GREMLIN Database
PROY - Proline-specific permease ProY
UniProt: P0AAE2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13609
Length: 457 (417)
Sequences: 24719 (15764)
Seq/√Len: 772.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
135_C339_T4.3431.00
321_I333_V4.3091.00
381_A385_R3.3001.00
52_G244_L3.1731.00
373_I409_L3.1551.00
324_K333_V3.0631.00
230_K234_R2.9861.00
12_S226_K2.8171.00
225_A231_S2.7371.00
76_S315_Q2.6771.00
313_A323_S2.6111.00
92_G312_M2.6021.00
227_D230_K2.6001.00
167_G253_V2.5461.00
17_R238_S2.5091.00
128_L343_L2.4871.00
326_S332_W2.4701.00
321_I324_K2.4481.00
281_F285_I2.4191.00
432_G436_I2.3771.00
13_T238_S2.3521.00
223_G314_E2.3291.00
165_V169_G2.2791.00
376_L408_G2.2731.00
80_Q88_G2.1741.00
64_E383_R2.1731.00
136_A140_M2.1431.00
224_E307_R2.1431.00
336_L340_T2.1211.00
310_H314_E2.1211.00
16_I225_A2.0551.00
436_I439_L2.0501.00
13_T17_R2.0411.00
143_K147_E2.0411.00
13_T231_S2.0401.00
234_R238_S2.0311.00
135_C335_V2.0311.00
132_L343_L2.0271.00
139_L332_W1.9861.00
272_L275_Q1.9851.00
438_V442_G1.9821.00
127_V346_V1.9621.00
154_F158_A1.9541.00
83_L381_A1.9491.00
406_I410_I1.9441.00
17_R242_R1.9201.00
61_A376_L1.9071.00
80_Q85_P1.9061.00
96_C338_M1.9001.00
316_G320_K1.8831.00
322_F337_V1.8821.00
36_A44_V1.8791.00
12_S15_H1.8761.00
128_L346_V1.8561.00
53_I57_I1.8431.00
7_L325_T1.8401.00
262_Q276_H1.8351.00
83_L377_L1.8241.00
259_P262_Q1.8071.00
436_I440_L1.8071.00
440_L444_M1.7981.00
377_L409_L1.7861.00
403_A407_G1.7771.00
326_S330_I1.7261.00
227_D231_S1.7011.00
237_N241_M1.6941.00
132_L339_T1.6911.00
272_L276_H1.6911.00
138_N299_N1.6891.00
79_A91_T1.6781.00
15_H150_F1.6611.00
410_I414_F1.6591.00
54_A411_F1.6591.00
103_A342_L1.6471.00
425_T428_S1.6471.00
139_L336_L1.6101.00
43_S201_M1.6071.00
426_R429_L1.6061.00
11_L15_H1.6051.00
91_T374_M1.5971.00
47_A204_S1.5971.00
131_V342_L1.5931.00
328_R332_W1.5871.00
20_A239_V1.5751.00
122_P125_I1.5551.00
107_V298_I1.5541.00
430_Y434_A1.5521.00
158_A162_I1.5321.00
241_M245_V1.5311.00
441_I445_F1.5271.00
429_L432_G1.5231.00
381_A384_R1.5161.00
8_K329_G1.4911.00
84_G87_A1.4911.00
114_M126_W1.4761.00
309_L334_T1.4611.00
159_T289_V1.4531.00
221_T303_F1.4411.00
275_Q283_A1.4401.00
439_L442_G1.4331.00
51_G208_V1.4141.00
53_I407_G1.4131.00
131_V339_T1.4051.00
140_M328_R1.4041.00
121_V125_I1.4041.00
333_V337_V1.4021.00
310_H325_T1.4001.00
168_F253_V1.4001.00
128_L132_L1.3931.00
227_D234_R1.3921.00
434_A438_V1.3911.00
57_I407_G1.3871.00
305_V338_M1.3841.00
110_F130_V1.3781.00
59_M240_P1.3751.00
83_L87_A1.3751.00
107_V131_V1.3601.00
320_K323_S1.3581.00
135_C336_L1.3541.00
400_G404_T1.3441.00
7_L310_H1.3341.00
