GALF - ECOLI - GREMLIN Contacts

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GALF - UTP--glucose-1-phosphate uridylyltransferase

UniProt:	P0AAB6	Sequences: MTNLKAVIPVAGLGMHMLPATKAIPKEMLPIVDKPMIQYIVDEIVAAGIKEILLVTHASKNAVENHFDTSYELESLLEQRVKRQLLAEVQSICPPGVTIMNVRQGEPLGLGHSILCARPAIGDNPFVVVLPDVVIDDASADPLRYNLAAMIARFNETGRSQVLAKRMPGDLSEYSVIQTKEPLDREGKVSRIVEFIEKPDQPQTLDSDIMAVGRYVLSADIWPELERTQPGAWGRIQLTDAIAELAKKQSVDAMLMTGDSYDCGKKMGYMQAFVKYGLRNLKEGAKFRKGIEKLLSE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13578
Length:	297 (236)
Sequences:	21539 (12972)
Seq/√Len:	844.4

ECOLI - GALF GALU RMLA1 RMLA2 GLGC GLMU
BACSU - YNGB RMLA GTAB YTDA RFBF GLMU GLGC GLGD
HALSA - Q9HQQ4 Q9HSV0 Q9HSZ9 Q9HSZ8 Q9HS61 Q9HSW4
SULSO - Q97VX4 Q97ZD1 Q97U06 Q7LXE7 Q980H9 Q97XG0 Q7LXK9 Q7LXG3 Q980D4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
118_R	226_E	3.487	1.00
34_K	42_D	2.732	1.00
178_Q	193_V	2.686	1.00
178_Q	194_E	2.685	1.00
159_R	252_D	2.539	1.00
108_L	112_H	2.538	1.00
51_E	98_T	2.519	1.00
38_Q	66_H	2.477	1.00
224_E	248_K	2.423	1.00
180_K	191_R	2.418	1.00
5_K	51_E	2.360	1.00
6_A	49_I	2.275	1.00
154_F	162_V	2.221	1.00
125_P	218_S	2.203	1.00
167_M	208_D	2.187	1.00
191_R	252_D	2.141	1.00
224_E	244_E	2.084	1.00
180_K	193_V	2.050	1.00
125_P	155_N	2.042	1.00
243_A	247_K	2.040	1.00
159_R	250_S	2.038	1.00
6_A	44_I	2.026	1.00
165_K	253_A	1.994	1.00
157_T	252_D	1.919	1.00
180_K	186_E	1.880	1.00
244_E	248_K	1.872	1.00
115_L	118_R	1.856	1.00
41_V	52_I	1.844	1.00
167_M	255_L	1.811	1.00
10_V	54_L	1.805	1.00
114_I	128_V	1.787	1.00
153_R	157_T	1.777	1.00
44_I	129_V	1.765	1.00
178_Q	207_S	1.753	1.00
261_Y	271_Q	1.751	1.00
7_V	117_A	1.749	1.00
102_V	116_C	1.743	1.00
61_N	65_N	1.738	1.00
209_I	255_L	1.734	1.00
244_E	247_K	1.703	1.00
51_E	100_M	1.684	1.00
153_R	254_M	1.681	1.00
24_I	30_P	1.592	1.00
179_T	209_I	1.586	1.00
38_Q	42_D	1.582	1.00
62_A	65_N	1.574	1.00
150_M	216_V	1.561	1.00
194_E	243_A	1.559	1.00
152_A	156_E	1.546	1.00
56_T	60_K	1.544	1.00
240_D	243_A	1.542	1.00
52_I	97_V	1.538	1.00
24_I	62_A	1.533	1.00
170_D	173_E	1.532	1.00
201_Q	206_D	1.518	1.00
148_A	152_A	1.518	1.00
53_L	120_A	1.488	1.00
192_I	253_A	1.486	1.00
160_S	218_S	1.466	1.00
18_L	22_K	1.450	1.00
28_M	62_A	1.426	1.00
125_P	216_V	1.396	1.00
177_I	192_I	1.393	1.00
192_I	251_V	1.382	1.00
121_I	126_F	1.376	1.00
269_Y	273_F	1.374	1.00
