	1.879	1.00
12_S	15_H	1.876	1.00
128_L	346_V	1.856	1.00
53_I	57_I	1.843	1.00
7_L	325_T	1.840	1.00
262_Q	276_H	1.835	1.00
83_L	377_L	1.824	1.00
259_P	262_Q	1.807	1.00
436_I	440_L	1.807	1.00
440_L	444_M	1.798	1.00
377_L	409_L	1.786	1.00
403_A	407_G	1.777	1.00
326_S	330_I	1.726	1.00
227_D	231_S	1.701	1.00
237_N	241_M	1.694	1.00
132_L	339_T	1.691	1.00
272_L	276_H	1.691	1.00
138_N	299_N	1.689	1.00
79_A	91_T	1.678	1.00
15_H	150_F	1.661	1.00
410_I	414_F	1.659	1.00
54_A	411_F	1.659	1.00
103_A	342_L	1.647	1.00
425_T	428_S	1.647	1.00
139_L	336_L	1.610	1.00
43_S	201_M	1.607	1.00
426_R	429_L	1.606	1.00
11_L	15_H	1.605	1.00
91_T	374_M	1.597	1.00
47_A	204_S	1.597	1.00
131_V	342_L	1.593	1.00
328_R	332_W	1.587	1.00
20_A	239_V	1.575	1.00
122_P	125_I	1.555	1.00
107_V	298_I	1.554	1.00
430_Y	434_A	1.552	1.00
158_A	162_I	1.532	1.00
241_M	245_V	1.531	1.00
441_I	445_F	1.527	1.00
429_L	432_G	1.523	1.00
381_A	384_R	1.516	1.00
8_K	329_G	1.491	1.00
84_G	87_A	1.491	1.00
114_M	126_W	1.476	1.00
309_L	334_T	1.461	1.00
159_T	289_V	1.453	1.00
221_T	303_F	1.441	1.00
275_Q	283_A	1.440	1.00
439_L	442_G	1.433	1.00
51_G	208_V	1.414	1.00
53_I	407_G	1.413	1.00
131_V	339_T	1.405	1.00
140_M	328_R	1.404	1.00
121_V	125_I	1.404	1.00
333_V	337_V	1.402	1.00
310_H	325_T	1.400	1.00
168_F	253_V	1.400	1.00
128_L	132_L	1.393	1.00
227_D	234_R	1.392	1.00
434_A	438_V	1.391	1.00
57_I	407_G	1.387	1.00
305_V	338_M	1.384	1.00
110_F	130_V	1.378	1.00
59_M	240_P	1.375	1.00
83_L	87_A	1.375	1.00
107_V	131_V	1.360	1.00
320_K	323_S	1.358	1.00
135_C	336_L	1.354	1.00
400_G	404_T	1.344	1.00
7_L	310_H	1.334	1.00
387_P	394_L	1.330	1.00
377_L	381_A	1.329	1.00
324_K	332_W	1.327	1.00
320_K	324_K	1.320	1.00
425_T	432_G	1.320	1.00
110_F	291_L	1.313	1.00
284_S	288_F	1.311	1.00
79_A	374_M	1.306	1.00
191_G	195_S	1.300	1.00
439_L	443_W	1.288	1.00
72_A	223_G	1.286	1.00
231_S	234_R	1.285	1.00
15_H	146_G	1.281	1.00
11_L	16_I	1.275	1.00
164_I	249_G	1.272	1.00
306_G	335_V	1.271	1.00
426_R	440_L	1.270	1.00
69_N	81_E	1.269	1.00
157_V	161_I	1.261	1.00
228_P	233_P	1.260	1.00
171_I	256_S	1.257	1.00
59_M	236_I	1.256	1.00
268_S	272_L	1.253	1.00
429_L	436_I	1.246	1.00
426_R	439_L	1.244	1.00
106_D	297_A	1.239	1.00
68_H	394_L	1.236	1.00
380_I	406_I	1.232	1.00
245_V	249_G	1.231	1.00
134_I	298_I	1.228	1.00
