GREMLIN Database
WZB - Low molecular weight protein-tyrosine-phosphatase wzb
UniProt: P0AAB2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13567
Length: 147 (139)
Sequences: 4681 (3568)
Seq/√Len: 302.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_Y136_R3.4211.00
20_E24_Q3.0391.00
68_I90_L2.8351.00
81_T90_L2.4491.00
114_P130_L2.3951.00
4_N31_K2.3661.00
53_A60_L2.1391.00
18_T49_A2.1221.00
84_K112_E2.1111.00
10_V86_H2.1031.00
55_E125_A1.8761.00
119_K123_T1.8251.00
7_V23_L1.7871.00
6_L35_A1.7741.00
33_E66_R1.7611.00
52_V125_A1.7311.00
87_I91_C1.6531.00
18_T53_A1.6421.00
102_M107_W1.6341.00
104_F135_A1.5761.00
5_I23_L1.5731.00
104_F131_L1.5631.00
56_H132_E1.5401.00
26_Y132_E1.5341.00
71_R75_N1.5171.00
81_T87_I1.5011.00
56_H128_Y1.4861.00
31_K75_N1.4681.00
52_V55_E1.4651.00
27_H30_L1.4591.00
33_E76_Y1.4481.00
22_L128_Y1.4051.00
27_H32_V1.3971.00
41_V65_A1.3971.00
10_V38_G1.3881.00
52_V128_Y1.3771.00
66_R72_L1.3761.00
37_L89_R1.3681.00
26_Y135_A1.3661.00
56_H129_T1.3511.00
45_A63_H1.3491.00
23_L32_V1.3461.00
41_V67_Q1.3321.00
22_L135_A1.3261.00
22_L131_L1.3261.00
84_K103_L1.3191.00
126_A130_L1.3151.00
44_G50_I1.3071.00
51_S121_R1.3041.00
45_A50_I1.2931.00
102_M106_H1.2751.00
105_G130_L1.2201.00
21_R58_L1.2171.00
21_R60_L1.2161.00
58_L132_E1.2091.00
50_I60_L1.1921.00
45_A60_L1.1661.00
87_I101_V1.1401.00
103_L112_E1.1361.00
107_W138_W1.1121.00
91_C101_V1.1121.00
50_I54_A1.0921.00
52_V56_H1.0911.00
35_A66_R1.0911.00
19_A82_M1.0881.00
24_Q32_V1.0871.00
120_S123_T1.0781.00
39_A67_Q1.0741.00
73_C97_M1.0691.00
73_C79_I1.0621.00
51_S55_E1.0571.00
132_E136_R1.0531.00
81_T103_L1.0361.00
107_W141_A1.0301.00
4_N75_N1.0301.00
137_Q140_Q1.0151.00
23_L135_A1.0081.00
74_R96_E1.0021.00
105_G134_S1.0011.00
49_A52_V1.0011.00
70_R93_M0.9941.00
89_R92_E0.9891.00
85_R89_R0.9741.00
78_L102_M0.9731.00
121_R125_A0.9711.00
78_L138_W0.9611.00
21_R24_Q0.9531.00
90_L101_V0.9491.00
106_H110_E0.9451.00
127_V131_L0.9441.00
82_M104_F0.9371.00
87_I103_L0.9351.00
83_E86_H0.9331.00
125_A129_T0.9301.00
18_T128_Y0.9271.00
80_L138_W0.9241.00
55_E121_R0.9241.00
47_P51_S0.9141.00
89_R93_M0.9061.00
38_G41_V0.9021.00
68_I73_C0.9011.00
7_V19_A0.8971.00
82_M113_I0.8861.00
10_V85_R0.8851.00
80_L102_M0.8751.00
6_L76_Y0.8741.00
21_R63_H0.8681.00
46_D124_F0.8671.00
97_M100_K0.8631.00
26_Y139_A0.8631.00
37_L90_L0.8581.00
104_F134_S0.8501.00
21_R45_A0.8421.00
71_R74_R0.8381.00
58_L128_Y0.8221.00
80_L107_W0.8131.00
27_H139_A0.8081.00
22_L58_L0.8071.00
94_A101_V0.8061.00
91_C94_A0.8051.00
107_W137_Q0.8031.00
35_A68_I0.7991.00
8_V90_L0.7961.00
8_V79_I0.7911.00
48_T121_R0.7880.99
54_A60_L0.7810.99
40_L43_K0.7780.99
73_C94_A0.7580.99
52_V121_R0.7550.99
138_W142_L0.7550.99
45_A53_A0.7530.99
110_E126_A0.7500.99
102_M141_A0.7490.99
94_A97_M0.7480.99
4_N76_Y0.7390.99
18_T52_V0.7360.99
44_G64_C0.7330.99
128_Y132_E0.7280.99
12_N16_S0.7040.99
74_R97_M0.7030.99
10_V83_E0.6980.99
79_I90_L0.6930.99
103_L106_H0.6850.99
19_A104_F0.6830.99
72_L76_Y0.6820.99
23_L26_Y0.6820.99
69_S72_L0.6770.98
73_C90_L0.6770.98
123_T126_A0.6750.98
70_R74_R0.6730.98
80_L104_F0.6650.98
6_L66_R0.6500.98
48_T119_K0.6350.98
78_L142_L0.6350.98
6_L79_I0.6320.98
50_I61_E0.6320.98
39_A43_K0.6290.98
19_A131_L0.6260.97
56_H125_A0.6240.97
4_N33_E0.6200.97
44_G63_H0.6180.97
108_D111_C0.6180.97
94_A99_G0.6150.97
73_C95_P0.6060.97
82_M86_H0.6030.97
35_A72_L0.6010.97
49_A53_A0.5960.97
18_T127_V0.5840.96
21_R59_S0.5830.96
118_R123_T0.5830.96
105_G112_E0.5800.96
33_E75_N0.5770.96
78_L107_W0.5690.96
127_V130_L0.5680.96
113_I130_L0.5680.96
69_S75_N0.5650.95
53_A58_L0.5640.95
38_G89_R0.5630.95
94_A100_K0.5580.95
113_I134_S0.5550.95
48_T120_S0.5540.95
104_F138_W0.5510.95
54_A59_S0.5490.95
22_L132_E0.5480.95
38_G67_Q0.5420.94
9_C12_N0.5390.94
43_K65_A0.5370.94
60_L63_H0.5360.94
46_D117_Y0.5330.94
23_L138_W0.5310.94
131_L135_A0.5300.94
36_G39_A0.5290.94
10_V89_R0.5280.93
21_R62_G0.5280.93
108_D133_R0.5240.93
66_R76_Y0.5230.93
84_K110_E0.5220.93
22_L26_Y0.5210.93
13_I124_F0.5160.93
118_R124_F0.5150.93
138_W141_A0.5110.92
5_I78_L0.5080.92
13_I46_D0.5070.92
6_L68_I0.5060.92
122_E125_A0.5040.92
106_H111_C0.5030.92
46_D118_R0.5000.92
123_T127_V0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fekA 1 0.9932 100 0.13 Contact Map
2wmyA 3 0.9796 100 0.144 Contact Map
2wjaA 1 0.9524 100 0.144 Contact Map
4picA 2 0.9864 100 0.145 Contact Map
4lrqA 2 0.966 100 0.164 Contact Map
4etnA 1 0.9524 100 0.168 Contact Map
2gi4A 1 0.9796 100 0.168 Contact Map
4egsA 2 0.9524 100 0.168 Contact Map
3jviA 1 0.9728 100 0.17 Contact Map
2cwdA 1 0.966 100 0.177 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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