GREMLIN Database
TYRP - Tyrosine-specific transport protein
UniProt: P0AAD4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11041
Length: 403 (371)
Sequences: 29960 (19561)
Seq/√Len: 1015.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_W226_L3.2971.00
260_Q263_R2.8231.00
132_G320_L2.8221.00
358_Q362_H2.8201.00
72_K80_Q2.8171.00
207_M213_K2.7491.00
9_V220_I2.6841.00
306_N309_G2.6641.00
212_R216_W2.6501.00
380_V384_G2.6091.00
312_L315_G2.4671.00
270_H274_A2.4591.00
216_W220_I2.4591.00
308_V312_L2.4221.00
209_G212_R2.3691.00
84_G301_L2.3121.00
309_G312_L2.2711.00
72_K77_R2.2291.00
356_T360_R2.2211.00
151_S155_I2.1931.00
133_G137_V2.1851.00
162_V166_P2.1671.00
213_K216_W2.1561.00
355_L359_S2.1371.00
206_Y296_D2.1101.00
71_A83_T2.0781.00
299_A303_Q2.0771.00
374_R378_V2.0551.00
358_Q361_K2.0391.00
9_V224_I2.0201.00
8_S207_M2.0071.00
373_G377_L2.0051.00
378_V382_L1.9821.00
241_D244_T1.9661.00
349_L355_L1.9201.00
368_Y371_K1.9051.00
308_V311_R1.8971.00
75_L79_G1.8591.00
386_A390_V1.8491.00
305_S308_V1.7921.00
304_R314_T1.7841.00
349_L353_S1.7641.00
169_H173_L1.7541.00
350_I381_F1.7451.00
140_S144_L1.7441.00
380_V383_C1.7371.00
307_T311_R1.7371.00
12_V221_G1.7281.00
102_A127_F1.7181.00
205_S303_Q1.7161.00
304_R307_T1.6691.00
45_A49_Y1.6691.00
258_L261_A1.6681.00
219_I223_A1.6651.00
382_L386_A1.6581.00
155_I159_V1.6561.00
260_Q264_E1.6481.00
61_V73_R1.6361.00
257_G260_Q1.6331.00
307_T312_L1.6331.00
375_P379_V1.6301.00
306_N313_Q1.6171.00
76_G79_G1.5981.00
351_I355_L1.5971.00
164_L235_A1.5961.00
307_T310_G1.5671.00
13_A224_I1.5631.00
306_N312_L1.5621.00
52_L219_I1.5611.00
347_L351_I1.5561.00
375_P378_V1.5511.00
309_G313_Q1.5511.00
43_L190_I1.5451.00
209_G213_K1.5341.00
273_L277_L1.5341.00
210_N213_K1.5241.00
136_C313_Q1.5101.00
223_A227_V1.5071.00
333_F337_L1.5051.00
370_V373_G1.4911.00
377_L380_V1.4871.00
161_L231_F1.4861.00
306_N310_G1.4821.00
174_L177_P1.4811.00
39_L186_A1.4801.00
125_L327_L1.4751.00
16_T225_P1.4701.00
129_F320_L1.4661.00
45_A379_V1.4631.00
317_I321_P1.4491.00
312_L316_A1.4491.00
361_K364_P1.4441.00
99_I287_F1.4441.00
119_S122_A1.4411.00
7_G147_R1.4411.00
75_L358_Q1.4191.00
156_F278_F1.4171.00
125_L129_F1.4001.00
168_I238_G1.3661.00
311_R314_T1.3661.00
51_A218_F1.3651.00
132_G316_A1.3641.00
99_I128_T1.3561.00
324_A328_F1.3541.00
372_G376_A1.3531.00
370_V377_L1.3461.00
37_L234_V1.3411.00
253_A257_G1.3381.00
48_C219_I1.3281.00
369_R373_G1.3261.00
169_H172_N1.3241.00
106_L123_G1.3191.00
7_G143_D1.3181.00
6_L10_F1.3171.00
172_N176_L1.3081.00
259_L262_L1.2981.00
344_L347_L1.2901.00
226_L230_I1.2841.00
149_L285_T1.2701.00
69_T73_R1.2671.00
203_I292_L1.2661.00
32_G35_V1.2601.00
354_L358_Q1.2601.00
385_I389_G1.2581.00
166_P170_K1.2411.00
258_L263_R1.2411.00
311_R315_G1.2411.00
377_L381_F1.2391.00
376_A380_V1.2301.00
348_A352_P1.2301.00
383_C387_V1.2281.00
131_A287_F1.2271.00
242_S245_F1.2251.00
269_P273_L1.2201.00
316_A319_F1.2171.00
26_L29_A1.2131.00
