GREMLIN Database
UBID - 3-octaprenyl-4-hydroxybenzoate carboxy-lyase
UniProt: P0AAB4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11396
Length: 497 (452)
Sequences: 1796 (947)
Seq/√Len: 44.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_R53_E5.0751.00
26_T53_E4.9171.00
17_E24_R4.7911.00
131_Q259_I4.7301.00
133_K313_E4.3171.00
28_P56_K4.2681.00
276_Y307_T4.0371.00
409_D412_D3.9741.00
371_K403_D3.8081.00
128_A256_V3.3411.00
32_H149_T3.3351.00
149_T157_P3.3091.00
141_D144_R3.2751.00
185_G188_K3.2481.00
224_D249_R3.2151.00
13_L63_L3.2131.00
141_D186_K3.1481.00
168_G205_E3.0931.00
382_M452_G3.0021.00
218_S258_C2.9621.00
21_E71_K2.9321.00
214_R279_Q2.8951.00
39_A64_C2.8581.00
8_D268_S2.8581.00
30_D56_K2.8521.00
421_M453_L2.8051.00
170_H205_E2.6711.00
284_P300_S2.6221.00
123_K254_E2.5781.00
31_P57_G2.4881.00
260_S308_H2.4781.00
254_E268_S2.4691.00
132_Q313_E2.4411.00
17_E53_E2.4261.00
258_C265_V2.4171.00
28_P54_N2.3471.00
214_R278_E2.3321.00
273_L306_V2.2971.00
257_K262_D2.2461.00
130_C310_T2.2381.00
60_M271_I2.2251.00
209_A282_T2.2081.00
35_I62_V2.1961.00
131_Q310_T2.1891.00
133_K311_Q2.1721.00
14_T17_E2.1311.00
427_T451_M2.1231.00
284_P298_V2.0981.00
257_K264_E2.0840.99
188_K305_T2.0700.99
60_M315_A2.0590.99
137_G140_V2.0420.99
174_Q264_E2.0390.99
175_N241_E2.0260.99
42_T50_L2.0230.99
181_Q189_L1.9980.99
421_M427_T1.9910.99
214_R276_Y1.9770.99
188_K283_A1.9550.99
221_L318_H1.9500.99
383_M430_V1.9280.99
190_I283_A1.9150.99
134_I259_I1.9050.99
406_N409_D1.9000.99
143_N183_L1.8150.99
51_L63_L1.8080.98
348_F384_G1.8040.98
142_L189_L1.7820.98
136_S308_H1.7640.98
276_Y305_T1.7540.98
219_V304_F1.7380.98
281_E305_T1.7370.98
10_R316_I1.7180.98
218_S261_N1.7170.98
156_A288_Y1.6950.98
147_I183_L1.6930.98
258_C261_N1.6910.98
218_S265_V1.6910.98
216_P261_N1.6780.98
63_L66_L1.6630.97
165_V242_Y1.6460.97
217_V304_F1.6440.97
184_I283_A1.6250.97
140_V187_N1.6120.97
51_L316_I1.6060.97
19_Q71_K1.6020.97
366_A395_T1.6000.97
131_Q134_I1.5970.97
399_I417_I1.5930.97
10_R314_D1.5730.96
258_C264_E1.5630.96
198_G241_E1.5610.96
184_I190_I1.5320.96
368_V385_V1.5310.96
21_E72_R1.5290.96
369_T407_A1.5280.96
220_A272_V1.5260.96
260_S310_T1.5220.96
396_K439_D1.5160.95
22_L51_L1.5050.95
165_V220_A1.4840.95
12_F76_G1.4810.95
142_L306_V1.4580.94
22_L49_A1.4580.94
29_V38_I1.4540.94
288_Y322_T1.4520.94
235_V244_F1.4450.94
