GREMLIN Database
TDCC - Threonine/serine transporter TdcC
UniProt: P0AAD8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10991
Length: 443 (407)
Sequences: 490 (245)
Seq/√Len: 12.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_F266_V4.8151.00
109_C374_S4.8111.00
17_W22_T4.7281.00
127_W133_F4.5681.00
263_M329_K3.4540.98
124_M135_P3.4290.98
370_F374_S3.2100.97
282_N285_E3.2070.97
171_F263_M3.0840.96
171_F329_K3.0510.96
172_I262_L3.0350.96
109_C370_F2.8150.94
116_G149_M2.7520.93
282_N300_H2.6240.91
71_A232_V2.5980.91
107_A393_G2.5910.91
416_A419_R2.5480.90
54_L433_L2.5420.90
171_F266_V2.4750.89
223_N226_P2.4680.89
81_S236_R2.4510.88
285_E289_Q2.3830.87
230_S336_L2.3140.85
164_M329_K2.3070.85
216_S221_S2.2820.84
216_S229_S2.2680.84
266_V329_K2.2590.84
343_N367_S2.2450.83
54_L207_I2.2370.83
150_A331_F2.2120.82
216_S222_F2.1490.80
21_D251_K2.1260.80
147_L372_M2.0520.77
157_K339_L2.0410.77
59_A218_M2.0240.76
406_M423_D2.0200.76
216_S224_F2.0090.75
415_L419_R1.9680.74
384_N387_D1.9450.73
215_I434_T1.9190.72
171_F179_S1.8900.71
263_M266_V1.8590.69
106_F393_G1.8310.68
403_L407_Y1.8060.67
386_L418_Y1.8050.67
124_M141_V1.7810.66
109_C277_T1.7810.66
142_A303_S1.7500.65
367_S377_V1.7450.64
180_L381_A1.7400.64
125_T298_A1.7320.64
166_Y191_I1.7290.64
222_F229_S1.7020.62
212_W216_S1.6950.62
410_R428_T1.6800.61
425_V429_V1.6690.61
164_M263_M1.6590.60
114_I266_V1.6500.60
76_S91_H1.6490.60
161_V171_F1.6420.59
30_G327_I1.6370.59
70_L400_L1.6240.59
69_A119_I1.6230.58
216_S228_V1.6140.58
143_L372_M1.6120.58
347_L367_S1.6020.57
112_L331_F1.6020.57
327_I426_F1.5970.57
17_W21_D1.5970.57
259_A266_V1.5890.57
124_M128_E1.5710.56
27_G174_S1.5660.56
13_K102_F1.5640.56
260_S266_V1.5570.55
37_V329_K1.5570.55
387_D390_E1.5560.55
377_V439_V1.5540.55
363_L420_G1.5500.55
58_L436_L1.5490.55
345_L427_V1.5310.54
183_I433_L1.5270.54
403_L428_T1.5240.54
217_I226_P1.5230.53
143_L254_Q1.5220.53
126_F324_L1.5170.53
98_V345_L1.5110.53
59_A75_L1.5040.53
218_M229_S1.4900.52
89_E348_K1.4800.51
111_L397_I1.4750.51
366_I370_F1.4720.51
132_G144_F1.4660.51
251_K254_Q1.4490.50
46_F64_F1.4350.49
126_F320_S1.4280.49
212_W228_V1.4200.48
221_S229_S1.4160.48
212_W224_F1.4100.48
329_K332_F1.4080.48
229_S232_V1.4070.48
213_L220_F1.3880.47
124_M136_L1.3860.47
143_L147_L1.3800.46
60_Y77_G1.3730.46
208_L407_Y1.3710.46
342_L346_V1.3610.45
179_S269_F1.3500.45
343_N364_N1.3500.45
212_W222_F1.3470.45
224_F232_V1.3440.44
224_F229_S1.3350.44
235_K252_C1.3310.44
66_C211_V1.3260.44
407_Y420_G1.3230.43
27_G179_S1.3150.43
182_L330_S1.3140.43
127_W131_L1.3070.43