58_I	376_L	1.221	1.00
82_N	378_S	1.217	1.00
60_R	237_N	1.212	1.00
45_L	252_F	1.208	1.00
43_S	194_F	1.200	1.00
11_L	146_G	1.199	1.00
61_A	405_T	1.198	1.00
373_I	413_L	1.196	1.00
275_Q	280_T	1.188	1.00
13_T	234_R	1.187	1.00
86_L	443_W	1.186	1.00
77_R	81_E	1.185	1.00
431_V	434_A	1.180	1.00
24_A	243_I	1.177	1.00
425_T	429_L	1.174	1.00
124_W	128_L	1.174	1.00
169_G	174_G	1.170	1.00
14_R	18_F	1.153	1.00
309_L	318_A	1.145	1.00
163_M	167_G	1.137	1.00
260_W	263_V	1.136	1.00
401_G	405_T	1.136	1.00
31_Y	109_A	1.129	1.00
384_R	387_P	1.125	1.00
426_R	430_Y	1.124	1.00
93_W	436_I	1.122	1.00
137_V	148_L	1.122	1.00
148_L	152_F	1.120	1.00
427_I	431_V	1.115	1.00
62_L	75_F	1.114	1.00
426_R	433_F	1.114	1.00
16_I	235_A	1.110	1.00
226_K	231_S	1.109	1.00
432_G	435_W	1.108	1.00
167_G	257_I	1.102	1.00
162_I	166_A	1.101	1.00
71_A	77_R	1.097	1.00
435_W	439_L	1.097	1.00
427_I	430_Y	1.093	1.00
426_R	432_G	1.092	1.00
432_G	440_L	1.088	1.00
433_F	437_V	1.084	1.00
429_L	434_A	1.083	1.00
149_E	299_N	1.083	1.00
402_V	406_I	1.077	1.00
409_L	413_L	1.074	1.00
440_L	443_W	1.074	1.00
424_D	427_I	1.074	1.00
414_F	418_L	1.073	1.00
20_A	218_I	1.069	1.00
10_G	226_K	1.062	1.00
424_D	428_S	1.062	1.00
384_R	402_V	1.058	1.00
432_G	439_L	1.058	1.00
430_Y	433_F	1.057	1.00
168_F	172_I	1.053	1.00
89_Y	93_W	1.051	1.00
66_S	78_Y	1.048	1.00
96_C	309_L	1.048	1.00
437_V	441_I	1.047	1.00
19_M	221_T	1.047	1.00
21_L	242_R	1.047	1.00
431_V	435_W	1.036	1.00
181_P	184_I	1.035	1.00
314_E	323_S	1.027	1.00
64_E	67_V	1.023	1.00
192_G	195_S	1.020	1.00
379_Q	405_T	1.017	1.00
76_S	311_G	1.017	1.00
403_A	406_I	1.015	1.00
340_T	344_F	1.007	1.00
111_G	126_W	1.006	1.00
325_T	329_G	1.006	1.00
435_W	438_V	1.002	1.00
125_I	129_S	1.002	1.00
194_F	197_G	1.001	1.00
333_V	336_L	1.000	1.00
114_M	291_L	0.998	1.00
37_I	44_V	0.995	1.00
129_S	133_I	0.995	1.00
81_E	386_L	0.988	1.00
413_L	417_G	0.987	1.00
266_A	272_L	0.981	1.00
400_G	403_A	0.978	1.00
79_A	87_A	0.978	1.00
21_L	243_I	0.972	1.00
417_G	421_Y	0.972	1.00
49_I	248_V	0.970	1.00
157_V	246_F	0.969	1.00
161_I	165_V	0.963	1.00
71_A	81_E	0.961	1.00
428_S	431_V	0.961	1.00
427_I	436_I	0.958	1.00
383_R	387_P	0.957	1.00
142_V	303_F	0.954	1.00
408_G	412_L	0.953	1.00
169_G	173_W	0.944	1.00
147_E	151_W	0.943	1.00
164_I	253_V	0.940	1.00
135_C	139_L	0.938	1.00
