GREMLIN Database
YBHL - Inner membrane protein YbhL
UniProt: P0AAC4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13668
Length: 234 (207)
Sequences: 3155 (2004)
Seq/√Len: 139.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_Y186_T3.8851.00
174_G225_M3.5991.00
127_S186_T3.1801.00
141_G184_Y2.8441.00
172_Y229_I2.8361.00
31_G89_F2.5331.00
118_V230_F2.4571.00
60_I64_I2.4281.00
104_F112_I2.4171.00
126_M179_V2.3821.00
175_V222_L2.3481.00
68_A72_V2.3011.00
185_D218_D2.2561.00
115_T229_I2.2541.00
25_Y127_S2.2341.00
125_A149_I2.1831.00
224_L228_R2.1601.00
155_S170_V2.1491.00
66_Q96_T2.0741.00
182_T222_L2.0471.00
144_L180_G2.0011.00
115_T226_L1.9761.00
35_T216_Y1.9481.00
165_A169_A1.9421.00
157_V161_L1.9221.00
145_F149_I1.9151.00
23_Q208_S1.8931.00
144_L184_Y1.8381.00
169_A173_I1.7451.00
64_I68_A1.7361.00
84_V87_M1.6961.00
188_K214_T1.6941.00
151_I174_G1.6851.00
128_L132_T1.6691.00
107_Y231_G1.6631.00
29_T124_G1.6561.00
179_V222_L1.6531.00
217_L221_N1.6371.00
127_S131_Y1.6191.00
167_M228_R1.6101.00
185_D188_K1.6021.00
87_M91_L1.5851.00
66_Q99_T1.5601.00
71_I75_A1.5571.00
36_A117_V1.5541.00
66_Q70_V1.5391.00
152_V156_L1.5331.00
172_Y176_I1.5301.00
118_V226_L1.5281.00
173_I177_V1.5061.00
148_L152_V1.4811.00
149_I153_L1.4761.00
84_V88_L1.4701.00
117_V121_G1.4631.00
14_R18_Q1.4491.00
121_G153_L1.4411.00
72_V88_L1.4321.00
130_G187_Q1.3711.00
108_T111_S1.3681.00
133_T187_Q1.3471.00
38_V94_A1.3411.00
178_F217_L1.3361.00
103_I224_L1.3331.00
188_K218_D1.3331.00
168_W229_I1.3321.00
133_T137_L1.3261.00
137_L183_A1.3221.00
27_W86_T1.3091.00
100_L224_L1.2801.00
111_S230_F1.2361.00
92_Y96_T1.2111.00
129_Y133_T1.2001.00
72_V75_A1.1961.00
63_I67_L1.1951.00
151_I177_V1.1821.00
16_G193_G1.1700.99
129_Y135_R1.1660.99
61_G68_A1.1660.99
45_S48_V1.1620.99
215_L218_D1.1560.99
86_T90_M1.1520.99
225_M228_R1.1510.99
148_L217_L1.1500.99
178_F221_N1.1350.99
158_N161_L1.1290.99
115_T118_V1.1250.99
168_W172_Y1.1150.99
135_R139_G1.1100.99
33_L37_F1.1060.99
42_A48_V1.0920.99
122_M126_M1.0910.99
37_F41_Y1.0850.99
187_Q191_N1.0710.99
113_A117_V1.0610.99
91_L95_L1.0600.99
154_A170_V1.0580.99
185_D217_L1.0520.99
139_G142_N1.0390.99
40_W44_N1.0360.99
122_M125_A1.0340.99
158_N163_S1.0260.99
62_L66_Q1.0250.99
123_F219_F1.0100.98
123_F182_T1.0100.98
69_L95_L1.0070.98
111_S115_T1.0040.98
65_A95_L0.9950.98
82_A86_T0.9950.98
70_V74_S0.9910.98
86_T209_I0.9890.98
177_V181_L0.9790.98
57_V61_G0.9740.98
166_L170_V0.9670.98
143_M147_A0.9610.98
135_R140_F0.9560.98
114_S230_F0.9540.98
158_N162_K0.9440.98
118_V157_V0.9390.98
140_F144_L0.9370.98
19_T23_Q0.9330.97
171_T228_R0.9260.97
118_V175_V0.9040.97
177_V180_G0.9020.97
70_V92_Y0.9010.97
81_S84_V0.8970.97
28_M215_L0.8920.97
122_M179_V0.8900.97
83_G87_M0.8900.97
168_W171_T0.8880.97
162_K165_A0.8820.96
27_W209_I0.8810.96
147_A177_V0.8700.96
174_G178_F0.8660.96
122_M222_L0.8640.96
31_G93_S0.8640.96
148_L221_N0.8630.96
17_L20_Y0.8590.96
139_G143_M0.8550.96
69_L73_L0.8500.96
178_F185_D0.8500.96
156_L159_F0.8490.96
170_V173_I0.8490.96
176_I180_G0.8490.96
148_L181_L0.8480.96
67_L70_V0.8330.95
178_F181_L0.8310.95
189_L211_G0.8300.95
61_G64_I0.8280.95
58_F61_G0.8240.95
23_Q26_G0.8240.95
82_A206_K0.8150.95
171_T175_V0.8080.94
189_L215_L0.8050.94
80_L88_L0.7970.94
22_A26_G0.7960.94
148_L177_V0.7900.94
148_L222_L0.7900.94
126_M183_A0.7890.94
96_T99_T0.7890.94
152_V177_V0.7860.93
171_T225_M0.7820.93
