GREMLIN Database
USPE - Universal stress protein E
UniProt: P0AAC0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11246
Length: 316 (264)
Sequences: 8419 (6886)
Seq/√Len: 423.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
143_W297_L3.3811.00
155_K191_E3.2801.00
157_L263_A3.2501.00
6_N34_K2.9131.00
155_K193_H2.8721.00
114_K134_L2.8511.00
94_N99_A2.7201.00
155_K264_G2.7061.00
36_K89_K2.5791.00
8_L109_H2.5771.00
76_A80_L2.5471.00
179_E297_L2.5331.00
34_K87_E2.5131.00
193_H244_H2.4981.00
268_L288_V2.4611.00
248_G253_V2.4511.00
244_H257_L2.4171.00
191_E242_M2.2731.00
22_R78_Y2.2291.00
258_A266_V2.1731.00
112_V138_C2.1561.00
69_T73_H2.1441.00
6_N36_K2.1301.00
36_K87_E2.0411.00
33_G110_D2.0071.00
158_V177_V1.9571.00
257_L261_L1.9241.00
266_V294_C1.8981.00
112_V140_S1.8911.00
76_A88_I1.8591.00
191_E240_E1.8481.00
38_F103_E1.8421.00
159_A254_I1.8091.00
89_K103_E1.7671.00
34_K85_P1.7621.00
36_K103_E1.7131.00
9_V24_A1.7021.00
111_L143_W1.6831.00
23_R143_W1.6741.00
251_E287_Q1.6741.00
146_K295_D1.6651.00
75_Q79_Y1.6431.00
222_R226_L1.6321.00
97_F133_H1.6211.00
265_I297_L1.6021.00
40_P99_A1.6001.00
258_A294_C1.5921.00
157_L257_L1.5761.00
65_I69_T1.5571.00
10_V100_I1.5481.00
7_M111_L1.5441.00
259_E293_R1.5251.00
193_H242_M1.4951.00
73_H77_K1.4751.00
258_A293_R1.4611.00
62_Q66_S1.4341.00
36_K109_H1.4261.00
157_L195_V1.4251.00
292_L296_L1.4201.00
157_L266_V1.4151.00
197_A253_V1.4131.00
195_V257_L1.4081.00
159_A268_L1.3991.00
258_A263_A1.3891.00
195_V254_I1.3771.00
21_L37_A1.3641.00
154_G190_T1.3631.00
68_R90_V1.3571.00
66_S70_A1.3541.00
138_C142_V1.3291.00
23_R145_V1.3191.00
226_L230_K1.3151.00
228_A231_A1.3061.00
183_L187_V1.3051.00
270_T298_V1.3041.00
181_I239_N1.2911.00
72_I76_A1.2811.00
233_R243_T1.2801.00
24_A35_I1.2761.00
288_V296_L1.2721.00
11_I37_A1.2701.00
24_A28_H1.2671.00
99_A102_Q1.2651.00
266_V292_L1.2341.00
178_K182_E1.2291.00
37_A75_Q1.2161.00
132_W286_E1.1921.00
270_T285_A1.1921.00
37_A79_Y1.1861.00
158_V176_L1.1861.00
227_L230_K1.1831.00
193_H257_L1.1771.00
18_Q78_Y1.1731.00
91_V99_A1.1701.00
40_P94_N1.1681.00
194_L229_M1.1641.00
10_V114_K1.1631.00
275_G278_A1.1601.00
12_D17_D1.1591.00
9_V21_L1.1581.00
70_A74_E1.1521.00
131_D144_M1.1481.00
71_W75_Q1.1381.00
141_P300_K1.1331.00
178_K232_L1.1301.00
116_A146_K1.1241.00
135_L298_V1.1151.00
163_A272_G1.1031.00
253_V256_D1.0901.00
187_V264_G1.0871.00
287_Q291_H1.0841.00
27_L183_L1.0821.00
6_N110_D1.0791.00
29_Q83_G1.0751.00
179_E299_I1.0651.00
270_T300_K1.0641.00
26_Y30_R1.0621.00
223_G227_L1.0551.00
156_A184_A1.0531.00
257_L263_A1.0501.00
39_L71_W1.0491.00
11_I17_D1.0461.00
8_L38_F1.0461.00
61_R65_I1.0431.00
64_V68_R1.0411.00
175_K178_K1.0361.00
95_R98_E1.0351.00
153_G264_G1.0321.00
60_M63_G1.0281.00
106_S139_P1.0271.00
31_I110_D1.0231.00
158_V180_T1.0171.00
197_A250_P1.0171.00
