YPDA - ECOLI - GREMLIN Contacts

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YPDA - Sensor histidine kinase YpdA

UniProt:	P0AA93	Sequences: MHEIFNMLLAVFDRAALMLICLFFLIRIRLFRELLHKSAHSPKELLAVTAIFSLFALFSTWSGVPVEGSLVNVRIIAVMSGGILFGPWVGIITGVIAGIHRYLIDIGGVTAIPCFITSILAGCISGWINLKIPKAQRWRVGILGGMLCETLTMILVIVWAPTTALGIDIVSKIGIPMILGSVCIGFIVLLVQSVEGEKEASAARQAKLALDIANKTLPLFRHVNSESLRKVCEIIRDDIHADAVAITNTDHVLAYVGVGEHNYQNGDDFISPTTRQAMNYGKIIIKNNDEAHRTPEIHSMLVIPLWEKGVVTGTLKIYYCHAHQITSSLQEMAVGLSQIISTQLEVSRAEQLREMANKAELRALQSKINPHFLFNALNAISSSIRLNPDTARQLIFNLSRYLRYNIELKDDEQIDIKKELYQIKDYIAIEQARFGDKLTVIYDIDEEVNCCIPSLLIQPLVENAIVHGIQPCKGKGVVTISVAECGNRVRIAVRDTGHGIDPKVIERVEANEMPGNKIGLLNVHHRVKLLYGEGLHIRRLEPGTEIAFYIPNQRTPVASQATLLL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG14148
Length:	565 (460)
Sequences:	4312 (3985)
Seq/√Len:	185.8

ECOLI - YPDA YEHU BARA KDPD RCSD
BACSU - LYTS
HALSA - Q9HQG5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
494_R	545_E	4.290	1.00
523_V	535_L	4.036	1.00
491_I	548_F	3.836	1.00
539_R	542_P	3.635	1.00
524_H	528_K	3.559	1.00
354_E	358_K	3.395	1.00
505_I	537_I	3.289	1.00
526_R	530_L	3.272	1.00
527_V	548_F	3.260	1.00
536_H	547_A	3.204	1.00
495_D	499_G	3.174	1.00
481_S	492_A	3.096	1.00
490_R	549_Y	3.053	1.00
456_L	527_V	3.039	1.00
537_I	546_I	2.989	1.00
359_A	362_R	2.837	1.00
353_R	356_A	2.785	1.00
477_V	496_T	2.686	1.00
456_L	526_R	2.647	1.00
364_L	367_K	2.641	1.00
384_I	387_N	2.641	1.00
492_A	547_A	2.619	1.00
371_H	376_A	2.601	1.00
488_R	549_Y	2.559	1.00
354_E	361_L	2.546	1.00
358_K	362_R	2.469	1.00
372_F	376_A	2.453	1.00
387_N	390_T	2.429	1.00
476_G	496_T	2.429	1.00
356_A	360_E	2.428	1.00
527_V	532_G	2.401	1.00
353_R	357_N	2.364	1.00
462_E	466_V	2.333	1.00
483_A	492_A	2.289	1.00
443_D	481_S	2.288	1.00
357_N	360_E	2.259	1.00
489_V	552_N	2.259	1.00
481_S	494_R	2.241	1.00
501_D	504_V	2.216	1.00
492_A	545_E	2.134	1.00
371_H	375_N	2.091	1.00
347_S	350_E	2.083	1.00
472_C	496_T	2.082	1.00
383_S	386_L	2.065	1.00
484_E	552_N	2.052	1.00
485_C	490_R	2.043	1.00
538_R	545_E	1.995	1.00
456_L	523_V	1.983	1.00
369_N	375_N	1.941	1.00
369_N	376_A	1.932	1.00
533_E	536_H	1.931	1.00
203_A	206_A	1.924	1.00
439_T	477_V	1.920	1.00
357_N	362_R	1.920	1.00
355_M	358_K	1.894	1.00
538_R	547_A	1.857	1.00
357_N	361_L	1.847	1.00
457_I	491_I	1.828	1.00
441_I	479_T	1.803	1.00
360_E	363_A	1.793	1.00
483_A	490_R	1.775	1.00
353_R	358_K	1.765	1.00
358_K	361_L	1.753	1.00
369_N	372_F	1.745	1.00
415_D	418_K	1.734	1.00
362_R	365_Q	1.716	1.00
