GREMLIN Database
ISCA - Iron-binding protein IscA
UniProt: P0AAC8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12132
Length: 107 (104)
Sequences: 3515 (1834)
Seq/√Len: 179.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
76_Q91_T4.5251.00
12_R15_T3.5021.00
65_D68_S3.1161.00
10_A58_K3.1091.00
25_G63_V3.0581.00
29_G41_V2.8181.00
4_T76_Q2.6931.00
95_V98_E2.5871.00
56_E61_K2.5451.00
7_D58_K2.4571.00
54_V61_K2.4141.00
22_K46_D2.1231.00
31_R41_V2.1011.00
27_R52_D2.0051.00
3_I77_L1.9741.00
6_S78_D1.9311.00
48_P63_V1.8611.00
75_T90_F1.8601.00
56_E59_G1.8061.00
14_N59_G1.7341.00
81_K86_E1.7201.00
14_N18_A1.5681.00
25_G61_K1.5581.00
38_M71_F1.5431.00
48_P54_V1.4601.00
7_D57_D1.4061.00
80_V89_K1.3271.00
8_S78_D1.3071.00
33_S83_G1.2631.00
45_V48_P1.2371.00
11_A14_N1.2311.00
97_D106_H1.2201.00
5_L13_V1.2161.00
13_V26_L1.2081.00
53_I66_G1.1991.00
7_D11_A1.1981.00
45_V49_T1.1841.00
70_Q73_D1.1471.00
20_R24_F1.1391.00
28_L72_L1.1041.00
12_R88_F1.0561.00
82_E89_K1.0551.00
36_S106_H1.0531.00
67_K70_Q1.0401.00
8_S11_A0.9950.99
75_T103_E0.9850.99
12_R16_F0.9740.99
80_V85_N0.9490.99
10_A60_V0.9460.99
66_G70_Q0.9330.99
17_L23_G0.9260.99
55_F69_L0.9200.99
32_T36_S0.9130.99
49_T52_D0.9130.99
10_A57_D0.9000.99
5_L62_V0.8810.98
9_A100_G0.8530.98
33_S39_A0.8450.98
24_F48_P0.8240.98
26_L88_F0.8200.98
11_A58_K0.8180.97
53_I69_L0.8110.97
18_A21_G0.8100.97
74_G93_P0.8100.97
82_E87_G0.8000.97
20_R46_D0.7990.97
33_S95_V0.7880.97
12_R84_L0.7850.97
5_L57_D0.7810.97
48_P61_K0.7740.96
68_S77_L0.7730.96
25_G48_P0.7700.96
96_K106_H0.7690.96
5_L88_F0.7690.96
17_L24_F0.7680.96
12_R79_F0.7630.96
72_L94_N0.7400.95
30_V105_F0.7380.95
14_N58_K0.7290.95
82_E86_E0.7280.95
29_G43_E0.7240.95
82_E85_N0.7190.95
7_D10_A0.7180.95
36_S105_F0.7120.94
42_L71_F0.7050.94
80_V87_G0.7040.94
38_M105_F0.7010.94
17_L25_G0.6970.94
69_L73_D0.6940.94
28_L77_L0.6920.94
14_N60_V0.6900.93
5_L10_A0.6880.93
74_G94_N0.6850.93
13_V60_V0.6840.93
27_R45_V0.6830.93
11_A18_A0.6730.93
53_I73_D0.6720.93
17_L44_F0.6580.92
9_A85_N0.6580.92
38_M42_L0.6500.91
101_C104_S0.6480.91
12_R81_K0.6440.91
10_A59_G0.6410.91
24_F46_D0.6340.90
36_S97_D0.6290.90
13_V88_F0.6290.90
9_A96_K0.6260.90
95_V105_F0.6230.89
80_V84_L0.6190.89
15_T18_A0.6170.89
32_T38_M0.6060.88
14_N17_L0.6040.88
42_L85_N0.6020.88
30_V33_S0.5980.87
36_S71_F0.5970.87
3_I75_T0.5950.87
5_L77_L0.5950.87
102_G105_F0.5880.87
92_N95_V0.5820.86
16_F88_F0.5790.86
32_T67_K0.5700.85
57_D62_V0.5640.84
17_L22_K0.5590.84
23_G44_F0.5590.84
54_V63_V0.5580.84
21_G46_D0.5570.84
38_M100_G0.5560.83
79_F86_E0.5550.83
53_I70_Q0.5550.83
4_T74_G0.5520.83
13_V17_L0.5490.83
67_K71_F0.5460.82
16_F44_F0.5440.82
81_K100_G0.5440.82
69_L89_K0.5420.82
32_T42_L0.5400.82
101_C105_F0.5360.81
18_A22_K0.5330.81
33_S36_S0.5280.80
42_L75_T0.5260.80
68_S72_L0.5230.80
32_T106_H0.5230.80
98_E103_E0.5230.80
38_M86_E0.5230.80
25_G62_V0.5210.79
45_V52_D0.5200.79
18_A49_T0.5190.79
33_S98_E0.5180.79
10_A14_N0.5120.78
38_M66_G0.5080.78
36_S86_E0.5040.77
22_K47_E0.5030.77
12_R38_M0.5030.77
3_I74_G0.5030.77
40_Y102_G0.5020.77
90_F103_E0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2d2aA 2 1 100 0.114 Contact Map
1r94A 3 0.9065 100 0.134 Contact Map
1nwbA 1 0.8692 100 0.145 Contact Map
1x0gA 4 0.9907 100 0.156 Contact Map
2apnA 1 1 100 0.156 Contact Map
2k4zA 1 0.9252 100 0.318 Contact Map
2p2eA 1 0.9626 99.9 0.434 Contact Map
2qgoA 1 0.8411 99.9 0.46 Contact Map
2oxgY 1 0.3271 15 0.93 Contact Map
3butA 2 0.3458 11.9 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.006 seconds.