GREMLIN Database
CYCA - D-serine/D-alanine/glycine transporter
UniProt: P0AAE0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12504
Length: 470 (423)
Sequences: 24842 (16028)
Seq/√Len: 779.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_L352_C4.4671.00
334_A346_K4.2841.00
396_V400_Q3.3781.00
388_T423_M3.1931.00
64_G257_I3.1831.00
337_K346_K3.0691.00
243_K247_R3.0011.00
24_T239_K2.8851.00
88_S328_E2.7221.00
238_T244_S2.7051.00
104_G325_L2.6581.00
339_S345_A2.6191.00
240_D243_K2.6101.00
326_A336_A2.5371.00
29_Q251_S2.4801.00
334_A337_K2.4601.00
140_L356_L2.4491.00
179_G266_V2.4421.00
25_N251_S2.4281.00
236_A327_Q2.4091.00
294_A298_V2.3741.00
448_L451_I2.2861.00
76_E398_R2.2691.00
444_L448_L2.2611.00
177_V181_V2.2141.00
148_T152_A2.2041.00
25_N244_S2.1711.00
92_S100_G2.1641.00
237_E320_R2.1341.00
349_T353_I2.1241.00
155_K159_E2.1041.00
323_F327_Q2.0981.00
391_L422_C2.0971.00
28_I238_T2.0861.00
25_N29_Q2.0841.00
147_L348_L2.0821.00
144_V356_L2.0761.00
420_W424_A2.0451.00
151_L345_A2.0351.00
285_E288_V2.0151.00
95_L396_V1.9741.00
166_M170_V1.9591.00
359_V363_Y1.9581.00
24_T27_H1.9341.00
450_F454_G1.9231.00
73_A391_L1.9221.00
247_R251_S1.9061.00
48_T56_I1.9031.00
19_L338_L1.9021.00
335_F350_F1.8721.00
92_S97_P1.8711.00
329_G333_K1.8641.00
108_W351_S1.8641.00
95_L392_C1.8441.00
65_F69_F1.8411.00
285_E289_L1.8351.00
275_S289_L1.8311.00
272_P275_S1.8271.00
454_G458_L1.7681.00
27_H162_F1.7571.00
55_S214_F1.7391.00
144_V352_C1.7391.00
250_N254_I1.7141.00
115_G355_L1.7001.00
417_L421_V1.7001.00
150_N312_N1.6941.00
240_D244_S1.6891.00
96_G99_A1.6841.00
91_A103_T1.6811.00
29_Q255_R1.6711.00
103_T389_I1.6701.00
453_L456_G1.6681.00
140_L361_M1.6651.00
451_I455_L1.6631.00
59_V217_G1.6491.00
32_A252_I1.6421.00
339_S343_V1.6411.00
66_M425_F1.6411.00
119_V311_A1.6231.00
143_I355_L1.6181.00
170_V174_S1.6071.00
151_L349_T1.5951.00
424_A428_F1.5871.00
392_C423_M1.5591.00
95_L99_A1.5581.00
195_A198_A1.5561.00
23_L27_H1.5531.00
279_E285_E1.5351.00
396_V399_K1.5271.00
126_A138_A1.5121.00
346_K350_F1.5081.00
288_V296_A1.5061.00
446_T450_F1.4881.00
322_L347_G1.4881.00
254_I258_M1.4861.00
69_F421_V1.4811.00
171_A302_V1.4791.00
234_T316_F1.4671.00
63_I221_A1.4561.00
452_A456_G1.4561.00
91_A389_I1.4491.00
119_V143_I1.4421.00
134_S137_V1.4381.00
442_A446_T1.4351.00
318_T351_S1.4261.00
240_D247_R1.4241.00
143_I352_C1.4181.00
323_F338_L1.4181.00
19_L323_F1.4121.00
438_D441_Q1.4111.00
392_C396_V1.4091.00
84_Y236_A1.3771.00
71_M253_P1.3681.00
333_K336_A1.3651.00
147_L349_T1.3621.00
448_L452_A1.3621.00
65_F421_V1.3571.00
180_L266_V1.3501.00
122_I304_L1.3491.00
169_I173_V1.3481.00
297_S301_F1.3411.00
27_H158_G1.3391.00