339_I	342_T	1.715	1.00
490_R	547_A	1.705	1.00
180_G	188_V	1.693	1.00
452_I	455_L	1.684	1.00
180_G	187_I	1.649	1.00
375_N	379_A	1.637	1.00
500_I	508_V	1.637	1.00
387_N	391_A	1.634	1.00
364_L	369_N	1.623	1.00
231_V	235_I	1.611	1.00
325_I	329_L	1.604	1.00
422_Q	426_Y	1.603	1.00
333_A	339_I	1.595	1.00
356_A	362_R	1.571	1.00
518_I	522_N	1.571	1.00
388_P	391_A	1.561	1.00
359_A	371_H	1.558	1.00
502_P	505_I	1.557	1.00
479_T	494_R	1.533	1.00
365_Q	369_N	1.532	1.00
354_E	357_N	1.509	1.00
210_L	213_A	1.504	1.00
122_G	126_G	1.500	1.00
342_T	346_V	1.500	1.00
336_L	340_I	1.499	1.00
349_A	352_L	1.499	1.00
338_Q	343_Q	1.490	1.00
206_A	209_A	1.487	1.00
275_R	279_N	1.477	1.00
441_I	477_V	1.471	1.00
419_E	422_Q	1.464	1.00
509_E	535_L	1.462	1.00
339_I	343_Q	1.461	1.00
500_I	504_V	1.461	1.00
194_V	197_E	1.445	1.00
363_A	367_K	1.441	1.00
339_I	344_L	1.441	1.00
375_N	382_S	1.438	1.00
188_V	191_V	1.429	1.00
383_S	387_N	1.423	1.00
228_L	232_C	1.417	1.00
500_I	544_T	1.410	1.00
457_I	461_V	1.409	1.00
509_E	546_I	1.402	1.00
397_N	452_I	1.399	1.00
421_Y	425_D	1.398	1.00
353_R	359_A	1.395	1.00
359_A	364_L	1.391	1.00
375_N	378_N	1.379	1.00
357_N	365_Q	1.376	1.00
369_N	374_F	1.373	1.00
527_V	550_I	1.373	1.00
371_H	374_F	1.351	1.00
340_I	344_L	1.351	1.00
364_L	376_A	1.347	1.00
329_L	333_A	1.344	1.00
125_S	130_L	1.341	1.00
340_I	343_Q	1.338	1.00
379_A	382_S	1.333	1.00
208_L	211_D	1.333	1.00
456_L	548_F	1.321	1.00
472_C	476_G	1.320	1.00
374_F	382_S	1.315	1.00
364_L	371_H	1.315	1.00
485_C	549_Y	1.311	1.00
362_R	367_K	1.311	1.00
326_T	329_L	1.310	1.00
333_A	336_L	1.307	1.00
360_E	365_Q	1.302	1.00
183_C	187_I	1.285	1.00
501_D	540_L	1.276	1.00
346_V	349_A	1.273	1.00
122_G	127_W	1.266	1.00
206_A	210_L	1.263	1.00
356_A	361_L	1.263	1.00
313_G	316_K	1.261	1.00
504_V	507_R	1.255	1.00
533_E	549_Y	1.253	1.00
117_T	123_C	1.252	1.00
537_I	544_T	1.238	1.00
209_A	213_A	1.238	1.00
276_Q	280_Y	1.231	1.00
443_D	479_T	1.230	1.00
342_T	345_E	1.215	1.00
412_E	450_C	1.213	1.00
467_H	513_M	1.212	1.00
498_H	513_M	1.211	1.00
217_L	220_F	1.206	1.00
173_I	176_P	1.196	1.00
149_E	153_M	1.190	1.00
353_R	361_L	1.188	1.00
180_G	183_C	1.188	1.00
528_K	533_E	1.180	1.00
482_V	489_V	1.178	1.00
226_E	232_C	1.177	1.00
187_I	190_L	1.171	1.00
372_F	375_N	1.166	1.00
127_W	131_K	1.157	1.00
94_G	98_G	1.156	1.00
426_Y	429_I	1.156	1.00
473_K	496_T	1.152	1.00
467_H	512_E	1.151	1.00
376_A	379_A	1.148	1.00
373_L	394_L	1.144	1.00
285_I	288_N	1.138	1.00
532_G	551_P	1.135	1.00
256_V	259_G	1.135	1.00
