GREMLIN Database
SDAC - Serine transporter
UniProt: P0AAD6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12142
Length: 429 (408)
Sequences: 488 (242)
Seq/√Len: 12.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_W23_T5.0931.00
128_M134_M5.0411.00
30_Y261_T4.9661.00
110_Y359_T4.8941.00
277_D280_A3.4390.98
355_F359_T3.4100.98
125_E136_P3.3860.98
258_M315_K3.3670.98
173_V257_M3.2740.97
172_F315_K3.0700.96
172_F258_M3.0590.96
117_S150_M2.9970.96
110_Y355_F2.9190.95
72_T232_A2.8970.95
108_A378_G2.8230.94
277_D295_H2.8100.94
55_I418_I2.6410.91
401_R404_S2.6240.91
55_I207_L2.5730.90
230_S322_L2.4540.88
172_F261_T2.4540.88
60_A218_M2.3710.86
143_S298_A2.3540.86
329_N352_T2.3390.85
280_A284_Q2.3210.85
148_V357_L2.3000.84
165_M315_K2.2920.84
82_G236_R2.2810.84
151_M317_F2.2670.83
22_D246_K2.2320.82
400_M404_S2.2090.82
388_L392_Y2.2030.82
261_T315_K2.1990.81
391_M408_S2.1630.80
158_E325_R2.0940.78
376_T427_L2.0460.76
369_S372_G2.0240.75
410_V414_V1.9920.74
133_G145_I1.9870.74
172_F180_A1.9350.72
110_Y272_S1.9040.71
362_I424_F1.8980.71
215_I419_A1.8970.70
125_E142_L1.8730.69
167_I192_L1.8570.69
107_F378_G1.8560.69
348_L405_G1.8550.69
371_L403_Y1.8490.68
352_T362_I1.8260.67
126_S293_A1.8120.67
144_L357_L1.7910.66
258_M261_T1.7910.66
395_Q413_V1.7730.65
77_S92_H1.7690.65
333_I352_T1.7580.64
162_V172_F1.7370.63
18_W22_D1.7350.63
28_G175_V1.7250.63
313_I411_F1.7140.62
125_E129_S1.7050.62
127_F310_I1.7040.62
31_G313_I1.6890.61
67_A211_L1.6840.61
115_V261_T1.6790.61
254_A261_T1.6760.60
351_I355_F1.6440.59
14_S103_L1.6430.59
372_G375_E1.6400.59
90_E334_K1.6320.58
331_M412_V1.6300.58
47_V65_F1.6250.58
59_L421_S1.5940.56
181_L366_L1.5630.55
184_I418_I1.5610.55
235_K247_C1.5540.55
165_M258_M1.5500.54
255_H261_T1.5490.54
60_A214_A1.5460.54
144_L148_V1.5460.54
225_S263_M1.5300.53
38_V315_K1.5220.53
112_I382_I1.5190.53
328_F332_V1.5180.53
131_Q176_L1.5070.52
60_A76_L1.5020.52
144_L249_K1.4940.52
232_A247_C1.4800.51
388_L413_V1.4690.50
329_N349_N1.4650.50
221_S308_I1.4570.50
235_K238_E1.4550.50
223_N226_P1.4530.49
284_Q301_I1.4260.48
80_N163_K1.3940.46
180_A264_F1.3940.46
28_G180_A1.3810.46
108_A311_I1.3780.46
315_K318_L1.3720.45
113_L317_F1.3720.45
99_K331_M1.3640.45
279_A283_E1.3330.43
392_Y405_G1.3300.43
246_K249_K1.3220.43
58_I163_K1.3210.43
85_I321_Y1.3080.42
317_F321_Y1.3070.42
70_G120_I1.2980.42
178_L283_E1.2970.42
378_G404_S1.2960.42
124_V146_L1.2930.42
93_F386_L1.2890.41
78_G227_I1.2780.41
107_F156_F1.2760.41
38_V258_M1.2730.41
165_M172_F1.2700.40
103_L402_K1.2700.40
118_V156_F1.2680.40
34_I172_F1.2660.40
