GREMLIN Database
DOSC - Diguanylate cyclase DosC
UniProt: P0AA89 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13793
Length: 460 (396)
Sequences: 1722 (1624)
Seq/√Len: 81.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
336_K450_R6.5471.00
365_R368_D6.1341.00
330_L394_A5.4441.00
330_L420_I5.0801.00
445_A454_E4.1421.00
328_S424_M3.8571.00
293_H297_M3.7981.00
395_E398_R3.7331.00
402_E451_N3.5451.00
401_V418_L3.4881.00
439_D443_Y3.0251.00
346_H439_D2.8061.00
352_I416_L2.7761.00
316_E319_H2.7501.00
422_A453_V2.7101.00
436_Q440_E2.6261.00
342_D443_Y2.6131.00
346_H443_Y2.5261.00
303_L357_S2.5251.00
309_L371_F2.5011.00
309_L379_I2.4981.00
313_F431_Y2.4441.00
334_V356_V2.4081.00
342_D346_H2.4021.00
364_V370_V2.3731.00
347_N436_Q2.3401.00
335_D419_S2.2921.00
322_R365_R2.2861.00
382_L393_T2.2321.00
338_K342_D2.2161.00
328_S390_T2.2071.00
332_I420_I2.1671.00
374_G443_Y2.1471.00
430_D433_R2.1421.00
360_F370_V2.1381.00
334_V418_L2.1211.00
376_D417_S2.1201.00
342_D439_D2.0981.00
340_I352_I2.0841.00
338_K443_Y2.0711.00
331_I442_L2.0661.00
331_I435_I2.0591.00
374_G439_D2.0421.00
304_L308_F2.0371.00
338_K346_H2.0031.00
375_G439_D1.9961.00
365_R396_R1.9911.00
417_S451_N1.9821.00
386_S389_E1.9811.00
445_A449_G1.9711.00
303_L370_V1.9561.00
333_D338_K1.9441.00
375_G443_Y1.9361.00
445_A452_R1.9301.00
334_V353_L1.9281.00
359_A405_K1.9051.00
330_L382_L1.8921.00
312_I315_R1.8561.00
398_R453_V1.8501.00
304_L369_Y1.8251.00
330_L380_I1.8001.00
296_G308_F1.7911.00
312_I371_F1.7571.00
394_A420_I1.7441.00
333_D346_H1.7401.00
390_T394_A1.7361.00
346_H377_E1.7101.00
398_R451_N1.7061.00
342_D375_G1.7041.00
429_P437_I1.6961.00
308_F312_I1.6951.00
379_I435_I1.6921.00
284_R288_E1.6671.00
333_D443_Y1.6481.00
426_N437_I1.6311.00
423_A434_L1.6211.00
301_T353_L1.6161.00
319_H322_R1.6151.00
309_L435_I1.6031.00
377_E443_Y1.5961.00
398_R402_E1.5941.00
390_T422_A1.5891.00
421_G438_A1.5631.00
373_Y435_I1.5611.00
346_H375_G1.5531.00
303_L360_F1.5431.00
448_R452_R1.5290.99
331_I376_D1.5260.99
331_I379_I1.5260.99
355_K358_Q1.5100.99
371_F379_I1.5060.99
308_F369_Y1.4900.99
352_I376_D1.4800.99
357_S370_V1.4760.99
337_F445_A1.4710.99
339_E376_D1.4650.99
357_S360_F1.4540.99
333_D375_G1.4490.99
368_D396_R1.4340.99
393_T396_R1.4190.99
448_R454_E1.4170.99
425_F434_L1.4090.99
341_N349_G1.3880.99
352_I442_L1.3720.99
325_T384_E1.3700.99
376_D442_L1.3680.99
444_I454_E1.3530.99
316_E383_T1.3470.99
335_D450_R1.3450.99
376_D452_R1.3390.99
338_K439_D1.3380.99
373_Y379_I1.3300.99
334_V417_S1.3300.99
