GREMLIN Database
YCCA - Modulator of FtsH protease YccA
UniProt: P0AAC6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11113
Length: 219 (199)
Sequences: 3189 (2061)
Seq/√Len: 146.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_Y180_T3.6631.00
168_F208_S3.4831.00
121_S180_T3.0411.00
68_K71_N2.6141.00
166_A212_I2.6041.00
135_G178_F2.5431.00
94_L106_I2.5271.00
31_T79_A2.4231.00
112_G213_L2.3781.00
120_C173_S2.3331.00
169_I205_I2.3121.00
109_A212_I2.1751.00
149_M164_I2.1551.00
25_Y121_S2.1411.00
53_I57_V2.1391.00
179_E201_S2.0531.00
35_S199_Y2.0531.00
97_Y214_G1.9631.00
139_M143_V1.9621.00
207_V211_S1.9601.00
119_C143_V1.9161.00
109_A209_L1.9051.00
159_A163_A1.8651.00
23_N191_Y1.7861.00
138_L174_G1.7421.00
29_S118_F1.7231.00
60_Y64_F1.7161.00
138_L178_F1.6991.00
176_I205_I1.6921.00
163_A167_V1.6891.00
151_A155_L1.6651.00
200_V204_N1.6311.00
167_V171_I1.6201.00
122_A126_T1.5981.00
146_L150_V1.5851.00
142_I146_L1.5641.00
145_V168_F1.5521.00
152_N157_L1.5501.00
166_A170_L1.5281.00
111_G115_L1.5231.00
62_L66_T1.5181.00
173_S205_I1.5131.00
121_S125_L1.5071.00
162_L212_I1.4751.00
60_Y67_Y1.4751.00
179_E182_N1.4691.00
161_H211_S1.4671.00
112_G209_L1.4661.00
77_I81_A1.4581.00
63_M67_Y1.4571.00
49_S53_I1.4411.00
182_N197_S1.4371.00
59_M63_M1.4291.00
143_V147_I1.4281.00
14_L18_H1.4151.00
55_T59_M1.4041.00
74_T77_I1.3931.00
74_T78_S1.3841.00
54_L58_G1.3631.00
102_M105_V1.3401.00
36_A111_G1.3191.00
124_V181_S1.3171.00
105_V213_L1.3081.00
27_L76_I1.2871.00
61_G65_L1.2701.00
131_M177_L1.2581.00
127_T131_M1.2551.00
172_S200_V1.2491.00
47_L51_G1.2471.00
123_Y127_T1.2361.00
93_I207_V1.2091.00
90_L207_V1.1901.00
142_I200_V1.1901.00
208_S211_S1.1851.00
82_F86_L1.1821.00
123_Y129_K1.1731.00
58_G61_G1.1701.00
134_L138_L1.1691.00
182_N201_S1.1511.00
115_L147_I1.1451.00
50_P53_I1.1390.99
59_M66_T1.1340.99
109_A112_G1.1280.99
81_A85_F1.1260.99
53_I60_Y1.1230.99
133_F136_G1.1190.99
198_L201_S1.1190.99
52_L56_L1.1110.99
57_V61_G1.1100.99
60_Y63_M1.1030.99
179_E200_V1.1010.99
37_I41_A1.0970.99
127_T181_S1.0940.99
107_A111_G1.0830.99
58_G63_M1.0820.99
38_T84_G1.0770.99
40_T44_V1.0730.99
61_G64_F1.0700.99
172_S204_N1.0590.99
116_V120_C1.0540.99
129_K133_F1.0470.99
76_I80_F1.0380.99
58_G65_L1.0380.99
53_I56_L1.0330.99
76_I192_I1.0290.99
148_G164_I1.0130.99
68_K72_K0.9960.99
61_G85_F0.9770.98
63_M66_T0.9760.98
57_V60_Y0.9700.98
162_L166_A0.9680.98
46_M49_S0.9560.98
145_V171_I0.9560.98
117_F202_L0.9560.98
160_L164_I0.9530.98
47_L50_P0.9400.98
56_L59_M0.9390.98
48_P51_G0.9360.98
58_G66_T0.9350.98
28_L198_L0.9290.98
117_F176_I0.9180.98
31_T83_T0.9090.97
152_N155_L0.9080.97
42_S91_G0.9050.97
165_S169_I0.8980.97
181_S185_H0.8950.97
38_T42_S0.8800.97
129_K134_L0.8680.97
19_K23_N0.8670.97
165_S211_S0.8640.97
50_P57_V0.8570.96
116_V173_S0.8560.96
27_L192_I0.8420.96
17_T20_V0.8400.96
110_L114_A0.8400.96
112_G151_A0.8400.96
142_I175_A0.8400.96
49_S52_L0.8380.96
137_M141_G0.8350.96
116_V205_I0.8300.96
171_I174_G0.8290.96
164_I167_V0.8290.96
29_S33_A0.8270.96
33_A37_I0.8270.96
168_F172_S0.8230.95
86_L89_I0.8220.95
26_F30_L0.8210.95
170_L174_G0.8210.95
112_G169_I0.8190.95
141_G171_I0.8180.95
150_V153_I0.8050.95
54_L61_G0.8020.95
72_K76_I0.8010.95
139_M175_A0.8010.95
142_I204_N0.8000.95
133_F137_M0.7880.94
