GREMLIN Database
WZXE - Protein WzxE
UniProt: P0AAA7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11486
Length: 416 (401)
Sequences: 33052 (26441)
Seq/√Len: 1320.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_N75_Q4.5231.00
41_A255_Q3.6601.00
144_D147_G3.4841.00
215_G219_K3.4521.00
101_A104_P3.3881.00
128_G184_A3.3411.00
319_I330_M2.8811.00
314_L317_F2.8631.00
103_A116_Q2.8561.00
116_Q120_R2.7261.00
117_G173_E2.6161.00
359_S362_F2.5841.00
67_A281_S2.5061.00
283_L286_K2.5031.00
253_I329_A2.4311.00
103_A107_Q2.4181.00
312_W335_A2.3641.00
359_S408_V2.3341.00
285_E288_D2.3331.00
331_R335_A2.3091.00
316_D320_W2.2521.00
315_R331_R2.2461.00
283_L288_D2.2411.00
315_R335_A2.2011.00
62_V83_S2.1981.00
211_N215_G2.1921.00
78_R210_D2.1651.00
284_T287_R2.1651.00
343_L399_I2.1311.00
361_R365_L2.0851.00
69_Y75_Q2.0851.00
316_D331_R1.9981.00
291_R295_K1.9951.00
143_R282_R1.9821.00
294_V298_K1.9811.00
66_V141_G1.9751.00
146_A150_L1.9701.00
386_G389_G1.9701.00
151_S189_P1.9511.00
124_L127_M1.9401.00
27_L164_Y1.9261.00
98_F123_A1.9091.00
158_I185_L1.9001.00
332_D388_L1.8911.00
276_L296_S1.8671.00
155_G186_V1.8621.00
99_V120_R1.8511.00
33_G36_G1.8221.00
39_L114_D1.8181.00
317_F320_W1.8121.00
102_A120_R1.8121.00
75_Q78_R1.7911.00
11_A271_S1.7901.00
293_V353_L1.7811.00
151_S190_A1.7651.00
290_T294_V1.7621.00
121_L173_E1.7591.00
370_Q401_Y1.7581.00
293_V350_F1.7551.00
336_W392_Q1.7391.00
284_T288_D1.7391.00
27_L167_Y1.7331.00
114_D117_G1.7021.00
226_I364_I1.7021.00
210_D213_L1.7011.00
247_S250_E1.6751.00
131_W187_V1.6611.00
389_G393_A1.6261.00
173_E177_L1.6121.00
25_G259_S1.6071.00
241_L382_I1.6041.00
403_S407_G1.5761.00
125_V180_A1.5741.00
128_G187_V1.5701.00
188_I192_I1.5511.00
385_H392_Q1.5431.00
104_P107_Q1.5351.00
102_A116_Q1.5231.00
336_W388_L1.5131.00
373_L400_V1.5081.00
171_G174_G1.5041.00
366_A404_L1.4951.00
380_W384_A1.4931.00
385_H389_G1.4801.00
87_V134_L1.4601.00
104_P108_G1.4571.00
238_M254_W1.4531.00
121_L176_L1.4481.00
280_L289_I1.4461.00
82_T214_A1.4441.00
28_L175_A1.4391.00
64_K68_Q1.4291.00
393_A397_T1.4231.00
80_V138_L1.4211.00
310_T314_L1.4141.00
230_T368_V1.4111.00
343_L402_F1.3971.00
308_S312_W1.3851.00
70_H76_L1.3821.00
241_L378_A1.3801.00
163_Y178_G1.3701.00
164_Y168_R1.3541.00
30_V324_S1.3501.00
329_A332_D1.3481.00
69_Y72_N1.3461.00
65_Y220_F1.3441.00
74_Q78_R1.3421.00
165_V169_L1.3401.00
365_L369_S1.3301.00
238_M378_A1.3281.00
336_W395_M1.3281.00
7_S275_Y1.3201.00
212_G215_G1.3151.00
325_N328_T1.3151.00
121_L177_L1.3151.00