64_E	103_R	1.371	1.00
126_F	219_A	1.359	1.00
112_H	116_C	1.340	1.00
35_P	38_Q	1.337	1.00
150_M	164_A	1.331	1.00
53_L	102_V	1.323	1.00
224_E	241_A	1.320	1.00
45_V	97_V	1.303	1.00
220_D	223_P	1.277	1.00
100_M	120_A	1.274	1.00
227_R	244_E	1.271	1.00
149_A	152_A	1.263	1.00
60_K	103_R	1.258	1.00
115_L	226_E	1.249	1.00
165_K	177_I	1.245	1.00
259_D	275_K	1.244	1.00
265_K	268_G	1.243	1.00
160_S	249_Q	1.219	1.00
227_R	248_K	1.218	1.00
112_H	115_L	1.210	1.00
263_C	272_A	1.192	1.00
186_E	191_R	1.175	1.00
223_P	227_R	1.174	1.00
38_Q	70_S	1.167	1.00
191_R	250_S	1.159	1.00
178_Q	196_I	1.157	1.00
13_L	107_P	1.156	1.00
224_E	227_R	1.156	1.00
124_N	219_A	1.154	1.00
181_E	186_E	1.149	1.00
60_K	64_E	1.148	1.00
127_V	216_V	1.147	1.00
223_P	226_E	1.134	1.00
270_M	274_V	1.124	1.00
53_L	117_A	1.116	1.00
217_L	242_I	1.113	1.00
261_Y	275_K	1.113	1.00
179_T	253_A	1.111	1.00
161_Q	217_L	1.108	1.00
268_G	271_Q	1.106	1.00
125_P	219_A	1.090	1.00
130_L	213_G	1.078	1.00
153_R	252_D	1.075	1.00
49_I	127_V	1.072	1.00
165_K	168_P	1.059	1.00
175_S	197_E	1.058	1.00
149_A	153_R	1.053	1.00
28_M	66_H	1.048	1.00
160_S	250_S	1.047	1.00
274_V	277_G	1.045	1.00
36_M	263_C	1.041	1.00
17_M	29_L	1.033	1.00
7_V	126_F	1.031	1.00
11_A	55_V	1.030	1.00
201_Q	205_L	1.024	1.00
196_I	206_D	1.016	1.00
37_I	67_F	1.014	1.00
128_V	217_L	1.011	1.00
123_D	220_D	1.006	1.00
136_D	279_R	0.999	1.00
56_T	103_R	0.999	1.00
59_S	62_A	0.981	1.00
56_T	101_N	0.978	1.00
42_D	45_V	0.971	1.00
56_T	64_E	0.970	1.00
37_I	54_L	0.965	1.00
53_L	100_M	0.964	1.00
173_E	268_G	0.961	1.00
4_L	124_N	0.961	1.00
37_I	63_V	0.960	1.00
127_V	151_I	0.960	1.00
239_T	243_A	0.958	1.00
57_H	60_K	0.957	1.00
270_M	273_F	0.957	1.00
115_L	225_L	0.955	1.00
165_K	209_I	0.951	1.00
46_A	138_A	0.943	1.00
64_E	101_N	0.937	1.00
158_G	218_S	0.925	1.00
47_A	148_A	0.925	1.00
34_K	39_Y	0.921	1.00
68_D	101_N	0.901	1.00
33_D	39_Y	0.897	1.00
267_M	271_Q	0.895	1.00
149_A	254_M	0.895	1.00
56_T	63_V	0.893	1.00
176_V	210_M	0.889	1.00
118_R	222_W	0.885	1.00
242_I	251_V	0.882	1.00
167_M	209_I	0.880	1.00
119_P	233_W	0.879	1.00
166_R	255_L	0.879	1.00
5_K	124_N	0.874	1.00
35_P	66_H	0.867	1.00
5_K	53_L	0.863	1.00
17_M	21_T	0.862	1.00
41_V	67_F	0.858	1.00
159_R	191_R	0.858	1.00
133_V	260_S	0.851	1.00
271_Q	274_V	0.848	1.00
61_N	64_E	0.845	1.00
136_D	259_D	0.843	1.00
137_D	259_D	0.842	1.00