353_R	360_E	1.133	1.00
343_Q	346_V	1.131	1.00
96_I	99_I	1.130	1.00
339_I	346_V	1.130	1.00
227_S	231_V	1.128	1.00
180_G	186_F	1.116	1.00
300_M	304_P	1.115	1.00
98_G	102_Y	1.114	1.00
347_S	351_Q	1.110	1.00
187_I	191_V	1.106	1.00
354_E	362_R	1.101	1.00
460_L	546_I	1.099	1.00
94_G	97_A	1.099	1.00
173_I	177_M	1.088	1.00
378_N	382_S	1.084	1.00
197_E	201_S	1.084	1.00
141_G	145_G	1.078	1.00
117_T	122_G	1.078	1.00
233_E	237_D	1.077	1.00
350_E	353_R	1.072	1.00
110_T	114_C	1.072	1.00
355_M	361_L	1.071	1.00
371_H	378_N	1.069	1.00
145_G	149_E	1.063	1.00
358_K	365_Q	1.063	1.00
490_R	536_H	1.057	1.00
195_E	198_K	1.053	1.00
426_Y	430_E	1.052	1.00
509_E	537_I	1.043	1.00
185_G	188_V	1.043	1.00
536_H	548_F	1.041	1.00
500_I	505_I	1.041	1.00
495_D	543_G	1.035	1.00
276_Q	285_I	1.034	1.00
188_V	192_Q	1.034	1.00
416_I	489_V	1.034	1.00
122_G	130_L	1.023	1.00
344_L	347_S	1.019	1.00
271_S	274_T	1.019	1.00
126_G	130_L	1.016	1.00
361_L	364_L	1.016	1.00
532_G	550_I	1.013	1.00
392_R	396_F	1.007	0.99
141_G	149_E	0.997	0.99
207_K	214_N	0.996	0.99
153_M	156_V	0.994	0.99
213_A	216_T	0.993	0.99
199_E	202_A	0.990	0.99
341_S	344_L	0.990	0.99
355_M	362_R	0.990	0.99
355_M	359_A	0.990	0.99
373_L	376_A	0.987	0.99
97_A	100_H	0.986	0.99
125_S	131_K	0.983	0.99
172_K	177_M	0.981	0.99
338_Q	342_T	0.980	0.99
120_L	125_S	0.977	0.99
193_S	197_E	0.977	0.99
351_Q	358_K	0.974	0.99
508_V	537_I	0.973	0.99
114_C	117_T	0.973	0.99
180_G	185_G	0.972	0.99
150_T	154_I	0.969	0.99
420_L	423_I	0.968	0.99
181_S	188_V	0.967	0.99
197_E	200_A	0.964	0.99
164_A	168_D	0.960	0.99
527_V	535_L	0.959	0.99
358_K	364_L	0.957	0.99
453_P	530_L	0.956	0.99
482_V	491_I	0.954	0.99
93_T	97_A	0.952	0.99
382_S	386_L	0.950	0.99
139_R	143_L	0.949	0.99
90_G	94_G	0.947	0.99
209_A	214_N	0.947	0.99
198_K	202_A	0.943	0.99
359_A	372_F	0.935	0.99
401_Y	521_L	0.935	0.99
449_N	452_I	0.934	0.99
180_G	191_V	0.934	0.99
351_Q	354_E	0.932	0.99
399_S	402_L	0.932	0.99
137_R	141_G	0.931	0.99
94_G	100_H	0.930	0.99
117_T	125_S	0.929	0.99
125_S	129_N	0.928	0.99
214_N	218_P	0.926	0.99
467_H	511_N	0.924	0.99
327_S	330_Q	0.924	0.99
117_T	121_A	0.923	0.99
140_V	144_G	0.918	0.99
352_L	356_A	0.915	0.99
353_R	364_L	0.912	0.99
351_Q	357_N	0.912	0.99
276_Q	284_I	0.908	0.99
444_I	482_V	0.908	0.99
418_K	421_Y	0.907	0.99
335_G	340_I	0.904	0.99
153_M	157_I	0.901	0.99
460_L	548_F	0.901	0.99
229_R	232_C	0.900	0.99
414_I	453_P	0.899	0.99
360_E	367_K	0.895	0.99
354_E	359_A	0.895	0.99
97_A	101_R	0.893	0.99
329_L	337_S	0.891	0.99
152_T	156_V	0.890	0.99