407_G410_L1.3041.00
68_Q358_A1.3041.00
95_A99_V1.3021.00
378_A382_I1.3001.00
382_I390_A1.2911.00
73_P77_R1.2901.00
144_D197_R1.2901.00
162_A178_G1.2871.00
16_V153_I1.2861.00
161_L165_V1.2781.00
362_F408_V1.2741.00
24_V179_L1.2731.00
366_A405_C1.2711.00
241_L379_H1.2681.00
300_V345_V1.2601.00
333_L387_A1.2601.00
379_H383_P1.2601.00
170_G174_G1.2581.00
75_Q213_L1.2581.00
377_F393_A1.2511.00
223_M364_I1.2471.00
291_R294_V1.2461.00
95_A127_M1.2391.00
381_L385_H1.2351.00
135_L190_A1.2301.00
257_V333_L1.2261.00
174_G178_G1.2251.00
242_L390_A1.2211.00
376_V380_W1.2211.00
246_Y250_E1.2211.00
406_C410_L1.2101.00
242_L246_Y1.2071.00
304_V345_V1.2021.00
216_Q358_A1.1981.00
27_L163_Y1.1981.00
157_L161_L1.1901.00
191_A195_I1.1831.00
8_L12_A1.1821.00
112_N248_W1.1821.00
68_Q216_Q1.1811.00
150_L154_V1.1811.00
298_K302_P1.1801.00
86_M214_A1.1741.00
312_W338_L1.1551.00
222_L226_I1.1541.00
192_I196_K1.1541.00
121_L180_A1.1501.00
314_L318_A1.1461.00
147_G193_M1.1451.00
170_G177_L1.1441.00
346_G402_F1.1421.00
65_Y79_V1.1381.00
163_Y175_A1.1331.00
372_T376_V1.1311.00
106_S115_Y1.1251.00
253_I330_M1.1061.00
250_E387_A1.1061.00
350_F409_F1.0911.00
284_T357_K1.0881.00
289_I357_K1.0871.00
161_L164_Y1.0841.00
24_V159_G1.0831.00
83_S217_L1.0791.00
242_L254_W1.0771.00
300_V349_V1.0761.00
312_W316_D1.0731.00
284_T289_I1.0721.00
279_T292_E1.0671.00
166_S170_G1.0651.00
124_L180_A1.0631.00
282_R286_K1.0611.00
167_Y175_A1.0591.00
380_W383_P1.0581.00
89_G93_L1.0541.00
120_R124_L1.0511.00
62_V66_V1.0451.00
107_Q113_T1.0431.00
316_D335_A1.0411.00
347_A398_Y1.0331.00
78_R82_T1.0301.00
374_L378_A1.0271.00
79_V213_L1.0191.00
302_P306_A1.0161.00
67_A141_G1.0111.00
100_L104_P1.0101.00
280_L356_A1.0101.00
69_Y79_V1.0061.00
138_L142_F0.9961.00
177_L180_A0.9941.00
103_A120_R0.9941.00
9_W146_A0.9911.00
311_V338_L0.9901.00
12_A149_A0.9901.00
332_D335_A0.9901.00
237_M375_M0.9891.00
38_G252_G0.9891.00
381_L393_A0.9851.00
15_L19_G0.9841.00
323_L327_F0.9811.00
85_A89_G0.9711.00
289_I353_L0.9701.00
151_S193_M0.9701.00
317_F321_L0.9701.00
99_V103_A0.9691.00
315_R334_F0.9661.00
350_F406_C0.9651.00
295_K299_F0.9641.00
353_L409_F0.9621.00
306_A309_F0.9611.00
173_E176_L0.9611.00
177_L181_L0.9581.00
392_Q395_M0.9581.00
166_S169_L0.9551.00
366_A408_V0.9531.00
158_I162_A0.9521.00
97_V101_A0.9511.00
24_V163_Y0.9491.00
77_R81_G0.9491.00
397_T401_Y0.9471.00
230_T364_I0.9441.00
26_K29_A0.9441.00
374_L397_T0.9421.00
159_G163_Y0.9421.00
312_W315_R0.9421.00
240_K244_A0.9411.00
373_L377_F0.9391.00
26_K30_V0.9391.00