275_K	278_L	0.840	1.00
273_F	277_G	0.826	1.00
68_D	72_E	0.822	1.00
151_I	155_N	0.818	1.00
67_F	99_I	0.814	1.00
32_V	273_F	0.812	1.00
5_K	121_I	0.812	1.00
193_V	196_I	0.811	1.00
160_S	164_A	0.810	1.00
261_Y	272_A	0.809	1.00
151_I	216_V	0.806	1.00
5_K	122_G	0.800	1.00
9_P	130_L	0.800	1.00
252_D	255_L	0.799	1.00
34_K	38_Q	0.798	1.00
138_A	149_A	0.795	1.00
27_E	131_P	0.793	1.00
30_P	35_P	0.791	1.00
41_V	99_I	0.790	1.00
245_L	249_Q	0.790	1.00
163_L	168_P	0.790	1.00
271_Q	275_K	0.789	1.00
32_V	39_Y	0.788	1.00
163_L	167_M	0.788	1.00
138_A	148_A	0.788	1.00
152_A	155_N	0.788	1.00
8_I	131_P	0.786	1.00
102_V	117_A	0.780	1.00
220_D	224_E	0.776	1.00
65_N	68_D	0.776	1.00
49_I	151_I	0.776	1.00
36_M	40_I	0.774	1.00
25_P	62_A	0.774	1.00
229_Q	232_A	0.766	1.00
228_T	244_E	0.764	1.00
211_A	215_Y	0.762	1.00
21_T	29_L	0.760	1.00
230_P	233_W	0.753	1.00
110_L	130_L	0.741	1.00
150_M	254_M	0.740	1.00
154_F	218_S	0.737	1.00
114_I	221_I	0.736	1.00
39_Y	276_Y	0.734	1.00
64_E	68_D	0.733	1.00
164_A	167_M	0.733	1.00
56_T	61_N	0.731	1.00
121_I	222_W	0.726	1.00
7_V	55_V	0.725	1.00
45_V	50_K	0.724	1.00
221_I	245_L	0.720	1.00
209_I	253_A	0.717	1.00
123_D	219_A	0.716	1.00
229_Q	244_E	0.713	1.00
162_V	165_K	0.712	1.00
187_G	255_L	0.711	1.00
241_A	244_E	0.711	1.00
35_P	39_Y	0.710	1.00
55_V	117_A	0.707	1.00
148_A	151_I	0.707	1.00
161_Q	245_L	0.706	1.00
20_A	266_K	0.706	1.00
20_A	24_I	0.706	1.00
112_H	236_I	0.702	1.00
270_M	277_G	0.701	1.00
172_S	200_D	0.700	1.00
153_R	156_E	0.698	1.00
220_D	249_Q	0.698	1.00
274_V	278_L	0.697	1.00
50_K	98_T	0.695	1.00
102_V	120_A	0.695	1.00
177_I	253_A	0.694	1.00
220_D	248_K	0.693	1.00
195_F	211_A	0.691	1.00
4_L	155_N	0.689	1.00
42_D	70_S	0.685	1.00
122_G	219_A	0.683	1.00
6_A	52_I	0.682	1.00
118_R	126_F	0.676	1.00
43_E	47_A	0.676	1.00
45_V	52_I	0.673	1.00
39_Y	42_D	0.671	1.00
228_T	236_I	0.670	1.00
147_L	150_M	0.670	1.00
107_P	112_H	0.667	1.00
220_D	250_S	0.667	1.00
45_V	70_S	0.666	1.00
14_G	26_K	0.664	1.00
68_D	71_Y	0.661	1.00
150_M	162_V	0.661	1.00
161_Q	165_K	0.661	1.00
171_L	174_Y	0.660	1.00
31_I	273_F	0.659	1.00
146_N	259_D	0.659	1.00
41_V	54_L	0.657	1.00
146_N	151_I	0.655	1.00
54_L	67_F	0.655	1.00
173_E	265_K	0.654	1.00
146_N	149_A	0.651	1.00
219_A	222_W	0.649	1.00
223_P	248_K	0.649	1.00
240_D	244_E	0.648	1.00
224_E	245_L	0.648	1.00
166_R	208_D	0.647	1.00
101_N	104_Q	0.644	1.00