360_E	364_L	0.890	0.99
119_I	125_S	0.890	0.99
272_P	276_Q	0.889	0.99
217_L	221_R	0.889	0.99
196_G	199_E	0.888	0.99
115_F	118_S	0.887	0.99
212_I	216_T	0.886	0.99
205_Q	208_L	0.883	0.99
431_Q	434_F	0.882	0.99
149_E	157_I	0.882	0.99
130_L	134_K	0.881	0.99
228_L	235_I	0.880	0.99
257_G	260_E	0.880	0.99
216_T	221_R	0.879	0.99
126_G	129_N	0.878	0.99
452_I	467_H	0.877	0.99
94_G	102_Y	0.877	0.99
180_G	184_I	0.875	0.99
119_I	122_G	0.872	0.99
122_G	125_S	0.872	0.99
355_M	363_A	0.869	0.98
368_I	372_F	0.869	0.98
96_I	100_H	0.867	0.98
144_G	147_L	0.864	0.98
499_G	543_G	0.863	0.98
335_G	346_V	0.862	0.98
307_E	310_V	0.858	0.98
420_L	424_K	0.856	0.98
341_S	345_E	0.856	0.98
359_A	363_A	0.855	0.98
416_I	491_I	0.854	0.98
348_R	351_Q	0.853	0.98
452_I	526_R	0.852	0.98
232_C	238_D	0.851	0.98
168_D	177_M	0.850	0.98
429_I	433_R	0.850	0.98
174_G	178_I	0.848	0.98
206_A	221_R	0.848	0.98
171_S	174_G	0.845	0.98
140_V	143_L	0.844	0.98
380_I	383_S	0.843	0.98
369_N	382_S	0.841	0.98
462_E	467_H	0.839	0.98
400_R	404_Y	0.838	0.98
357_N	364_L	0.836	0.98
111_A	114_C	0.836	0.98
236_R	239_I	0.835	0.98
254_A	257_G	0.835	0.98
354_E	365_Q	0.834	0.98
333_A	337_S	0.832	0.98
207_K	211_D	0.832	0.98
361_L	367_K	0.830	0.98
336_L	339_I	0.828	0.98
428_A	431_Q	0.827	0.98
356_A	359_A	0.822	0.98
119_I	123_C	0.821	0.98
89_V	97_A	0.819	0.98
152_T	157_I	0.819	0.98
455_L	522_N	0.816	0.98
361_L	365_Q	0.816	0.98
325_I	333_A	0.814	0.98
218_P	221_R	0.814	0.98
149_E	156_V	0.811	0.98
212_I	215_K	0.810	0.98
226_E	229_R	0.810	0.98
346_V	350_E	0.808	0.98
488_R	533_E	0.808	0.98
205_Q	209_A	0.807	0.98
199_E	203_A	0.806	0.98
167_I	171_S	0.805	0.97
121_A	125_S	0.805	0.97
403_R	516_N	0.804	0.97
241_A	245_A	0.804	0.97
500_I	546_I	0.803	0.97
337_S	343_Q	0.802	0.97
143_L	150_T	0.801	0.97
92_I	97_A	0.800	0.97
109_V	114_C	0.799	0.97
357_N	371_H	0.796	0.97
355_M	360_E	0.795	0.97
143_L	153_M	0.795	0.97
329_L	339_I	0.791	0.97
276_Q	279_N	0.790	0.97
74_R	101_R	0.790	0.97
368_I	375_N	0.790	0.97
259_G	263_Y	0.789	0.97
461_V	480_I	0.788	0.97
330_Q	334_V	0.787	0.97
160_A	163_T	0.787	0.97
196_G	200_A	0.784	0.97
428_A	432_A	0.783	0.97
257_G	265_N	0.782	0.97
206_A	213_A	0.782	0.97
417_K	482_V	0.777	0.97
120_L	126_G	0.776	0.97
403_R	512_E	0.776	0.97
400_R	407_E	0.774	0.97
227_S	232_C	0.771	0.97
324_Q	327_S	0.770	0.97
110_T	115_F	0.768	0.97
359_A	376_A	0.768	0.97
382_S	455_L	0.767	0.97
374_F	379_A	0.766	0.97
141_G	144_G	0.764	0.97
95_V	100_H	0.764	0.97
90_G	101_R	0.763	0.97
123_C	131_K	0.761	0.96
285_I	289_D	0.761	0.96
