GREMLIN Database
GALF - UTP--glucose-1-phosphate uridylyltransferase
UniProt: P0AAB6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13578
Length: 297 (236)
Sequences: 21539 (12972)
Seq/√Len: 844.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
118_R226_E3.4871.00
34_K42_D2.7321.00
178_Q193_V2.6861.00
178_Q194_E2.6851.00
159_R252_D2.5391.00
108_L112_H2.5381.00
51_E98_T2.5191.00
38_Q66_H2.4771.00
224_E248_K2.4231.00
180_K191_R2.4181.00
5_K51_E2.3601.00
6_A49_I2.2751.00
154_F162_V2.2211.00
125_P218_S2.2031.00
167_M208_D2.1871.00
191_R252_D2.1411.00
224_E244_E2.0841.00
180_K193_V2.0501.00
125_P155_N2.0421.00
243_A247_K2.0401.00
159_R250_S2.0381.00
6_A44_I2.0261.00
165_K253_A1.9941.00
157_T252_D1.9191.00
180_K186_E1.8801.00
244_E248_K1.8721.00
115_L118_R1.8561.00
41_V52_I1.8441.00
167_M255_L1.8111.00
10_V54_L1.8051.00
114_I128_V1.7871.00
153_R157_T1.7771.00
44_I129_V1.7651.00
178_Q207_S1.7531.00
261_Y271_Q1.7511.00
7_V117_A1.7491.00
102_V116_C1.7431.00
61_N65_N1.7381.00
209_I255_L1.7341.00
244_E247_K1.7031.00
51_E100_M1.6841.00
153_R254_M1.6811.00
24_I30_P1.5921.00
179_T209_I1.5861.00
38_Q42_D1.5821.00
62_A65_N1.5741.00
150_M216_V1.5611.00
194_E243_A1.5591.00
152_A156_E1.5461.00
56_T60_K1.5441.00
240_D243_A1.5421.00
52_I97_V1.5381.00
24_I62_A1.5331.00
170_D173_E1.5321.00
201_Q206_D1.5181.00
148_A152_A1.5181.00
53_L120_A1.4881.00
192_I253_A1.4861.00
160_S218_S1.4661.00
18_L22_K1.4501.00
28_M62_A1.4261.00
125_P216_V1.3961.00
177_I192_I1.3931.00
192_I251_V1.3821.00
121_I126_F1.3761.00
269_Y273_F1.3741.00
64_E103_R1.3711.00
126_F219_A1.3591.00
112_H116_C1.3401.00
35_P38_Q1.3371.00
150_M164_A1.3311.00
53_L102_V1.3231.00
224_E241_A1.3201.00
45_V97_V1.3031.00
220_D223_P1.2771.00
100_M120_A1.2741.00
227_R244_E1.2711.00
149_A152_A1.2631.00
60_K103_R1.2581.00
115_L226_E1.2491.00
165_K177_I1.2451.00
259_D275_K1.2441.00
265_K268_G1.2431.00
160_S249_Q1.2191.00
227_R248_K1.2181.00
112_H115_L1.2101.00
263_C272_A1.1921.00
186_E191_R1.1751.00
223_P227_R1.1741.00
38_Q70_S1.1671.00
191_R250_S1.1591.00
178_Q196_I1.1571.00
13_L107_P1.1561.00
224_E227_R1.1561.00
124_N219_A1.1541.00
181_E186_E1.1491.00
60_K64_E1.1481.00
127_V216_V1.1471.00
223_P226_E1.1341.00
270_M274_V1.1241.00
53_L117_A1.1161.00
217_L242_I1.1131.00
261_Y275_K1.1131.00
179_T253_A1.1111.00
161_Q217_L1.1081.00
268_G271_Q1.1061.00
125_P219_A1.0901.00
130_L213_G1.0781.00
153_R252_D1.0751.00
49_I127_V1.0721.00
165_K168_P1.0591.00
175_S197_E1.0581.00
149_A153_R1.0531.00
28_M66_H1.0481.00
160_S250_S1.0471.00
274_V277_G1.0451.00
36_M263_C1.0411.00