181_L427_L1.2660.40
363_V378_G1.2630.40
300_V373_M1.2610.40
218_M255_H1.2590.40
19_R234_A1.2570.40
45_A263_M1.2500.39
55_I346_N1.2440.39
236_R246_K1.2400.39
168_L303_W1.2390.39
227_I315_K1.2360.39
128_M132_L1.2340.39
155_R305_A1.2260.38
141_I190_A1.2220.38
162_V315_K1.2200.38
181_L238_E1.2180.38
208_W392_Y1.2090.37
183_L316_S1.2080.37
65_F403_Y1.2080.37
40_F370_I1.2010.37
61_F78_G1.1960.37
395_Q404_S1.1890.37
58_I186_Q1.1890.37
231_F301_I1.1870.36
388_L417_L1.1860.36
70_G156_F1.1830.36
363_V402_K1.1800.36
163_K342_S1.1750.36
179_L262_V1.1740.36
280_A283_E1.1690.36
178_L264_F1.1680.36
308_I316_S1.1670.36
134_M206_G1.1550.35
54_I414_V1.1550.35
249_K310_I1.1540.35
30_Y315_K1.1530.35
240_G409_N1.1470.35
127_F306_P1.1450.35
158_E360_T1.1450.35
255_H258_M1.1440.34
232_A412_V1.1410.34
126_S301_I1.1360.34
139_R171_P1.1340.34
392_Y413_V1.1290.34
99_K103_L1.1280.34
258_M318_L1.1240.34
84_D88_V1.1170.33
168_L321_Y1.1150.33
217_V379_G1.1110.33
172_F316_S1.1050.33
172_F305_A1.0960.32
216_P221_S1.0960.32
174_G178_L1.0930.32
128_M135_T1.0890.32
58_I359_T1.0880.32
125_E137_P1.0860.32
18_W236_R1.0830.32
118_V370_I1.0820.32
160_M420_I1.0800.32
131_Q273_L1.0800.32
23_T356_M1.0760.31
40_F121_T1.0760.31
79_K417_L1.0730.31
77_S267_F1.0660.31
407_I417_L1.0590.31
113_L230_S1.0530.30
85_I374_I1.0510.30
103_L331_M1.0500.30
410_V413_V1.0500.30
114_L389_M1.0490.30
47_V178_L1.0410.30
45_A327_G1.0370.30
154_V172_F1.0360.30
354_L394_I1.0340.30
140_A424_F1.0330.30
88_V379_G1.0330.30
56_M89_V1.0270.29
96_G338_G1.0230.29
117_S161_I1.0220.29
382_I423_I1.0190.29
30_Y254_A1.0140.29
82_G147_I1.0140.29
117_S254_A1.0120.29
20_K120_I1.0080.29
223_N321_Y1.0060.29
394_I413_V1.0040.28
395_Q418_I0.9980.28
377_L424_F0.9970.28
63_M123_T0.9950.28
412_V417_L0.9930.28
165_M226_P0.9930.28
30_Y255_H0.9900.28
34_I261_T0.9870.28
100_L103_L0.9850.28
308_I351_I0.9780.27
62_P187_W0.9740.27
45_A218_M0.9710.27
34_I258_M0.9700.27
373_M379_G0.9660.27
277_D321_Y0.9630.27
174_G410_V0.9620.27
395_Q410_V0.9610.27
391_M413_V0.9610.27
158_E237_E0.9600.27
153_I417_L0.9580.27
287_S318_L0.9580.27
177_M426_S0.9550.26
17_A55_I0.9550.26
288_I321_Y0.9470.26
176_L411_F0.9460.26
216_P222_F0.9420.26
127_F291_Y0.9340.26
174_G181_L0.9340.26
166_S227_I0.9340.26
172_F255_H0.9340.26
161_I288_I0.9330.26
237_E304_M0.9290.25
26_M279_A0.9210.25
13_D307_I0.9200.25
178_L307_I0.9200.25
159_Q179_L0.9160.25
51_I54_I0.9150.25
64_T380_P0.9150.25
213_L284_Q0.9140.25
36_A41_L0.9120.25
58_I421_S0.9100.25
21_T235_K0.9060.25
14_S81_P0.9050.25
145_I148_V0.9020.24
378_G420_I0.9010.24
140_A365_T0.8990.24