78_R213_L0.9361.00
110_F113_T0.9301.00
139_M194_L0.9291.00
354_V408_V0.9281.00
404_L407_G0.9261.00
143_R279_T0.9261.00
34_P249_D0.9231.00
381_L384_A0.9221.00
127_M130_A0.9201.00
242_L387_A0.9171.00
340_G395_M0.9151.00
102_A119_V0.9131.00
350_F405_C0.9111.00
43_F119_V0.9071.00
70_H282_R0.9061.00
209_W214_A0.9051.00
335_A339_V0.9051.00
377_F381_L0.9041.00
135_L191_A0.9001.00
309_F313_L0.8991.00
159_G182_I0.8991.00
319_I331_R0.8961.00
243_A251_V0.8931.00
308_S342_V0.8931.00
220_F360_L0.8911.00
162_A166_S0.8911.00
219_K361_R0.8901.00
377_F396_A0.8891.00
213_L216_Q0.8871.00
229_V233_V0.8861.00
36_G114_D0.8851.00
13_S152_L0.8831.00
102_A123_A0.8821.00
388_L392_Q0.8801.00
369_S372_T0.8791.00
399_I403_S0.8781.00
61_G220_F0.8781.00
40_A172_Y0.8771.00
319_I334_F0.8761.00
154_V189_P0.8761.00
320_W328_T0.8721.00
135_L187_V0.8711.00
34_P252_G0.8701.00
261_S341_D0.8641.00
159_G179_L0.8631.00
261_S337_Q0.8631.00
339_V342_V0.8621.00
273_S352_Y0.8611.00
295_K298_K0.8591.00
61_G221_T0.8551.00
32_F36_G0.8551.00
19_G23_L0.8521.00
82_T209_W0.8441.00
119_V123_A0.8421.00
180_A184_A0.8411.00
223_M360_L0.8391.00
392_Q396_A0.8371.00
144_D193_M0.8371.00
106_S119_V0.8371.00
102_A106_S0.8351.00
100_L103_A0.8301.00
163_Y167_Y0.8291.00
377_F380_W0.8291.00
123_A127_M0.8241.00
29_A37_L0.8221.00
238_M394_Y0.8201.00
339_V395_M0.8181.00
28_L40_A0.8151.00
70_H142_F0.8141.00
124_L128_G0.8131.00
301_L305_A0.8111.00
374_L394_Y0.8091.00
352_Y356_A0.8091.00
81_G207_P0.8071.00
74_Q77_R0.8041.00
65_Y216_Q0.8031.00
378_A390_A0.8031.00
35_A248_W0.8011.00
303_A307_A0.8001.00
189_P193_M0.7991.00
41_A252_G0.7991.00
4_A8_L0.7971.00
78_R81_G0.7961.00
66_V76_L0.7931.00
87_V130_A0.7921.00
70_H73_P0.7891.00
193_M197_R0.7881.00
277_L355_I0.7861.00
315_R338_L0.7861.00
164_Y167_Y0.7841.00
312_W339_V0.7811.00
388_L391_A0.7801.00
224_A360_L0.7791.00
218_S221_T0.7791.00
336_W391_A0.7761.00
42_N243_A0.7731.00
305_A309_F0.7691.00
246_Y387_A0.7691.00
180_A183_P0.7681.00
333_L391_A0.7671.00
293_V409_F0.7641.00
25_G37_L0.7631.00
216_Q219_K0.7601.00
242_L251_V0.7591.00
184_A188_I0.7571.00
373_L376_V0.7561.00
75_Q79_V0.7541.00
10_T274_V0.7511.00
306_A310_T0.7501.00
400_V404_L0.7501.00
189_P192_I0.7461.00
249_D326_K0.7451.00
96_L100_L0.7431.00
117_G120_R0.7421.00
192_I195_I0.7411.00
362_F366_A0.7401.00
145_A275_Y0.7391.00
33_G327_F0.7391.00
65_Y69_Y0.7361.00
135_L194_L0.7351.00
139_M147_G0.7341.00
93_L96_L0.7331.00
5_K146_A0.7321.00
136_L140_K0.7301.00
101_A105_I0.7281.00
365_L368_V0.7281.00
52_V56_A0.7271.00
178_G182_I0.7261.00