122_I142_V1.3381.00
20_R342_A1.3281.00
442_A458_L1.3271.00
140_L144_V1.3201.00
288_V293_P1.3151.00
43_M121_A1.3151.00
319_S348_L1.3141.00
337_K345_A1.3141.00
415_G419_C1.3041.00
333_K337_K1.3021.00
241_P246_P1.2991.00
71_M249_I1.2971.00
437_D440_R1.2921.00
73_A419_C1.2921.00
244_S247_R1.2911.00
281_S285_E1.2861.00
81_N93_D1.2821.00
176_I262_F1.2641.00
25_N247_R1.2621.00
98_W457_W1.2601.00
23_L158_G1.2571.00
175_L179_G1.2531.00
401_R404_L1.2511.00
361_M364_V1.2491.00
183_V269_S1.2471.00
404_L408_S1.2451.00
70_V391_L1.2401.00
444_L451_I1.2401.00
422_C426_F1.2391.00
449_W453_L1.2361.00
80_S408_S1.2331.00
23_L28_I1.2311.00
57_I265_I1.2281.00
94_L393_S1.2261.00
258_M262_F1.2261.00
428_F432_L1.2181.00
72_R250_N1.2151.00
146_L311_A1.2141.00
322_L331_A1.2131.00
89_D93_D1.2121.00
26_R30_L1.2101.00
118_D310_S1.2081.00
180_L184_A1.2071.00
55_S207_F1.1911.00
36_A256_I1.1721.00
136_W140_L1.1721.00
133_L137_V1.1711.00
273_W276_V1.1471.00
416_K420_W1.1371.00
452_A458_L1.1351.00
452_A457_W1.1321.00
362_L366_P1.1291.00
32_A231_V1.1291.00
28_I248_A1.1241.00
414_L418_M1.1151.00
83_E89_D1.1111.00
239_K244_S1.1061.00
279_E282_P1.1031.00
451_I454_G1.1031.00
346_K349_T1.1021.00
31_I234_T1.1021.00
160_M164_F1.1021.00
402_P408_S1.0961.00
74_M87_F1.0961.00
49_I56_I1.0951.00
414_L417_L1.0931.00
149_L160_M1.0921.00
417_L420_W1.0891.00
193_V198_A1.0851.00
394_Y419_C1.0821.00
193_V196_S1.0821.00
395_L420_W1.0811.00
161_E312_N1.0791.00
159_E163_W1.0781.00
443_L446_T1.0751.00
33_I255_R1.0751.00
108_W322_L1.0721.00
22_N239_K1.0631.00
427_V431_V1.0591.00
101_Y105_W1.0561.00
78_L90_F1.0531.00
137_V141_A1.0481.00
327_Q336_A1.0481.00
405_H408_S1.0471.00
445_V449_W1.0451.00
76_E79_L1.0431.00
141_A145_L1.0371.00
179_G270_V1.0361.00
173_V177_V1.0341.00
454_G457_W1.0311.00
450_F453_L1.0291.00
83_E93_D1.0291.00
33_I256_I1.0271.00
123_T138_A1.0271.00
442_A455_L1.0261.00
154_V316_F1.0191.00
147_L151_L1.0181.00
338_L342_A1.0151.00
215_F428_F1.0141.00
88_S324_G1.0111.00
210_G213_G1.0111.00
151_L343_V1.0111.00
174_S178_V1.0051.00
388_T427_V1.0001.00
445_V448_L0.9951.00
144_V148_T0.9941.00
126_A304_L0.9941.00
69_F418_M0.9921.00
169_I259_F0.9851.00
444_L452_A0.9831.00
93_D401_R0.9811.00
453_L457_W0.9801.00
235_A245_L0.9791.00
444_L455_L0.9781.00
423_M427_V0.9761.00
444_L449_W0.9751.00
206_W209_K0.9711.00
448_L455_L0.9701.00
61_M261_V0.9671.00
448_L453_L0.9651.00
164_F309_S0.9531.00
363_Y366_P0.9531.00
442_A447_P0.9441.00
442_A449_W0.9421.00
80_S404_L0.9411.00
272_P289_L0.9361.00
442_A445_V0.9341.00
359_V364_V0.9341.00
447_P451_I0.9331.00
443_L447_P0.9321.00
151_L339_S0.9281.00
85_K89_D0.9231.00
359_V362_L0.9211.00
226_V383_F0.9201.00