119_I	127_W	0.760	0.96
120_L	127_W	0.760	0.96
352_L	357_N	0.758	0.96
115_F	119_I	0.758	0.96
169_I	172_K	0.756	0.96
99_I	102_Y	0.755	0.96
95_V	99_I	0.755	0.96
169_I	173_I	0.754	0.96
96_I	103_L	0.753	0.96
358_K	363_A	0.753	0.96
374_F	380_I	0.752	0.96
508_V	546_I	0.750	0.96
369_N	379_A	0.746	0.96
114_C	121_A	0.745	0.96
209_A	212_I	0.745	0.96
89_V	96_I	0.744	0.96
422_Q	425_D	0.743	0.96
377_L	395_I	0.742	0.96
335_G	339_I	0.741	0.96
86_G	97_A	0.741	0.96
166_G	177_M	0.739	0.96
350_E	357_N	0.737	0.96
335_G	338_Q	0.735	0.96
118_S	123_C	0.733	0.96
338_Q	341_S	0.732	0.96
215_K	219_L	0.731	0.96
352_L	355_M	0.730	0.96
420_L	426_Y	0.729	0.96
284_I	290_E	0.728	0.95
423_I	426_Y	0.728	0.95
168_D	171_S	0.727	0.95
163_T	167_I	0.727	0.95
145_G	155_L	0.726	0.95
423_I	461_V	0.726	0.95
375_N	467_H	0.723	0.95
211_D	215_K	0.721	0.95
525_H	528_K	0.716	0.95
183_C	188_V	0.716	0.95
371_H	379_A	0.715	0.95
302_V	316_K	0.713	0.95
455_L	526_R	0.708	0.95
171_S	177_M	0.707	0.95
213_A	217_L	0.706	0.95
452_I	530_L	0.705	0.95
114_C	125_S	0.705	0.95
117_T	130_L	0.704	0.95
203_A	209_A	0.702	0.94
270_I	273_T	0.701	0.94
364_L	372_F	0.700	0.94
207_K	210_L	0.698	0.94
372_F	455_L	0.698	0.94
149_E	152_T	0.697	0.94
392_R	405_N	0.696	0.94
323_H	327_S	0.696	0.94
183_C	189_L	0.695	0.94
404_Y	407_E	0.692	0.94
251_H	257_G	0.690	0.94
498_H	544_T	0.689	0.94
114_C	122_G	0.689	0.94
467_H	522_N	0.689	0.94
212_I	220_F	0.686	0.94
198_K	201_S	0.683	0.94
234_I	238_D	0.682	0.94
353_R	362_R	0.682	0.94
360_E	372_F	0.681	0.94
117_T	126_G	0.680	0.94
203_A	214_N	0.680	0.94
95_V	102_Y	0.678	0.93
118_S	121_A	0.678	0.93
454_S	458_Q	0.677	0.93
144_G	157_I	0.677	0.93
372_F	394_L	0.675	0.93
329_L	335_G	0.673	0.93
333_A	343_Q	0.671	0.93
335_G	343_Q	0.670	0.93
174_G	177_M	0.667	0.93
374_F	378_N	0.667	0.93
124_I	129_N	0.665	0.93
521_L	525_H	0.665	0.93
257_G	262_N	0.663	0.93
144_G	152_T	0.660	0.92
330_Q	333_A	0.660	0.92
95_V	98_G	0.660	0.92
173_I	178_I	0.659	0.92
460_L	523_V	0.656	0.92
381_S	384_I	0.655	0.92
398_L	405_N	0.654	0.92
500_I	537_I	0.651	0.92
74_R	86_G	0.650	0.92
421_Y	424_K	0.650	0.92
304_P	311_V	0.649	0.92
122_G	134_K	0.648	0.92
90_G	97_A	0.648	0.92
329_L	336_L	0.648	0.92
453_P	457_I	0.647	0.92
358_K	366_S	0.645	0.92
106_I	110_T	0.644	0.92
356_A	363_A	0.644	0.92
118_S	122_G	0.643	0.91
445_D	482_V	0.643	0.91
353_R	363_A	0.642	0.91
164_A	172_K	0.642	0.91
243_A	247_T	0.640	0.91
116_I	119_I	0.639	0.91
418_K	422_Q	0.637	0.91
536_H	549_Y	0.637	0.91
111_A	115_F	0.636	0.91
229_R	233_E	0.635	0.91