246_E253_V1.0151.00
182_E186_Q1.0151.00
73_H76_A1.0081.00
14_N17_D1.0081.00
230_K234_Q1.0031.00
180_T267_V1.0011.00
20_A113_L0.9981.00
18_Q22_R0.9941.00
27_L31_I0.9841.00
178_K235_K0.9801.00
28_H33_G0.9781.00
68_R71_W0.9691.00
30_R186_Q0.9671.00
21_L25_V0.9631.00
114_K131_D0.9551.00
181_I192_V0.9531.00
103_E106_S0.9501.00
226_L243_T0.9501.00
135_L142_V0.9491.00
19_P22_R0.9491.00
74_E78_Y0.9481.00
66_S69_T0.9461.00
227_L231_A0.9451.00
101_I137_K0.9421.00
71_W74_E0.9351.00
181_I236_F0.9351.00
9_V35_I0.9341.00
136_R286_E0.9321.00
162_L196_G0.9311.00
187_V190_T0.9251.00
193_H261_L0.9241.00
77_K81_N0.9221.00
221_I224_Q0.9181.00
144_M298_V0.9151.00
193_H263_A0.9101.00
154_G264_G0.9091.00
75_Q78_Y0.9081.00
25_V79_Y0.9071.00
246_E257_L0.9071.00
72_I90_V0.9061.00
226_L229_M0.9051.00
134_L142_V0.9051.00
118_Q128_T0.8981.00
232_L236_F0.8961.00
255_P288_V0.8941.00
72_I88_I0.8941.00
23_R295_D0.8931.00
38_F91_V0.8871.00
13_P162_L0.8851.00
231_A234_Q0.8841.00
156_A265_I0.8811.00
166_E176_L0.8791.00
22_R82_A0.8741.00
25_V35_I0.8731.00
39_L68_R0.8711.00
233_R236_F0.8601.00
57_R60_M0.8551.00
185_E238_I0.8521.00
269_G282_G0.8511.00
163_A166_E0.8501.00
74_E77_K0.8461.00
252_E256_D0.8441.00
255_P258_A0.8401.00
99_A103_E0.8371.00
31_I183_L0.8361.00
116_A144_M0.8351.00
155_K190_T0.8281.00
255_P292_L0.8261.00
14_N118_Q0.8251.00
38_F100_I0.8201.00
276_I279_A0.8191.00
254_I288_V0.8181.00
225_H229_M0.8131.00
97_F130_T0.8131.00
122_L126_I0.8111.00
60_M64_V0.8101.00
37_A76_A0.8041.00
11_I20_A0.8021.00
157_L258_A0.8021.00
118_Q129_P0.7981.00
122_L125_V0.7961.00
180_T192_V0.7931.00
253_V257_L0.7931.00
96_P130_T0.7881.00
28_H35_I0.7881.00
6_N109_H0.7881.00
118_Q127_F0.7861.00
96_P99_A0.7841.00
254_I266_V0.7831.00
153_G190_T0.7801.00
167_P228_A0.7801.00
56_E60_M0.7781.00
17_D20_A0.7691.00
91_V106_S0.7671.00
9_V20_A0.7611.00
40_P96_P0.7581.00
58_T62_Q0.7561.00
184_A190_T0.7551.00
161_N165_E0.7521.00
8_L112_V0.7461.00
161_N166_E0.7451.00
159_A266_V0.7431.00
158_V192_V0.7431.00
91_V103_E0.7431.00
68_R72_I0.7381.00
23_R153_G0.7371.00
56_E59_A0.7341.00
132_W290_D0.7341.00
24_A113_L0.7301.00
167_P178_K0.7291.00
113_L143_W0.7291.00
59_A63_G0.7281.00
65_I92_W0.7261.00
226_L231_A0.7241.00
184_A192_V0.7231.00
36_K107_G0.7221.00
268_L285_A0.7221.00
37_A88_I0.7201.00
97_F134_L0.7191.00
32_G85_P0.7181.00
18_Q74_E0.7181.00
67_Q70_A0.7161.00
55_D59_A0.7131.00
286_E290_D0.7111.00
144_M289_I0.7091.00
72_I75_Q0.7091.00
6_N232_L0.7061.00
175_K179_E0.7021.00
241_N245_V0.7021.00
134_L138_C0.7011.00
154_G262_Q0.6991.00
223_G226_L0.6971.00
201_T204_N0.6971.00
249_L252_E0.6951.00
57_R61_R0.6941.00
31_I186_Q0.6881.00
195_V246_E0.6861.00
25_V84_V0.6851.00
156_A192_V0.6821.00
8_L103_E0.6801.00
185_E236_F0.6781.00
13_P39_L0.6771.00
121_R124_A0.6761.00
98_E102_Q0.6761.00
11_I75_Q0.6741.00