158_E381_I0.8990.24
166_S172_F0.8990.24
145_I149_G0.8990.24
152_T207_L0.8970.24
181_L283_E0.8970.24
348_L427_L0.8870.24
131_Q171_P0.8850.24
30_Y78_G0.8830.24
65_F257_M0.8810.24
30_Y38_V0.8750.23
349_N396_K0.8740.23
346_N350_R0.8730.23
217_V232_A0.8720.23
31_G116_Y0.8700.23
100_L413_V0.8700.23
397_V404_S0.8680.23
23_T253_F0.8670.23
14_S174_G0.8670.23
235_K262_V0.8650.23
143_S361_W0.8630.23
145_I418_I0.8630.23
227_I254_A0.8620.23
83_E119_A0.8600.23
335_S358_V0.8600.23
175_V308_I0.8600.23
233_V259_V0.8560.23
232_A314_T0.8550.23
273_L293_A0.8540.23
54_I107_F0.8540.23
40_F122_N0.8510.23
391_M409_N0.8510.23
286_I311_I0.8490.23
152_T412_V0.8490.23
103_L189_G0.8490.23
85_I108_A0.8490.23
180_A254_A0.8480.23
245_Q418_I0.8450.22
122_N139_R0.8450.22
343_I366_L0.8400.22
107_F303_W0.8400.22
106_F380_P0.8370.22
147_I163_K0.8310.22
130_H180_A0.8310.22
115_V360_T0.8270.22
85_I327_G0.8260.22
34_I50_M0.8180.21
320_H364_A0.8180.21
184_I310_I0.8170.21
113_L274_T0.8080.21
175_V305_A0.8060.21
149_G351_I0.8060.21
30_Y161_I0.8050.21
138_P408_S0.8050.21
55_I370_I0.8040.21
119_A370_I0.8020.21
172_F308_I0.8020.21
180_A261_T0.7990.21
383_A386_L0.7980.21
157_G373_M0.7980.21
61_F162_V0.7960.21
92_H400_M0.7960.21
301_I385_I0.7950.21
167_I311_I0.7940.21
128_M168_L0.7940.21
30_Y172_F0.7910.21
395_Q400_M0.7900.21
29_L32_T0.7900.21
393_A409_N0.7880.20
51_I363_V0.7880.20
192_L298_A0.7850.20
116_Y187_W0.7850.20
382_I386_L0.7820.20
87_E348_L0.7810.20
29_L224_H0.7800.20
96_G417_L0.7750.20
244_E248_S0.7750.20
174_G244_E0.7740.20
140_A181_L0.7730.20
74_F389_M0.7730.20
128_M254_A0.7710.20
133_G351_I0.7680.20
51_I170_F0.7650.20
24_M61_F0.7640.20
275_P279_A0.7640.20
88_V98_G0.7620.20
254_A315_K0.7620.20
216_P224_H0.7590.20
231_F251_L0.7580.20
17_A96_G0.7580.20
141_I355_F0.7550.19
227_I261_T0.7520.19
112_I223_N0.7510.19
304_M322_L0.7510.19
117_S261_T0.7480.19
178_L300_V0.7470.19
59_L83_E0.7460.19
130_H388_L0.7460.19
402_K417_L0.7430.19
128_M181_L0.7400.19
263_M363_V0.7400.19
146_L361_W0.7390.19
237_E249_K0.7350.19
170_F227_I0.7350.19
352_T407_I0.7340.19
174_G397_V0.7320.19
373_M378_G0.7300.19
17_A346_N0.7280.19
72_T389_M0.7280.19
52_P73_R0.7260.19
362_I366_L0.7260.19
374_I379_G0.7250.18
110_Y344_E0.7240.18
98_G104_L0.7220.18
368_P379_G0.7200.18
165_M311_I0.7180.18
47_V247_C0.7180.18
30_Y72_T0.7170.18
54_I214_A0.7160.18
163_K262_V0.7160.18
150_M298_A0.7160.18
254_A259_V0.7150.18
88_V408_S0.7150.18
150_M318_L0.7140.18
155_R172_F0.7140.18
45_A259_V0.7120.18
19_R238_E0.7110.18
162_V258_M0.7100.18
184_I307_I0.7100.18
68_H368_P0.7090.18
309_A316_S0.7090.18