37_V263_M1.3060.43
106_F155_F1.2920.42
164_M171_F1.2880.42
212_W229_S1.2720.41
117_V155_F1.2690.41
84_I335_Y1.2660.41
222_F231_F1.2620.40
403_L432_L1.2580.40
217_I228_V1.2580.40
107_A325_V1.2570.40
140_F189_A1.2540.40
220_F225_S1.2540.40
289_Q315_L1.2510.40
167_L317_Y1.2460.40
393_G419_R1.2440.40
217_I222_F1.2400.39
225_S230_S1.2390.39
29_F329_K1.2380.39
285_E288_A1.2370.39
33_I171_F1.2350.39
44_A268_M1.2340.39
322_I330_S1.2240.39
263_M332_F1.2110.38
18_R234_S1.2100.38
378_V393_G1.2090.38
84_I226_P1.2080.38
57_V162_K1.2030.38
173_A177_L1.2020.38
161_V329_K1.1970.37
157_K375_T1.1870.37
92_F401_L1.1840.37
177_L288_A1.1770.36
260_S263_M1.1720.36
221_S225_S1.1700.36
331_F335_Y1.1650.36
39_F385_I1.1650.36
64_F418_Y1.1610.36
83_N87_T1.1560.35
98_V102_F1.1520.35
216_S232_V1.1480.35
171_F330_S1.1470.35
225_S268_M1.1450.35
123_F145_L1.1390.35
361_G365_T1.1310.34
225_S228_V1.1290.34
102_F345_L1.1270.34
129_N179_S1.1260.34
227_I329_K1.1250.34
216_S231_F1.1240.34
410_R419_R1.1220.34
314_T388_L1.1220.34
22_T371_I1.1190.34
57_V185_Y1.1180.34
282_N335_Y1.1140.33
125_T315_L1.1130.33
33_I266_V1.1020.33
221_S322_I1.1010.33
178_I267_V1.0910.32
157_K237_E1.0870.32
138_R170_P1.0850.32
154_W319_A1.0840.32
112_L230_S1.0830.32
76_S272_F1.0800.32
284_A288_A1.0780.32
358_V381_A1.0760.32
102_F417_K1.0700.32
293_V335_Y1.0650.31
44_A341_G1.0600.31
126_F296_Y1.0600.31
177_L269_F1.0540.31
153_I171_F1.0510.31
39_F120_T1.0490.31
79_N162_K1.0460.30
167_L335_Y1.0430.30
59_A214_G1.0380.30
116_G160_M1.0380.30
378_V417_K1.0370.30
54_L361_G1.0360.30
406_M428_T1.0340.30
171_F319_A1.0310.30
220_F230_S1.0300.30
280_P284_A1.0290.30
84_I389_I1.0250.30
322_I366_I1.0250.30
87_T394_A1.0150.29
407_Y428_T1.0140.29
17_W236_R1.0070.29
217_I394_A1.0060.29
224_F228_V0.9990.29
220_F226_P0.9890.28
222_F228_V0.9860.28
12_T321_I0.9820.28
392_M439_V0.9820.28
116_G259_A0.9800.28
218_M227_I0.9800.28
173_A180_L0.9790.28
223_N341_G0.9760.28
217_I232_V0.9730.27
29_F260_S0.9710.27
117_V385_I0.9680.27
29_F259_A0.9670.27
174_S322_I0.9600.27
222_F226_P0.9600.27
77_G227_I0.9590.27
171_F260_S0.9530.27
159_L435_I0.9500.27
46_F177_L0.9490.26
410_R433_L0.9460.26
35_A40_F0.9450.26
84_I107_A0.9400.26
29_F77_G0.9400.26
292_P332_F0.9390.26
33_I263_M0.9370.26
57_V374_S0.9350.26
393_G435_I0.9330.26
217_I224_F0.9320.26
236_R251_K0.9310.26
126_F331_F0.9280.26
191_I303_S0.9280.26
55_M88_V0.9250.26
106_F317_Y0.9240.26
19_K119_I0.9220.25
165_S227_I0.9200.25
164_M226_P0.9180.25
114_I375_T0.9170.25
220_F232_V0.9100.25
29_F37_V0.9090.25
125_T130_Q0.9080.25
62_I122_T0.9050.25
113_W404_L0.9050.25
