USPE - ECOLI - GREMLIN Contacts

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USPE - Universal stress protein E

UniProt:	P0AAC0	Sequences: MAMYQNMLVVIDPNQDDQPALRRAVYLHQRIGGKIKAFLPIYDFSYEMTTLLSPDERTAMRQGVISQRTAWIHEQAKYYLNAGVPIEIKVVWHNRPFEAIIQEVISGGHDLVLKMAHQHDRLEAVIFTPTDWHLLRKCPSPVWMVKDQPWPEGGKALVAVNLASEEPYHNALNEKLVKETIELAEQVNHTEVHLVGAYPVTPINIAIELPEFDPSVYNDAIRGQHLLAMKALRQKFGINENMTHVEKGLPEEVIPDLAEHLQAGIVVLGTVGRTGISAAFLGNTAEQVIDHLRCDLLVIKPDQYQTPVELDDEEDD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11246
Length:	316 (264)
Sequences:	8419 (6886)
Seq/√Len:	423.8

ECOLI - USPE
HALSA - Q9HHX5 Q9HHY0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
143_W	297_L	3.381	1.00
155_K	191_E	3.280	1.00
157_L	263_A	3.250	1.00
6_N	34_K	2.913	1.00
155_K	193_H	2.872	1.00
114_K	134_L	2.851	1.00
94_N	99_A	2.720	1.00
155_K	264_G	2.706	1.00
36_K	89_K	2.579	1.00
8_L	109_H	2.577	1.00
76_A	80_L	2.547	1.00
179_E	297_L	2.533	1.00
34_K	87_E	2.513	1.00
193_H	244_H	2.498	1.00
268_L	288_V	2.461	1.00
248_G	253_V	2.451	1.00
244_H	257_L	2.417	1.00
191_E	242_M	2.273	1.00
22_R	78_Y	2.229	1.00
258_A	266_V	2.173	1.00
112_V	138_C	2.156	1.00
69_T	73_H	2.144	1.00
6_N	36_K	2.130	1.00
36_K	87_E	2.041	1.00
33_G	110_D	2.007	1.00
158_V	177_V	1.957	1.00
257_L	261_L	1.924	1.00
266_V	294_C	1.898	1.00
112_V	140_S	1.891	1.00
76_A	88_I	1.859	1.00
191_E	240_E	1.848	1.00
38_F	103_E	1.842	1.00
159_A	254_I	1.809	1.00
89_K	103_E	1.767	1.00
34_K	85_P	1.762	1.00
36_K	103_E	1.713	1.00
9_V	24_A	1.702	1.00
111_L	143_W	1.683	1.00
23_R	143_W	1.674	1.00
251_E	287_Q	1.674	1.00
146_K	295_D	1.665	1.00
75_Q	79_Y	1.643	1.00
222_R	226_L	1.632	1.00
97_F	133_H	1.621	1.00
265_I	297_L	1.602	1.00
40_P	99_A	1.600	1.00
258_A	294_C	1.592	1.00
157_L	257_L	1.576	1.00
65_I	69_T	1.557	1.00
10_V	100_I	1.548	1.00
7_M	111_L	1.544	1.00
259_E	293_R	1.525	1.00
193_H	242_M	1.495	1.00
73_H	77_K	1.475	1.00
258_A	293_R	1.461	1.00
62_Q	66_S	1.434	1.00
36_K	109_H	1.426	1.00
157_L	195_V	1.425	1.00
292_L	296_L	1.420	1.00
157_L	266_V	1.415	1.00
197_A	253_V	1.413	1.00
195_V	257_L	1.408	1.00
159_A	268_L	1.399	1.00
258_A	263_A	1.389	1.00
195_V	254_I	1.377	1.00
21_L	37_A	1.364	1.00
154_G	190_T	1.363	1.00
68_R	90_V	1.357	1.00
66_S	70_A	1.354	1.00
138_C	142_V	1.329	1.00
23_R	145_V	1.319	1.00
226_L	230_K	1.315	1.00
228_A	231_A	1.306	1.00
183_L	187_V	1.305	1.00
270_T	298_V	1.304	1.00
181_I	239_N	1.291	1.00
72_I	76_A	1.281	1.00
233_R	243_T	1.280	1.00
24_A	35_I	1.276	1.00
288_V	296_L	1.272	1.00
11_I	37_A	1.270	1.00
24_A	28_H	1.267	1.00
