GREMLIN Database
MTR - Tryptophan-specific transport protein
UniProt: P0AAD2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10617
Length: 414 (379)
Sequences: 26894 (17948)
Seq/√Len: 921.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
323_L326_A4.3401.00
322_R325_T3.6911.00
322_R326_A3.4771.00
369_A373_R3.1561.00
314_G317_D3.0721.00
391_I395_G2.9511.00
12_S219_G2.9001.00
52_W237_L2.8481.00
317_D321_G2.8431.00
317_D320_V2.8281.00
220_K223_K2.6901.00
80_K88_N2.5171.00
218_Y224_T2.5061.00
17_V231_Y2.4941.00
223_K227_K2.4761.00
360_A366_L2.4251.00
319_A322_R2.3851.00
92_G312_L2.3691.00
281_S285_L2.3341.00
13_L231_Y2.3231.00
217_Y307_D2.3191.00
171_L246_A2.2941.00
169_G173_G2.2911.00
271_Q274_S2.2351.00
318_S321_G2.2231.00
12_S15_G2.2211.00
16_G218_Y2.2161.00
323_L327_L2.2071.00
13_L17_V2.1961.00
13_L224_T2.1941.00
389_A393_V2.1511.00
17_V235_M2.1221.00
344_F348_I2.1121.00
140_F144_L2.1071.00
220_K224_T2.0981.00
324_K327_L2.0951.00
227_K231_Y2.0801.00
269_L272_A2.0601.00
80_K85_K2.0511.00
366_L370_S2.0061.00
322_R333_P1.9971.00
269_L274_S1.9901.00
322_R327_L1.9801.00
369_A372_K1.9511.00
319_A323_L1.9441.00
20_I232_G1.8961.00
385_K389_A1.8881.00
147_K151_R1.8461.00
323_L334_V1.8211.00
379_F382_W1.8101.00
252_P255_E1.7831.00
230_V234_L1.7791.00
361_I392_L1.7681.00
322_R330_F1.7231.00
367_A371_R1.7021.00
83_L369_A1.7021.00
158_G162_I1.7011.00
83_L87_W1.6841.00
314_G318_S1.6741.00
344_F351_A1.6721.00
24_I236_A1.6561.00
393_V397_G1.6511.00
323_L330_F1.6421.00
234_L238_A1.6261.00
386_P390_L1.6201.00
21_G235_M1.6141.00
11_P15_G1.6121.00
79_T91_N1.6101.00
53_F57_H1.6011.00
314_G319_A1.5901.00
224_T227_K1.5811.00
175_V249_G1.5771.00
34_V37_S1.5671.00
324_K328_L1.5631.00
84_G87_W1.5531.00
322_R329_T1.5461.00
162_I166_L1.5401.00
388_I391_I1.5381.00
397_G401_V1.5371.00
362_V366_L1.5351.00
110_S291_N1.5341.00
15_G150_S1.5151.00
132_F136_L1.5141.00
51_T201_C1.5081.00
383_G387_M1.4891.00
47_A197_T1.4881.00
15_G154_A1.4801.00
323_L333_P1.4521.00
126_P129_A1.4411.00
358_W366_L1.4341.00
320_V323_L1.4211.00
237_L241_T1.4211.00
360_A364_A1.4171.00
16_G228_C1.3741.00
180_L184_A1.3711.00
384_G388_I1.3581.00
388_I392_L1.3571.00
327_L331_A1.3531.00
360_A363_P1.3511.00
161_V165_F1.3471.00
11_P16_G1.3401.00
168_F242_I1.3401.00
323_L331_A1.3351.00
255_E276_V1.3341.00
322_R331_A1.3321.00
364_A391_I1.3311.00
357_I360_A1.3291.00
172_L176_Q1.3151.00
114_L130_A1.3141.00