164_S167_P0.6721.00
12_D115_M0.6691.00
37_A72_I0.6681.00
180_T184_A0.6661.00
250_P253_V0.6661.00
127_F132_W0.6640.99
161_N272_G0.6600.99
58_T61_R0.6600.99
268_L298_V0.6590.99
272_G282_G0.6590.99
266_V288_V0.6580.99
41_I90_V0.6570.99
270_T273_R0.6570.99
229_M232_L0.6550.99
15_Q18_Q0.6530.99
273_R277_S0.6520.99
34_K110_D0.6500.99
37_A86_I0.6480.99
275_G279_A0.6470.99
284_T288_V0.6460.99
248_G252_E0.6450.99
251_E288_V0.6400.99
97_F101_I0.6400.99
28_H84_V0.6390.99
133_H137_K0.6390.99
10_V115_M0.6380.99
159_A269_G0.6380.99
251_E284_T0.6370.99
77_K80_L0.6350.99
101_I106_S0.6290.99
10_V20_A0.6280.99
7_M113_L0.6270.99
182_E185_E0.6250.99
29_Q82_A0.6240.99
167_P232_L0.6220.99
276_I280_F0.6200.99
112_V134_L0.6200.99
156_A267_V0.6190.99
27_L187_V0.6180.99
26_Y29_Q0.6170.99
148_Q293_R0.6170.99
16_D19_P0.6150.99
11_I21_L0.6130.99
38_F99_A0.6130.99
59_A62_Q0.6120.99
190_T264_G0.6120.99
91_V94_N0.6090.99
5_Q110_D0.6080.99
229_M233_R0.6070.99
9_V37_A0.6070.99
101_I134_L0.6050.99
181_I185_E0.6040.99
269_G299_I0.6040.99
10_V112_V0.6030.99
67_Q71_W0.6020.99
242_M246_E0.6000.99
160_V177_V0.5970.99
12_D20_A0.5970.99
118_Q130_T0.5960.99
20_A145_V0.5950.99
224_Q228_A0.5940.99
231_A235_K0.5920.99
101_I138_C0.5900.99
20_A24_A0.5890.99
62_Q65_I0.5880.99
17_D118_Q0.5870.99
78_Y81_N0.5860.99
132_W136_R0.5750.99
251_E291_H0.5710.98
127_F131_D0.5710.98
251_E255_P0.5710.98
274_T279_A0.5700.98
56_E61_R0.5690.98
272_G275_G0.5610.98
272_G277_S0.5610.98
42_Y94_N0.5610.98
114_K144_M0.5580.98
230_K243_T0.5570.98
106_S112_V0.5550.98
95_R99_A0.5470.98
7_M28_H0.5470.98
202_P205_I0.5460.98
280_F283_N0.5430.98
21_L79_Y0.5430.98
79_Y86_I0.5400.98
131_D135_L0.5380.98
106_S109_H0.5370.98
255_P259_E0.5370.98
132_W135_L0.5330.98
63_G67_Q0.5310.98
272_G300_K0.5300.98
197_A246_E0.5300.98
30_R187_V0.5300.98
135_L144_M0.5270.97
25_V29_Q0.5250.97
103_E109_H0.5250.97
24_A145_V0.5230.97
258_A288_V0.5180.97
225_H228_A0.5150.97
16_D147_D0.5150.97
28_H31_I0.5140.97
68_R79_Y0.5130.97
228_A232_L0.5130.97
226_L233_R0.5120.97
103_E107_G0.5120.97
118_Q121_R0.5120.97
155_K261_L0.5110.97
181_I232_L0.5110.97
130_T133_H0.5110.97
156_A183_L0.5100.97
61_R92_W0.5080.97
107_G139_P0.5080.97
183_L186_Q0.5050.97
70_A73_H0.5040.97
250_P284_T0.5040.97
155_K263_A0.5030.97
41_I68_R0.5020.97
55_D58_T0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r2kA 2 0.9778 100 0.208 Contact Map
4wy2A 2 0.9462 100 0.231 Contact Map
3mt0A 1 0.8797 100 0.244 Contact Map
3loqA 1 0.8481 100 0.272 Contact Map
3cisA 4 0.8956 100 0.286 Contact Map
3ab8A 2 0.8133 100 0.33 Contact Map
2dumA 2 0.4589 99.9 0.583 Contact Map
5ahwA 4 0.4589 99.9 0.599 Contact Map
1mjhA 2 0.4494 99.9 0.605 Contact Map
3s3tA 4 0.4494 99.9 0.611 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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