399_S	403_R	0.633	0.91
404_Y	467_H	0.632	0.91
271_S	275_R	0.631	0.91
204_R	207_K	0.630	0.91
143_L	157_I	0.630	0.91
205_Q	213_A	0.629	0.91
96_I	102_Y	0.629	0.91
277_A	285_I	0.628	0.91
114_C	120_L	0.628	0.91
331_E	335_G	0.627	0.90
455_L	458_Q	0.625	0.90
177_M	180_G	0.624	0.90
144_G	156_V	0.624	0.90
397_N	522_N	0.623	0.90
89_V	101_R	0.622	0.90
210_L	214_N	0.622	0.90
372_F	380_I	0.622	0.90
337_S	344_L	0.621	0.90
86_G	89_V	0.621	0.90
86_G	90_G	0.619	0.90
401_Y	516_N	0.618	0.90
114_C	118_S	0.617	0.90
185_G	190_L	0.617	0.90
151_L	155_L	0.616	0.90
203_A	207_K	0.616	0.90
359_A	367_K	0.614	0.90
120_L	123_C	0.614	0.90
182_V	186_F	0.614	0.90
467_H	496_T	0.611	0.89
113_P	117_T	0.610	0.89
357_N	363_A	0.610	0.89
333_A	340_I	0.610	0.89
367_K	372_F	0.609	0.89
348_R	352_L	0.609	0.89
458_Q	523_V	0.608	0.89
117_T	129_N	0.605	0.89
548_F	551_P	0.605	0.89
395_I	455_L	0.604	0.89
214_N	217_L	0.604	0.89
146_M	150_T	0.604	0.89
94_G	101_R	0.604	0.89
142_I	156_V	0.604	0.89
351_Q	355_M	0.602	0.89
92_I	95_V	0.602	0.89
138_W	142_I	0.602	0.89
208_L	212_I	0.601	0.89
299_S	303_I	0.601	0.89
402_L	406_I	0.601	0.89
359_A	366_S	0.600	0.88
255_Y	262_N	0.600	0.88
455_L	530_L	0.599	0.88
460_L	493_V	0.598	0.88
375_N	380_I	0.598	0.88
129_N	134_K	0.598	0.88
227_S	236_R	0.598	0.88
350_E	354_E	0.597	0.88
420_L	491_I	0.597	0.88
524_H	535_L	0.596	0.88
371_H	377_L	0.596	0.88
90_G	96_I	0.596	0.88
284_I	288_N	0.595	0.88
376_A	382_S	0.594	0.88
283_I	287_N	0.594	0.88
369_N	373_L	0.591	0.88
277_A	284_I	0.590	0.88
329_L	342_T	0.588	0.87
123_C	130_L	0.588	0.87
206_A	214_N	0.587	0.87
235_I	239_I	0.586	0.87
251_H	254_A	0.586	0.87
277_A	280_Y	0.586	0.87
248_N	252_V	0.583	0.87
364_L	374_F	0.583	0.87
114_C	123_C	0.583	0.87
403_R	406_I	0.583	0.87
130_L	133_P	0.583	0.87
111_A	117_T	0.582	0.87
254_A	263_Y	0.582	0.87
97_A	103_L	0.582	0.87
118_S	126_G	0.580	0.87
424_K	431_Q	0.579	0.87
107_G	111_A	0.579	0.87
206_A	216_T	0.578	0.87
356_A	367_K	0.578	0.87
330_Q	337_S	0.578	0.87
183_C	186_F	0.574	0.86
405_N	511_N	0.574	0.86
172_K	175_I	0.574	0.86
117_T	120_L	0.574	0.86
479_T	496_T	0.571	0.86
372_F	522_N	0.570	0.86
235_I	241_A	0.570	0.86
371_H	382_S	0.569	0.86
274_T	285_I	0.569	0.86
355_M	364_L	0.569	0.86
276_Q	290_E	0.569	0.86
169_I	174_G	0.568	0.86
372_F	382_S	0.568	0.86
209_A	215_K	0.564	0.85
203_A	216_T	0.564	0.85
94_G	99_I	0.563	0.85
172_K	176_P	0.563	0.85
204_R	210_L	0.560	0.85
273_T	277_A	0.560	0.85
461_V	465_I	0.559	0.85
430_E	433_R	0.557	0.85
148_C	153_M	0.557	0.85
219_L	222_H	0.556	0.84