99_A	102_Q	1.265	1.00
266_V	292_L	1.234	1.00
178_K	182_E	1.229	1.00
37_A	75_Q	1.216	1.00
132_W	286_E	1.192	1.00
270_T	285_A	1.192	1.00
37_A	79_Y	1.186	1.00
158_V	176_L	1.186	1.00
227_L	230_K	1.183	1.00
193_H	257_L	1.177	1.00
18_Q	78_Y	1.173	1.00
91_V	99_A	1.170	1.00
40_P	94_N	1.168	1.00
194_L	229_M	1.164	1.00
10_V	114_K	1.163	1.00
275_G	278_A	1.160	1.00
12_D	17_D	1.159	1.00
9_V	21_L	1.158	1.00
70_A	74_E	1.152	1.00
131_D	144_M	1.148	1.00
71_W	75_Q	1.138	1.00
141_P	300_K	1.133	1.00
178_K	232_L	1.130	1.00
116_A	146_K	1.124	1.00
135_L	298_V	1.115	1.00
163_A	272_G	1.103	1.00
253_V	256_D	1.090	1.00
187_V	264_G	1.087	1.00
287_Q	291_H	1.084	1.00
27_L	183_L	1.082	1.00
6_N	110_D	1.079	1.00
29_Q	83_G	1.075	1.00
179_E	299_I	1.065	1.00
270_T	300_K	1.064	1.00
26_Y	30_R	1.062	1.00
223_G	227_L	1.055	1.00
156_A	184_A	1.053	1.00
257_L	263_A	1.050	1.00
39_L	71_W	1.049	1.00
11_I	17_D	1.046	1.00
8_L	38_F	1.046	1.00
61_R	65_I	1.043	1.00
64_V	68_R	1.041	1.00
175_K	178_K	1.036	1.00
95_R	98_E	1.035	1.00
153_G	264_G	1.032	1.00
60_M	63_G	1.028	1.00
106_S	139_P	1.027	1.00
31_I	110_D	1.023	1.00
158_V	180_T	1.017	1.00
197_A	250_P	1.017	1.00
246_E	253_V	1.015	1.00
182_E	186_Q	1.015	1.00
73_H	76_A	1.008	1.00
14_N	17_D	1.008	1.00
230_K	234_Q	1.003	1.00
180_T	267_V	1.001	1.00
20_A	113_L	0.998	1.00
18_Q	22_R	0.994	1.00
27_L	31_I	0.984	1.00
178_K	235_K	0.980	1.00
28_H	33_G	0.978	1.00
68_R	71_W	0.969	1.00
30_R	186_Q	0.967	1.00
21_L	25_V	0.963	1.00
114_K	131_D	0.955	1.00
181_I	192_V	0.953	1.00
103_E	106_S	0.950	1.00
226_L	243_T	0.950	1.00
135_L	142_V	0.949	1.00
19_P	22_R	0.949	1.00
74_E	78_Y	0.948	1.00
66_S	69_T	0.946	1.00
227_L	231_A	0.945	1.00
101_I	137_K	0.942	1.00
71_W	74_E	0.935	1.00
181_I	236_F	0.935	1.00
9_V	35_I	0.934	1.00
136_R	286_E	0.932	1.00
162_L	196_G	0.931	1.00
187_V	190_T	0.925	1.00
193_H	261_L	0.924	1.00
77_K	81_N	0.922	1.00
221_I	224_Q	0.918	1.00
144_M	298_V	0.915	1.00
193_H	263_A	0.910	1.00
154_G	264_G	0.909	1.00
75_Q	78_Y	0.908	1.00
25_V	79_Y	0.907	1.00
246_E	257_L	0.907	1.00
72_I	90_V	0.906	1.00
226_L	229_M	0.905	1.00
134_L	142_V	0.905	1.00
118_Q	128_T	0.898	1.00
232_L	236_F	0.896	1.00
255_P	288_V	0.894	1.00
72_I	88_I	0.894	1.00
23_R	295_D	0.893	1.00
38_F	91_V	0.887	1.00
13_P	162_L	0.885	1.00
231_A	234_Q	0.884	1.00
156_A	265_I	0.881	1.00
166_E	176_L	0.879	1.00
22_R	82_A	0.874	1.00
25_V	35_I	0.873	1.00
39_L	68_R	0.871	1.00
233_R	236_F	0.860	1.00
57_R	60_M	0.855	1.00
185_E	238_I	0.852	1.00
269_G	282_G	0.851	1.00
163_A	166_E	0.850	1.00
74_E	77_K	0.846	1.00
252_E	256_D	0.844	1.00