389_A392_L1.3091.00
358_W362_V1.3031.00
371_R375_G1.3011.00
181_F184_A1.2961.00
60_L230_V1.2921.00
325_T328_L1.2891.00
388_I395_G1.2871.00
72_G216_K1.2841.00
13_L227_K1.2841.00
370_S373_R1.2761.00
83_L365_L1.2741.00
327_L330_F1.2711.00
326_A329_T1.2711.00
69_Y81_D1.2641.00
64_E371_R1.2611.00
107_I135_A1.2571.00
284_L288_V1.2191.00
45_M245_L1.2181.00
142_V299_L1.2131.00
267_D271_Q1.2111.00
317_D322_R1.2101.00
317_D323_L1.2081.00
355_A358_W1.2071.00
14_L18_V1.2071.00
110_S134_F1.2071.00
390_L394_F1.2061.00
71_I81_D1.1921.00
165_F169_G1.1921.00
328_L332_P1.1911.00
177_P180_L1.1731.00
214_L303_L1.1691.00
372_K375_G1.1621.00
391_I394_F1.1581.00
89_V93_I1.1561.00
326_A330_F1.1531.00
381_V384_G1.1481.00
321_G324_K1.1471.00
221_D226_V1.1441.00
355_A359_A1.1431.00
107_I298_F1.1421.00
323_L328_L1.1381.00
318_S322_R1.1371.00
53_F390_L1.1361.00
156_V296_S1.1321.00
13_L228_C1.1301.00
178_A181_F1.1291.00
62_I75_F1.1261.00
187_N190_Y1.1221.00
387_M391_I1.1201.00
56_L230_V1.1171.00
314_G321_G1.1171.00
395_G398_N1.1131.00
338_L341_P1.1111.00
270_V273_L1.1101.00
172_L246_A1.1091.00
366_L373_R1.0951.00
322_R332_P1.0941.00
365_L369_A1.0921.00
56_L60_L1.0911.00
220_K227_K1.0851.00
266_I269_L1.0841.00
392_L395_G1.0791.00
238_A242_I1.0701.00
360_A370_S1.0661.00
392_L396_V1.0631.00
396_V400_L1.0591.00
370_S375_G1.0581.00
153_T299_L1.0521.00
171_L250_N1.0491.00
163_T289_F1.0451.00
128_R132_F1.0431.00
106_Y297_S1.0421.00
364_A367_A1.0401.00
133_G137_L1.0391.00
360_A369_A1.0361.00
42_F194_L1.0361.00
355_A366_L1.0361.00
136_L140_F1.0351.00
366_L369_A1.0241.00
359_A363_P1.0231.00
357_I366_L1.0181.00
179_T184_A1.0161.00
355_A360_A1.0161.00
334_V338_L1.0131.00
322_R334_V1.0131.00
139_A331_A1.0041.00
360_A367_A1.0031.00
323_L341_P1.0031.00
363_P366_L1.0001.00
357_I364_A0.9971.00
139_A143_W0.9971.00
179_T183_V0.9951.00
125_V129_A0.9941.00
52_W205_F0.9941.00
167_T171_L0.9881.00
140_F143_W0.9811.00
394_F398_N0.9781.00
280_R284_L0.9771.00
86_G90_V0.9741.00
79_T87_W0.9721.00
314_G320_V0.9701.00
177_P181_F0.9691.00
128_R131_G0.9681.00
386_P389_A0.9641.00
10_S219_G0.9621.00
335_V339_L0.9591.00
326_A334_V0.9551.00
25_I28_G0.9551.00
385_K392_L0.9541.00
77_T81_D0.9541.00
68_N377_P0.9481.00
221_D224_T0.9451.00
58_S208_H0.9291.00
66_N78_I0.9261.00
379_F385_K0.9191.00
152_M156_V0.9161.00
190_Y193_Y0.9151.00
346_Y349_G0.9111.00
385_K388_I0.9071.00
129_A133_G0.9061.00
96_A309_L0.9051.00