419_E	423_I	0.555	0.84
148_C	151_L	0.554	0.84
141_G	152_T	0.553	0.84
352_L	362_R	0.553	0.84
185_G	189_L	0.553	0.84
274_T	287_N	0.552	0.84
394_L	402_L	0.552	0.84
86_G	93_T	0.551	0.84
511_N	525_H	0.550	0.84
455_L	523_V	0.550	0.84
93_T	96_I	0.549	0.84
308_K	311_V	0.549	0.84
143_L	147_L	0.549	0.84
311_V	314_T	0.548	0.84
276_Q	288_N	0.548	0.84
368_I	371_H	0.548	0.84
184_I	191_V	0.546	0.83
122_G	129_N	0.545	0.83
379_A	383_S	0.545	0.83
140_V	147_L	0.544	0.83
472_C	475_K	0.544	0.83
372_F	378_N	0.544	0.83
106_I	120_L	0.544	0.83
353_R	371_H	0.543	0.83
452_I	456_L	0.542	0.83
89_V	92_I	0.542	0.83
323_H	326_T	0.540	0.83
255_Y	259_G	0.540	0.83
107_G	114_C	0.539	0.83
415_D	421_Y	0.539	0.83
354_E	360_E	0.539	0.83
168_D	172_K	0.538	0.82
273_T	276_Q	0.538	0.82
164_A	177_M	0.538	0.82
375_N	381_S	0.537	0.82
89_V	94_G	0.537	0.82
110_T	113_P	0.536	0.82
127_W	130_L	0.535	0.82
142_I	151_L	0.534	0.82
466_V	513_M	0.534	0.82
252_V	256_V	0.533	0.82
461_V	478_V	0.532	0.82
131_K	134_K	0.532	0.82
124_I	131_K	0.531	0.82
86_G	100_H	0.530	0.81
317_I	321_H	0.529	0.81
209_A	220_F	0.529	0.81
284_I	287_N	0.528	0.81
168_D	173_I	0.525	0.81
379_A	386_L	0.525	0.81
213_A	220_F	0.525	0.81
234_I	237_D	0.524	0.81
376_A	522_N	0.523	0.81
283_I	286_K	0.523	0.81
109_V	112_I	0.523	0.81
97_A	102_Y	0.523	0.81
118_S	127_W	0.523	0.81
309_G	312_T	0.522	0.81
459_P	520_L	0.521	0.80
443_D	483_A	0.520	0.80
285_I	290_E	0.520	0.80
214_N	220_F	0.520	0.80
108_G	112_I	0.519	0.80
384_I	388_P	0.518	0.80
147_L	150_T	0.518	0.80
472_C	478_V	0.518	0.80
368_I	373_L	0.516	0.80
254_A	259_G	0.516	0.80
151_L	156_V	0.515	0.80
373_L	395_I	0.513	0.79
144_G	154_I	0.513	0.79
106_I	114_C	0.510	0.79
257_G	264_Q	0.507	0.79
327_S	331_E	0.507	0.79
305_L	313_G	0.506	0.78
374_F	392_R	0.505	0.78
397_N	402_L	0.504	0.78
378_N	381_S	0.503	0.78
98_G	101_R	0.502	0.78
166_G	169_I	0.502	0.78
272_P	275_R	0.501	0.78
212_I	219_L	0.500	0.78
457_I	480_I	0.500	0.78
502_P	539_R	0.500	0.78
416_I	419_E	0.500	0.78

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4i5sA	2	0.4425	100	0.595	Contact Map
3a0rA	2	0.5381	100	0.599	Contact Map
4gczA	2	0.5912	100	0.603	Contact Map
4bixA	2	0.3593	100	0.615	Contact Map
4ctiA	2	0.3717	100	0.62	Contact Map
4q20A	2	0.3558	100	0.625	Contact Map
4mpcA	2	0.5044	100	0.627	Contact Map
3d36A	2	0.3398	100	0.629	Contact Map
2q8gA	2	0.5009	100	0.632	Contact Map
3jz3A	2	0.2442	100	0.634	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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