22_R26_F0.7870.94
79_A83_T0.7850.94
171_I175_A0.7760.94
105_V216_A0.7730.94
162_L165_S0.7730.94
116_V119_C0.7730.94
105_V109_A0.7720.94
59_M86_L0.7710.94
19_K22_R0.7560.93
183_I198_L0.7560.93
59_M65_L0.7560.93
60_Y65_L0.7560.93
152_N156_Q0.7530.93
57_V63_M0.7520.93
50_P54_L0.7480.93
108_M213_L0.7480.93
61_G67_Y0.7430.92
165_S208_S0.7410.92
120_C177_L0.7390.92
60_Y66_T0.7380.92
15_L19_K0.7320.92
58_G62_L0.7310.92
73_P77_I0.7310.92
137_M170_L0.7280.91
158_P161_H0.7250.91
30_L80_F0.7250.91
30_L34_F0.7220.91
209_L213_L0.7210.91
97_Y207_V0.7200.91
79_A196_V0.7170.91
54_L59_M0.7170.91
208_S212_I0.7160.91
140_A144_V0.7130.91
49_S58_G0.7120.91
23_N26_F0.7120.91
49_S54_L0.7080.90
172_S175_A0.7070.90
46_M50_P0.7060.90
58_G67_Y0.7050.90
41_A45_L0.6990.90
191_Y194_A0.6980.90
156_Q159_A0.6930.89
146_L171_I0.6880.89
56_L60_Y0.6870.89
116_V209_L0.6840.89
183_I186_G0.6840.89
51_G65_L0.6820.89
147_I151_A0.6820.89
197_S201_S0.6800.88
30_L33_A0.6790.88
106_I210_L0.6740.88
53_I58_G0.6730.88
172_S179_E0.6720.88
177_L181_S0.6720.88
142_I205_I0.6700.88
27_L80_F0.6700.88
93_I97_Y0.6700.88
133_F173_S0.6690.88
104_D108_M0.6670.88
26_F29_S0.6650.87
125_L180_T0.6650.87
80_F83_T0.6640.87
180_T198_L0.6630.87
120_C131_M0.6600.87
54_L60_Y0.6570.87
109_A113_T0.6560.87
39_A91_G0.6490.86
69_T78_S0.6420.85
144_V148_G0.6370.85
105_V108_M0.6360.85
51_G55_T0.6360.85
142_I171_I0.6350.85
145_V208_S0.6340.85
51_G63_M0.6330.85
62_L65_L0.6310.85
82_F196_V0.6300.84
37_I56_L0.6290.84
186_G194_A0.6230.84
142_I172_S0.6210.84
57_V65_L0.6190.83
34_F80_F0.6190.83
160_L163_A0.6150.83
52_L66_T0.6120.83
168_F211_S0.6100.82
24_T183_I0.6080.82
59_M62_L0.6050.82
142_I149_M0.6040.82
146_L149_M0.6000.81
52_L55_T0.5980.81
115_L119_C0.5980.81
175_A179_E0.5960.81
47_L64_F0.5920.81
124_V184_I0.5910.80
70_A75_G0.5900.80
132_S181_S0.5890.80
59_M67_Y0.5880.80
141_G182_N0.5880.80
61_G66_T0.5860.80
198_L202_L0.5840.80
172_S201_S0.5840.80
117_F198_L0.5840.80
64_F67_Y0.5820.79
138_L141_G0.5800.79
110_L202_L0.5790.79
161_H165_S0.5750.79
152_N164_I0.5680.78
58_G85_F0.5680.78
20_V183_I0.5680.78
125_L184_I0.5680.78
69_T72_K0.5680.78
109_A213_L0.5670.78
24_T194_A0.5620.77
149_M166_A0.5600.77
28_L195_T0.5570.76
51_G58_G0.5560.76
105_V215_F0.5530.76
71_N74_T0.5500.76
204_N207_V0.5480.75
34_F83_T0.5480.75
55_T58_G0.5450.75
58_G64_F0.5450.75
183_I194_A0.5410.74
20_V24_T0.5400.74
93_I106_I0.5370.74
159_A162_L0.5350.74
136_G140_A0.5350.74
135_G174_G0.5240.72
61_G81_A0.5230.72
211_S215_F0.5210.72
133_F177_L0.5200.71
133_F181_S0.5180.71
174_G178_F0.5180.71
34_F38_T0.5170.71
130_D149_M0.5160.71
40_T107_A0.5150.71
70_A74_T0.5140.71
122_A125_L0.5130.70
129_K181_S0.5120.70
142_I145_V0.5110.70
15_L18_H0.5040.69
186_G190_N0.5010.69
211_S214_G0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pgrA 1 0.9224 100 0.19 Contact Map
3w9iA 3 0.9087 7.5 0.953 Contact Map
4k0jA 3 0.7991 7.1 0.954 Contact Map
4cbfA 7 0.3196 6.2 0.955 Contact Map
3j27A 7 0.3196 5.9 0.955 Contact Map
4cctA 7 0.3196 5.8 0.956 Contact Map
4mt1A 3 0.8584 4.9 0.957 Contact Map
4i0uA 4 0.3014 4.1 0.959 Contact Map
4ev6A 3 0.3151 3.6 0.96 Contact Map
3ne5A 3 0.7443 3.5 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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