270_V274_S0.9041.00
381_V388_I0.9041.00
17_V228_C0.9031.00
71_I77_T0.9001.00
334_V337_G0.8971.00
59_G233_T0.8961.00
49_I241_T0.8951.00
318_S323_L0.8941.00
355_A362_V0.8941.00
330_F334_V0.8931.00
354_A357_I0.8911.00
357_I362_V0.8841.00
132_F338_L0.8841.00
325_T333_P0.8781.00
191_A195_L0.8781.00
40_W43_W0.8751.00
136_L139_A0.8731.00
18_V154_A0.8701.00
61_M364_A0.8671.00
380_R384_G0.8651.00
11_P150_S0.8611.00
337_G341_P0.8591.00
59_G229_L0.8581.00
168_F246_A0.8581.00
57_H61_M0.8551.00
367_A370_S0.8541.00
34_V38_G0.8521.00
185_E188_A0.8521.00
380_R385_K0.8501.00
383_G388_I0.8491.00
362_V369_A0.8481.00
399_A403_I0.8481.00
357_I361_I0.8471.00
166_L170_S0.8451.00
219_G224_T0.8441.00
326_A333_P0.8431.00
395_G399_A0.8431.00
26_G240_Y0.8431.00
54_C394_F0.8421.00
323_L329_T0.8371.00
384_G387_M0.8351.00
364_A368_R0.8351.00
337_G340_F0.8331.00
42_F187_N0.8331.00
20_I211_V0.8321.00
146_T303_L0.8311.00
115_H119_A0.8301.00
381_V385_K0.8261.00
366_L371_R0.8261.00
278_N282_L0.8241.00
104_Y347_A0.8241.00
269_L273_L0.8211.00
191_A194_L0.8191.00
325_T329_T0.8191.00
178_A182_N0.8191.00
160_K293_A0.8161.00
367_A388_I0.8161.00
335_V338_L0.8121.00
358_W364_A0.8101.00
323_L336_G0.8081.00
360_A373_R0.8041.00
32_L244_L0.8011.00
365_L392_L0.7991.00
91_N362_V0.7981.00
324_K331_A0.7941.00
267_D270_V0.7911.00
326_A337_G0.7891.00
25_I239_L0.7861.00
398_N401_V0.7841.00
345_L348_I0.7821.00
324_K335_V0.7791.00
111_G131_G0.7781.00
330_F333_P0.7751.00
267_D272_A0.7741.00
333_P337_G0.7721.00
64_E67_L0.7701.00
363_P370_S0.7701.00
370_S374_F0.7681.00
19_I214_L0.7661.00
320_V324_K0.7651.00
130_A133_G0.7641.00
116_H287_V0.7601.00
358_W361_I0.7591.00
324_K329_T0.7591.00
382_W385_K0.7591.00
141_V152_M0.7571.00
383_G386_P0.7531.00
46_A50_F0.7511.00
361_I396_V0.7511.00
76_D88_N0.7501.00
45_M49_I0.7501.00
369_A374_F0.7491.00
150_S154_A0.7481.00
328_L331_A0.7461.00
109_A113_I0.7461.00
398_N402_H0.7451.00
95_I99_L0.7431.00
324_K330_F0.7421.00
67_L378_K0.7411.00
108_S347_A0.7391.00
322_R338_L0.7381.00
100_Y104_Y0.7381.00
317_D324_K0.7361.00
23_T300_G0.7351.00
14_L17_V0.7341.00
324_K334_V0.7331.00
381_V387_M0.7331.00
127_A131_G0.7321.00
252_P276_V0.7291.00
325_T332_P0.7291.00
279_S282_L0.7261.00
65_A78_I0.7261.00
66_N212_P0.7261.00
61_M388_I0.7261.00
111_G130_A0.7241.00
76_D311_D0.7241.00
179_T182_N0.7211.00
319_A324_K0.7211.00
358_W365_L0.7211.00
377_P380_R0.7201.00
346_Y350_Y0.7191.00