144_F148_L0.9020.25
232_V252_C0.9010.25
69_A155_F0.9010.25
177_L321_I0.8990.25
127_W134_A0.8990.25
99_V428_T0.8980.25
205_D209_I0.8960.24
64_F262_L0.8950.24
16_S54_L0.8950.24
13_K80_P0.8950.24
218_M233_V0.8900.24
369_I409_I0.8900.24
220_F223_N0.8880.24
81_S146_L0.8880.24
44_A218_M0.8870.24
29_F71_A0.8870.24
61_P186_W0.8860.24
397_I438_I0.8860.24
218_M260_S0.8840.24
409_I428_T0.8820.24
142_A376_W0.8810.24
146_L162_K0.8790.24
240_E424_N0.8780.24
422_L432_L0.8770.24
388_L394_A0.8750.24
171_F322_I0.8730.24
78_S432_L0.8710.24
410_R425_V0.8700.24
99_V102_F0.8630.23
427_V432_L0.8610.23
29_F160_M0.8590.23
158_D166_Y0.8580.23
259_A329_K0.8510.23
127_W180_L0.8510.23
39_F121_N0.8490.23
218_M226_P0.8490.23
102_F188_S0.8470.23
144_F369_I0.8430.23
213_L289_Q0.8410.22
254_Q324_L0.8400.22
217_I221_S0.8400.22
425_V428_T0.8380.22
165_S171_F0.8380.22
235_K238_E0.8350.22
33_I49_L0.8340.22
130_Q278_L0.8310.22
29_F171_F0.8270.22
406_M424_N0.8270.22
84_I341_G0.8260.22
268_M378_V0.8220.22
173_A425_V0.8160.22
180_L238_E0.8150.22
87_T97_G0.8150.22
95_T432_L0.8140.22
398_A401_L0.8140.22
175_L426_F0.8140.22
86_E363_L0.8140.22
291_I325_V0.8130.21
30_G115_Y0.8120.21
105_F395_P0.8110.21
278_L298_A0.8100.21
222_F227_I0.8080.21
157_K396_I0.8080.21
91_H415_L0.8070.21
158_D178_I0.8070.21
25_T284_A0.8060.21
116_G266_V0.8040.21
233_V264_V0.8040.21
160_M293_V0.8030.21
216_S227_I0.8030.21
139_G380_Y0.8000.21
183_I324_L0.7990.21
54_L385_I0.7970.21
50_I53_L0.7960.21
408_A424_N0.7940.21
63_A395_P0.7930.21
53_L429_V0.7930.21
321_I360_L0.7930.21
44_A223_N0.7920.21
127_W167_L0.7880.21
139_G439_V0.7870.21
232_V328_F0.7840.21
164_M325_V0.7840.21
410_R415_L0.7830.20
152_V432_L0.7830.20
176_V441_K0.7820.20
20_S235_K0.7810.20
334_H379_A0.7800.20
137_N423_D0.7800.20
100_I149_M0.7800.20
155_F291_I0.7790.20
397_I401_L0.7770.20
121_N138_R0.7730.20
144_F433_L0.7730.20
112_L279_S0.7720.20
179_S266_V0.7700.20
349_F373_G0.7680.20
59_A292_P0.7670.20
249_E253_S0.7640.20
127_W259_A0.7590.20
139_G180_L0.7580.20
206_G357_K0.7550.20
174_S272_F0.7510.19
218_M222_F0.7500.19
217_I229_S0.7470.19
146_L375_T0.7460.19
148_L366_I0.7440.19
97_G103_L0.7440.19
151_F180_L0.7390.19
162_K267_V0.7340.19
128_E135_P0.7320.19
57_V436_L0.7310.19
78_S90_E0.7310.19
354_D364_N0.7280.19
121_N382_N0.7280.19
99_V207_I0.7270.19
54_L357_K0.7270.19
405_P431_G0.7260.19
161_V263_M0.7260.19
156_G388_L0.7240.19
191_I331_F0.7240.19
373_G377_V0.7240.19
28_L401_L0.7220.19
145_L376_W0.7150.18
154_W171_F0.7150.18
131_L149_M0.7130.18
412_A419_R0.7120.18
75_L292_P0.7110.18
133_F206_G0.7090.18