15_A19_T0.7770.93
50_E54_T0.7700.93
163_S166_L0.7680.93
139_G179_V0.7650.92
122_M226_L0.7640.92
26_G30_V0.7610.92
59_L63_I0.7580.92
89_F213_L0.7570.92
29_T33_L0.7530.92
103_I107_Y0.7530.92
143_M176_I0.7510.92
192_M211_G0.7450.91
183_A187_Q0.7450.91
226_L230_F0.7430.91
214_T218_D0.7420.91
112_I227_L0.7410.91
181_L185_D0.7380.91
30_V34_L0.7380.91
131_Y186_T0.7330.91
60_I63_I0.7330.91
41_Y45_S0.7320.91
17_L193_G0.7260.90
30_V90_M0.7240.90
126_M137_L0.7210.90
70_V213_L0.7190.90
121_G125_A0.7180.90
151_I225_M0.7180.90
164_E167_M0.7150.90
225_M229_I0.7140.90
20_Y189_L0.7070.89
80_L210_L0.7000.89
38_V42_A0.7000.89
161_L164_E0.6990.89
145_F181_L0.6980.89
125_A129_Y0.6910.88
80_L84_V0.6910.88
24_V189_L0.6870.88
186_T215_L0.6850.88
19_T22_A0.6850.88
42_A52_L0.6790.87
34_L38_V0.6780.87
90_M93_S0.6780.87
153_L157_V0.6770.87
107_Y224_L0.6770.87
34_L90_M0.6650.86
89_F93_S0.6630.86
64_I67_L0.6630.86
148_L155_S0.6630.86
151_I173_I0.6590.86
80_L85_T0.6580.85
92_Y213_L0.6570.85
42_A101_S0.6560.85
62_L98_L0.6560.85
228_R231_G0.6540.85
189_L192_M0.6540.85
111_S231_G0.6520.85
131_Y190_K0.6490.85
178_F218_D0.6460.84
31_G94_A0.6440.84
150_G154_A0.6410.84
13_P18_Q0.6400.84
159_F162_K0.6390.84
71_I78_Q0.6380.84
72_V84_V0.6380.84
73_L209_I0.6380.84
146_M150_G0.6370.84
110_A114_S0.6320.83
70_V73_L0.6310.83
24_V211_G0.6270.83
26_G29_T0.6230.82
115_T230_F0.6220.82
116_F120_A0.6220.82
135_R187_Q0.6200.82
33_L72_V0.6190.82
208_S211_G0.6180.82
130_G190_K0.6150.81
138_S187_Q0.6150.81
166_L169_A0.6130.81
69_L88_L0.6130.81
115_T119_T0.6100.81
66_Q69_L0.6100.81
20_Y24_V0.6070.81
71_I74_S0.6070.81
152_V155_S0.6040.80
14_R17_L0.5970.80
69_L91_L0.5970.80
155_S172_Y0.5960.79
176_I179_V0.5960.79
174_G228_R0.5950.79
78_Q81_S0.5940.79
73_L77_I0.5910.79
181_L218_D0.5880.78
154_A158_N0.5870.78
147_A151_I0.5850.78
151_I170_V0.5850.78
149_I152_V0.5850.78
77_I85_T0.5840.78
221_N224_L0.5810.78
55_N58_F0.5800.78
178_F188_K0.5780.77
215_L219_F0.5760.77
72_V79_K0.5750.77
111_S114_S0.5730.77
142_N146_M0.5690.76
126_M139_G0.5680.76
158_N170_V0.5670.76
221_N225_M0.5670.76
180_G184_Y0.5670.76
144_L147_A0.5660.76
79_K88_L0.5630.75
30_V33_L0.5580.75
122_M176_I0.5580.75
123_F215_L0.5560.75
141_G180_G0.5550.74
27_W90_M0.5530.74
223_F227_L0.5530.74
48_V54_T0.5510.74
33_L142_N0.5500.74
148_L178_F0.5480.74
68_A71_I0.5470.73
39_A101_S0.5470.73
137_L142_N0.5460.73
50_E53_F0.5450.73
139_G183_A0.5410.73
42_A98_L0.5350.72
184_Y188_K0.5330.71
56_R59_L0.5320.71
43_A105_I0.5320.71
45_S55_N0.5310.71
116_F219_F0.5290.71
165_A168_W0.5290.71
128_L131_Y0.5280.71
34_L93_S0.5270.71
67_L71_I0.5230.70
20_Y23_Q0.5200.70
40_W113_A0.5190.69
167_M171_T0.5180.69
125_A153_L0.5170.69
178_F216_Y0.5120.68
25_Y123_F0.5120.68
62_L68_A0.5110.68
33_L120_A0.5090.68
27_W212_A0.5090.68
20_Y193_G0.5080.68
39_A43_A0.5060.68
20_Y211_G0.5030.67
144_L181_L0.5010.67
32_L35_T0.5000.67
69_L72_V0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pgrA 1 0.8547 100 0.234 Contact Map
4i0uA 4 0.3162 21 0.945 Contact Map
4ev6A 3 0.3205 20.8 0.945 Contact Map
2mv6A 1 0.1752 7.2 0.956 Contact Map
2xq2A 2 0.7521 4.1 0.96 Contact Map
4p6vE 1 0.7009 3.9 0.961 Contact Map
3aqpA 1 0.7521 3.3 0.962 Contact Map
3w9iA 3 0.8419 2.8 0.964 Contact Map
4p02A 1 0.4744 2.5 0.964 Contact Map
4dx5A 3 0.8419 2.4 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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