442_G	445_F	0.938	1.00
132_L	136_A	0.938	1.00
426_R	443_W	0.936	1.00
152_F	296_S	0.934	1.00
222_A	232_I	0.932	1.00
376_L	409_L	0.932	1.00
441_I	444_M	0.914	1.00
57_I	404_T	0.913	1.00
238_S	242_R	0.913	1.00
429_L	433_F	0.911	1.00
202_V	414_F	0.908	1.00
18_F	150_F	0.907	1.00
274_F	277_M	0.902	1.00
73_S	77_R	0.902	1.00
373_I	412_L	0.898	1.00
139_L	330_I	0.897	1.00
427_I	440_L	0.892	1.00
213_G	368_T	0.892	1.00
302_V	339_T	0.889	1.00
257_I	273_T	0.888	1.00
216_E	220_I	0.884	1.00
45_L	255_M	0.877	1.00
114_M	118_F	0.876	1.00
133_I	295_L	0.872	1.00
427_I	444_M	0.867	1.00
67_V	395_K	0.866	1.00
402_V	405_T	0.865	1.00
326_S	329_G	0.863	1.00
134_I	299_N	0.862	1.00
394_L	397_K	0.861	1.00
93_W	318_A	0.860	1.00
244_L	248_V	0.860	1.00
80_Q	315_Q	0.859	1.00
126_W	129_S	0.857	1.00
105_A	361_A	0.855	1.00
433_F	436_I	0.853	1.00
322_F	333_V	0.848	1.00
25_I	28_G	0.848	1.00
73_S	76_S	0.847	1.00
105_A	210_F	0.846	1.00
203_M	207_M	0.846	1.00
139_L	326_S	0.844	1.00
111_G	127_V	0.841	1.00
52_G	212_Y	0.840	1.00
264_G	267_G	0.837	1.00
259_P	276_H	0.833	1.00
416_I	419_I	0.833	1.00
318_A	322_F	0.833	1.00
373_I	377_L	0.832	1.00
194_F	201_M	0.832	1.00
414_F	417_G	0.827	1.00
424_D	429_L	0.827	1.00
436_I	443_W	0.827	1.00
198_W	201_M	0.822	1.00
339_T	343_L	0.819	1.00
191_G	194_F	0.817	1.00
10_G	143_K	0.817	1.00
431_V	436_I	0.814	1.00
164_I	168_F	0.814	1.00
440_L	445_F	0.812	1.00
14_R	150_F	0.811	1.00
388_P	394_L	0.810	1.00
412_L	415_I	0.804	1.00
217_I	304_G	0.803	1.00
15_H	147_E	0.803	1.00
332_W	336_L	0.803	1.00
156_K	293_A	0.799	1.00
393_A	397_K	0.797	1.00
280_T	284_S	0.794	1.00
46_L	201_M	0.791	1.00
65_M	379_Q	0.790	1.00
56_Y	60_R	0.788	1.00
147_E	150_F	0.786	1.00
438_V	441_I	0.784	1.00
405_T	409_L	0.779	1.00
436_I	445_F	0.776	1.00
84_G	444_M	0.775	1.00
428_S	439_L	0.775	1.00
189_S	192_G	0.771	1.00
429_L	443_W	0.771	1.00
124_W	346_V	0.771	1.00
13_T	235_A	0.770	1.00
49_I	53_I	0.770	1.00
363_L	367_A	0.768	1.00
268_S	271_V	0.766	1.00
171_I	174_G	0.764	1.00
379_Q	383_R	0.764	1.00
110_F	294_S	0.764	1.00
184_I	256_S	0.763	1.00
169_G	172_I	0.762	1.00
427_I	432_G	0.761	1.00
265_T	269_P	0.760	1.00
111_G	123_H	0.760	1.00
428_S	432_G	0.759	1.00
79_A	378_S	0.757	1.00
269_P	274_F	0.756	1.00
426_R	441_I	0.755	1.00
57_I	61_A	0.755	1.00
264_G	269_P	0.753	1.00