387_P394_L1.3301.00
377_L381_A1.3291.00
324_K332_W1.3271.00
320_K324_K1.3201.00
425_T432_G1.3201.00
110_F291_L1.3131.00
284_S288_F1.3111.00
79_A374_M1.3061.00
191_G195_S1.3001.00
439_L443_W1.2881.00
72_A223_G1.2861.00
231_S234_R1.2851.00
15_H146_G1.2811.00
11_L16_I1.2751.00
164_I249_G1.2721.00
306_G335_V1.2711.00
426_R440_L1.2701.00
69_N81_E1.2691.00
157_V161_I1.2611.00
228_P233_P1.2601.00
171_I256_S1.2571.00
59_M236_I1.2561.00
268_S272_L1.2531.00
429_L436_I1.2461.00
426_R439_L1.2441.00
106_D297_A1.2391.00
68_H394_L1.2361.00
380_I406_I1.2321.00
245_V249_G1.2311.00
134_I298_I1.2281.00
58_I376_L1.2211.00
82_N378_S1.2171.00
60_R237_N1.2121.00
45_L252_F1.2081.00
43_S194_F1.2001.00
11_L146_G1.1991.00
61_A405_T1.1981.00
373_I413_L1.1961.00
275_Q280_T1.1881.00
13_T234_R1.1871.00
86_L443_W1.1861.00
77_R81_E1.1851.00
431_V434_A1.1801.00
24_A243_I1.1771.00
425_T429_L1.1741.00
124_W128_L1.1741.00
169_G174_G1.1701.00
14_R18_F1.1531.00
309_L318_A1.1451.00
163_M167_G1.1371.00
260_W263_V1.1361.00
401_G405_T1.1361.00
31_Y109_A1.1291.00
384_R387_P1.1251.00
426_R430_Y1.1241.00
93_W436_I1.1221.00
137_V148_L1.1221.00
148_L152_F1.1201.00
427_I431_V1.1151.00
62_L75_F1.1141.00
426_R433_F1.1141.00
16_I235_A1.1101.00
226_K231_S1.1091.00
432_G435_W1.1081.00
167_G257_I1.1021.00
162_I166_A1.1011.00
71_A77_R1.0971.00
435_W439_L1.0971.00
427_I430_Y1.0931.00
426_R432_G1.0921.00
432_G440_L1.0881.00
433_F437_V1.0841.00
429_L434_A1.0831.00
149_E299_N1.0831.00
402_V406_I1.0771.00
409_L413_L1.0741.00
440_L443_W1.0741.00
424_D427_I1.0741.00
414_F418_L1.0731.00
20_A218_I1.0691.00
10_G226_K1.0621.00
424_D428_S1.0621.00
384_R402_V1.0581.00
432_G439_L1.0581.00
430_Y433_F1.0571.00
168_F172_I1.0531.00
89_Y93_W1.0511.00
66_S78_Y1.0481.00
96_C309_L1.0481.00
437_V441_I1.0471.00
19_M221_T1.0471.00
21_L242_R1.0471.00
431_V435_W1.0361.00
181_P184_I1.0351.00
314_E323_S1.0271.00
64_E67_V1.0231.00
192_G195_S1.0201.00
379_Q405_T1.0171.00
76_S311_G1.0171.00
403_A406_I1.0151.00
340_T344_F1.0071.00
111_G126_W1.0061.00
325_T329_G1.0061.00
435_W438_V1.0021.00
125_I129_S1.0021.00
194_F197_G1.0011.00
333_V336_L1.0001.00
114_M291_L0.9981.00
37_I44_V0.9951.00
129_S133_I0.9951.00
81_E386_L0.9881.00
413_L417_G0.9871.00
266_A272_L0.9811.00
400_G403_A0.9781.00
79_A87_A0.9781.00
21_L243_I0.9721.00
417_G421_Y0.9721.00
49_I248_V0.9701.00
157_V246_F0.9691.00
161_I165_V0.9631.00
71_A81_E0.9611.00
428_S431_V0.9611.00
427_I436_I0.9581.00
383_R387_P0.9571.00
142_V303_F0.9541.00
408_G412_L0.9531.00
169_G173_W0.9441.00
147_E151_W0.9431.00
164_I253_V0.9401.00
135_C139_L0.9381.00
442_G445_F0.9381.00
132_L136_A0.9381.00
426_R443_W0.9361.00