395_Q415_M0.7060.18
117_S360_T0.7030.18
83_E91_E0.7020.18
66_F236_R0.7000.18
192_L370_I0.6940.18
307_I345_I0.6930.18
147_I360_T0.6920.18
60_A256_I0.6910.17
132_L150_M0.6910.17
331_M338_G0.6880.17
366_L413_V0.6820.17
62_P116_Y0.6810.17
258_M313_I0.6800.17
363_V375_E0.6790.17
358_V362_I0.6780.17
60_A287_S0.6770.17
150_M314_T0.6740.17
392_Y409_N0.6740.17
162_V318_L0.6740.17
216_P229_S0.6700.17
154_V180_A0.6690.17
88_V361_W0.6680.17
28_G162_V0.6680.17
164_A302_A0.6670.17
254_A258_M0.6670.17
173_V207_L0.6670.17
218_M233_V0.6650.17
255_H315_K0.6640.17
272_S296_F0.6640.17
172_F254_A0.6610.17
253_F373_M0.6610.17
159_Q167_I0.6600.17
222_F229_S0.6590.17
38_V159_Q0.6580.17
117_S414_V0.6580.17
86_T106_F0.6570.17
278_L288_I0.6560.16
221_S347_K0.6530.16
116_Y312_A0.6520.16
119_A255_H0.6510.16
170_F176_L0.6490.16
129_S136_P0.6480.16
257_M283_E0.6470.16
15_R163_K0.6470.16
161_I322_L0.6450.16
143_S353_A0.6440.16
17_A362_I0.6430.16
405_G410_V0.6430.16
54_I331_M0.6420.16
167_I241_D0.6400.16
287_S422_A0.6400.16
24_M30_Y0.6400.16
180_A305_A0.6380.16
69_R176_L0.6380.16
407_I414_V0.6380.16
344_E351_I0.6370.16
206_G342_S0.6360.16
217_V375_E0.6330.16
221_S331_M0.6320.16
152_T181_L0.6320.16
196_S207_L0.6310.16
71_L385_I0.6280.16
172_F227_I0.6280.16
93_F309_A0.6280.16
177_M181_L0.6280.16
133_G280_A0.6270.16
38_V261_T0.6270.16
158_E310_I0.6270.16
173_V192_L0.6260.16
130_H294_N0.6250.16
29_L386_L0.6250.16
67_A405_G0.6240.16
353_A381_I0.6240.16
101_I150_M0.6240.16
28_G172_F0.6240.16
34_I311_I0.6220.16
286_I290_S0.6210.16
67_A70_G0.6210.16
405_G408_S0.6210.16
181_L372_G0.6200.16
100_L207_L0.6200.16
126_S294_N0.6190.15
55_I351_I0.6180.15
175_V267_F0.6170.15
28_G315_K0.6160.15
218_M227_I0.6150.15
45_A223_N0.6150.15
103_L335_S0.6150.15
21_T157_G0.6140.15
33_A105_Y0.6110.15
237_E246_K0.6110.15
80_N181_L0.6100.15
165_M318_L0.6090.15
104_L262_V0.6090.15
27_L61_F0.6090.15
133_G350_R0.6080.15
30_Y258_M0.6070.15
29_L33_A0.6060.15
255_H318_L0.6060.15
225_S361_W0.6050.15
161_I315_K0.6040.15
395_Q409_N0.6040.15
34_I315_K0.6040.15
390_P416_G0.6040.15
272_S336_L0.6020.15
61_F165_M0.6020.15
96_G404_S0.6000.15
96_G99_K0.5990.15
362_I412_V0.5980.15
415_M424_F0.5980.15
61_F218_M0.5980.15
154_V258_M0.5980.15
166_S218_M0.5970.15
16_S335_S0.5950.15
224_H385_I0.5950.15
112_I216_P0.5910.15
178_L358_V0.5910.15
332_V353_A0.5910.15
51_I249_K0.5880.15
251_L301_I0.5870.15
328_F352_T0.5860.15
130_H396_K0.5850.15
93_F375_E0.5840.15
38_V238_E0.5830.15
66_F163_K0.5830.15
99_K270_V0.5810.15
265_F316_S0.5800.14
212_W228_I0.5790.14
263_M318_L0.5790.14
377_L385_I0.5790.14