180_L183_V0.7191.00
195_L397_G0.7161.00
161_V239_L0.7091.00
45_M248_M0.7081.00
357_I363_P0.7081.00
21_G236_A0.7051.00
176_Q179_T0.7031.00
87_W90_V0.7031.00
373_R377_P0.7031.00
245_L249_G0.7021.00
173_G176_Q0.7021.00
220_K226_V0.6971.00
393_V396_V0.6961.00
368_R389_A0.6951.00
364_A370_S0.6941.00
314_G322_R0.6911.00
138_V298_F0.6901.00
363_P367_A0.6881.00
376_S379_F0.6881.00
356_T360_A0.6881.00
168_F172_L0.6861.00
148_A151_R0.6851.00
177_P183_V0.6841.00
106_Y298_F0.6811.00
114_L118_F0.6811.00
151_R155_I0.6801.00
364_A371_R0.6801.00
76_D92_G0.6791.00
368_R372_K0.6771.00
327_L334_V0.6761.00
154_A158_G0.6751.00
322_R335_V0.6731.00
103_T302_T0.6701.00
124_N127_A0.6691.00
176_Q180_L0.6681.00
180_L249_G0.6671.00
319_A327_L0.6651.00
101_I104_Y0.6651.00
369_A375_G0.6641.00
29_M243_W0.6641.00
346_Y351_A0.6631.00
82_L370_S0.6621.00
231_Y235_M0.6621.00
336_G340_F0.6611.00
22_G157_L0.6611.00
49_I53_F0.6601.00
217_Y310_A0.6591.00
115_H127_A0.6591.00
216_K310_A0.6581.00
380_R383_G0.6581.00
281_S284_L0.6581.00
244_L248_M0.6581.00
210_N304_G0.6561.00
342_N345_L0.6551.00
321_G325_T0.6551.00
314_G323_L0.6531.00
10_S146_T0.6531.00
64_E68_N0.6531.00
322_R328_L0.6511.00
58_S364_A0.6501.00
14_L151_R0.6501.00
285_L289_F0.6481.00
367_A372_K0.6461.00
323_L337_G0.6451.00
21_G25_I0.6451.00
215_M225_I0.6441.00
51_T202_L0.6431.00
366_L375_G0.6431.00
57_H390_L0.6431.00
27_A106_Y0.6421.00
356_T359_A0.6421.00
362_V365_L0.6401.00
348_I352_G0.6381.00
68_N375_G0.6381.00
186_S190_Y0.6371.00
356_T366_L0.6371.00
177_P182_N0.6361.00
153_T160_K0.6341.00
361_I368_R0.6341.00
344_F350_Y0.6331.00
209_G213_S0.6321.00
400_L403_I0.6311.00
355_A369_A0.6301.00
391_I397_G0.6291.00
35_V39_A0.6281.00
319_A325_T0.6281.00
180_L248_M0.6251.00
329_T333_P0.6251.00
274_S283_D0.6231.00
178_A183_V0.6231.00
151_R154_A0.6221.00
175_V246_A0.6221.00
394_F397_G0.6211.00
344_F349_G0.6211.00
246_A249_G0.6191.00
336_G339_L0.6181.00
321_G326_A0.6171.00
138_V299_L0.6171.00
55_M58_S0.6161.00
356_T364_A0.6141.00
178_A184_A0.6141.00
57_H387_M0.6121.00
39_A42_F0.6121.00
105_A203_A0.6081.00
397_G400_L0.6071.00
322_R337_G0.6071.00
298_F333_P0.6051.00
139_A327_L0.6051.00
100_Y332_P0.6021.00
280_R283_D0.6011.00
108_S112_S0.5991.00
157_L160_K0.5981.00
25_I160_K0.5961.00
16_G214_L0.5921.00
382_W386_P0.5921.00
383_G389_A0.5911.00
127_A132_F0.5901.00
395_G402_H0.5881.00
129_A132_F0.5881.00
231_Y234_L0.5871.00
86_G89_V0.5871.00