10_R312_R1.4400.94
6_Y15_L1.4400.94
122_T246_G1.4380.94
429_L451_M1.4370.94
10_R270_E1.4110.93
283_A303_V1.3960.93
15_L19_Q1.3900.93
262_D310_T1.3690.92
135_V139_D1.3640.92
159_I221_L1.3470.92
205_E210_H1.3450.92
21_E75_M1.3420.91
181_Q219_V1.3350.91
189_L304_F1.3290.91
174_Q240_S1.3190.91
125_L128_A1.3190.91
422_D441_A1.3030.90
424_A449_S1.3030.90
40_D44_R1.2760.89
220_A223_A1.2750.89
37_E41_R1.2740.89
212_G279_Q1.2730.89
365_L418_T1.2720.89
134_I308_H1.2520.88
16_L49_A1.2500.88
153_E469_R1.2470.88
135_V311_Q1.2460.88
368_V400_V1.2450.88
415_W419_T1.2440.88
401_C455_A1.2420.88
352_V369_T1.2410.88
386_W452_G1.2390.88
124_R264_E1.2330.88
7_N251_T1.2300.87
423_P449_S1.2300.87
148_M319_S1.2280.87
379_K428_V1.2180.87
13_L316_I1.2110.87
155_A182_Q1.2070.86
19_Q75_M1.2050.86
261_N264_E1.2010.86
15_L75_M1.1900.86
29_V35_I1.1860.85
367_V414_I1.1850.85
218_S263_L1.1850.85
125_L267_A1.1820.85
382_M386_W1.1760.85
417_I453_L1.1720.85
187_N273_L1.1670.84
369_T401_C1.1670.84
166_T199_G1.1650.84
355_Y408_R1.1650.84
397_F423_P1.1610.84
376_G447_L1.1560.84
184_I188_K1.1520.84
278_E281_E1.1490.83
168_G171_K1.1480.83
271_I311_Q1.1420.83
140_V186_K1.1390.83
136_S259_I1.1380.83
187_N305_T1.1370.83
74_A78_G1.1370.83
62_V148_M1.1290.82
229_L336_L1.1280.82
424_A431_E1.1270.82
154_D288_Y1.1260.82
145_I271_I1.1200.82
224_D227_T1.1100.81
143_N157_P1.1070.81
260_S307_T1.1060.81
306_V309_I1.0970.81
429_L449_S1.0930.80
59_S144_R1.0870.80
88_V339_V1.0850.80
333_G362_S1.0840.80
17_E20_G1.0790.79
219_V273_L1.0780.79
401_C413_V1.0770.79
191_M304_F1.0760.79
391_Q394_Y1.0740.79
234_P328_E1.0700.79
177_G199_G1.0660.79
183_L306_V1.0640.78
367_V413_V1.0550.78
367_V399_I1.0550.78
143_N186_K1.0520.78
17_E26_T1.0470.77
38_I41_R1.0420.77
259_I308_H1.0390.77
412_D415_W1.0240.76
281_E303_V1.0230.76
200_A204_Q1.0210.76
416_A419_T1.0190.75
189_L219_V1.0100.75
194_L296_N1.0060.74
185_G283_A1.0050.74
135_V144_R1.0030.74
134_I311_Q1.0000.74
161_W318_H0.9980.74
132_Q312_R0.9900.73
216_P276_Y0.9900.73
352_V371_K0.9890.73
13_L22_L0.9890.73
15_L18_Q0.9880.73
163_L176_L0.9810.73
251_T254_E0.9770.72
352_V403_D0.9760.72
159_I317_Y0.9740.72
423_P451_M0.9670.71
166_T202_D0.9610.71
39_A43_L0.9560.71
110_K114_F0.9550.70
232_V336_L0.9540.70
435_I440_F0.9540.70
32_H157_P0.9530.70
271_I317_Y0.9510.70
432_N447_L0.9500.70
226_A249_R0.9490.70
36_T150_C0.9420.69
35_I148_M0.9400.69