17_M29_L1.0331.00
7_V126_F1.0311.00
11_A55_V1.0301.00
201_Q205_L1.0241.00
196_I206_D1.0161.00
37_I67_F1.0141.00
128_V217_L1.0111.00
123_D220_D1.0061.00
136_D279_R0.9991.00
56_T103_R0.9991.00
59_S62_A0.9811.00
56_T101_N0.9781.00
42_D45_V0.9711.00
56_T64_E0.9701.00
37_I54_L0.9651.00
53_L100_M0.9641.00
173_E268_G0.9611.00
4_L124_N0.9611.00
37_I63_V0.9601.00
127_V151_I0.9601.00
239_T243_A0.9581.00
57_H60_K0.9571.00
270_M273_F0.9571.00
115_L225_L0.9551.00
165_K209_I0.9511.00
46_A138_A0.9431.00
64_E101_N0.9371.00
158_G218_S0.9251.00
47_A148_A0.9251.00
34_K39_Y0.9211.00
68_D101_N0.9011.00
33_D39_Y0.8971.00
267_M271_Q0.8951.00
149_A254_M0.8951.00
56_T63_V0.8931.00
176_V210_M0.8891.00
118_R222_W0.8851.00
242_I251_V0.8821.00
167_M209_I0.8801.00
119_P233_W0.8791.00
166_R255_L0.8791.00
5_K124_N0.8741.00
35_P66_H0.8671.00
5_K53_L0.8631.00
17_M21_T0.8621.00
41_V67_F0.8581.00
159_R191_R0.8581.00
133_V260_S0.8511.00
271_Q274_V0.8481.00
61_N64_E0.8451.00
136_D259_D0.8431.00
137_D259_D0.8421.00
275_K278_L0.8401.00
273_F277_G0.8261.00
68_D72_E0.8221.00
151_I155_N0.8181.00
67_F99_I0.8141.00
32_V273_F0.8121.00
5_K121_I0.8121.00
193_V196_I0.8111.00
160_S164_A0.8101.00
261_Y272_A0.8091.00
151_I216_V0.8061.00
5_K122_G0.8001.00
9_P130_L0.8001.00
252_D255_L0.7991.00
34_K38_Q0.7981.00
138_A149_A0.7951.00
27_E131_P0.7931.00
30_P35_P0.7911.00
41_V99_I0.7901.00
245_L249_Q0.7901.00
163_L168_P0.7901.00
271_Q275_K0.7891.00
32_V39_Y0.7881.00
163_L167_M0.7881.00
138_A148_A0.7881.00
152_A155_N0.7881.00
8_I131_P0.7861.00
102_V117_A0.7801.00
220_D224_E0.7761.00
65_N68_D0.7761.00
49_I151_I0.7761.00
36_M40_I0.7741.00
25_P62_A0.7741.00
229_Q232_A0.7661.00
228_T244_E0.7641.00
211_A215_Y0.7621.00
21_T29_L0.7601.00
230_P233_W0.7531.00
110_L130_L0.7411.00
150_M254_M0.7401.00
154_F218_S0.7371.00
114_I221_I0.7361.00
39_Y276_Y0.7341.00
64_E68_D0.7331.00
164_A167_M0.7331.00
56_T61_N0.7311.00
121_I222_W0.7261.00
7_V55_V0.7251.00
45_V50_K0.7241.00
221_I245_L0.7201.00
209_I253_A0.7171.00
123_D219_A0.7161.00
229_Q244_E0.7131.00
162_V165_K0.7121.00
187_G255_L0.7111.00
241_A244_E0.7111.00
35_P39_Y0.7101.00
55_V117_A0.7071.00
148_A151_I0.7071.00
161_Q245_L0.7061.00
20_A266_K0.7061.00
20_A24_I0.7061.00
112_H236_I0.7021.00
270_M277_G0.7011.00
172_S200_D0.7001.00
153_R156_E0.6981.00
220_D249_Q0.6981.00
274_V278_L0.6971.00
50_K98_T0.6951.00
102_V120_A0.6951.00
177_I253_A0.6941.00
220_D248_K0.6931.00
195_F211_A0.6911.00
4_L155_N0.6891.00
42_D70_S0.6851.00
122_G219_A0.6831.00
6_A52_I0.6821.00
118_R126_F0.6761.00
43_E47_A0.6761.00
45_V52_I0.6731.00
