GREMLIN Database
YEAY - Uncharacterized lipoprotein YeaY
UniProt: P0AA91 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13511
Length: 193 (168)
Sequences: 387 (317)
Seq/√Len: 24.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_V77_A3.8691.00
44_V58_F3.6521.00
73_R100_D3.4631.00
76_I115_V3.2591.00
77_A121_I3.1371.00
99_A141_V2.9371.00
161_D164_F2.9301.00
75_E136_F2.9221.00
97_I137_M2.8190.99
74_L105_L2.7470.99
110_F144_Y2.5540.99
113_Q146_R2.2730.97
104_F107_P2.2270.97
75_E134_Y2.1790.97
12_L21_S2.1300.96
86_R114_L2.0880.96
106_D109_D2.0710.96
75_E127_G2.0160.95
29_A145_K1.9930.94
74_L115_V1.9120.93
101_V105_L1.8980.93
57_R85_A1.8910.93
41_L44_V1.8700.92
41_L78_T1.7840.90
57_R65_V1.7370.89
73_R98_Y1.7250.89
168_R171_P1.7200.89
27_P143_G1.7110.88
159_P163_W1.6860.88
127_G136_F1.6710.87
101_V141_V1.6690.87
67_N104_F1.6450.86
62_V146_R1.6240.86
30_I57_R1.6230.85
68_Q71_K1.5290.82
57_R107_P1.5100.81
100_D125_V1.5070.81
137_M172_Y1.5060.81
59_G81_L1.4480.78
113_Q134_Y1.4310.77
125_V138_V1.4140.76
124_A135_K1.3950.75
48_P51_Y1.3850.75
64_A75_E1.3630.74
27_P57_R1.3620.74
126_D135_K1.3410.72
56_A139_M1.3360.72
58_F81_L1.3270.72
58_F79_V1.2950.70
38_Q56_A1.2870.69
161_D173_G1.2300.66
57_R104_F1.2300.66
115_V144_Y1.2290.66
41_L129_I1.2280.66
65_V107_P1.2220.65
73_R138_V1.1840.63
117_V139_M1.1750.62
21_S153_V1.1390.60
68_Q131_N1.1220.58
24_V102_N1.1090.57
93_S161_D1.1020.57
20_L99_A1.0930.56
164_F173_G1.0890.56
11_I15_T1.0870.56
166_G172_Y1.0700.55
10_G13_A1.0690.55
63_V136_F1.0600.54
19_M106_D1.0590.54
171_P175_G1.0530.54
83_S140_Q1.0410.53
16_F20_L1.0380.52
114_L150_T1.0330.52
58_F148_H1.0310.52
121_I153_V1.0310.52
30_I51_Y1.0240.51
89_L151_Q1.0170.51
27_P30_I0.9950.49
105_L141_V0.9950.49
34_S40_D0.9880.49
49_Q90_G0.9590.47
129_I136_F0.9550.47
62_V113_Q0.9550.47
57_R118_V0.9540.46
167_G170_W0.9460.46
31_K101_V0.9440.46
71_K100_D0.9380.45
173_G176_G0.9380.45
78_T94_R0.9370.45
57_R129_I0.9350.45
67_N73_R0.9300.45
70_G118_V0.9290.45
79_V89_L0.9280.45
62_V109_D0.9210.44
168_R173_G0.9160.44
22_G92_P0.9120.43
81_L151_Q0.9100.43
11_I70_G0.9060.43
63_V166_G0.9030.43
18_L33_S0.9020.43
40_D43_R0.8910.42
138_V161_D0.8770.41
121_I159_P0.8750.41
91_E114_L0.8730.41
10_G14_G0.8710.41
64_A111_R0.8690.40
65_V77_A0.8650.40
74_L144_Y0.8570.40
106_D158_Q0.8450.39
93_S151_Q0.8410.39
44_V117_V0.8350.38
59_G125_V0.8290.38
115_V176_G0.8290.38
38_Q54_Q0.8150.37
99_A128_K0.8090.36
65_V104_F0.8060.36
80_P165_Y0.8050.36
22_G37_P0.8040.36
30_I35_P0.8030.36
13_A117_V0.8020.36
39_Q85_A0.7960.36
113_Q136_F0.7950.35
22_G136_F0.7930.35
67_N85_A0.7920.35
83_S172_Y0.7910.35
64_A126_D0.7880.35
58_F97_I0.7860.35
102_N154_I0.7840.35
79_V118_V0.7800.34
26_V85_A0.7780.34
72_T113_Q0.7780.34
46_S128_K0.7750.34
17_A112_G0.7740.34
115_V133_P0.7730.34