371_K375_P1.2131.00
160_M164_L1.2091.00
353_S356_T1.2001.00
102_A280_D1.1911.00
347_L355_L1.1881.00
71_A79_G1.1881.00
323_L327_L1.1871.00
107_A111_S1.1861.00
125_L324_A1.1811.00
257_G263_R1.1811.00
98_Y286_S1.1781.00
346_V353_S1.1771.00
135_V288_L1.1641.00
227_V231_F1.1491.00
54_L67_L1.1441.00
51_A222_S1.1431.00
384_G388_I1.1431.00
328_F331_R1.1371.00
168_I171_V1.1361.00
346_V351_I1.1351.00
344_L351_I1.1271.00
379_V383_C1.1171.00
305_S312_L1.1151.00
56_E360_R1.1141.00
165_L235_A1.1121.00
8_S217_V1.1101.00
314_T317_I1.1081.00
154_I158_V1.1071.00
323_L326_A1.1071.00
234_V238_G1.1061.00
165_L169_H1.1061.00
326_A330_P1.1051.00
378_V381_F1.1041.00
384_G387_V1.1021.00
263_R272_E1.1021.00
324_A327_L1.1011.00
46_L383_C1.0991.00
355_L358_Q1.0961.00
344_L348_A1.0891.00
64_D205_S1.0851.00
306_N311_R1.0811.00
353_S380_V1.0741.00
315_G319_F1.0691.00
63_A69_T1.0631.00
132_G136_C1.0611.00
78_Y82_L1.0591.00
171_V174_L1.0571.00
123_G126_L1.0571.00
184_L386_A1.0561.00
81_W85_F1.0561.00
106_L110_I1.0561.00
369_R372_G1.0431.00
344_L355_L1.0431.00
257_G261_A1.0421.00
346_V349_L1.0411.00
327_L330_P1.0411.00
144_L148_F1.0391.00
370_V374_R1.0381.00
305_S310_G1.0321.00
166_P169_H1.0311.00
359_S362_H1.0291.00
377_L383_C1.0271.00
41_I230_I1.0221.00
164_L239_S1.0201.00
144_L147_R1.0191.00
121_T124_V1.0171.00
63_A73_R1.0161.00
372_G375_P1.0141.00
313_Q317_I1.0131.00
158_V162_V1.0111.00
173_L177_P1.0111.00
122_A126_L1.0111.00
352_P355_L1.0091.00
381_F385_I1.0081.00
270_H273_L1.0081.00
344_L349_L1.0071.00
267_A271_V1.0061.00
210_N215_R1.0051.00
314_T318_T1.0041.00
137_V309_G1.0031.00
75_L354_L1.0001.00
387_V391_Q0.9991.00
333_F340_A0.9961.00
124_V327_L0.9941.00
48_C52_L0.9911.00
53_L353_S0.9881.00
26_L30_G0.9851.00
369_R377_L0.9821.00
209_G216_W0.9781.00
347_L350_I0.9771.00
58_Y70_L0.9761.00
178_L181_G0.9751.00
374_R377_L0.9731.00
368_Y372_G0.9711.00
305_S309_G0.9701.00
171_V175_T0.9691.00
384_G391_Q0.9661.00
244_T264_E0.9651.00
83_T351_I0.9641.00
383_C386_A0.9641.00
355_L362_H0.9591.00
360_R364_P0.9581.00
364_P367_G0.9571.00
327_L331_R0.9571.00
88_M298_L0.9541.00
126_L130_V0.9521.00
170_K173_L0.9511.00
350_I354_L0.9411.00
185_S189_V0.9391.00
49_Y53_L0.9371.00
254_G257_G0.9331.00
347_L353_S0.9331.00
349_L352_P0.9261.00
121_T125_L0.9241.00
130_V284_A0.9231.00
346_V350_I0.9231.00
274_A278_F0.9171.00
56_E59_Q0.9121.00
10_F147_R0.9101.00
208_D213_K0.9081.00
6_L9_V0.9081.00
294_L319_F0.9071.00
356_T359_S0.9051.00
92_Y96_A0.9031.00
372_G377_L0.9031.00
136_C317_I0.9011.00
44_W194_F0.8981.00
122_A125_L0.8961.00
145_F149_L0.8941.00
345_A348_A0.8931.00
96_A336_A0.8921.00
49_Y379_V0.8901.00
129_F324_A0.8901.00
129_F133_G0.8871.00
359_S363_N0.8861.00
147_R151_S0.8851.00
368_Y374_R0.8811.00
326_A329_Y0.8781.00
172_N175_T0.8681.00
53_L377_L0.8651.00
370_V376_A0.8641.00
134_V145_F0.8631.00
388_I392_F0.8611.00
349_L356_T0.8601.00
388_I391_Q0.8581.00
255_L258_L0.8571.00
141_L144_L0.8561.00
356_T377_L0.8531.00