428_H437_I1.3180.98
299_V307_R1.3120.98
342_D377_E1.2820.98
276_V279_I1.2450.98
374_G377_E1.2440.98
394_A422_A1.2360.98
359_A404_T1.2340.98
328_S385_A1.2230.97
336_K442_L1.2200.97
288_E292_R1.2110.97
316_E322_R1.2110.97
382_L390_T1.2100.97
337_F353_L1.2040.97
206_L210_L1.1940.97
377_E439_D1.1940.97
271_Q274_N1.1830.97
279_I282_L1.1720.97
172_F176_E1.1710.97
385_A389_E1.1690.97
350_D439_D1.1660.97
346_H374_G1.1610.96
317_I425_F1.1590.96
395_E399_S1.1590.96
292_R296_G1.1590.96
333_D446_K1.1540.96
376_D451_N1.1520.96
398_R417_S1.1480.96
420_I453_V1.1390.96
376_D453_V1.1390.96
333_D377_E1.1350.96
336_K376_D1.1330.96
322_R367_S1.1330.96
348_T409_A1.1280.96
310_P371_F1.1280.96
350_D375_G1.1260.96
176_E180_E1.1240.96
309_L381_V1.1220.96
294_E307_R1.1120.95
333_D342_D1.1110.95
439_D450_R1.1090.95
347_N435_I1.1040.95
306_R350_D1.0990.95
337_F441_A1.0990.95
155_F158_S1.0860.95
348_T414_I1.0700.94
338_K375_G1.0660.94
312_I369_Y1.0570.94
442_L450_R1.0570.94
323_T384_E1.0520.94
333_D439_D1.0490.94
417_S442_L1.0450.94
349_G375_G1.0410.94
351_E355_K1.0310.93
331_I438_A1.0300.93
297_M303_L1.0290.93
443_Y450_R1.0180.93
335_D442_L1.0170.93
183_E187_A1.0140.93
317_I434_L1.0130.93
346_H419_S1.0120.93
394_A418_L1.0110.93
376_D398_R1.0080.92
376_D443_Y1.0060.92
351_E354_R1.0060.92
296_G304_L1.0040.92
341_N377_E1.0010.92
329_V435_I0.9990.92
198_Y206_L0.9960.92
219_L223_H0.9910.92
441_A445_A0.9900.92
335_D417_S0.9900.92
335_D439_D0.9880.92
332_I360_F0.9870.92
284_R287_F0.9810.91
309_L313_F0.9810.91
337_F376_D0.9750.91
316_E327_L0.9720.91
375_G446_K0.9700.91
339_E343_T0.9650.91
434_L437_I0.9650.91
297_M304_L0.9620.91
186_I190_L0.9600.91
342_D419_S0.9600.91
423_A438_A0.9590.90
308_F371_F0.9560.90
426_N434_L0.9530.90
327_L381_V0.9520.90
337_F352_I0.9460.90
344_W352_I0.9440.90
338_K377_E0.9370.89
333_D376_D0.9370.89
377_E446_K0.9360.89
333_D341_N0.9360.89
88_I93_T0.9340.89
313_F381_V0.9310.89
346_H450_R0.9310.89
208_S268_F0.9300.89
242_I246_D0.9280.89
338_K341_N0.9270.89
439_D446_K0.9250.89
297_M442_L0.9250.89
356_V401_V0.9160.88
338_K374_G0.9140.88
59_E63_R0.9140.88
342_D446_K0.9100.88
374_G419_S0.9050.88
294_E299_V0.8970.87
317_I371_F0.8960.87
405_K409_A0.8930.87
308_F311_T0.8910.87
346_H446_K0.8910.87
78_S82_D0.8860.87
341_N375_G0.8840.86
330_L422_A0.8840.86
360_F397_I0.8840.86
449_G452_R0.8830.86
261_N264_L0.8830.86
376_D450_R0.8820.86
275_T279_I0.8810.86
320_A327_L0.8760.86
197_I210_L0.8750.86
419_S439_D0.8720.86
282_L286_L0.8680.85
332_I380_I0.8660.85
204_S221_F0.8640.85
198_Y275_T0.8640.85