391_L423_M0.9191.00
123_T139_S0.9101.00
181_V184_A0.9091.00
229_E233_T0.9081.00
168_K306_S0.9031.00
145_L308_A0.9021.00
176_I180_L0.9001.00
437_D441_Q0.8991.00
204_G208_P0.8961.00
22_N155_K0.8951.00
426_F429_V0.8941.00
282_P287_F0.8931.00
57_I268_M0.8901.00
257_I261_V0.8851.00
444_L453_L0.8841.00
194_E197_F0.8831.00
91_A99_A0.8821.00
430_V433_L0.8791.00
85_K88_S0.8771.00
64_G225_F0.8741.00
30_L162_F0.8741.00
419_C423_M0.8731.00
395_L419_C0.8711.00
345_A349_T0.8711.00
388_T392_C0.8691.00
117_A223_F0.8681.00
337_K340_K0.8661.00
207_F214_F0.8651.00
139_S360_V0.8621.00
315_V352_C0.8591.00
27_H159_E0.8551.00
442_A448_L0.8521.00
270_V286_L0.8511.00
251_S255_R0.8501.00
415_G418_M0.8471.00
80_S409_I0.8471.00
443_L453_L0.8461.00
37_I40_G0.8441.00
19_L320_R0.8441.00
175_L287_F0.8411.00
399_K416_K0.8401.00
444_L450_F0.8381.00
455_L458_L0.8371.00
79_L409_I0.8371.00
282_P286_L0.8371.00
138_A141_A0.8361.00
428_F431_V0.8361.00
340_K345_A0.8321.00
122_I307_A0.8321.00
293_P297_S0.8291.00
362_L365_N0.8291.00
194_E198_A0.8261.00
126_A130_F0.8261.00
335_F346_K0.8251.00
146_L315_V0.8251.00
179_G183_V0.8251.00
61_M65_F0.8241.00
148_T151_L0.8241.00
291_G295_A0.8241.00
96_G458_L0.8241.00
146_L312_N0.8231.00
19_L22_N0.8231.00
92_S328_E0.8221.00
230_L317_S0.8221.00
176_I266_V0.8211.00
117_A376_T0.8211.00
265_I269_S0.8201.00
107_Y111_W0.8191.00
434_T437_D0.8191.00
105_W331_A0.8171.00
25_N248_A0.8151.00
211_L214_F0.8141.00
26_R162_F0.8111.00
287_F290_V0.8021.00
68_F72_R0.8011.00
91_A393_S0.8001.00
403_H408_S0.8001.00
127_Q131_P0.7941.00
443_L452_A0.7941.00
443_L450_F0.7941.00
68_F250_N0.7941.00
19_L237_E0.7931.00
444_L456_G0.7901.00
216_A220_I0.7891.00
120_V375_I0.7841.00
292_L295_A0.7831.00
393_S397_Y0.7821.00
58_F214_F0.7801.00
112_V354_C0.7741.00
388_T426_F0.7721.00
446_T452_A0.7711.00
159_E162_F0.7701.00
352_C356_L0.7701.00
48_T52_A0.7701.00
378_V382_L0.7681.00
402_P405_H0.7681.00
123_T135_D0.7651.00
122_I308_A0.7651.00
419_C422_C0.7641.00
69_F73_A0.7621.00
331_A335_F0.7611.00
353_I356_L0.7591.00
95_L98_W0.7561.00
183_V266_V0.7551.00
442_A453_L0.7541.00
70_V426_F0.7531.00
29_Q248_A0.7501.00
184_A194_E0.7481.00
431_V435_L0.7441.00
443_L448_L0.7401.00
98_W102_F0.7401.00
152_A156_M0.7401.00
99_A389_I0.7381.00
180_L262_F0.7361.00
448_L457_W0.7341.00
444_L454_G0.7291.00
442_A456_G0.7291.00
176_I263_A0.7271.00
136_W139_S0.7251.00
77_L394_Y0.7231.00
226_V387_W0.7231.00
114_T379_S0.7191.00
105_W448_L0.7151.00
29_Q32_A0.7141.00
37_I168_K0.7121.00
26_R159_E0.7111.00
446_T449_W0.7111.00
77_L90_F0.7081.00
281_S284_V0.7071.00
395_L399_K0.7061.00
193_V197_F0.7021.00
197_F269_S0.7021.00
150_N348_L0.7011.00
202_N205_G0.6991.00
41_L263_A0.6981.00