235_M239_L0.5871.00
35_V38_G0.5861.00
46_A194_L0.5851.00
368_R373_R0.5811.00
117_T291_N0.5801.00
382_W388_I0.5791.00
10_S14_L0.5781.00
41_F45_M0.5781.00
361_I365_L0.5781.00
354_A366_L0.5771.00
348_I351_A0.5761.00
226_V229_L0.5761.00
196_M200_F0.5751.00
376_S380_R0.5751.00
365_L368_R0.5731.00
56_L233_T0.5711.00
79_T362_V0.5711.00
193_Y196_M0.5701.00
55_M208_H0.5701.00
59_G208_H0.5681.00
73_S77_T0.5681.00
307_D310_A0.5641.00
15_G151_R0.5641.00
60_L64_E0.5631.00
113_I290_S0.5631.00
319_A326_A0.5611.00
23_T210_N0.5601.00
347_A351_A0.5601.00
27_A203_A0.5581.00
102_L105_A0.5581.00
35_V43_W0.5561.00
96_A100_Y0.5551.00
398_N403_I0.5531.00
79_T88_N0.5531.00
302_T306_F0.5521.00
327_L337_G0.5521.00
399_A402_H0.5521.00
134_F138_V0.5491.00
364_A392_L0.5471.00
361_I364_A0.5471.00
36_M40_W0.5461.00
255_E258_G0.5451.00
329_T332_P0.5451.00
323_L332_P0.5441.00
76_D80_K0.5431.00
206_G209_G0.5421.00
85_K88_N0.5421.00
39_A43_W0.5411.00
357_I370_S0.5371.00
334_V339_L0.5371.00
132_F142_V0.5361.00
110_S294_V0.5351.00
68_N378_K0.5351.00
359_A366_L0.5341.00
323_L339_L0.5331.00
331_A335_V0.5331.00
345_L349_G0.5321.00
358_W370_S0.5301.00
10_S147_K0.5291.00
149_V153_T0.5281.00
204_S240_Y0.5261.00
359_A367_A0.5261.00
137_L140_F0.5261.00
106_Y109_A0.5251.00
242_I246_A0.5251.00
78_I212_P0.5241.00
159_A163_T0.5241.00
148_A152_M0.5231.00
88_N92_G0.5231.00
65_A82_L0.5221.00
253_R256_F0.5211.00
266_I270_V0.5211.00
103_T298_F0.5211.00
195_L199_P0.5201.00
359_A362_V0.5201.00
139_A330_F0.5191.00
355_A370_S0.5181.00
85_K89_V0.5181.00
391_I399_A0.5181.00
23_T301_V0.5161.00
162_I165_F0.5151.00
107_I110_S0.5151.00
133_G136_L0.5141.00
172_L242_I0.5101.00
327_L339_L0.5071.00
104_Y107_I0.5061.00
35_V40_W0.5061.00
144_L148_A0.5051.00
170_S279_S0.5041.00
381_V391_I0.5031.00
48_L244_L0.5031.00
170_S174_H0.5021.00
271_Q276_V0.5021.00
364_A369_A0.5011.00
218_Y228_C0.5011.00
118_F124_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.9324 100 0.354 Contact Map
3giaA 1 0.942 100 0.409 Contact Map
4djkA 2 0.9203 100 0.445 Contact Map
2jlnA 1 0.9589 99.1 0.794 Contact Map
4wgvA 2 0.8889 98.6 0.822 Contact Map
3dh4A 3 0.9155 98.5 0.83 Contact Map
2xq2A 2 0.9155 98.4 0.836 Contact Map
4us3A 1 0.93 98.3 0.84 Contact Map
2a65A 2 0.9638 98 0.851 Contact Map
4xp4A 1 0.9614 97.8 0.858 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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