55_P62_V0.9370.69
430_V452_G0.9370.69
10_R311_Q0.9360.69
165_V176_L0.9360.69
129_P268_S0.9350.69
188_K281_E0.9280.68
416_A420_R0.9270.68
399_I455_A0.9260.68
218_S272_V0.9250.68
370_I400_V0.9250.68
124_R255_V0.9140.67
31_P55_P0.9090.67
89_G93_A0.9060.66
320_T323_G0.9050.66
130_C308_H0.8950.65
159_I162_G0.8950.65
351_I354_F0.8920.65
348_F388_F0.8920.65
261_N307_T0.8880.65
273_L309_I0.8780.64
163_L223_A0.8770.64
10_R13_L0.8750.64
30_D57_G0.8740.64
406_N412_D0.8740.64
334_V355_Y0.8730.63
69_T72_R0.8720.63
29_V36_T0.8690.63
220_A266_P0.8670.63
14_T18_Q0.8650.63
330_A358_P0.8640.63
296_N363_Y0.8630.63
289_G295_Y0.8610.62
218_S264_E0.8600.62
258_C263_L0.8510.61
324_R412_D0.8500.61
167_R262_D0.8490.61
167_R216_P0.8480.61
365_L414_I0.8460.61
35_I319_S0.8430.61
263_L266_P0.8430.61
367_V401_C0.8420.61
163_L227_T0.8420.61
410_W414_I0.8400.60
197_R392_F0.8380.60
209_A215_F0.8350.60
68_G72_R0.8340.60
221_L317_Y0.8330.60
404_D420_R0.8320.60
35_I55_P0.8310.60
167_R261_N0.8300.60
189_L277_I0.8280.59
385_V398_V0.8280.59
121_P243_A0.8270.59
315_A318_H0.8250.59
50_L64_C0.8230.59
422_D449_S0.8220.59
109_D123_K0.8220.59
290_D338_E0.8180.58
301_F437_Y0.8180.58
35_I64_C0.8160.58
36_T321_Y0.8140.58
23_K27_L0.8120.58
182_Q287_P0.8110.58
179_Y193_W0.8110.58
353_D408_R0.8090.58
368_V381_V0.8090.58
110_K113_Q0.8080.57
353_D407_A0.8070.57
130_C267_A0.8040.57
265_V310_T0.8010.57
242_Y255_V0.7970.56
377_H459_W0.7960.56
414_I417_I0.7950.56
106_D109_D0.7950.56
348_F381_V0.7950.56
289_G294_Y0.7880.56
216_P262_D0.7880.56
278_E305_T0.7880.56
196_H387_S0.7870.55
201_L205_E0.7850.55
214_R280_G0.7840.55
139_D186_K0.7810.55
180_R285_E0.7780.55
382_M428_V0.7780.55
333_G438_L0.7730.54
212_G215_F0.7730.54
175_N198_G0.7730.54
129_P132_Q0.7720.54
351_I368_V0.7720.54
191_M277_I0.7720.54
258_C310_T0.7710.54
134_I310_T0.7650.53
255_V261_N0.7650.53
270_E312_R0.7650.53
286_G289_G0.7640.53
217_V279_Q0.7620.53
131_Q260_S0.7620.53
409_D413_V0.7600.53
167_R264_E0.7590.53
261_N308_H0.7580.53
337_N360_G0.7580.53
168_G172_E0.7560.53
13_L371_K0.7550.52
223_A273_L0.7530.52
47_G72_R0.7520.52
162_G178_I0.7490.52
405_V416_A0.7450.51
220_A265_V0.7430.51
437_Y440_F0.7430.51
105_R109_D0.7430.51
130_C260_S0.7410.51
204_Q210_H0.7400.51
210_H213_E0.7390.51
430_V433_T0.7380.51
162_G189_L0.7370.51
213_E279_Q0.7370.51
120_M247_L0.7360.51
198_G237_D0.7340.50