154_A157_F0.8570.85
171_I179_E0.8570.85
332_I418_L0.8570.85
338_K450_R0.8540.85
346_H350_D0.8500.84
335_D451_N0.8490.84
219_L255_N0.8430.84
162_A166_D0.8420.84
130_A134_L0.8390.84
100_R103_I0.8370.83
338_K349_G0.8290.83
280_I285_E0.8270.83
213_S223_H0.8270.83
376_D445_A0.8260.83
242_I248_I0.8250.82
87_L91_Q0.8220.82
335_D449_G0.8200.82
376_D439_D0.8160.82
333_D349_G0.8160.82
206_L213_S0.8150.82
419_S443_Y0.8120.81
398_R418_L0.8110.81
279_I284_R0.8100.81
402_E417_S0.8060.81
431_Y435_I0.8050.81
261_N268_F0.8040.81
337_F442_L0.8020.81
385_A390_T0.8010.81
337_F449_G0.7990.80
333_D374_G0.7940.80
444_I447_R0.7900.80
254_R258_N0.7870.79
423_A437_I0.7810.79
350_D372_R0.7810.79
212_L215_A0.7790.79
72_W76_V0.7780.79
299_V373_Y0.7770.79
87_L94_V0.7730.78
300_L377_E0.7720.78
308_F442_L0.7720.78
355_K359_A0.7720.78
340_I405_K0.7710.78
88_I94_V0.7700.78
409_A412_E0.7690.78
263_S269_L0.7680.78
342_D374_G0.7670.78
168_N175_L0.7670.78
376_D449_G0.7660.78
237_H240_R0.7660.78
374_G446_K0.7640.77
210_L279_I0.7630.77
242_I245_F0.7620.77
93_T96_E0.7620.77
289_E292_R0.7600.77
365_R393_T0.7600.77
340_I415_A0.7590.77
63_R68_A0.7580.77
417_S449_G0.7580.77
342_D450_R0.7560.77
365_R385_A0.7550.77
398_R401_V0.7540.76
308_F416_L0.7470.76
287_F291_S0.7460.76
331_I373_Y0.7440.75
344_W376_D0.7440.75
306_R374_G0.7440.75
297_M376_D0.7430.75
342_D350_D0.7420.75
254_R257_R0.7400.75
427_G455_L0.7380.75
352_I409_A0.7380.75
341_N346_H0.7360.75
352_I371_F0.7300.74
299_V310_P0.7280.74
327_L425_F0.7280.74
168_N172_F0.7280.74
290_V294_E0.7270.74
443_Y446_K0.7270.74
73_I80_Q0.7260.74
295_V308_F0.7250.74
322_R368_D0.7250.74
368_D393_T0.7250.74
285_E288_E0.7230.73
296_G307_R0.7220.73
421_G443_Y0.7220.73
176_E186_I0.7210.73
344_W414_I0.7210.73
444_I448_R0.7210.73
311_T315_R0.7190.73
186_I193_E0.7150.73
119_L123_I0.7090.72
328_S422_A0.7080.72
162_A165_E0.7060.72
304_L331_I0.7030.71
352_I406_L0.7030.71
306_R346_H0.7020.71
70_E73_I0.6960.71
349_G377_E0.6950.70
385_A424_M0.6930.70
356_V416_L0.6920.70
146_I151_M0.6900.70
95_A102_G0.6850.69
154_A159_D0.6840.69
68_A76_V0.6830.69
338_K446_K0.6830.69
340_I343_T0.6830.69
364_V393_T0.6820.69
182_K185_Q0.6820.69
67_S74_I0.6810.69
62_E75_N0.6790.69
199_K210_L0.6790.69
180_E183_E0.6780.69
307_R352_I0.6780.69
277_S280_I0.6760.68
371_F431_Y0.6740.68
423_A441_A0.6730.68
300_L349_G0.6690.67
109_E113_R0.6680.67
98_H103_I0.6680.67
337_F419_S0.6680.67
295_V342_D0.6670.67
349_G446_K0.6660.67
300_L333_D0.6640.67
307_R365_R0.6640.67
276_V280_I0.6640.67
121_P126_S0.6630.67