373_G376_A0.8511.00
133_G136_C0.8481.00
139_T292_L0.8471.00
51_A197_H0.8431.00
9_V217_V0.8421.00
146_N288_L0.8421.00
108_S276_H0.8411.00
377_L384_G0.8401.00
88_M319_F0.8321.00
159_V163_L0.8311.00
387_V390_V0.8301.00
167_H170_K0.8271.00
352_P359_S0.8271.00
131_A288_L0.8171.00
103_G123_G0.8161.00
169_H177_P0.8131.00
320_L324_A0.8071.00
60_H366_A0.8051.00
118_M122_A0.8041.00
204_V214_L0.8031.00
102_A284_A0.8001.00
350_I385_I0.7951.00
386_A389_G0.7941.00
321_P325_F0.7931.00
352_P356_T0.7911.00
335_M338_G0.7891.00
263_R269_P0.7871.00
199_S293_G0.7841.00
111_S117_S0.7801.00
344_L353_S0.7781.00
325_F328_F0.7771.00
380_V391_Q0.7751.00
161_L165_L0.7741.00
15_T289_G0.7701.00
163_L167_H0.7691.00
351_I354_L0.7691.00
34_S183_A0.7681.00
128_T323_L0.7671.00
346_V355_L0.7661.00
333_F341_G0.7651.00
182_L185_S0.7631.00
103_G124_V0.7621.00
319_F322_P0.7621.00
316_A320_L0.7611.00
380_V387_V0.7461.00
37_L41_I0.7431.00
269_P272_E0.7431.00
313_Q316_A0.7421.00
68_G84_G0.7411.00
77_R81_W0.7381.00
258_L262_L0.7371.00
43_L191_F0.7341.00
233_Q237_L0.7341.00
102_A283_L0.7281.00
320_L323_L0.7261.00
87_M91_M0.7261.00
13_A225_P0.7251.00
357_W378_V0.7251.00
350_I353_S0.7221.00
334_V337_L0.7211.00
14_G150_F0.7201.00
57_V70_L0.7201.00
312_L319_F0.7191.00
383_C392_F0.7171.00
60_H364_P0.7161.00
357_W361_K0.7131.00
371_K377_L0.7131.00
50_T197_H0.7131.00
389_G392_F0.7131.00
345_A353_S0.7131.00
34_S38_I0.7111.00
369_R374_R0.7101.00
161_L235_A0.7101.00
101_G105_L0.7101.00
359_S364_P0.7091.00
38_I41_I0.7081.00
31_V35_V0.7061.00
56_E60_H0.7051.00
334_V338_G0.7051.00
310_G314_T0.7031.00
363_N366_A0.7011.00
80_Q84_G0.7001.00
348_A351_I0.7001.00
371_K374_R0.6981.00
308_V315_G0.6971.00
79_G82_L0.6971.00
298_L315_G0.6951.00
153_K282_A0.6951.00
317_I320_L0.6941.00
12_V200_V0.6941.00
95_T291_A0.6931.00
50_T353_S0.6931.00
356_T361_K0.6911.00
380_V386_A0.6901.00
65_T69_T0.6861.00
305_S311_R0.6821.00
97_A192_T0.6811.00
102_A106_L0.6771.00
224_I228_A0.6761.00
137_V141_L0.6741.00
173_L176_L0.6741.00
12_V16_T0.6741.00
346_V352_P0.6731.00
370_V380_V0.6731.00
31_V34_S0.6711.00
339_Y342_V0.6691.00
166_P171_V0.6641.00
21_M232_W0.6631.00
68_G300_D0.6611.00
353_S359_S0.6601.00
173_L238_G0.6581.00
38_I42_G0.6541.00
37_L237_L0.6531.00
357_W360_R0.6531.00
11_I203_I0.6531.00
100_S104_E0.6491.00
377_L391_Q0.6481.00
168_I172_N0.6481.00
268_S271_V0.6481.00
337_L341_G0.6441.00
381_F390_V0.6441.00
47_M197_H0.6421.00
143_D147_R0.6421.00
17_I228_A0.6401.00
33_F237_L0.6351.00
33_F37_L0.6341.00
373_G380_V0.6341.00
216_W219_I0.6331.00
198_G202_S0.6301.00
381_F384_G0.6301.00
96_A99_I0.6291.00
48_C222_S0.6281.00
8_S203_I0.6281.00
86_S90_L0.6281.00
355_L360_R0.6281.00
321_P324_A0.6271.00
68_G72_K0.6271.00
349_L359_S0.6261.00
135_V292_L0.6261.00
74_Y359_S0.6261.00
58_Y201_P0.6251.00
307_T314_T0.6241.00
287_F322_P0.6231.00
220_I223_A0.6221.00
147_R150_F0.6211.00
380_V392_F0.6201.00
348_A355_L0.6201.00
98_Y287_F0.6191.00