152_F296_S0.9341.00
222_A232_I0.9321.00
376_L409_L0.9321.00
441_I444_M0.9141.00
57_I404_T0.9131.00
238_S242_R0.9131.00
429_L433_F0.9111.00
202_V414_F0.9081.00
18_F150_F0.9071.00
274_F277_M0.9021.00
73_S77_R0.9021.00
373_I412_L0.8981.00
139_L330_I0.8971.00
427_I440_L0.8921.00
213_G368_T0.8921.00
302_V339_T0.8891.00
257_I273_T0.8881.00
216_E220_I0.8841.00
45_L255_M0.8771.00
114_M118_F0.8761.00
133_I295_L0.8721.00
427_I444_M0.8671.00
67_V395_K0.8661.00
402_V405_T0.8651.00
326_S329_G0.8631.00
134_I299_N0.8621.00
394_L397_K0.8611.00
93_W318_A0.8601.00
244_L248_V0.8601.00
80_Q315_Q0.8591.00
126_W129_S0.8571.00
105_A361_A0.8551.00
433_F436_I0.8531.00
322_F333_V0.8481.00
25_I28_G0.8481.00
73_S76_S0.8471.00
105_A210_F0.8461.00
203_M207_M0.8461.00
139_L326_S0.8441.00
111_G127_V0.8411.00
52_G212_Y0.8401.00
264_G267_G0.8371.00
259_P276_H0.8331.00
416_I419_I0.8331.00
318_A322_F0.8331.00
373_I377_L0.8321.00
194_F201_M0.8321.00
414_F417_G0.8271.00
424_D429_L0.8271.00
436_I443_W0.8271.00
198_W201_M0.8221.00
339_T343_L0.8191.00
191_G194_F0.8171.00
10_G143_K0.8171.00
431_V436_I0.8141.00
164_I168_F0.8141.00
440_L445_F0.8121.00
14_R150_F0.8111.00
388_P394_L0.8101.00
412_L415_I0.8041.00
217_I304_G0.8031.00
15_H147_E0.8031.00
332_W336_L0.8031.00
156_K293_A0.7991.00
393_A397_K0.7971.00
280_T284_S0.7941.00
46_L201_M0.7911.00
65_M379_Q0.7901.00
56_Y60_R0.7881.00
147_E150_F0.7861.00
438_V441_I0.7841.00
405_T409_L0.7791.00
436_I445_F0.7761.00
84_G444_M0.7751.00
428_S439_L0.7751.00
189_S192_G0.7711.00
429_L443_W0.7711.00
124_W346_V0.7711.00
13_T235_A0.7701.00
49_I53_I0.7701.00
363_L367_A0.7681.00
268_S271_V0.7661.00
171_I174_G0.7641.00
379_Q383_R0.7641.00
110_F294_S0.7641.00
184_I256_S0.7631.00
169_G172_I0.7621.00
427_I432_G0.7611.00
265_T269_P0.7601.00
111_G123_H0.7601.00
428_S432_G0.7591.00
79_A378_S0.7571.00
269_P274_F0.7561.00
426_R441_I0.7551.00
57_I61_A0.7551.00
264_G269_P0.7531.00
108_T360_I0.7511.00
380_I384_R0.7481.00
252_F256_S0.7471.00
87_A374_M0.7461.00
136_A139_L0.7451.00
380_I402_V0.7451.00
426_R445_F0.7451.00
401_G404_T0.7431.00
68_H395_K0.7421.00
322_F334_T0.7371.00
197_G200_G0.7361.00
433_F439_L0.7361.00
56_Y237_N0.7361.00
278_G282_A0.7321.00
58_I412_L0.7301.00
432_G444_M0.7291.00
7_L307_R0.7281.00
168_F249_G0.7261.00
279_I282_A0.7251.00
425_T439_L0.7251.00
10_G142_V0.7231.00
415_I419_I0.7211.00
95_Y99_I0.7201.00
193_F196_N0.7191.00
7_L224_E0.7191.00
86_L90_I0.7181.00
227_D233_P0.7101.00
82_N381_A0.7101.00
140_M144_V0.7101.00
434_A437_V0.7091.00
430_Y436_I0.7091.00
100_L341_A0.7061.00
432_G437_V0.7051.00
25_I30_F0.7041.00
429_L440_L0.7041.00
36_A40_A0.7041.00