189_I194_I0.6620.67
62_E65_L0.6620.67
226_R242_I0.6610.67
295_V373_Y0.6610.67
266_V273_R0.6600.66
196_I216_D0.6560.66
333_D372_R0.6560.66
333_D350_D0.6550.66
156_T162_A0.6550.66
74_I78_S0.6530.66
215_A223_H0.6530.66
372_R419_S0.6520.66
346_H349_G0.6520.66
399_S402_E0.6510.65
191_S196_I0.6500.65
59_E78_S0.6470.65
365_R382_L0.6460.65
387_E455_L0.6450.65
275_T280_I0.6450.65
311_T369_Y0.6430.64
238_I241_L0.6410.64
360_F364_V0.6400.64
60_Q65_L0.6390.64
296_G312_I0.6390.64
336_K340_I0.6390.64
58_N63_R0.6380.64
179_E183_E0.6380.64
342_D349_G0.6380.64
206_L211_P0.6370.64
124_F130_A0.6370.64
61_V64_Q0.6350.63
60_Q63_R0.6340.63
302_K354_R0.6330.63
338_K376_D0.6330.63
356_V418_L0.6320.63
185_Q203_D0.6300.63
157_F161_S0.6290.63
244_D248_I0.6280.63
317_I320_A0.6280.63
370_V380_I0.6260.62
72_W78_S0.6250.62
342_D376_D0.6250.62
78_S84_V0.6240.62
291_S294_E0.6240.62
343_T397_I0.6240.62
359_A363_N0.6230.62
126_S140_S0.6230.62
196_I199_K0.6230.62
61_V68_A0.6230.62
91_Q95_A0.6220.62
138_H142_N0.6210.62
407_K413_D0.6210.62
63_R66_K0.6210.62
59_E68_A0.6190.62
395_E453_V0.6170.61
75_N79_A0.6170.61
114_V117_K0.6160.61
66_K81_V0.6160.61
191_S216_D0.6160.61
417_S450_R0.6150.61
279_I285_E0.6140.61
254_R271_Q0.6130.61
352_I398_R0.6130.61
306_R310_P0.6110.61
189_I200_I0.6080.60
99_A105_V0.6070.60
383_T390_T0.6070.60
300_L341_N0.6060.60
186_I197_I0.6060.60
346_H376_D0.6050.60
91_Q104_P0.6050.60
304_L379_I0.6040.60
336_K339_E0.6040.60
334_V442_L0.6030.60
296_G371_F0.6030.60
68_A74_I0.6030.60
70_E78_S0.6020.59
409_A414_I0.6010.59
86_R90_I0.6010.59
195_D278_Q0.6010.59
328_S394_A0.6000.59
110_M116_K0.5980.59
74_I80_Q0.5980.59
169_Y172_F0.5970.59
130_A133_K0.5950.58
425_F428_H0.5930.58
135_Q144_I0.5930.58
241_L245_F0.5930.58
340_I414_I0.5920.58
391_L453_V0.5910.58
391_L395_E0.5910.58
295_V439_D0.5910.58
239_S242_I0.5900.58
320_A425_F0.5900.58
61_V70_E0.5890.58
364_V368_D0.5880.58
183_E189_I0.5880.58
310_P432_E0.5880.58
107_I112_F0.5860.57
147_A160_S0.5860.57
295_V436_Q0.5840.57
423_A426_N0.5840.57
335_D346_H0.5830.57
104_P108_V0.5830.57
205_D210_L0.5820.57
346_H442_L0.5810.57
319_H383_T0.5800.57
339_E417_S0.5760.56
174_L177_N0.5760.56
360_F451_N0.5760.56
240_R253_M0.5750.56
320_A324_G0.5720.56
332_I435_I0.5720.56
91_Q98_H0.5720.56
234_E241_L0.5710.55
263_S278_Q0.5710.55
96_E103_I0.5700.55
345_G349_G0.5690.55
133_K136_V0.5690.55
196_I200_I0.5680.55
147_A155_F0.5680.55
161_S168_N0.5680.55
199_K202_L0.5680.55
212_L219_L0.5680.55
387_E424_M0.5660.55
330_L393_T0.5650.55
406_L416_L0.5640.54