150_C319_S0.7340.50
356_L366_A0.7300.50
90_K93_A0.7300.50
216_P275_G0.7300.50
189_L306_V0.7290.50
230_G245_A0.7280.50
130_C256_V0.7240.49
131_Q262_D0.7240.49
130_C269_A0.7230.49
8_D11_D0.7230.49
367_V407_A0.7230.49
181_Q273_L0.7220.49
223_A318_H0.7200.49
437_Y446_G0.7200.49
162_G181_Q0.7180.49
384_G388_F0.7180.49
38_I52_F0.7180.49
31_P56_K0.7170.49
128_A255_V0.7160.49
274_E310_T0.7130.48
328_E332_L0.7120.48
155_A288_Y0.7120.48
376_G380_R0.7090.48
125_L256_V0.7090.48
209_A278_E0.7090.48
382_M398_V0.7080.48
25_I311_Q0.7080.48
337_N341_V0.7080.48
166_T177_G0.7070.48
179_Y199_G0.7060.48
30_D34_E0.7050.48
412_D416_A0.7040.47
359_E411_N0.7020.47
120_M252_K0.7020.47
341_V345_Q0.7010.47
125_L254_E0.7010.47
128_A267_A0.6990.47
122_T255_V0.6960.47
294_Y438_L0.6960.47
128_A149_T0.6950.47
158_L430_V0.6940.47
135_V316_I0.6920.46
428_V452_G0.6910.46
164_T181_Q0.6910.46
438_L441_A0.6840.46
65_N151_W0.6840.46
87_E314_D0.6820.45
140_V309_I0.6820.45
314_D409_D0.6800.45
36_T148_M0.6800.45
211_P214_R0.6800.45
166_T179_Y0.6790.45
272_V371_K0.6780.45
379_K382_M0.6780.45
194_L392_F0.6760.45
250_G254_E0.6760.45
183_L189_L0.6740.45
256_V265_V0.6730.44
192_R394_Y0.6710.44
25_I50_L0.6710.44
140_V273_L0.6690.44
211_P279_Q0.6680.44
63_L316_I0.6680.44
179_Y328_E0.6670.44
11_D14_T0.6670.44
279_Q282_T0.6660.44
372_K459_W0.6650.44
17_E22_L0.6650.44
54_N57_G0.6640.44
173_R238_T0.6640.44
142_L212_G0.6640.44
176_L242_Y0.6630.44
379_K452_G0.6630.44
55_P403_D0.6610.43
365_L399_I0.6610.43
367_V410_W0.6600.43
267_A312_R0.6590.43
215_F277_I0.6590.43
87_E90_K0.6590.43
31_P279_Q0.6590.43
129_P256_V0.6590.43
153_E295_Y0.6590.43
214_R307_T0.6580.43
182_Q286_G0.6580.43
132_Q311_Q0.6580.43
294_Y441_A0.6570.43
379_K430_V0.6570.43
165_V258_C0.6540.43
378_A387_S0.6490.42
383_M428_V0.6490.42
136_S139_D0.6480.42
221_L273_L0.6460.42
20_G27_L0.6460.42
141_D169_P0.6460.42
194_L299_D0.6450.42
112_P116_Q0.6430.42
37_E42_T0.6390.41
404_D416_A0.6380.41
223_A269_A0.6370.41
128_A132_Q0.6370.41
436_D440_F0.6370.41
335_A339_V0.6360.41
381_V398_V0.6360.41
35_I52_F0.6360.41
10_R14_T0.6360.41
25_I28_P0.6350.41
12_F292_T0.6330.41
151_W192_R0.6310.41
181_Q202_D0.6310.41
167_R174_Q0.6310.41
137_G308_H0.6300.40
17_E28_P0.6290.40
93_A345_Q0.6290.40
141_D185_G0.6290.40
164_T217_V0.6280.40
394_Y450_K0.6270.40
27_L37_E0.6260.40
241_E323_G0.6260.40
379_K431_E0.6260.40
13_L66_L0.6260.40