39_Y42_D0.6711.00
228_T236_I0.6701.00
147_L150_M0.6701.00
107_P112_H0.6671.00
220_D250_S0.6671.00
45_V70_S0.6661.00
14_G26_K0.6641.00
68_D71_Y0.6611.00
150_M162_V0.6611.00
161_Q165_K0.6611.00
171_L174_Y0.6601.00
31_I273_F0.6591.00
146_N259_D0.6591.00
41_V54_L0.6571.00
146_N151_I0.6551.00
54_L67_F0.6551.00
173_E265_K0.6541.00
146_N149_A0.6511.00
219_A222_W0.6491.00
223_P248_K0.6491.00
240_D244_E0.6481.00
224_E245_L0.6481.00
166_R208_D0.6471.00
101_N104_Q0.6441.00
192_I195_F0.6431.00
102_V105_G0.6411.00
161_Q251_V0.6381.00
29_L269_Y0.6361.00
125_P151_I0.6351.00
118_R122_G0.6291.00
162_V166_R0.6271.00
38_Q67_F0.6251.00
4_L151_I0.6251.00
9_P110_L0.6241.00
151_I154_F0.6231.00
226_E233_W0.6211.00
134_V272_A0.6171.00
224_E228_T0.6151.00
7_V53_L0.6071.00
5_K126_F0.6051.00
154_F216_V0.6031.00
8_I40_I0.6021.00
20_A23_A0.6011.00
20_A29_L0.6001.00
16_H26_K0.5981.00
43_E214_R0.5971.00
171_L176_V0.5931.00
118_R121_I0.5921.00
55_V113_S0.5921.00
160_S220_D0.5921.00
163_L177_I0.5911.00
231_G237_Q0.5901.00
127_V147_L0.5901.00
32_V276_Y0.5821.00
196_I199_P0.5811.00
44_I127_V0.5791.00
154_F158_G0.5781.00
229_Q233_W0.5781.00
162_V252_D0.5741.00
129_V147_L0.5721.00
266_K270_M0.5671.00
44_I49_I0.5671.00
164_A168_P0.5651.00
275_K279_R0.5641.00
129_V214_R0.5641.00
130_L133_V0.5631.00
7_V114_I0.5551.00
106_E112_H0.5551.00
157_T162_V0.5541.00
8_I129_V0.5501.00
174_Y262_D0.5491.00
70_S101_N0.5491.00
115_L236_I0.5491.00
119_P122_G0.5481.00
228_T241_A0.5461.00
135_I212_V0.5451.00
40_I129_V0.5441.00
24_I29_L0.5431.00
166_R212_V0.5401.00
54_L99_I0.5381.00
243_A246_A0.5371.00
57_H107_P0.5371.00
28_M60_K0.5331.00
42_D46_A0.5311.00
55_V102_V0.5281.00
108_L236_I0.5261.00
229_Q236_I0.5241.00
224_E249_Q0.5241.00
150_M154_F0.5231.00
137_D257_T0.5211.00
261_Y268_G0.5191.00
124_N218_S0.5181.00
40_I43_E0.5161.00
168_P171_L0.5131.00
60_K63_V0.5131.00
172_S176_V0.5111.00
4_L50_K0.5091.00
26_K132_D0.5091.00
212_V256_M0.5081.00
27_E63_V0.5051.00
212_V260_S0.5041.00
117_A120_A0.5021.00
118_R223_P0.5011.00
228_T240_D0.5011.00
9_P113_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2e3dA 3 0.9663 100 0.311 Contact Map
2ux8A 4 0.9562 100 0.336 Contact Map
2pa4A 3 0.9663 100 0.337 Contact Map
3jukA 3 0.8855 100 0.352 Contact Map
1iimA 3 0.8653 100 0.362 Contact Map
1lvwA 3 0.862 100 0.372 Contact Map
4ho4A 3 0.8552 100 0.376 Contact Map
1tzfA 4 0.8418 100 0.377 Contact Map
3brkX 2 0.8552 100 0.38 Contact Map
1mc3A 3 0.862 100 0.381 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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