108_T	360_I	0.751	1.00
380_I	384_R	0.748	1.00
252_F	256_S	0.747	1.00
87_A	374_M	0.746	1.00
136_A	139_L	0.745	1.00
380_I	402_V	0.745	1.00
426_R	445_F	0.745	1.00
401_G	404_T	0.743	1.00
68_H	395_K	0.742	1.00
322_F	334_T	0.737	1.00
197_G	200_G	0.736	1.00
433_F	439_L	0.736	1.00
56_Y	237_N	0.736	1.00
278_G	282_A	0.732	1.00
58_I	412_L	0.730	1.00
432_G	444_M	0.729	1.00
7_L	307_R	0.728	1.00
168_F	249_G	0.726	1.00
279_I	282_A	0.725	1.00
425_T	439_L	0.725	1.00
10_G	142_V	0.723	1.00
415_I	419_I	0.721	1.00
95_Y	99_I	0.720	1.00
193_F	196_N	0.719	1.00
7_L	224_E	0.719	1.00
86_L	90_I	0.718	1.00
227_D	233_P	0.710	1.00
82_N	381_A	0.710	1.00
140_M	144_V	0.710	1.00
434_A	437_V	0.709	1.00
430_Y	436_I	0.709	1.00
100_L	341_A	0.706	1.00
432_G	437_V	0.705	1.00
25_I	30_F	0.704	1.00
429_L	440_L	0.704	1.00
36_A	40_A	0.704	1.00
110_F	295_L	0.702	1.00
111_G	114_M	0.701	1.00
17_R	235_A	0.697	1.00
429_L	439_L	0.697	1.00
131_V	346_V	0.694	1.00
428_S	433_F	0.691	1.00
425_T	442_G	0.691	1.00
115_G	119_P	0.690	1.00
102_V	364_A	0.689	1.00
425_T	440_L	0.689	1.00
281_F	284_S	0.688	1.00
25_I	156_K	0.687	1.00
134_I	302_V	0.687	1.00
426_R	435_W	0.684	1.00
171_I	253_V	0.679	1.00
139_L	328_R	0.679	1.00
76_S	80_Q	0.679	1.00
24_A	239_V	0.678	1.00
55_A	215_I	0.677	1.00
172_I	181_P	0.676	1.00
327_R	332_W	0.676	1.00
124_W	127_V	0.675	1.00
429_L	437_V	0.675	1.00
164_I	250_T	0.674	1.00
436_I	444_M	0.669	1.00
146_G	150_F	0.669	1.00
46_L	49_I	0.664	1.00
306_G	334_T	0.663	1.00
321_I	337_V	0.660	1.00
45_L	49_I	0.660	1.00
398_V	401_G	0.659	1.00
307_R	310_H	0.659	1.00
394_L	398_V	0.658	1.00
14_R	147_E	0.658	1.00
29_L	250_T	0.656	1.00
26_G	30_F	0.656	1.00
138_N	335_V	0.656	1.00
380_I	405_T	0.656	1.00
340_T	343_L	0.656	1.00
436_I	441_I	0.655	1.00
65_M	78_Y	0.655	1.00
425_T	434_A	0.654	1.00
425_T	430_Y	0.654	1.00
274_F	279_I	0.653	1.00
200_G	203_M	0.652	1.00
60_R	404_T	0.652	1.00
202_V	418_L	0.651	1.00
213_G	372_W	0.649	1.00
347_Y	350_Y	0.648	1.00
46_L	50_I	0.647	1.00
42_P	255_M	0.646	1.00
313_A	322_F	0.645	1.00
331_P	334_T	0.644	1.00
425_T	436_I	0.642	1.00
128_L	347_Y	0.642	1.00
163_M	274_F	0.642	1.00
139_L	335_V	0.641	1.00
388_P	393_A	0.640	1.00
233_P	236_I	0.640	1.00
399_P	403_A	0.639	1.00
266_A	269_P	0.639	1.00
134_I	295_L	0.639	1.00
138_N	303_F	0.638	1.00
229_E	395_K	0.638	1.00