289_I293_V0.7241.00
218_S222_L0.7231.00
42_N251_V0.7231.00
291_R298_K0.7211.00
100_L120_R0.7211.00
212_G216_Q0.7201.00
198_G201_P0.7181.00
353_L357_K0.7171.00
93_L97_V0.7161.00
95_A124_L0.7161.00
257_V330_M0.7121.00
144_D148_N0.7111.00
246_Y382_I0.7101.00
324_S327_F0.7091.00
355_I363_Y0.7091.00
22_L26_K0.7091.00
313_L317_F0.7081.00
88_L92_T0.7061.00
150_L153_I0.7051.00
376_V379_H0.7041.00
311_V334_F0.7011.00
339_V343_L0.7001.00
256_G330_M0.6961.00
234_A374_L0.6951.00
121_L124_L0.6951.00
68_Q281_S0.6951.00
54_A130_A0.6951.00
132_G186_V0.6941.00
34_P325_N0.6881.00
280_L353_L0.6881.00
82_T86_M0.6881.00
140_K148_N0.6871.00
26_K322_L0.6861.00
106_S116_Q0.6821.00
96_L99_V0.6821.00
65_Y68_Q0.6821.00
92_T96_L0.6811.00
125_V183_P0.6811.00
238_M374_L0.6801.00
29_A256_G0.6791.00
381_L389_G0.6781.00
30_V168_R0.6781.00
57_G221_T0.6771.00
252_G256_G0.6741.00
40_A44_R0.6741.00
378_A394_Y0.6741.00
182_I186_V0.6731.00
307_A310_T0.6711.00
154_V157_L0.6711.00
57_G61_G0.6681.00
89_G92_T0.6671.00
296_S349_V0.6671.00
328_T331_R0.6671.00
304_V338_L0.6661.00
256_G323_L0.6661.00
62_V79_V0.6641.00
260_I311_V0.6621.00
137_A140_K0.6591.00
13_S149_A0.6591.00
14_T18_I0.6581.00
166_S181_L0.6581.00
175_A179_L0.6571.00
123_A126_Q0.6551.00
154_V158_I0.6551.00
224_A355_I0.6541.00
271_S275_Y0.6531.00
350_F402_F0.6521.00
65_Y217_L0.6511.00
158_I182_I0.6491.00
39_L115_Y0.6481.00
45_Q239_R0.6481.00
305_A342_V0.6481.00
27_L168_R0.6481.00
151_S155_G0.6481.00
222_L225_L0.6471.00
302_P305_A0.6461.00
85_A209_W0.6441.00
128_G180_A0.6441.00
283_L287_R0.6421.00
63_T137_A0.6421.00
366_A370_Q0.6411.00
88_L131_W0.6401.00
208_S211_N0.6391.00
389_G392_Q0.6381.00
162_A181_L0.6381.00
313_L316_D0.6351.00
237_M241_L0.6351.00
83_S134_L0.6321.00
254_W391_A0.6321.00
6_A145_A0.6281.00
91_S95_A0.6281.00
35_A114_D0.6261.00
6_A9_W0.6251.00
297_L346_G0.6251.00
276_L280_L0.6211.00
249_D329_A0.6211.00
360_L363_Y0.6211.00
250_E329_A0.6201.00
140_K145_A0.6141.00
375_M379_H0.6141.00
91_S123_A0.6111.00
37_L256_G0.6111.00
280_L293_V0.6111.00
230_T371_F0.6091.00
257_V334_F0.6081.00
236_I239_R0.6071.00
386_G393_A0.6071.00
260_I318_A0.6061.00
36_G171_G0.6031.00
277_L281_S0.6031.00
85_A207_P0.6021.00
187_V191_A0.5981.00
132_G187_V0.5981.00
64_K220_F0.5981.00
76_L80_V0.5971.00
368_V372_T0.5971.00
220_F224_A0.5961.00
277_L352_Y0.5951.00
308_S338_L0.5941.00
164_Y169_L0.5941.00
301_L346_G0.5941.00
347_A402_F0.5931.00
117_G121_L0.5921.00
366_A369_S0.5891.00
43_F122_V0.5891.00
81_G85_A0.5871.00
333_L388_L0.5851.00