297_M340_I0.5620.54
359_A398_R0.5620.54
68_A73_I0.5610.54
402_E415_A0.5600.54
88_I103_I0.5590.54
278_Q282_L0.5590.54
115_L120_Y0.5590.54
161_S164_K0.5580.54
352_I369_Y0.5580.54
306_R439_D0.5570.54
306_R345_G0.5570.54
398_R450_R0.5570.54
190_L193_E0.5550.53
337_F394_A0.5550.53
307_R376_D0.5520.53
334_V398_R0.5520.53
70_E75_N0.5520.53
304_L371_F0.5510.53
323_T367_S0.5510.53
387_E390_T0.5500.53
77_L81_V0.5490.53
179_E185_Q0.5490.53
392_R396_R0.5480.52
295_V419_S0.5470.52
87_L98_H0.5440.52
305_N378_F0.5440.52
72_W79_A0.5430.52
348_T351_E0.5430.52
67_S70_E0.5430.52
344_W442_L0.5420.52
389_E392_R0.5420.52
59_E79_A0.5400.51
177_N181_E0.5400.51
300_L353_L0.5400.51
60_Q77_L0.5400.51
277_S281_T0.5390.51
84_V87_L0.5380.51
372_R375_G0.5380.51
312_I316_E0.5380.51
175_L183_E0.5370.51
380_I422_A0.5360.51
257_R260_N0.5360.51
73_I78_S0.5350.51
69_M72_W0.5340.51
364_V397_I0.5340.51
94_V103_I0.5330.50
145_D159_D0.5320.50
160_S165_E0.5310.50
226_R249_F0.5310.50
58_N62_E0.5310.50
150_V154_A0.5310.50
258_N265_R0.5300.50
317_I431_Y0.5290.50
185_Q199_K0.5290.50
170_R175_L0.5280.50
151_M154_A0.5270.50
223_H231_G0.5250.49
158_S161_S0.5250.49
312_I381_V0.5250.49
74_I77_L0.5240.49
303_L352_I0.5240.49
62_E68_A0.5230.49
358_Q361_Y0.5230.49
67_S73_I0.5220.49
285_E289_E0.5220.49
345_G406_L0.5210.49
226_R229_F0.5210.49
407_K411_G0.5210.49
62_E80_Q0.5200.49
414_I442_L0.5180.48
229_F232_I0.5170.48
71_R74_I0.5170.48
334_V436_Q0.5170.48
223_H229_F0.5160.48
296_G431_Y0.5150.48
237_H244_D0.5130.48
365_R443_Y0.5120.48
440_E447_R0.5120.48
297_M331_I0.5120.48
327_L384_E0.5120.48
280_I288_E0.5110.48
162_A172_F0.5110.48
76_V80_Q0.5080.47
58_N77_L0.5080.47
150_V209_S0.5080.47
259_L264_L0.5080.47
220_W225_G0.5070.47
446_K450_R0.5070.47
369_Y381_V0.5060.47
300_L372_R0.5060.47
308_F316_E0.5060.47
120_Y127_D0.5060.47
119_L126_S0.5050.47
136_V139_F0.5050.47
238_I242_I0.5040.47
146_I169_Y0.5030.47
382_L441_A0.5020.46
196_I334_V0.5020.46
254_R260_N0.5020.46
179_E184_R0.5010.46
183_E186_I0.5010.46
61_V71_R0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w25A 2 0.6457 100 0.473 Contact Map
4h54A 2 0.5891 100 0.495 Contact Map
4j40A 2 0 100 0.499 Contact Map
3pjxA 1 0.3848 100 0.507 Contact Map
3ezuA 2 0.663 100 0.511 Contact Map
4rnhA 2 0.3457 100 0.517 Contact Map
3i5cA 2 0.4196 100 0.522 Contact Map
3tvkA 1 0.3609 100 0.529 Contact Map
3ignA 1 0.3587 100 0.531 Contact Map
3mtkA 2 0.3457 100 0.532 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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