36_A252_I0.6971.00
204_G207_F0.6971.00
432_L436_E0.6971.00
205_G208_P0.6951.00
394_Y398_R0.6921.00
246_P249_I0.6901.00
72_R418_M0.6861.00
320_R323_F0.6851.00
447_P453_L0.6851.00
242_E409_I0.6831.00
449_W455_L0.6821.00
74_M390_I0.6821.00
113_V378_V0.6811.00
240_D246_P0.6781.00
408_S412_M0.6781.00
408_S411_K0.6771.00
67_L228_I0.6761.00
34_G165_A0.6741.00
443_L457_W0.6741.00
322_L350_F0.6731.00
94_L396_V0.6701.00
429_V433_L0.6661.00
22_N154_V0.6661.00
334_A350_F0.6651.00
80_S402_P0.6641.00
443_L454_G0.6621.00
58_F62_I0.6601.00
213_G216_A0.6591.00
116_M375_I0.6581.00
54_P268_M0.6571.00
358_G365_N0.6571.00
123_T126_A0.6571.00
442_A454_G0.6571.00
359_V365_N0.6561.00
315_V319_S0.6561.00
447_P450_F0.6561.00
445_V450_F0.6561.00
255_R259_F0.6561.00
245_L249_I0.6551.00
420_W423_M0.6551.00
158_G162_F0.6511.00
57_I61_M0.6511.00
127_Q135_D0.6491.00
262_F266_V0.6491.00
382_L386_V0.6491.00
150_N316_F0.6481.00
22_N26_R0.6471.00
156_M159_E0.6461.00
236_A323_F0.6461.00
425_F429_V0.6451.00
84_Y323_F0.6451.00
444_L447_P0.6431.00
35_G314_G0.6421.00
106_T386_V0.6411.00
211_L215_F0.6391.00
45_S264_L0.6391.00
429_V432_L0.6391.00
35_G313_S0.6381.00
128_F300_N0.6371.00
335_F347_G0.6371.00
451_I457_W0.6361.00
110_C383_F0.6361.00
339_S342_A0.6341.00
151_L348_L0.6331.00
306_S309_S0.6331.00
114_T117_A0.6311.00
125_Y303_V0.6311.00
294_A297_S0.6301.00
207_F210_G0.6301.00
282_P290_V0.6291.00
419_C433_L0.6291.00
88_S92_S0.6271.00
449_W452_A0.6261.00
44_G376_T0.6261.00
154_V234_T0.6251.00
144_V147_L0.6241.00
446_T457_W0.6231.00
62_I218_F0.6231.00
439_T443_L0.6211.00
95_L393_S0.6201.00
419_C426_F0.6191.00
341_R345_A0.6181.00
58_F61_M0.6181.00
71_M228_I0.6171.00
447_P454_G0.6171.00
319_S347_G0.6151.00
146_L308_A0.6151.00
449_W456_G0.6141.00
251_S254_I0.6141.00
444_L457_W0.6131.00
360_V363_Y0.6121.00
196_S269_S0.6101.00
37_I259_F0.6091.00
129_W301_F0.6091.00
344_P347_G0.6081.00
111_W314_G0.6071.00
69_F422_C0.6071.00
126_A142_V0.6071.00
87_F229_E0.6071.00
37_I42_F0.6061.00
360_V364_V0.6051.00
128_F131_P0.6051.00
215_F432_L0.6051.00
283_F287_F0.6031.00
451_I456_G0.6021.00
75_G79_L0.6021.00
153_T156_M0.6011.00
132_D135_D0.5991.00
450_F456_G0.5981.00
232_G249_I0.5971.00
47_K373_T0.5971.00
142_V311_A0.5951.00
18_S21_R0.5951.00
78_L232_G0.5951.00
446_T451_I0.5941.00
94_L397_Y0.5941.00
442_A450_F0.5911.00
443_L456_G0.5901.00
178_V182_M0.5901.00
158_G312_N0.5881.00
46_G49_I0.5881.00
412_M415_G0.5871.00
301_F305_T0.5861.00
88_S104_G0.5861.00
73_A422_C0.5861.00
326_A335_F0.5851.00
33_I165_A0.5851.00
450_F457_W0.5851.00
422_C425_F0.5841.00
78_L245_L0.5811.00
318_T322_L0.5811.00
280_K287_F0.5811.00
410_Y413_P0.5801.00
56_I264_L0.5791.00