95_T287_F0.6171.00
17_I20_G0.6171.00
70_L201_P0.6171.00
9_V12_V0.6151.00
337_L340_A0.6151.00
95_T323_L0.6151.00
362_H366_A0.6151.00
296_D299_A0.6121.00
347_L354_L0.6111.00
338_G341_G0.6101.00
108_S111_S0.6091.00
267_A270_H0.6081.00
291_A294_L0.6071.00
387_V392_F0.6061.00
349_L362_H0.6051.00
235_A238_G0.6051.00
140_S143_D0.6051.00
273_L276_H0.6041.00
168_I173_L0.6031.00
335_M339_Y0.6021.00
172_N177_P0.6011.00
127_F131_A0.6011.00
312_L326_A0.5991.00
376_A383_C0.5941.00
78_Y81_W0.5911.00
98_Y101_G0.5901.00
373_G378_V0.5861.00
345_A349_L0.5861.00
179_Q182_L0.5861.00
55_L59_Q0.5851.00
49_Y376_A0.5841.00
344_L358_Q0.5841.00
11_I14_G0.5841.00
349_L358_Q0.5821.00
259_L263_R0.5821.00
287_F290_V0.5821.00
306_N314_T0.5801.00
307_T313_Q0.5781.00
347_L359_S0.5781.00
296_D302_F0.5771.00
360_R363_N0.5741.00
107_A120_A0.5731.00
348_A353_S0.5721.00
207_M217_V0.5711.00
291_A295_F0.5711.00
319_F323_L0.5701.00
184_L188_P0.5661.00
268_S272_E0.5661.00
82_L86_S0.5651.00
346_V359_S0.5611.00
64_D299_A0.5591.00
350_I384_G0.5591.00
132_G317_I0.5591.00
141_L145_F0.5541.00
344_L357_W0.5541.00
150_F153_K0.5541.00
130_V133_G0.5501.00
207_M214_L0.5491.00
58_Y214_L0.5481.00
232_W236_T0.5471.00
163_L166_P0.5461.00
94_L98_Y0.5461.00
371_K376_A0.5451.00
154_I228_A0.5441.00
77_R80_Q0.5441.00
91_M290_V0.5441.00
312_L330_P0.5431.00
57_V74_Y0.5421.00
383_C391_Q0.5421.00
52_L56_E0.5411.00
61_V74_Y0.5401.00
351_I358_Q0.5391.00
311_R316_A0.5381.00
337_L342_V0.5381.00
25_P29_A0.5381.00
23_A101_G0.5381.00
315_G318_T0.5381.00
92_Y322_P0.5361.00
368_Y373_G0.5351.00
88_M92_Y0.5351.00
132_G291_A0.5321.00
322_P326_A0.5301.00
71_A355_L0.5301.00
99_I102_A0.5301.00
381_F388_I0.5281.00
294_L298_L0.5251.00
168_I235_A0.5241.00
348_A356_T0.5241.00
304_R313_Q0.5211.00
215_R218_F0.5211.00
220_I224_I0.5211.00
6_L144_L0.5211.00
68_G80_Q0.5201.00
41_I226_L0.5201.00
106_L127_F0.5181.00
142_V146_N0.5181.00
350_I357_W0.5171.00
43_L46_L0.5161.00
106_L280_D0.5161.00
47_M50_T0.5151.00
209_G215_R0.5151.00
354_L381_F0.5141.00
107_A123_G0.5131.00
41_I45_A0.5121.00
40_L233_Q0.5121.00
345_A355_L0.5121.00
344_L359_S0.5101.00
312_L317_I0.5101.00
224_I227_V0.5091.00
71_A80_Q0.5091.00
205_S299_A0.5081.00
87_M90_L0.5081.00
242_S246_M0.5081.00
246_M253_A0.5061.00
354_L357_W0.5051.00
224_I231_F0.5031.00
39_L183_A0.5031.00
27_A30_G0.5031.00
165_L231_F0.5021.00
170_K174_L0.5021.00
117_S120_A0.5011.00
146_N153_K0.5011.00
263_R266_V0.5001.00
71_A351_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.9429 100 0.356 Contact Map
3giaA 1 0.9578 100 0.404 Contact Map
4djkA 2 0.9578 100 0.437 Contact Map
2jlnA 1 0.9504 98.4 0.829 Contact Map
4wgvA 2 0.8958 98.4 0.833 Contact Map
3dh4A 3 0.9256 98.2 0.84 Contact Map
2xq2A 2 0.928 98 0.848 Contact Map
4xp4A 1 0.9702 96.7 0.88 Contact Map
2a65A 2 0.9777 96.3 0.884 Contact Map
4us3A 1 0.9404 96.2 0.886 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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