110_F295_L0.7021.00
111_G114_M0.7011.00
17_R235_A0.6971.00
429_L439_L0.6971.00
131_V346_V0.6941.00
428_S433_F0.6911.00
425_T442_G0.6911.00
115_G119_P0.6901.00
102_V364_A0.6891.00
425_T440_L0.6891.00
281_F284_S0.6881.00
25_I156_K0.6871.00
134_I302_V0.6871.00
426_R435_W0.6841.00
171_I253_V0.6791.00
139_L328_R0.6791.00
76_S80_Q0.6791.00
24_A239_V0.6781.00
55_A215_I0.6771.00
172_I181_P0.6761.00
327_R332_W0.6761.00
124_W127_V0.6751.00
429_L437_V0.6751.00
164_I250_T0.6741.00
436_I444_M0.6691.00
146_G150_F0.6691.00
46_L49_I0.6641.00
306_G334_T0.6631.00
321_I337_V0.6601.00
45_L49_I0.6601.00
398_V401_G0.6591.00
307_R310_H0.6591.00
394_L398_V0.6581.00
14_R147_E0.6581.00
29_L250_T0.6561.00
26_G30_F0.6561.00
138_N335_V0.6561.00
380_I405_T0.6561.00
340_T343_L0.6561.00
436_I441_I0.6551.00
65_M78_Y0.6551.00
425_T434_A0.6541.00
425_T430_Y0.6541.00
274_F279_I0.6531.00
200_G203_M0.6521.00
60_R404_T0.6521.00
202_V418_L0.6511.00
213_G372_W0.6491.00
347_Y350_Y0.6481.00
46_L50_I0.6471.00
42_P255_M0.6461.00
313_A322_F0.6451.00
331_P334_T0.6441.00
425_T436_I0.6421.00
128_L347_Y0.6421.00
163_M274_F0.6421.00
139_L335_V0.6411.00
388_P393_A0.6401.00
233_P236_I0.6401.00
399_P403_A0.6391.00
266_A269_P0.6391.00
134_I295_L0.6391.00
138_N303_F0.6381.00
229_E395_K0.6381.00
386_L394_L0.6371.00
190_N194_F0.6351.00
378_S382_F0.6341.00
427_I439_L0.6331.00
432_G443_W0.6331.00
242_R246_F0.6321.00
62_L375_I0.6311.00
10_G14_R0.6301.00
115_G123_H0.6281.00
429_L438_V0.6281.00
113_Y290_V0.6261.00
22_G153_S0.6251.00
273_T277_M0.6241.00
219_G236_I0.6221.00
83_L378_S0.6211.00
238_S241_M0.6211.00
302_V306_G0.6211.00
144_V147_E0.6201.00
23_S300_S0.6181.00
309_L337_V0.6181.00
427_I434_A0.6161.00
249_G253_V0.6161.00
293_A296_S0.6151.00
223_G310_H0.6141.00
405_T419_I0.6111.00
430_Y435_W0.6111.00
99_I301_D0.6111.00
82_N382_F0.6101.00
395_K398_V0.6101.00
132_L135_C0.6091.00
44_V251_L0.6091.00
242_R245_V0.6081.00
425_T444_M0.6071.00
33_S251_L0.6051.00
189_S193_F0.6031.00
101_I363_L0.6021.00
213_G216_E0.6001.00
116_V287_N0.5991.00
305_V309_L0.5981.00
171_I257_I0.5961.00
232_I236_I0.5951.00
425_T443_W0.5951.00
66_S232_I0.5951.00
23_S301_D0.5951.00
66_S219_G0.5941.00
72_A310_H0.5941.00
17_R20_A0.5931.00
384_R388_P0.5921.00
63_G67_V0.5911.00
430_Y437_V0.5901.00
198_W202_V0.5891.00
84_G88_G0.5881.00
425_T435_W0.5881.00
425_T433_F0.5871.00
166_A170_I0.5821.00
102_V105_A0.5821.00
50_I205_L0.5821.00
60_R399_P0.5791.00
114_M130_V0.5791.00
104_I360_I0.5781.00
45_L248_V0.5771.00
94_T371_V0.5771.00
76_S92_G0.5761.00
14_R17_R0.5761.00
76_S88_G0.5761.00
428_S440_L0.5741.00
32_G361_A0.5741.00
427_I433_F0.5731.00
75_F216_E0.5731.00