184_I260_L0.5780.14
178_L354_L0.5780.14
345_I354_L0.5770.14
324_A371_L0.5710.14
176_L370_I0.5710.14
382_I399_A0.5710.14
332_V345_I0.5700.14
384_M388_L0.5700.14
373_M381_I0.5700.14
280_A417_L0.5700.14
21_T250_I0.5660.14
76_L287_S0.5640.14
122_N367_N0.5620.14
112_I228_I0.5600.14
151_M321_Y0.5580.14
60_A318_L0.5570.14
78_G261_T0.5570.14
362_I410_V0.5560.14
108_A212_W0.5560.14
292_L408_S0.5550.14
350_R401_R0.5550.14
68_H319_G0.5550.14
153_I414_V0.5550.14
232_A417_L0.5540.14
34_I180_A0.5530.14
291_Y320_H0.5520.14
154_V227_I0.5520.14
52_P275_P0.5510.14
182_Y266_V0.5500.14
223_N374_I0.5500.14
256_I414_V0.5490.14
41_L121_T0.5490.14
36_A68_H0.5490.14
152_T350_R0.5470.14
19_R300_V0.5470.14
170_F324_A0.5450.14
226_P380_P0.5420.14
122_N231_F0.5400.14
45_A85_I0.5390.14
58_I276_A0.5390.14
263_M327_G0.5390.14
32_T68_H0.5390.14
204_G401_R0.5380.13
293_A307_I0.5370.13
247_C394_I0.5360.13
28_G212_W0.5360.13
157_G236_R0.5350.13
211_L276_A0.5330.13
413_V422_A0.5330.13
66_F119_A0.5330.13
133_G307_I0.5330.13
143_S419_A0.5330.13
231_F273_L0.5320.13
211_L335_S0.5310.13
147_I413_V0.5310.13
29_L183_L0.5280.13
159_Q412_V0.5280.13
29_L222_F0.5280.13
164_A318_L0.5270.13
292_L316_S0.5260.13
272_S404_S0.5260.13
418_I421_S0.5250.13
375_E386_L0.5250.13
241_D286_I0.5240.13
85_I165_M0.5240.13
19_R239_Y0.5230.13
127_F317_F0.5220.13
34_I227_I0.5220.13
108_A214_A0.5220.13
208_W366_L0.5210.13
85_I226_P0.5200.13
168_L177_M0.5200.13
83_E133_G0.5200.13
217_V299_P0.5200.13
182_Y313_I0.5200.13
331_M335_S0.5190.13
314_T354_L0.5190.13
47_V193_E0.5190.13
260_L384_M0.5190.13
331_M389_M0.5180.13
168_L381_I0.5170.13
145_I354_L0.5170.13
327_G374_I0.5170.13
30_Y180_A0.5160.13
115_V161_I0.5140.13
162_V261_T0.5140.13
156_F286_I0.5130.13
103_L413_V0.5110.13
109_I389_M0.5100.13
79_K214_A0.5100.13
300_V403_Y0.5090.13
132_L218_M0.5080.13
181_L302_A0.5080.13
107_F358_V0.5060.13
158_E329_N0.5040.13
54_I160_M0.5030.13
128_M137_P0.5030.13
20_K394_I0.5020.13
168_L398_P0.5020.13
26_M308_I0.5020.13
75_V108_A0.5010.13
211_L418_I0.5010.13
60_A415_M0.5010.13
109_I320_H0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.8811 99.8 0.866 Contact Map
3giaA 1 0.8998 99.7 0.879 Contact Map
4djkA 2 0.8834 99.4 0.906 Contact Map
4wgvA 2 0.8298 98.4 0.935 Contact Map
2a65A 2 0.8811 95.6 0.959 Contact Map
4us3A 1 0.8671 94.4 0.962 Contact Map
4xp4A 1 0.8951 94.1 0.962 Contact Map
3dh4A 3 0.8741 92.6 0.964 Contact Map
2jlnA 1 0.8718 90 0.966 Contact Map
2xq2A 2 0.8741 87.6 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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