386_L	394_L	0.637	1.00
190_N	194_F	0.635	1.00
378_S	382_F	0.634	1.00
427_I	439_L	0.633	1.00
432_G	443_W	0.633	1.00
242_R	246_F	0.632	1.00
62_L	375_I	0.631	1.00
10_G	14_R	0.630	1.00
115_G	123_H	0.628	1.00
429_L	438_V	0.628	1.00
113_Y	290_V	0.626	1.00
22_G	153_S	0.625	1.00
273_T	277_M	0.624	1.00
219_G	236_I	0.622	1.00
83_L	378_S	0.621	1.00
238_S	241_M	0.621	1.00
302_V	306_G	0.621	1.00
144_V	147_E	0.620	1.00
23_S	300_S	0.618	1.00
309_L	337_V	0.618	1.00
427_I	434_A	0.616	1.00
249_G	253_V	0.616	1.00
293_A	296_S	0.615	1.00
223_G	310_H	0.614	1.00
405_T	419_I	0.611	1.00
430_Y	435_W	0.611	1.00
99_I	301_D	0.611	1.00
82_N	382_F	0.610	1.00
395_K	398_V	0.610	1.00
132_L	135_C	0.609	1.00
44_V	251_L	0.609	1.00
242_R	245_V	0.608	1.00
425_T	444_M	0.607	1.00
33_S	251_L	0.605	1.00
189_S	193_F	0.603	1.00
101_I	363_L	0.602	1.00
213_G	216_E	0.600	1.00
116_V	287_N	0.599	1.00
305_V	309_L	0.598	1.00
171_I	257_I	0.596	1.00
232_I	236_I	0.595	1.00
425_T	443_W	0.595	1.00
66_S	232_I	0.595	1.00
23_S	301_D	0.595	1.00
66_S	219_G	0.594	1.00
72_A	310_H	0.594	1.00
17_R	20_A	0.593	1.00
384_R	388_P	0.592	1.00
63_G	67_V	0.591	1.00
430_Y	437_V	0.590	1.00
198_W	202_V	0.589	1.00
84_G	88_G	0.588	1.00
425_T	435_W	0.588	1.00
425_T	433_F	0.587	1.00
166_A	170_I	0.582	1.00
102_V	105_A	0.582	1.00
50_I	205_L	0.582	1.00
60_R	399_P	0.579	1.00
114_M	130_V	0.579	1.00
104_I	360_I	0.578	1.00
45_L	248_V	0.577	1.00
94_T	371_V	0.577	1.00
76_S	92_G	0.576	1.00
14_R	17_R	0.576	1.00
76_S	88_G	0.576	1.00
428_S	440_L	0.574	1.00
32_G	361_A	0.574	1.00
427_I	433_F	0.573	1.00
75_F	216_E	0.573	1.00
39_M	203_M	0.572	1.00
366_F	429_L	0.572	1.00
410_I	413_L	0.572	1.00
100_L	338_M	0.570	1.00
428_S	434_A	0.570	1.00
59_M	215_I	0.569	1.00
228_P	231_S	0.568	1.00
367_A	371_V	0.566	1.00
437_V	440_L	0.566	1.00
48_Y	211_A	0.566	1.00
427_I	443_W	0.565	1.00
417_G	420_G	0.565	1.00
57_I	408_G	0.565	1.00
409_L	412_L	0.564	1.00
220_I	304_G	0.564	1.00
61_A	408_G	0.563	1.00
428_S	435_W	0.563	1.00
426_R	434_A	0.562	1.00
155_F	289_V	0.560	1.00
130_V	298_I	0.559	1.00
433_F	443_W	0.559	1.00
373_I	416_I	0.558	1.00
225_A	232_I	0.557	1.00
424_D	439_L	0.557	1.00
51_G	209_M	0.557	1.00
427_I	437_V	0.556	1.00
109_A	113_Y	0.555	1.00
426_R	437_V	0.554	1.00
20_A	24_A	0.554	1.00
141_S	144_V	0.554	1.00