192_I	195_F	0.643	1.00
102_V	105_G	0.641	1.00
161_Q	251_V	0.638	1.00
29_L	269_Y	0.636	1.00
125_P	151_I	0.635	1.00
118_R	122_G	0.629	1.00
162_V	166_R	0.627	1.00
38_Q	67_F	0.625	1.00
4_L	151_I	0.625	1.00
9_P	110_L	0.624	1.00
151_I	154_F	0.623	1.00
226_E	233_W	0.621	1.00
134_V	272_A	0.617	1.00
224_E	228_T	0.615	1.00
7_V	53_L	0.607	1.00
5_K	126_F	0.605	1.00
154_F	216_V	0.603	1.00
8_I	40_I	0.602	1.00
20_A	23_A	0.601	1.00
20_A	29_L	0.600	1.00
16_H	26_K	0.598	1.00
43_E	214_R	0.597	1.00
171_L	176_V	0.593	1.00
118_R	121_I	0.592	1.00
55_V	113_S	0.592	1.00
160_S	220_D	0.592	1.00
163_L	177_I	0.591	1.00
231_G	237_Q	0.590	1.00
127_V	147_L	0.590	1.00
32_V	276_Y	0.582	1.00
196_I	199_P	0.581	1.00
44_I	127_V	0.579	1.00
154_F	158_G	0.578	1.00
229_Q	233_W	0.578	1.00
162_V	252_D	0.574	1.00
129_V	147_L	0.572	1.00
266_K	270_M	0.567	1.00
44_I	49_I	0.567	1.00
164_A	168_P	0.565	1.00
275_K	279_R	0.564	1.00
129_V	214_R	0.564	1.00
130_L	133_V	0.563	1.00
7_V	114_I	0.555	1.00
106_E	112_H	0.555	1.00
157_T	162_V	0.554	1.00
8_I	129_V	0.550	1.00
174_Y	262_D	0.549	1.00
70_S	101_N	0.549	1.00
115_L	236_I	0.549	1.00
119_P	122_G	0.548	1.00
228_T	241_A	0.546	1.00
135_I	212_V	0.545	1.00
40_I	129_V	0.544	1.00
24_I	29_L	0.543	1.00
166_R	212_V	0.540	1.00
54_L	99_I	0.538	1.00
243_A	246_A	0.537	1.00
57_H	107_P	0.537	1.00
28_M	60_K	0.533	1.00
42_D	46_A	0.531	1.00
55_V	102_V	0.528	1.00
108_L	236_I	0.526	1.00
229_Q	236_I	0.524	1.00
224_E	249_Q	0.524	1.00
150_M	154_F	0.523	1.00
137_D	257_T	0.521	1.00
261_Y	268_G	0.519	1.00
124_N	218_S	0.518	1.00
40_I	43_E	0.516	1.00
168_P	171_L	0.513	1.00
60_K	63_V	0.513	1.00
172_S	176_V	0.511	1.00
4_L	50_K	0.509	1.00
26_K	132_D	0.509	1.00
212_V	256_M	0.508	1.00
27_E	63_V	0.505	1.00
212_V	260_S	0.504	1.00
117_A	120_A	0.502	1.00
118_R	223_P	0.501	1.00
228_T	240_D	0.501	1.00
9_P	113_S	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2e3dA	3	0.9663	100	0.311	Contact Map
2ux8A	4	0.9562	100	0.336	Contact Map
2pa4A	3	0.9663	100	0.337	Contact Map
3jukA	3	0.8855	100	0.352	Contact Map
1iimA	3	0.8653	100	0.362	Contact Map
1lvwA	3	0.862	100	0.372	Contact Map
4ho4A	3	0.8552	100	0.376	Contact Map
1tzfA	4	0.8418	100	0.377	Contact Map
3brkX	2	0.8552	100	0.38	Contact Map
1mc3A	3	0.862	100	0.381	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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