29_A323_L0.5851.00
64_K358_A0.5841.00
347_A401_Y0.5841.00
7_S11_A0.5801.00
158_I161_L0.5791.00
190_A193_M0.5791.00
23_L160_V0.5791.00
249_D253_I0.5781.00
160_V164_Y0.5771.00
151_S186_V0.5771.00
277_L356_A0.5761.00
256_G327_F0.5751.00
223_M361_R0.5751.00
257_V337_Q0.5741.00
81_G206_K0.5711.00
398_Y401_Y0.5691.00
137_A141_G0.5671.00
36_G39_L0.5661.00
12_A16_V0.5661.00
84_S135_L0.5651.00
34_P253_I0.5651.00
360_L364_I0.5641.00
77_R203_S0.5641.00
85_A88_L0.5631.00
253_I333_L0.5621.00
76_L142_F0.5611.00
153_I157_L0.5611.00
326_K329_A0.5601.00
92_T95_A0.5601.00
47_I122_V0.5581.00
92_T127_M0.5581.00
203_S206_K0.5571.00
163_Y179_L0.5571.00
395_M399_I0.5561.00
182_I185_L0.5551.00
344_K398_Y0.5551.00
44_R48_T0.5551.00
332_D336_W0.5501.00
28_L167_Y0.5501.00
378_A381_L0.5491.00
32_F172_Y0.5461.00
347_A405_C0.5461.00
373_L397_T0.5461.00
42_N115_Y0.5451.00
298_K301_L0.5451.00
185_L189_P0.5451.00
66_V142_F0.5431.00
219_K222_L0.5421.00
303_A306_A0.5401.00
79_V83_S0.5391.00
64_K360_L0.5381.00
206_K209_W0.5381.00
147_G189_P0.5371.00
24_V160_V0.5371.00
48_T52_V0.5371.00
294_V297_L0.5361.00
211_N214_A0.5361.00
61_G64_K0.5361.00
236_I240_K0.5351.00
72_N78_R0.5351.00
340_G398_Y0.5341.00
86_M90_F0.5341.00
338_L341_D0.5331.00
91_S130_A0.5331.00
233_V371_F0.5321.00
116_Q119_V0.5321.00
297_L350_F0.5311.00
58_I83_S0.5301.00
163_Y174_G0.5291.00
272_F300_V0.5291.00
279_T282_R0.5291.00
232_P236_I0.5281.00
340_G343_L0.5281.00
239_R243_A0.5251.00
283_L292_E0.5251.00
297_L349_V0.5241.00
35_A38_G0.5241.00
301_L304_V0.5231.00
310_T313_L0.5231.00
269_T345_V0.5221.00
198_G202_L0.5211.00
272_F296_S0.5201.00
374_L377_F0.5201.00
98_F102_A0.5201.00
95_A98_F0.5191.00
9_W13_S0.5171.00
139_M190_A0.5161.00
118_L176_L0.5161.00
384_A388_L0.5151.00
95_A123_A0.5151.00
84_S87_V0.5141.00
25_G323_L0.5141.00
99_V123_A0.5131.00
34_P327_F0.5131.00
63_T67_A0.5121.00
166_S178_G0.5091.00
32_F38_G0.5091.00
26_K323_L0.5091.00
39_L172_Y0.5081.00
398_Y402_F0.5071.00
347_A351_G0.5071.00
162_A165_V0.5051.00
139_M193_M0.5041.00
287_R290_T0.5011.00
194_L197_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lz6A 1 0.9952 100 0.19 Contact Map
4humA 1 0.9904 100 0.202 Contact Map
3mktA 1 0.988 100 0.216 Contact Map
3w4tA 1 0.9832 100 0.218 Contact Map
1pw4A 1 0.8822 30.3 0.94 Contact Map
2cfqA 1 0.8918 26.1 0.942 Contact Map
4tphA 2 0.8702 25.9 0.942 Contact Map
3wdoA 1 0.8774 16.6 0.947 Contact Map
4xnjA 1 0.8966 15.9 0.947 Contact Map
2gfpA 2 0.8534 12.5 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0124 seconds.