60_Y161_V0.7090.18
115_Y186_W0.7080.18
367_S422_L0.7060.18
95_T203_G0.7050.18
131_L152_V0.7040.18
259_A263_M0.7010.18
29_F263_M0.7010.18
149_M332_F0.7000.18
28_L31_T0.7000.18
50_I378_V0.6990.18
166_Y325_V0.6980.18
318_A336_L0.6970.18
129_N299_N0.6960.18
260_S329_K0.6940.18
292_P437_N0.6930.18
44_A264_V0.6920.18
180_L288_A0.6920.18
50_I169_W0.6920.18
346_V360_L0.6920.18
16_S377_V0.6900.18
58_L234_S0.6890.18
263_M327_I0.6860.17
132_G365_T0.6840.17
103_L267_V0.6840.17
23_T60_Y0.6830.17
144_F147_L0.6820.17
82_G118_T0.6800.17
53_L106_F0.6780.17
377_V427_V0.6770.17
364_N411_K0.6760.17
410_R420_G0.6750.17
377_V381_A0.6710.17
140_F370_F0.6700.17
179_S259_A0.6700.17
54_L211_V0.6660.17
164_M332_F0.6640.17
115_Y326_A0.6640.17
111_L223_N0.6640.17
217_I223_N0.6630.17
420_G425_V0.6610.17
177_L373_G0.6570.17
171_F259_A0.6550.17
161_V332_F0.6550.17
27_G161_V0.6540.17
227_I259_A0.6540.17
142_A215_I0.6530.17
116_G375_T0.6530.17
223_N228_V0.6500.16
15_S349_F0.6500.16
283_M293_V0.6500.16
85_T105_F0.6480.16
231_F315_L0.6470.16
210_T216_S0.6470.16
262_L288_A0.6450.16
222_F225_S0.6450.16
118_T385_I0.6420.16
216_S225_S0.6410.16
256_I315_L0.6400.16
177_L369_I0.6380.16
37_V266_V0.6360.16
388_L393_G0.6350.16
259_A264_V0.6330.16
114_I215_I0.6320.16
210_T289_Q0.6320.16
267_V292_P0.6300.16
268_M332_F0.6290.16
132_G285_E0.6280.16
87_T376_W0.6270.16
212_W221_S0.6250.16
377_V425_V0.6230.16
183_I288_A0.6210.16
82_G90_E0.6210.16
33_I329_K0.6200.16
173_A249_E0.6200.16
118_T260_S0.6190.16
277_T301_F0.6190.16
67_H383_P0.6190.16
221_S231_F0.6180.16
54_L366_I0.6160.16
23_T29_F0.6150.16
14_Q162_K0.6130.15
84_I225_S0.6130.15
389_I394_A0.6130.15
297_L330_S0.6120.15
224_F271_A0.6120.15
277_T350_G0.6110.15
99_V355_K0.6110.15
32_A104_Y0.6090.15
50_I254_Q0.6070.15
160_M329_K0.6070.15
71_A404_L0.6060.15
226_P395_P0.6040.15
44_A84_I0.6030.15
207_I375_T0.6030.15
183_I265_A0.6020.15
76_S279_S0.6020.15
33_I179_S0.6010.15
232_V427_V0.6010.15
57_V281_A0.6010.15
61_P115_Y0.6010.15
360_L369_I0.5980.15
346_V368_M0.5970.15
40_F120_T0.5960.15
381_A428_T0.5950.15
323_A330_S0.5950.15
260_S332_F0.5950.15
71_A102_F0.5930.15
102_F349_F0.5910.15
27_G171_F0.5910.15
383_P394_A0.5910.15
397_I414_S0.5900.15
194_V369_I0.5890.15
410_R430_I0.5890.15
378_V390_E0.5890.15
304_M315_L0.5880.15
167_L413_P0.5870.15
95_T98_V0.5840.15
84_I164_M0.5840.15
84_I223_N0.5820.15
125_T299_N0.5810.15
216_S223_N0.5810.15
217_I304_M0.5810.15
296_Y334_H0.5810.15
107_A212_W0.5800.15
195_D291_I0.5800.15
233_V236_R0.5790.15
153_I263_M0.5790.15
172_I191_I0.5790.15
422_L429_V0.5780.15
403_L436_L0.5760.15