255_P	258_A	0.840	1.00
99_A	103_E	0.837	1.00
31_I	183_L	0.836	1.00
116_A	144_M	0.835	1.00
155_K	190_T	0.828	1.00
255_P	292_L	0.826	1.00
14_N	118_Q	0.825	1.00
38_F	100_I	0.820	1.00
276_I	279_A	0.819	1.00
254_I	288_V	0.818	1.00
225_H	229_M	0.813	1.00
97_F	130_T	0.813	1.00
122_L	126_I	0.811	1.00
60_M	64_V	0.810	1.00
37_A	76_A	0.804	1.00
11_I	20_A	0.802	1.00
157_L	258_A	0.802	1.00
118_Q	129_P	0.798	1.00
122_L	125_V	0.796	1.00
180_T	192_V	0.793	1.00
253_V	257_L	0.793	1.00
96_P	130_T	0.788	1.00
28_H	35_I	0.788	1.00
6_N	109_H	0.788	1.00
118_Q	127_F	0.786	1.00
96_P	99_A	0.784	1.00
254_I	266_V	0.783	1.00
153_G	190_T	0.780	1.00
167_P	228_A	0.780	1.00
56_E	60_M	0.778	1.00
17_D	20_A	0.769	1.00
91_V	106_S	0.767	1.00
9_V	20_A	0.761	1.00
40_P	96_P	0.758	1.00
58_T	62_Q	0.756	1.00
184_A	190_T	0.755	1.00
161_N	165_E	0.752	1.00
8_L	112_V	0.746	1.00
161_N	166_E	0.745	1.00
159_A	266_V	0.743	1.00
158_V	192_V	0.743	1.00
91_V	103_E	0.743	1.00
68_R	72_I	0.738	1.00
23_R	153_G	0.737	1.00
56_E	59_A	0.734	1.00
132_W	290_D	0.734	1.00
24_A	113_L	0.730	1.00
167_P	178_K	0.729	1.00
113_L	143_W	0.729	1.00
59_A	63_G	0.728	1.00
65_I	92_W	0.726	1.00
226_L	231_A	0.724	1.00
184_A	192_V	0.723	1.00
36_K	107_G	0.722	1.00
268_L	285_A	0.722	1.00
37_A	88_I	0.720	1.00
97_F	134_L	0.719	1.00
32_G	85_P	0.718	1.00
18_Q	74_E	0.718	1.00
67_Q	70_A	0.716	1.00
55_D	59_A	0.713	1.00
286_E	290_D	0.711	1.00
144_M	289_I	0.709	1.00
72_I	75_Q	0.709	1.00
6_N	232_L	0.706	1.00
175_K	179_E	0.702	1.00
241_N	245_V	0.702	1.00
134_L	138_C	0.701	1.00
154_G	262_Q	0.699	1.00
223_G	226_L	0.697	1.00
201_T	204_N	0.697	1.00
249_L	252_E	0.695	1.00
57_R	61_R	0.694	1.00
31_I	186_Q	0.688	1.00
195_V	246_E	0.686	1.00
25_V	84_V	0.685	1.00
156_A	192_V	0.682	1.00
8_L	103_E	0.680	1.00
185_E	236_F	0.678	1.00
13_P	39_L	0.677	1.00
121_R	124_A	0.676	1.00
98_E	102_Q	0.676	1.00
11_I	75_Q	0.674	1.00
164_S	167_P	0.672	1.00
12_D	115_M	0.669	1.00
37_A	72_I	0.668	1.00
180_T	184_A	0.666	1.00
250_P	253_V	0.666	1.00
127_F	132_W	0.664	0.99
161_N	272_G	0.660	0.99
58_T	61_R	0.660	0.99
268_L	298_V	0.659	0.99
272_G	282_G	0.659	0.99
266_V	288_V	0.658	0.99
41_I	90_V	0.657	0.99
270_T	273_R	0.657	0.99
229_M	232_L	0.655	0.99
15_Q	18_Q	0.653	0.99
273_R	277_S	0.652	0.99
34_K	110_D	0.650	0.99
37_A	86_I	0.648	0.99
275_G	279_A	0.647	0.99
284_T	288_V	0.646	0.99
248_G	252_E	0.645	0.99
251_E	288_V	0.640	0.99
97_F	101_I	0.640	0.99
28_H	84_V	0.639	0.99
133_H	137_K	0.639	0.99
10_V	115_M	0.638	0.99
159_A	269_G	0.638	0.99
251_E	284_T	0.637	0.99
77_K	80_L	0.635	0.99