85_L89_G0.6250.40
164_T191_M0.6240.40
333_G404_D0.6230.40
125_L129_P0.6220.40
133_K310_T0.6210.40
160_T288_Y0.6210.40
157_P183_L0.6200.40
156_A323_G0.6200.40
127_G131_Q0.6190.39
175_N288_Y0.6190.39
322_T390_R0.6170.39
399_I453_L0.6160.39
233_T336_L0.6160.39
130_C312_R0.6160.39
169_P211_P0.6140.39
412_D419_T0.6140.39
170_H215_F0.6130.39
145_I315_A0.6130.39
19_Q80_E0.6120.39
179_Y289_G0.6110.39
104_F108_F0.6110.39
8_D13_L0.6090.38
381_V385_V0.6090.38
151_W322_T0.6080.38
145_I309_I0.6070.38
26_T54_N0.6060.38
132_Q267_A0.6050.38
135_V140_V0.6040.38
202_D215_F0.6030.38
198_G202_D0.6030.38
316_I379_K0.6020.38
23_K50_L0.6020.38
259_I262_D0.6000.38
151_W328_E0.5980.37
192_R363_Y0.5980.37
31_P58_Y0.5980.37
18_Q26_T0.5950.37
234_P363_Y0.5930.37
296_N437_Y0.5910.37
43_L330_A0.5890.37
192_R296_N0.5890.37
140_V143_N0.5890.37
140_V144_R0.5880.37
256_V259_I0.5870.36
36_T319_S0.5860.36
284_P299_D0.5860.36
30_D231_A0.5860.36
204_Q209_A0.5860.36
144_R305_T0.5860.36
18_Q27_L0.5850.36
260_S274_E0.5850.36
227_T449_S0.5840.36
218_S275_G0.5840.36
272_V406_N0.5830.36
309_I454_D0.5830.36
14_T19_Q0.5830.36
20_G313_E0.5820.36
127_G132_Q0.5820.36
170_H173_R0.5820.36
256_V267_A0.5820.36
438_L450_K0.5810.36
388_F398_V0.5800.36
29_V52_F0.5800.36
20_G48_P0.5800.36
49_A75_M0.5790.36
328_E335_A0.5790.36
26_T126_R0.5780.36
123_K450_K0.5770.36
7_N11_D0.5770.36
162_G334_V0.5770.36
116_Q119_N0.5740.35
205_E211_P0.5720.35
25_I409_D0.5720.35
372_K375_A0.5710.35
73_V335_A0.5710.35
120_M246_G0.5710.35
292_T361_C0.5700.35
256_V266_P0.5700.35
91_L250_G0.5670.35
60_M145_I0.5670.35
353_D369_T0.5660.35
459_W462_E0.5650.35
12_F75_M0.5640.34
259_I310_T0.5640.34
356_L361_C0.5630.34
60_M314_D0.5630.34
350_E377_H0.5620.34
373_Q377_H0.5610.34
190_I297_E0.5610.34
190_I296_N0.5610.34
28_P55_P0.5600.34
164_T255_V0.5590.34
77_M226_A0.5590.34
171_K205_E0.5570.34
174_Q261_N0.5570.34
359_E414_I0.5570.34
258_C262_D0.5560.34
175_N363_Y0.5550.34
124_R411_N0.5550.34
138_D186_K0.5530.34
151_W289_G0.5530.34
175_N179_Y0.5510.33
402_D454_D0.5510.33
64_C319_S0.5510.33
33_L302_P0.5510.33
360_G432_N0.5510.33
290_D450_K0.5500.33
202_D237_D0.5490.33
229_L232_V0.5490.33
221_L271_I0.5480.33
273_L308_H0.5480.33
71_K217_V0.5460.33
355_Y358_P0.5460.33
203_Y215_F0.5460.33
291_H329_P0.5450.33
116_Q120_M0.5450.33
257_K261_N0.5430.33
265_V272_V0.5420.33
183_L309_I0.5420.33
