GREMLIN Database
USPD - Universal stress protein D
UniProt: P0AAB8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11877
Length: 142 (131)
Sequences: 20960 (17089)
Seq/√Len: 1493.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_T85_R2.9741.00
7_G104_C2.8181.00
5_H35_T2.7641.00
92_P125_G2.7021.00
22_K135_L2.4311.00
5_H33_H2.4141.00
33_H83_K2.3681.00
106_L135_L2.2701.00
85_R98_I2.1691.00
107_L132_A2.0021.00
63_K67_D1.9851.00
109_C126_M1.9441.00
35_T104_C1.9371.00
89_G94_T1.8871.00
35_T83_K1.8801.00
87_E94_T1.8501.00
35_T98_I1.7811.00
124_R128_N1.7781.00
99_M107_L1.7441.00
8_V23_A1.7391.00
37_I98_I1.7241.00
9_A109_C1.6961.00
39_I94_T1.6651.00
9_A95_L1.6591.00
94_T97_E1.5141.00
26_L30_N1.4801.00
33_H81_K1.4511.00
32_A105_D1.4261.00
107_L130_M1.4131.00
125_G129_K1.4101.00
100_Q131_S1.4031.00
67_D71_Y1.3891.00
96_L129_K1.3701.00
66_S70_L1.3481.00
8_V20_V1.3341.00
23_A27_A1.3291.00
91_M122_A1.2921.00
59_L63_K1.2681.00
69_K72_K1.2431.00
87_E98_I1.2331.00
98_I104_C1.2241.00
71_Y75_K1.2161.00
99_M131_S1.2161.00
21_N73_L1.2091.00
107_L126_M1.1871.00
62_L66_S1.1791.00
71_Y84_L1.1731.00
99_M132_A1.1641.00
5_H105_D1.1571.00
66_S69_K1.1511.00
39_I91_M1.1411.00
115_F118_R1.1301.00
62_L65_K1.1171.00
12_G38_H1.1061.00
69_K73_L1.0991.00
37_I87_E1.0991.00
65_K69_K1.0751.00
5_H104_C1.0671.00
22_K137_V1.0641.00
60_Q64_N1.0541.00
130_M134_L1.0491.00
64_N68_N1.0421.00
118_R124_R1.0351.00
40_D88_R1.0291.00
38_H66_S1.0161.00
109_C123_Y1.0031.00
37_I95_L0.9971.00
67_D84_L0.9921.00
99_M104_C0.9901.00
25_E29_H0.9881.00
56_E60_Q0.9871.00
74_T77_I0.9851.00
127_I136_I0.9841.00
73_L77_I0.9781.00
16_D19_L0.9751.00
113_H117_N0.9641.00
73_L76_N0.9521.00
22_K26_L0.9491.00
20_V36_L0.9451.00
96_L99_M0.9421.00
65_K68_N0.9211.00
23_A108_V0.9201.00
71_Y74_T0.9171.00
13_N16_D0.9171.00
22_K25_E0.9141.00
27_A34_L0.9001.00
10_I36_L0.8881.00
59_L62_L0.8801.00
6_I106_L0.8791.00
54_A57_D0.8791.00
74_T84_L0.8761.00
23_A34_L0.8761.00
22_K133_D0.8701.00
17_A69_K0.8681.00
7_G37_I0.8641.00
68_N72_K0.8601.00
10_I19_L0.8471.00
56_E59_L0.8441.00
9_A110_G0.8391.00
30_N105_D0.8371.00
47_Y50_I0.8241.00
96_L130_M0.8181.00
96_L126_M0.8111.00
40_D86_I0.8101.00
7_G98_I0.8091.00
77_I80_P0.8081.00
72_K75_K0.8041.00
72_K76_N0.8031.00
123_Y136_I0.8011.00
7_G107_L0.8001.00
21_N76_N0.7961.00
49_G52_F0.7951.00
90_E93_E0.7921.00
18_L21_N0.7891.00
10_I20_V0.7871.00
24_L77_I0.7861.00
24_L28_R0.7861.00
67_D70_L0.7851.00
74_T78_Q0.7831.00
17_A21_N0.7831.00
92_P122_A0.7821.00
10_I17_A0.7751.00
8_V19_L0.7741.00
20_V24_L0.7651.00
8_V34_L0.7591.00
108_V135_L0.7561.00
94_T98_I0.7461.00
109_C136_I0.7451.00
36_L70_L0.7371.00
63_K66_S0.7331.00
26_L29_H0.7311.00
36_L82_T0.7081.00
24_L80_P0.7061.00
58_I62_L0.7061.00
37_I94_T0.7021.00
60_Q63_K0.6991.00
68_N71_Y0.6981.00
27_A30_N0.6951.00
6_I108_V0.6921.00
55_T59_L0.6891.00
61_L64_N0.6861.00
61_L65_K0.6841.00
95_L126_M0.6781.00
108_V137_V0.6731.00
25_E28_R0.6681.00
17_A73_L0.6631.00
103_Q132_A0.6571.00
57_D61_L0.6531.00
27_A32_A0.6481.00
57_D60_Q0.6431.00
119_L123_Y0.6391.00
100_Q132_A0.6371.00
58_I61_L0.6361.00
70_L74_T0.6171.00
92_P96_L0.6161.00
13_N112_H0.6141.00
26_L108_V0.6131.00
64_N67_D0.6101.00
23_A32_A0.6081.00
39_I89_G0.6071.00
66_S77_I0.6051.00
92_P129_K0.6051.00
10_I16_D0.6041.00
15_E18_L0.5981.00
25_E77_I0.5971.00
53_P57_D0.5941.00
55_T58_I0.5941.00
96_L125_G0.5921.00
6_I27_A0.5911.00
126_M134_L0.5891.00
92_P126_M0.5861.00
82_T85_R0.5831.00
43_L46_L0.5831.00
112_H115_F0.5791.00
112_H119_L0.5761.00
111_H123_Y0.5741.00
110_G137_V0.5721.00
67_D73_L0.5671.00
51_Y54_A0.5661.00
74_T79_W0.5631.00
127_I134_L0.5601.00
28_R80_P0.5601.00
19_L108_V0.5501.00
21_N77_I0.5431.00
53_P56_E0.5411.00
11_S16_D0.5411.00
28_R77_I0.5391.00
14_E17_A0.5371.00
89_G97_E0.5371.00
20_V73_L0.5361.00
93_E97_E0.5341.00
75_K78_Q0.5231.00
70_L73_L0.5221.00
40_D59_L0.5181.00
42_G45_E0.5121.00
17_A76_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jmvA 4 0.9859 99.9 0.17 Contact Map
3tnjA 2 0.9155 99.9 0.224 Contact Map
5ahwA 4 0.9859 99.9 0.226 Contact Map
2dumA 2 0.9648 99.9 0.231 Contact Map
3s3tA 4 0.9648 99.9 0.235 Contact Map
4wnyA 2 0.8803 99.8 0.248 Contact Map
3fg9A 3 0.9507 99.8 0.254 Contact Map
3fdxA 2 0.8521 99.8 0.255 Contact Map
1mjhA 2 0.9437 99.8 0.259 Contact Map
3mt0A 1 0.9085 99.8 0.262 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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