208_L433_L0.5760.15
132_G366_I0.5750.14
324_L375_T0.5740.14
57_V441_K0.5730.14
116_G429_V0.5730.14
285_E432_L0.5700.14
169_W227_I0.5700.14
270_F330_S0.5690.14
402_C434_T0.5670.14
46_F252_C0.5660.14
20_S156_G0.5660.14
268_M341_G0.5660.14
22_T258_R0.5650.14
212_W220_F0.5650.14
162_K357_K0.5650.14
238_E432_L0.5640.14
59_A227_I0.5640.14
179_S319_A0.5640.14
157_K324_L0.5620.14
217_I390_E0.5620.14
221_S224_F0.5600.14
229_S326_A0.5600.14
27_G329_K0.5600.14
203_G216_S0.5590.14
178_I292_P0.5580.14
20_S255_I0.5560.14
342_L367_S0.5550.14
236_R410_R0.5550.14
317_Y321_I0.5540.14
220_F228_V0.5540.14
60_Y164_M0.5530.14
82_G132_G0.5530.14
258_R388_L0.5520.14
60_Y221_S0.5510.14
221_S345_L0.5500.14
217_I230_S0.5500.14
150_A335_Y0.5500.14
204_H416_A0.5490.14
37_V164_M0.5490.14
169_W175_L0.5470.14
26_L60_Y0.5440.14
252_C409_I0.5440.14
51_P72_R0.5430.14
151_F427_V0.5430.14
18_R239_Y0.5430.14
59_A332_F0.5430.14
14_Q18_R0.5430.14
92_F390_E0.5420.14
102_F221_S0.5420.14
29_F179_S0.5410.14
250_R433_L0.5400.14
142_A368_M0.5400.14
216_S230_S0.5390.14
224_F227_I0.5390.14
33_I325_V0.5390.14
296_Y331_F0.5380.14
149_M328_F0.5380.14
218_M223_N0.5380.14
130_Q175_L0.5370.14
176_V180_L0.5370.14
65_Y162_K0.5360.14
87_T423_D0.5350.14
237_E318_A0.5350.14
213_L216_S0.5330.13
173_A412_A0.5320.13
237_E254_Q0.5310.13
327_I393_G0.5310.13
42_I175_L0.5300.13
368_M396_I0.5300.13
20_S375_T0.5300.13
345_L404_L0.5300.13
390_E401_L0.5290.13
218_M224_F0.5290.13
410_R424_N0.5280.13
143_L376_W0.5270.13
315_L400_L0.5260.13
108_I404_L0.5250.13
181_S271_A0.5240.13
28_L224_F0.5230.13
160_M266_V0.5230.13
153_I179_S0.5220.13
95_T419_R0.5210.13
23_T33_I0.5210.13
291_I295_S0.5180.13
151_F365_T0.5170.13
407_Y424_N0.5160.13
175_L299_N0.5160.13
98_V275_L0.5150.13
169_W338_T0.5150.13
223_N335_Y0.5100.13
31_T67_H0.5100.13
156_G293_V0.5100.13
66_C69_A0.5090.13
220_F227_I0.5090.13
359_S366_I0.5090.13
109_C359_S0.5070.13
77_G87_T0.5070.13
92_F323_A0.5060.13
142_A434_T0.5060.13
228_V233_V0.5050.13
211_V217_I0.5010.13
74_C107_A0.5010.13
167_L176_V0.5000.13
16_S95_T0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.851 99.8 0.873 Contact Map
3giaA 1 0.8736 99.8 0.883 Contact Map
4djkA 2 0.8555 99.3 0.914 Contact Map
4wgvA 2 0.8375 98.1 0.943 Contact Map
4us3A 1 0.842 94.7 0.962 Contact Map
4xp4A 1 0.8555 93.9 0.964 Contact Map
2a65A 2 0.8555 92.8 0.965 Contact Map
3dh4A 3 0.8375 91.2 0.967 Contact Map
2jlnA 1 0.8284 90.3 0.967 Contact Map
2xq2A 2 0.8488 83.5 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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