101_I	106_S	0.629	0.99
10_V	20_A	0.628	0.99
7_M	113_L	0.627	0.99
182_E	185_E	0.625	0.99
29_Q	82_A	0.624	0.99
167_P	232_L	0.622	0.99
276_I	280_F	0.620	0.99
112_V	134_L	0.620	0.99
156_A	267_V	0.619	0.99
27_L	187_V	0.618	0.99
26_Y	29_Q	0.617	0.99
148_Q	293_R	0.617	0.99
16_D	19_P	0.615	0.99
11_I	21_L	0.613	0.99
38_F	99_A	0.613	0.99
59_A	62_Q	0.612	0.99
190_T	264_G	0.612	0.99
91_V	94_N	0.609	0.99
5_Q	110_D	0.608	0.99
229_M	233_R	0.607	0.99
9_V	37_A	0.607	0.99
101_I	134_L	0.605	0.99
181_I	185_E	0.604	0.99
269_G	299_I	0.604	0.99
10_V	112_V	0.603	0.99
67_Q	71_W	0.602	0.99
242_M	246_E	0.600	0.99
160_V	177_V	0.597	0.99
12_D	20_A	0.597	0.99
118_Q	130_T	0.596	0.99
20_A	145_V	0.595	0.99
224_Q	228_A	0.594	0.99
231_A	235_K	0.592	0.99
101_I	138_C	0.590	0.99
20_A	24_A	0.589	0.99
62_Q	65_I	0.588	0.99
17_D	118_Q	0.587	0.99
78_Y	81_N	0.586	0.99
132_W	136_R	0.575	0.99
251_E	291_H	0.571	0.98
127_F	131_D	0.571	0.98
251_E	255_P	0.571	0.98
274_T	279_A	0.570	0.98
56_E	61_R	0.569	0.98
272_G	275_G	0.561	0.98
272_G	277_S	0.561	0.98
42_Y	94_N	0.561	0.98
114_K	144_M	0.558	0.98
230_K	243_T	0.557	0.98
106_S	112_V	0.555	0.98
95_R	99_A	0.547	0.98
7_M	28_H	0.547	0.98
202_P	205_I	0.546	0.98
280_F	283_N	0.543	0.98
21_L	79_Y	0.543	0.98
79_Y	86_I	0.540	0.98
131_D	135_L	0.538	0.98
106_S	109_H	0.537	0.98
255_P	259_E	0.537	0.98
132_W	135_L	0.533	0.98
63_G	67_Q	0.531	0.98
272_G	300_K	0.530	0.98
197_A	246_E	0.530	0.98
30_R	187_V	0.530	0.98
135_L	144_M	0.527	0.97
25_V	29_Q	0.525	0.97
103_E	109_H	0.525	0.97
24_A	145_V	0.523	0.97
258_A	288_V	0.518	0.97
225_H	228_A	0.515	0.97
16_D	147_D	0.515	0.97
28_H	31_I	0.514	0.97
68_R	79_Y	0.513	0.97
228_A	232_L	0.513	0.97
226_L	233_R	0.512	0.97
103_E	107_G	0.512	0.97
118_Q	121_R	0.512	0.97
155_K	261_L	0.511	0.97
181_I	232_L	0.511	0.97
130_T	133_H	0.511	0.97
156_A	183_L	0.510	0.97
61_R	92_W	0.508	0.97
107_G	139_P	0.508	0.97
183_L	186_Q	0.505	0.97
70_A	73_H	0.504	0.97
250_P	284_T	0.504	0.97
155_K	263_A	0.503	0.97
41_I	68_R	0.502	0.97
55_D	58_T	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4r2kA	2	0.9778	100	0.208	Contact Map
4wy2A	2	0.9462	100	0.231	Contact Map
3mt0A	1	0.8797	100	0.244	Contact Map
3loqA	1	0.8481	100	0.272	Contact Map
3cisA	4	0.8956	100	0.286	Contact Map
3ab8A	2	0.8133	100	0.33	Contact Map
2dumA	2	0.4589	99.9	0.583	Contact Map
5ahwA	4	0.4589	99.9	0.599	Contact Map
1mjhA	2	0.4494	99.9	0.605	Contact Map
3s3tA	4	0.4494	99.9	0.611	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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