426_R	436_I	0.554	1.00
51_G	212_Y	0.554	1.00
429_L	435_W	0.553	1.00
166_A	279_I	0.552	1.00
107_V	111_G	0.552	1.00
427_I	445_F	0.550	1.00
158_A	161_I	0.550	1.00
68_H	387_P	0.550	1.00
35_D	358_L	0.549	1.00
288_F	292_T	0.549	1.00
358_L	361_A	0.548	1.00
408_G	411_F	0.547	1.00
426_R	444_M	0.547	1.00
110_F	114_M	0.547	1.00
142_V	221_T	0.547	1.00
104_I	345_A	0.546	1.00
106_D	294_S	0.545	1.00
224_E	331_P	0.544	1.00
36_A	208_V	0.543	1.00
250_T	254_I	0.543	1.00
94_T	370_W	0.542	1.00
146_G	299_N	0.542	1.00
433_F	438_V	0.541	1.00
131_V	343_L	0.541	1.00
401_G	406_I	0.540	1.00
265_T	268_S	0.539	1.00
65_M	82_N	0.539	1.00
382_F	387_P	0.539	1.00
59_M	63_G	0.538	1.00
98_E	368_T	0.537	1.00
366_F	416_I	0.537	1.00
150_F	154_F	0.536	1.00
106_D	109_A	0.535	1.00
406_I	409_L	0.534	1.00
135_C	302_V	0.532	1.00
398_V	404_T	0.530	1.00
75_F	220_I	0.528	1.00
321_I	325_T	0.527	1.00
224_E	325_T	0.527	1.00
285_I	289_V	0.526	1.00
253_V	256_S	0.525	1.00
430_Y	439_L	0.523	1.00
405_T	412_L	0.523	1.00
61_A	398_V	0.522	1.00
437_V	443_W	0.522	1.00
432_G	441_I	0.522	1.00
18_F	153_S	0.520	1.00
435_W	440_L	0.520	1.00
430_Y	438_V	0.520	1.00
412_L	416_I	0.519	1.00
435_W	442_G	0.518	1.00
194_F	198_W	0.518	1.00
25_I	32_G	0.517	1.00
153_S	156_K	0.517	1.00
7_L	10_G	0.516	1.00
129_S	132_L	0.516	1.00
183_G	189_S	0.515	1.00
155_F	159_T	0.515	1.00
116_V	119_P	0.514	1.00
254_I	270_F	0.514	1.00
274_F	282_A	0.513	1.00
426_R	431_V	0.512	1.00
368_T	371_V	0.512	1.00
26_G	247_Y	0.512	1.00
428_S	443_W	0.508	1.00
9_R	226_K	0.507	1.00
144_V	148_L	0.507	1.00
405_T	408_G	0.506	1.00
404_T	408_G	0.506	1.00
325_T	328_R	0.506	1.00
145_F	303_F	0.505	1.00
159_T	285_I	0.505	1.00
117_W	288_F	0.504	1.00
424_D	440_L	0.503	1.00
434_A	439_L	0.503	1.00
130_V	295_L	0.501	1.00
112_I	123_H	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3l1lA	2	0.9125	100	0.287	Contact Map
4djkA	2	0.8972	100	0.345	Contact Map
3giaA	1	0.9256	100	0.354	Contact Map
3dh4A	3	0.9278	99.1	0.849	Contact Map
2xq2A	2	0.93	99	0.854	Contact Map
2jlnA	1	0.9103	98.9	0.857	Contact Map
2a65A	2	0.9256	97.9	0.894	Contact Map
4wgvA	2	0.8053	97.8	0.898	Contact Map
4us3A	1	0.8425	97	0.911	Contact Map
4xp4A	1	0.9387	96.8	0.913	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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