262_D398_V0.5410.32
14_T23_K0.5410.32
181_Q304_F0.5400.32
23_K48_P0.5400.32
370_I377_H0.5390.32
296_N336_L0.5380.32
114_F255_V0.5380.32
219_V306_V0.5380.32
290_D438_L0.5370.32
365_L397_F0.5370.32
423_P427_T0.5360.32
148_M317_Y0.5360.32
396_K441_A0.5360.32
322_T363_Y0.5350.32
18_Q32_H0.5350.32
13_L38_I0.5350.32
211_P215_F0.5350.32
235_V241_E0.5340.32
289_G328_E0.5340.32
329_P362_S0.5330.32
223_A351_I0.5310.32
192_R290_D0.5310.32
413_V416_A0.5300.32
105_R108_F0.5300.32
429_L460_P0.5300.32
42_T47_G0.5300.32
25_I54_N0.5290.31
117_V314_D0.5290.31
85_L92_L0.5280.31
24_R51_L0.5280.31
401_C453_L0.5270.31
156_A241_E0.5270.31
23_K187_N0.5260.31
194_L363_Y0.5250.31
194_L364_R0.5240.31
31_P148_M0.5240.31
223_A427_T0.5230.31
397_F451_M0.5230.31
336_L363_Y0.5220.31
77_M89_G0.5210.31
159_I271_I0.5200.31
80_E145_I0.5190.31
147_I189_L0.5180.31
283_A446_G0.5180.31
435_I448_G0.5170.30
20_G24_R0.5170.30
178_I363_Y0.5170.30
383_M433_T0.5160.30
182_Q289_G0.5160.30
161_W322_T0.5160.30
269_A310_T0.5140.30
170_H211_P0.5140.30
267_A311_Q0.5140.30
9_L12_F0.5130.30
212_G411_N0.5130.30
282_T300_S0.5110.30
241_E285_E0.5110.30
69_T73_V0.5100.30
30_D373_Q0.5100.30
131_Q308_H0.5100.30
249_R254_E0.5100.30
420_R457_N0.5090.30
20_G403_D0.5090.30
91_L116_Q0.5090.30
39_A68_G0.5090.30
130_C258_C0.5090.30
126_R139_D0.5090.30
129_P251_T0.5080.30
80_E309_I0.5080.30
36_T64_C0.5070.30
18_Q159_I0.5070.30
392_F436_D0.5070.30
197_R331_V0.5070.30
197_R290_D0.5060.30
422_D425_R0.5060.30
152_P181_Q0.5060.30
250_G312_R0.5060.30
158_L182_Q0.5060.30
132_Q314_D0.5060.30
271_I407_A0.5050.29
109_D112_P0.5050.29
220_A269_A0.5050.29
364_R448_G0.5050.29
135_V309_I0.5040.29
218_S266_P0.5030.29
412_D451_M0.5030.29
13_L424_A0.5020.29
151_W290_D0.5020.29
269_A350_E0.5020.29
209_A280_G0.5020.29
162_G232_V0.5010.29
32_H54_N0.5010.29
9_L13_L0.5010.29
39_A42_T0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2idbA 3 0.9557 100 0.05 Contact Map
4ip2A 2 0.9416 100 0.125 Contact Map
4za9A 2 0.9376 100 0.143 Contact Map
4zadA 2 0.9376 100 0.144 Contact Map
4zacA 2 0.9416 100 0.144 Contact Map
4kunA 2 0.1509 32.3 0.979 Contact Map
4lvnP 1 0.0644 20.8 0.981 Contact Map
2ru9A 1 0.1247 10.5 0.983 Contact Map
4u1eG 1 0.1087 10.3 0.983 Contact Map
2d5mA 2 0.3581 8.7 0.984 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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