GREMLIN Database
ZRAP - Zinc resistance-associated protein
UniProt: P0AAA9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11918
Length: 141 (133)
Sequences: 100 (93)
Seq/√Len: 8.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_I108_R3.7820.96
54_D111_A3.4780.94
112_M116_G2.4140.73
22_T25_F2.2350.67
75_A116_G2.1070.62
46_T50_K2.0810.61
16_A124_G2.0810.61
31_G122_G2.0800.61
55_F60_S2.0770.61
66_L101_L2.0500.60
73_Y90_V2.0240.59
93_E97_L2.0050.58
52_H105_R1.9180.55
59_S63_Q1.7930.49
10_V21_S1.7930.49
44_Q80_N1.7400.47
43_E129_G1.7250.47
68_T73_Y1.7140.46
46_T63_Q1.6500.44
67_V71_Y1.6360.43
76_L87_I1.6030.42
94_M117_I1.5950.41
79_A82_P1.5750.41
125_M130_C1.5670.40
65_Q100_S1.5450.39
7_I28_G1.5410.39
21_S40_L1.5340.39
44_Q115_A1.5280.39
79_A83_D1.5250.39
47_A51_I1.5220.39
119_R127_Y1.4960.38
72_E76_L1.4810.37
49_Q118_P1.4600.36
86_K90_V1.4290.35
90_V100_S1.4000.34
22_T30_H1.3980.34
70_R87_I1.3940.34
131_G135_H1.3870.33
17_M49_Q1.3640.33
11_M15_S1.3200.31
73_Y104_L1.3010.30
22_T117_I1.2980.30
55_F112_M1.2880.30
55_F82_P1.2800.30
48_W95_E1.2520.29
110_I114_E1.2370.28
46_T87_I1.2160.27
69_K93_E1.2000.27
39_P47_A1.2000.27
49_Q62_L1.1970.27
39_P55_F1.1800.26
46_T135_H1.1800.26
94_M111_A1.1670.26
30_H113_A1.1530.25
49_Q66_L1.1380.25
55_F59_S1.1350.25
5_T33_W1.1200.24
82_P122_G1.1140.24
65_Q69_K1.1070.24
120_G130_C1.1030.24
30_H55_F1.0800.23
91_A95_E1.0790.23
40_L69_K1.0760.23
5_T20_G1.0720.23
50_K120_G1.0510.22
58_Q79_A1.0460.22
50_K54_D1.0450.22
77_L106_V1.0410.22
34_Q41_T1.0360.22
29_G69_K1.0350.22
13_A87_I1.0100.21
111_A114_E1.0070.21
32_M136_M0.9990.21
47_A121_A0.9950.21
52_H110_I0.9870.21
85_S133_G0.9810.20
86_K94_M0.9790.20
12_M132_G0.9690.20
19_M55_F0.9630.20
43_E137_G0.9620.20
43_E126_G0.9570.20
55_F113_A0.9530.20
41_T76_L0.9510.20
20_G135_H0.9450.19
22_T55_F0.9320.19
28_G129_G0.9300.19
35_Q128_G0.9250.19
30_H34_Q0.9200.19
125_M134_G0.9130.19
20_G76_L0.8830.18
16_A28_G0.8780.18
38_A114_E0.8780.18
124_G133_G0.8760.18
58_Q104_L0.8600.17
6_K110_I0.8540.17
11_M32_M0.8500.17
24_A76_L0.8490.17
17_M61_A0.8480.17
35_Q62_L0.8450.17
46_T58_Q0.8370.17
82_P99_Q0.8340.17
38_A69_K0.8340.17
5_T110_I0.8280.17
11_M16_A0.8280.17
66_L86_K0.8250.17
86_K89_A0.8220.17
69_K126_G0.8200.16
19_M22_T0.8180.16
68_T90_V0.8080.16
8_A37_A0.8070.16
32_M125_M0.7850.16
11_M20_G0.7780.16
48_W52_H0.7740.15
14_L59_S0.7710.15
15_S46_T0.7710.15
33_W133_G0.7660.15
68_T71_Y0.7620.15
104_L116_G0.7570.15
50_K62_L0.7560.15
22_T65_Q0.7540.15
10_V123_M0.7530.15
57_A101_L0.7500.15
21_S65_Q0.7480.15
71_Y106_V0.7440.15
118_P129_G0.7360.15
5_T78_A0.7280.14
66_L94_M0.7270.14
79_A110_I0.7250.14
34_Q130_C0.7190.14
69_K86_K0.7190.14
73_Y109_D0.7120.14
7_I70_R0.7110.14
35_Q122_G0.7010.14
52_H56_Y0.7000.14
64_Q106_V0.6990.14
17_M100_S0.6930.14
34_Q98_R0.6930.14
33_W69_K0.6890.14
43_E87_I0.6890.14
35_Q127_Y0.6880.14
93_E112_M0.6870.14
56_Y60_S0.6860.14
18_A21_S0.6830.14
116_G131_G0.6760.13
27_H63_Q0.6760.13
80_N85_S0.6730.13
73_Y115_A0.6710.13
88_N96_N0.6710.13
59_S104_L0.6690.13
77_L97_L0.6590.13
118_P124_G0.6540.13
51_I104_L0.6490.13
44_Q91_A0.6460.13
56_Y66_L0.6390.13
31_G89_A0.6370.13
51_I59_S0.6360.13
38_A45_Q0.6340.13
46_T109_D0.6320.13
21_S121_A0.6280.13
30_H133_G0.6260.13
84_S99_Q0.6230.12
18_A93_E0.6180.12
51_I79_A0.6090.12
35_Q43_E0.6070.12
22_T74_N0.6060.12
45_Q75_A0.6000.12
11_M18_A0.5960.12
64_Q93_E0.5940.12
13_A91_A0.5910.12
90_V131_G0.5870.12
34_Q40_L0.5830.12
13_A26_A0.5820.12
13_A61_A0.5750.12
42_S68_T0.5720.12
41_T74_N0.5710.12
71_Y76_L0.5700.12
46_T86_K0.5670.11
65_Q70_R0.5660.11
42_S100_S0.5640.11
64_Q85_S0.5630.11
133_G136_M0.5610.11
10_V76_L0.5580.11
48_W80_N0.5560.11
62_L105_R0.5560.11
82_P108_R0.5540.11
46_T66_L0.5500.11
73_Y87_I0.5470.11
10_V107_K0.5450.11
128_G134_G0.5420.11
72_E83_D0.5380.11
90_V110_I0.5370.11
37_A64_Q0.5370.11
11_M19_M0.5330.11
77_L83_D0.5280.11
48_W112_M0.5270.11
80_N84_S0.5110.11
44_Q56_Y0.5070.11
14_L41_T0.5030.10
96_N108_R0.5020.10
50_K72_E0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3layA 5 0.5745 100 0.348 Contact Map
3zg1A 2 0.7092 99 0.758 Contact Map
3itfA 2 0.6879 98.7 0.781 Contact Map
3oeoA 3 0.617 98.4 0.804 Contact Map
3o39A 2 0.6596 97.9 0.828 Contact Map
4wwfA 2 0.7589 97.6 0.837 Contact Map
4q4gX 1 0 94.1 0.883 Contact Map
4cgkA 3 0.5674 90.7 0.895 Contact Map
4oe8C 1 0.2199 73.1 0.915 Contact Map
3x2dB 3 0.4965 52.4 0.926 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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