14_G42_V0.7730.34
51_Y149_L0.7690.34
106_D127_G0.7580.33
93_S130_G0.7560.33
13_A17_A0.7550.33
40_D136_F0.7540.33
80_P167_G0.7530.33
167_G171_P0.7500.33
116_T147_W0.7480.32
94_R105_L0.7460.32
56_A144_Y0.7440.32
129_I165_Y0.7400.32
98_Y125_V0.7320.31
53_G121_I0.7290.31
54_Q74_L0.7280.31
63_V133_P0.7280.31
48_P134_Y0.7260.31
29_A118_V0.7190.31
13_A21_S0.7190.31
60_G119_G0.7170.31
39_Q97_I0.7150.30
103_G139_M0.7130.30
19_M126_D0.7110.30
61_K112_G0.7070.30
22_G134_Y0.7070.30
56_A86_R0.7030.30
112_G154_I0.7030.30
120_P140_Q0.7020.30
15_T82_D0.6970.29
39_Q112_G0.6950.29
70_G135_K0.6920.29
117_V141_V0.6900.29
21_S145_K0.6840.29
29_A88_T0.6830.29
19_M22_G0.6820.28
24_V85_A0.6820.28
32_G110_F0.6800.28
96_R134_Y0.6760.28
117_V171_P0.6690.28
19_M159_P0.6690.28
28_D126_D0.6660.28
81_L121_I0.6660.28
77_A136_F0.6650.27
51_Y123_G0.6640.27
16_F21_S0.6590.27
79_V91_E0.6550.27
80_P88_T0.6530.27
165_Y172_Y0.6490.27
35_P57_R0.6450.26
26_V53_G0.6420.26
85_A132_T0.6420.26
163_W169_G0.6400.26
42_V45_M0.6400.26
80_P176_G0.6340.26
110_F118_V0.6330.26
163_W175_G0.6310.26
99_A117_V0.6310.26
96_R130_G0.6250.25
34_S118_V0.6240.25
15_T21_S0.6210.25
12_L16_F0.6170.25
91_E109_D0.6100.24
66_Q125_V0.6090.24
105_L114_L0.6020.24
24_V62_V0.5960.24
99_A157_P0.5950.24
31_K150_T0.5920.23
79_V106_D0.5890.23
30_I48_P0.5850.23
60_G147_W0.5840.23
65_V101_V0.5830.23
17_A48_P0.5810.23
60_G87_P0.5800.23
30_I133_P0.5770.23
53_G81_L0.5760.23
16_F42_V0.5730.23
41_L45_M0.5720.22
41_L79_V0.5700.22
48_P53_G0.5700.22
24_V83_S0.5650.22
28_D101_V0.5640.22
18_L171_P0.5630.22
22_G84_G0.5620.22
120_P176_G0.5600.22
56_A114_L0.5560.22
18_L164_F0.5540.22
80_P91_E0.5500.21
78_T97_I0.5490.21
81_L86_R0.5470.21
110_F115_V0.5470.21
53_G174_Y0.5460.21
43_R106_D0.5430.21
162_P172_Y0.5420.21
14_G21_S0.5410.21
145_K148_H0.5380.21
108_V136_F0.5340.21
59_G147_W0.5330.21
65_V105_L0.5310.20
88_T136_F0.5310.20
63_V79_V0.5310.20
57_R71_K0.5300.20
87_P116_T0.5270.20
99_A140_Q0.5220.20
76_I142_T0.5210.20
66_Q73_R0.5200.20
20_L23_C0.5180.20
86_R144_Y0.5170.20
56_A152_Q0.5150.20
164_F175_G0.5130.20
69_Q139_M0.5120.20
58_F129_I0.5120.20
30_I58_F0.5110.20
65_V72_T0.5100.20
38_Q58_F0.5090.19
63_V108_V0.5070.19
74_L109_D0.5060.19
10_G129_I0.5060.19
41_L109_D0.5050.19
27_P65_V0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zbiC 1 0.1399 74.2 0.935 Contact Map
2hyxA 2 0.8653 61.7 0.94 Contact Map
2w7yA 1 0.6166 52.2 0.944 Contact Map
1sr3A 1 0.5078 30.1 0.951 Contact Map
1r9dA 2 0.4041 29.1 0.951 Contact Map
4utoA 1 0.6218 27.1 0.952 Contact Map
2y8nA 2 0.4041 24.3 0.953 Contact Map
4jg9A 2 0.5855 20.4 0.955 Contact Map
5a0uA 2 0.4093 20 0.955 Contact Map
2vozA 3 0.7358 19.9 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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