39_M203_M0.5721.00
366_F429_L0.5721.00
410_I413_L0.5721.00
100_L338_M0.5701.00
428_S434_A0.5701.00
59_M215_I0.5691.00
228_P231_S0.5681.00
367_A371_V0.5661.00
437_V440_L0.5661.00
48_Y211_A0.5661.00
427_I443_W0.5651.00
417_G420_G0.5651.00
57_I408_G0.5651.00
409_L412_L0.5641.00
220_I304_G0.5641.00
61_A408_G0.5631.00
428_S435_W0.5631.00
426_R434_A0.5621.00
155_F289_V0.5601.00
130_V298_I0.5591.00
433_F443_W0.5591.00
373_I416_I0.5581.00
225_A232_I0.5571.00
424_D439_L0.5571.00
51_G209_M0.5571.00
427_I437_V0.5561.00
109_A113_Y0.5551.00
426_R437_V0.5541.00
20_A24_A0.5541.00
141_S144_V0.5541.00
426_R436_I0.5541.00
51_G212_Y0.5541.00
429_L435_W0.5531.00
166_A279_I0.5521.00
107_V111_G0.5521.00
427_I445_F0.5501.00
158_A161_I0.5501.00
68_H387_P0.5501.00
35_D358_L0.5491.00
288_F292_T0.5491.00
358_L361_A0.5481.00
408_G411_F0.5471.00
426_R444_M0.5471.00
110_F114_M0.5471.00
142_V221_T0.5471.00
104_I345_A0.5461.00
106_D294_S0.5451.00
224_E331_P0.5441.00
36_A208_V0.5431.00
250_T254_I0.5431.00
94_T370_W0.5421.00
146_G299_N0.5421.00
433_F438_V0.5411.00
131_V343_L0.5411.00
401_G406_I0.5401.00
265_T268_S0.5391.00
65_M82_N0.5391.00
382_F387_P0.5391.00
59_M63_G0.5381.00
98_E368_T0.5371.00
366_F416_I0.5371.00
150_F154_F0.5361.00
106_D109_A0.5351.00
406_I409_L0.5341.00
135_C302_V0.5321.00
398_V404_T0.5301.00
75_F220_I0.5281.00
321_I325_T0.5271.00
224_E325_T0.5271.00
285_I289_V0.5261.00
253_V256_S0.5251.00
430_Y439_L0.5231.00
405_T412_L0.5231.00
61_A398_V0.5221.00
437_V443_W0.5221.00
432_G441_I0.5221.00
18_F153_S0.5201.00
435_W440_L0.5201.00
430_Y438_V0.5201.00
412_L416_I0.5191.00
435_W442_G0.5181.00
194_F198_W0.5181.00
25_I32_G0.5171.00
153_S156_K0.5171.00
7_L10_G0.5161.00
129_S132_L0.5161.00
183_G189_S0.5151.00
155_F159_T0.5151.00
116_V119_P0.5141.00
254_I270_F0.5141.00
274_F282_A0.5131.00
426_R431_V0.5121.00
368_T371_V0.5121.00
26_G247_Y0.5121.00
428_S443_W0.5081.00
9_R226_K0.5071.00
144_V148_L0.5071.00
405_T408_G0.5061.00
404_T408_G0.5061.00
325_T328_R0.5061.00
145_F303_F0.5051.00
159_T285_I0.5051.00
117_W288_F0.5041.00
424_D440_L0.5031.00
434_A439_L0.5031.00
130_V295_L0.5011.00
112_I123_H0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.9125 100 0.287 Contact Map
4djkA 2 0.8972 100 0.345 Contact Map
3giaA 1 0.9256 100 0.354 Contact Map
3dh4A 3 0.9278 99.1 0.849 Contact Map
2xq2A 2 0.93 99 0.854 Contact Map
2jlnA 1 0.9103 98.9 0.857 Contact Map
2a65A 2 0.9256 97.9 0.894 Contact Map
4wgvA 2 0.8053 97.8 0.898 Contact Map
4us3A 1 0.8425 97 0.911 Contact Map
4xp4A 1 0.9387 96.8 0.913 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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