88_S100_G0.5781.00
373_T376_T0.5771.00
237_E344_P0.5751.00
442_A451_I0.5751.00
278_P282_P0.5741.00
395_L416_K0.5731.00
143_I356_L0.5731.00
119_V123_T0.5731.00
60_Y224_A0.5721.00
263_A267_I0.5711.00
57_I261_V0.5711.00
358_G363_Y0.5711.00
446_T453_L0.5701.00
33_I36_A0.5701.00
32_A36_A0.5691.00
167_I171_A0.5691.00
399_K402_P0.5691.00
443_L449_W0.5681.00
63_I225_F0.5681.00
129_W300_N0.5671.00
442_A452_A0.5661.00
238_T245_L0.5661.00
226_V229_E0.5661.00
183_V270_V0.5651.00
63_I222_V0.5641.00
443_L458_L0.5641.00
77_L94_L0.5631.00
202_N206_W0.5631.00
162_F166_M0.5621.00
35_G230_L0.5611.00
241_P244_S0.5601.00
26_R29_Q0.5601.00
255_R258_M0.5591.00
233_T317_S0.5591.00
118_D311_A0.5581.00
413_P417_L0.5581.00
87_F233_T0.5581.00
198_A202_N0.5581.00
114_T118_D0.5571.00
112_V351_S0.5571.00
156_M160_M0.5561.00
284_V288_V0.5561.00
71_M75_G0.5541.00
118_D121_A0.5541.00
51_L216_A0.5531.00
434_T438_D0.5521.00
243_K246_P0.5511.00
165_A168_K0.5501.00
414_L419_C0.5491.00
96_G100_G0.5481.00
446_T456_G0.5451.00
418_M422_C0.5441.00
452_A455_L0.5441.00
157_F316_F0.5421.00
372_F376_T0.5421.00
19_L84_Y0.5421.00
226_V379_S0.5421.00
431_V434_T0.5411.00
255_R262_F0.5381.00
451_I458_L0.5361.00
449_W457_W0.5351.00
167_I302_V0.5331.00
405_H409_I0.5331.00
271_T275_S0.5321.00
57_I60_Y0.5311.00
121_A125_Y0.5301.00
384_M426_F0.5291.00
118_D307_A0.5291.00
445_V456_G0.5281.00
103_T386_V0.5281.00
345_A348_L0.5271.00
266_V269_S0.5261.00
122_I126_A0.5261.00
207_F211_L0.5251.00
287_F292_L0.5241.00
163_W166_M0.5241.00
86_S232_G0.5231.00
167_I305_T0.5231.00
91_A100_G0.5211.00
152_A341_R0.5191.00
59_V62_I0.5161.00
24_T155_K0.5161.00
147_L315_V0.5141.00
320_R338_L0.5141.00
154_V158_G0.5141.00
388_T430_V0.5141.00
436_E440_R0.5121.00
298_V302_V0.5121.00
47_K50_S0.5121.00
319_S351_S0.5111.00
38_G260_Y0.5101.00
152_A155_K0.5101.00
442_A457_W0.5071.00
41_L44_G0.5071.00
322_L326_A0.5061.00
43_M46_G0.5061.00
196_S202_N0.5051.00
45_S267_I0.5041.00
449_W458_L0.5041.00
106_T385_F0.5041.00
231_V245_L0.5041.00
170_V173_V0.5021.00
106_T110_C0.5021.00
263_A283_F0.5021.00
412_M418_M0.5011.00
320_R344_P0.5001.00
48_T217_G0.5001.00
116_M355_L0.5001.00
398_R415_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.8915 100 0.319 Contact Map
4djkA 2 0.8766 100 0.381 Contact Map
3giaA 1 0.8979 100 0.381 Contact Map
3dh4A 3 0.9021 99.2 0.844 Contact Map
2xq2A 2 0.9064 99.1 0.85 Contact Map
2jlnA 1 0.9021 99.1 0.85 Contact Map
4wgvA 2 0.783 98 0.894 Contact Map
2a65A 2 0.9 97.1 0.911 Contact Map
4xp4A 1 0.9064 96.7 0.915 Contact Map
4us3A 1 0.8213 96.6 0.916 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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